Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individ... See more...
Aliases for FLG Gene
External Ids for FLG Gene
- HGNC: 3748
- Entrez Gene: 2312
- Ensembl: ENSG00000143631
- OMIM: 135940
- UniProtKB: P20930
Previous GeneCards Identifiers for FLG Gene
- GC01M150115
- GC01M148057
- GC01M149049
- GC01M149491
- GC01M149089
- GC01M150541
- GC01M123649
Summaries for FLG Gene
-
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
GeneCards Summary for FLG Gene
FLG (Filaggrin) is a Protein Coding gene. Diseases associated with FLG include Dermatitis, Atopic, 2 and Ichthyosis Vulgaris. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural molecule activity. An important paralog of this gene is HRNR.
UniProtKB/Swiss-Prot Summary for FLG Gene
-
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Additional gene information for FLG Gene
- HGNC(3748)
- Entrez Gene(2312)
- Ensembl(ENSG00000143631)
- OMIM(135940)
- UniProtKB(P20930)
- Open Targets Platform(ENSG00000143631)
- Monarch Initiative
- Search for FLG at DataMed
- Search for FLG at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FLG Gene
Genomics for FLG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FLG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FLG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FLG
- Top Transcription factor binding sites by QIAGEN in the FLG gene promoter:
-
- AML1a
- C/EBPalpha
- CUTL1
- E47
- Lmo2
- Pax-3
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- STAT5A
- Tal-1
Genomic Locations for FLG Gene
Genomic Locations for FLG Gene
- chr1:152,302,165-152,325,239
- (GRCh38/hg38)
- Size:
- 23,075 bases
- Orientation:
- Minus strand
- chr1:152,274,651-152,297,679
- (GRCh37/hg19)
- Size:
- 23,029 bases
- Orientation:
- Minus strand
Genomic View for FLG Gene
Genes around FLG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by HGNC
- 1q21.3 by Entrez Gene
- 1q21.3 by Ensembl
FLG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FLG Gene
Proteins for FLG Gene
-
Protein details for FLG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20930-FILA_HUMAN
- Recommended name:
- Filaggrin
- Protein Accession:
- P20930
- Q01720
- Q5T583
- Q9UC71
Protein attributes for FLG Gene
- Size:
- 4061 amino acids
- Molecular mass:
- 435170 Da
- Quaternary structure:
- No Data Available
Protein Expression for FLG Gene
Post-translational modifications for FLG Gene
- Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.
- Undergoes deimination of some arginine residues (citrullination).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FLG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FILA Polyclonal Antibody
- NSJ Bioreagents Filaggrin Antibody (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for FLG
- Novus Biologicals Antibodies for FLG
-
Abcam antibodies for FLG
- Invitrogen Antibodies for FLG (AFLGC-FLG)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FLG
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FLG
- Origene Custom Protein Services for FLG
- Novus Biologicals proteins for FLG
Assay Products
- G Biosciences Immunotag™ Human FLG (Filaggrin) ELISA and Immunotag™ Filaggrin ELISA Kit
-
Signalway ELISA kits for FLG
No data available for DME Specific Peptides for FLG Gene
Domains & Families for FLG Gene
Gene Families for FLG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FLG Gene
- InterPro:
- Blocks:
-
- Calcium-binding protein, S-100/ICaBP type
- ProtoNet:
Suggested Antigen Peptide Sequences for FLG Gene
- GenScript: Design optimal peptide antigens:
-
- Filaggrin (FILA_HUMAN)
- Profilaggrin (Q03837_HUMAN)
- Profilaggrin (Q03838_HUMAN)
- Profilaggrin (Q03839_HUMAN)
- Profilaggrin (Q15206_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P20930- Family:
-
- Belongs to the S100-fused protein family.
Function for FLG Gene
Molecular function for FLG Gene
- UniProtKB/Swiss-Prot Function:
- Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
- UniProtKB/Swiss-Prot Induction:
- In cultured foreskin fibroblasts, up-regulated in response to Ca(2+) stimulation.
