Aliases for FLG2 Gene
External Ids for FLG2 Gene
Previous GeneCards Identifiers for FLG2 Gene
The filaggrin-like protein encoded by this gene is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. The encoded protein is required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa. [provided by RefSeq, Dec 2015]
GeneCards Summary for FLG2 Gene
FLG2 (Filaggrin Family Member 2) is a Protein Coding gene. Diseases associated with FLG2 include Peeling Skin Syndrome 6 and Peeling Skin Syndrome Type A. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural molecule activity. An important paralog of this gene is FLG.
UniProtKB/Swiss-Prot Summary for FLG2 Gene
Essential for normal cell-cell adhesion in the cornified cell layers (PubMed:29758285). Important for proper integrity and mechanical strength of the stratum corneum of the epidermis (PubMed:29505760).