- GENATLAS Biochemistry:
- filaggrin,44kDa,intermediate filament associated protein (IFAP,type I),expressed in the horny layer of stratified epithelia,aggregating keratin filaments and promoting disulfite-bonding,component of the epidermal differentiation complex (EDC@)
Phenotypes From GWAS Catalog for FLG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | NAS | 2740331 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 23629652 |
| GO:0030280 | structural constituent of epidermis | IDA | 7543090 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for FLG Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FLG - Select products 50% OFF >
- * FLG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FLG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLG
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLG
miRNA for FLG Gene
- miRTarBase miRNAs that target FLG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLG
- Browse OriGene Inhibitory RNA Products For FLG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLG
Clone Products
- Applied Biological Materials (abm): Clones for FLG - Select products 50% OFF >
- * FLG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLG
Cell Line Products
-
Horizon Cell Lines for FLG
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FLG Gene
Localization for FLG Gene
Subcellular locations from UniProtKB/Swiss-Prot for FLG Gene
- Cytoplasmic granule. Note=In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). {ECO:0000269 PubMed:1429717, ECO:0000269 PubMed:21531719}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| extracellular | 4 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytoplasmic bodies (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | IBA,IDA | 7543090 |
| GO:0005634 | nucleus | HDA | 21630459 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | NAS | 2740331 |
| GO:0036457 | keratohyalin granule | IBA,IDA | 1429717 |
Pathways & Interactions for FLG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratinization |
.33
|
|
| 2 | Developmental Biology | ||
Pathways by source for FLG Gene
3 Reactome pathways for FLG Gene
Interacting Proteins for FLG Gene
Selected Interacting proteins:
P20930-FILA_HUMAN
ENSP00000357789
for FLG Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FLG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | NAS | 2740331 |
| GO:0018149 | peptide cross-linking | IDA | 7543090 |
| GO:0030216 | keratinocyte differentiation | TAS | 17704059 |
| GO:0061436 | establishment of skin barrier | IBA,IEP | 23403047 |
| GO:0070268 | cornification | TAS | -- |
Transcripts for FLG Gene
mRNA/cDNA for FLG Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000368799 12793 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FLG - Select products 50% OFF >
- * FLG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FLG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLG
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLG
- Browse OriGene Inhibitory RNA Products For FLG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLG
Clone Products
- Applied Biological Materials (abm): Clones for FLG - Select products 50% OFF >
- * FLG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLG
Relevant External Links for FLG Gene
- GeneLoc Exon Structure for
- FLG
Expression for FLG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Epidermis (Integumentary System)
- Epithelial Cells
- Hair
mRNA differential expression in normal tissues according to GTEx for FLG Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x31.1) and Skin - Not Sun Exposed (Suprapubic) (x17.7).
This gene is overexpressed in Urinary Bladder (31.0) and Skin (12.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FLG Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FLG
SOURCE GeneReport for Unigene cluster for FLG Gene:
Hs.654510mRNA Expression by UniProt/SwissProt for FLG Gene:
P20930-FILA_HUMAN
Tissue specificity:
Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417).
Evidence on tissue expression from TISSUES for FLG Gene
- Skin(4.7)
- Liver(4.4)
- Blood(2.8)
- Nervous system(2.5)
- Kidney(2.3)
- Lung(2.2)
- Spleen(2.1)
- Lymph node(2.1)
- Intestine(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FLG Gene
Germ Layers:
- ectoderm
Systems:
- integumentary
Regions:
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for FLG
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for FLG Gene
Orthologs for FLG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FLG 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Oppossum (Monodelphis domestica) |
Mammalia | FLG 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CRNN 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
- Species where no ortholog for FLG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for FLG Gene
- ENSEMBL:
- Gene Tree for FLG (if available)
- TreeFam:
- Gene Tree for FLG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FLG: view image
Paralogs for FLG Gene
(10) SIMAP similar genes for FLG Gene using alignment to 14 proteins:
- FILA_HUMAN
- I0B0K3_HUMAN
- I0B0K4_HUMAN
- I0B0K5_HUMAN
- I0B0K6_HUMAN
- I0B0K7_HUMAN
- I0B0K8_HUMAN
- L8E7P6_HUMAN
- Q03837_HUMAN
- Q03838_HUMAN
- Q03839_HUMAN
- Q15206_HUMAN
- Q16824_HUMAN
- Q4JFL9_HUMAN
Variants for FLG Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FLG Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 638422 | Likely Pathogenic: Ichthyosis vulgaris | 152,306,000(-) | CT/C | FRAMESHIFT_VARIANT | |
| 666623 | Benign: not specified | 152,313,454(-) | G/A | MISSENSE_VARIANT | |
| 666624 | Benign: not specified | 152,313,526(-) | T/C | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 678544 | Likely Benign: not provided | 152,311,732(-) | T/C | MISSENSE_VARIANT | |
| 681084 | Benign: not provided | 152,305,366(-) | T/C | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1003613 | OTHER | inversion | 20482838 |
| esv1330223 | CNV | deletion | 17803354 |
| esv25681 | CNV | loss | 19812545 |
| esv2665362 | CNV | deletion | 23128226 |
| esv2669572 | CNV | deletion | 23128226 |
| esv2671163 | CNV | deletion | 23128226 |
| esv2718117 | CNV | deletion | 23290073 |
| esv2718128 | CNV | deletion | 23290073 |
| esv3394198 | CNV | duplication | 20981092 |
| esv3587546 | CNV | gain | 21293372 |
| nsv1014095 | CNV | gain | 25217958 |
| nsv1110152 | CNV | duplication | 24896259 |
| nsv1115370 | CNV | duplication | 24896259 |
| nsv1152559 | CNV | duplication | 26484159 |
| nsv159623 | CNV | deletion | 16902084 |
| nsv471348 | CNV | gain | 19718026 |
| nsv7183 | OTHER | inversion | 18451855 |
| nsv821364 | CNV | duplication | 20802225 |
| nsv824653 | CNV | loss | 20364138 |
| nsv952208 | CNV | deletion | 24416366 |
| nsv998298 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
27.35;
99.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FLG Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLG Gene
Disorders for FLG Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dermatitis, atopic, 2 |
|
|
| ichthyosis vulgaris |
|
|
| dermatitis, atopic |
|
|
| paroxysmal dystonia |
|
|
| isolated cerebellar agenesis |
|
|
Search FLG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FILA_HUMAN- Ichthyosis vulgaris (VI) [MIM:146700]: The most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. {ECO:0000269 PubMed:16444271}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Dermatitis atopic 2 (ATOD2) [MIM:605803]: Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE-mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. {ECO:0000269 PubMed:16550169, ECO:0000269 PubMed:16815158, ECO:0000269 PubMed:17030239, ECO:0000269 PubMed:17291859}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for FLG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for FLG Gene
Publications for FLG Gene
- Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. (PMID: 17291859) Nomura T … Shimizu H (The Journal of allergy and clinical immunology 2007) 3 4 23 41
- Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. (PMID: 16815158) Weidinger S … Novak N (The Journal of allergy and clinical immunology 2006) 3 4 23 41
- Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus. (PMID: 20513523) Cramer C … LISAplus Study Group and the GINIplus Study Group (The Journal of allergy and clinical immunology 2010) 3 23 41
- Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations. (PMID: 20109745) O'Regan GM … Brown SJ (The Journal of allergy and clinical immunology 2010) 3 23 41
- Human leukocyte antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 haplotypes are associated with humoral responses to early food allergens in children. (PMID: 20016199) Savilahti EM … Savilahti E (International archives of allergy and immunology 2010) 3 23 41
ExternalLinks
Products for FLG Gene
- Custom Antibody ServicesOriGene Antibodies for FLG
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FLG
- Origene Custom Protein Services for FLG
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLG
- Browse OriGene Inhibitory RNA Products For FLG
- OriGene qPCR primer pairs for FLG
- OriGene CRISPR knockouts for FLG
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FLG
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FLG
- Novus Biologicals proteins for FLG
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FLG
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for FLG (AFLGC-FLG)
- VectorBuilder Custom and pre-made DNA vectors for FLG (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FLG (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FLG (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FLG CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FLG
- antibodies-online: Show 29 available Filaggrin Antibodies ranked by validation data
- Compare Top Filaggrin Antibodies
- antibodies-online: Show 32 available Filaggrin Elisa Kits ranked by validation data
- Compare Top Filaggrin Elisa Kits
- antibodies-online: Show 7 available Filaggrin Proteins ranked by validation data
- Compare Top Filaggrin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FLG
- Search Santa Cruz Biotechnology (SCBT) for FLG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FLG
- Horizon Cell Lines for FLG
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLG
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FLG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLG
Sources for FLG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB