Aliases for FLG Gene
External Ids for FLG Gene
- HGNC: 3748
- Entrez Gene: 2312
- Ensembl: ENSG00000143631
- OMIM: 135940
- UniProtKB: P20930
Previous GeneCards Identifiers for FLG Gene
- GC01M150115
- GC01M148057
- GC01M149049
- GC01M149491
- GC01M149089
- GC01M150541
- GC01M123649
Summaries for FLG Gene
-
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
GeneCards Summary for FLG Gene
FLG (Filaggrin) is a Protein Coding gene. Diseases associated with FLG include Dermatitis, Atopic, 2 and Ichthyosis Vulgaris. Among its related pathways are Keratinization and Developmental Biology. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural molecule activity. An important paralog of this gene is FLG2.
UniProtKB/Swiss-Prot for FLG Gene
-
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Additional gene information for FLG Gene
- Monarch Initiative
- Search for FLG at DataMed
- Search for FLG at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FLG Gene
Genomics for FLG Gene
GeneHancer (GH) Regulatory Elements for FLG Gene
Promoters and enhancers for FLG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FLG on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FLG gene promoter:
-
- C/EBPalpha
- E47
- Pax-3
- Lmo2
- AML1a
- Tal-1
- CUTL1
- STAT5A
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
Regulatory Element Products
Genomic Locations for FLG Gene
Genomic Locations for FLG Gene
- chr1:152,302,163-152,325,257
- (GRCh38/hg38)
- Size:
- 23,095 bases
- Orientation:
- Minus strand
- chr1:152,274,651-152,297,679
- (GRCh37/hg19)
- Size:
- 23,029 bases
- Orientation:
- Minus strand
Genomic View for FLG Gene
Genes around FLG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
- 1q21.3 by Ensembl
FLG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FLG Gene
Proteins for FLG Gene
-
Protein details for FLG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20930-FILA_HUMAN
- Recommended name:
- Filaggrin
- Protein Accession:
- P20930
- Q01720
- Q5T583
- Q9UC71
Protein attributes for FLG Gene
- Size:
- 4061 amino acids
- Molecular mass:
- 435170 Da
- Quaternary structure:
- No Data Available
Protein Expression for FLG Gene
Post-translational modifications for FLG Gene
- Filaggrin is initially synthesized as a large, insoluble, highly phosphorylated precursor containing many tandem copies of 324 AA, which are not separated by large linker sequences. During terminal differentiation it is dephosphorylated and proteolytically cleaved. The N-terminal of the mature protein is heterogeneous, and is blocked by the formation of pyroglutamate.
- Undergoes deimination of some arginine residues (citrullination).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FLG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FLG
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-
Abcam antibodies for FLG
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-
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Protein Products
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Assay Products
No data available for DME Specific Peptides for FLG Gene
Domains & Families for FLG Gene
Gene Families for FLG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for FLG Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FLG Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20930- Family:
-
- Belongs to the S100-fused protein family.
Function for FLG Gene
Molecular function for FLG Gene
- UniProtKB/Swiss-Prot Function:
- Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
- UniProtKB/Swiss-Prot Induction:
- In cultured foreskin fibroblasts, up-regulated in response to Ca(2+) stimulation.
- GENATLAS Biochemistry:
- filaggrin,44kDa,intermediate filament associated protein (IFAP,type I),expressed in the horny layer of stratified epithelia,aggregating keratin filaments and promoting disulfite-bonding,component of the epidermal differentiation complex (EDC@)
Phenotypes From GWAS Catalog for FLG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | NAS | 2740331 |
| GO:0005509 | calcium ion binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 23629652 |
| GO:0030280 | structural constituent of epidermis | IDA | 7543090 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for FLG Gene
- GenomeRNAi human phenotypes for FLG:
-
- Increased G1 DNA content
- Increased cell size
- Increased cilium length after serum starvation
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Increased viability
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-
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-
OriGene CRISPR knockouts for FLG
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- genomics-online: gRNA clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for FLG Gene
- miRTarBase miRNAs that target FLG
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- Overview of 23 available Filaggrin gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FLG
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLG
- Applied Biological Materials Clones for FLG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FLG
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FLG Gene
Localization for FLG Gene
Subcellular locations from UniProtKB/Swiss-Prot for FLG Gene
- Cytoplasmic granule. Note=In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). {ECO:0000269 PubMed:1429717, ECO:0000269 PubMed:21531719}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| peroxisome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | IDA | 7543090 |
| GO:0005634 | nucleus | IBA,HDA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005882 | intermediate filament | NAS | 2740331 |
| GO:0036457 | keratohyalin granule | IDA | 1429717 |
Pathways & Interactions for FLG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratinization |
.33
|
|
| 2 | Developmental Biology | ||
Pathways by source for FLG Gene
3 Reactome pathways for FLG Gene
Interacting Proteins for FLG Gene
Selected Interacting proteins:
ENSP00000357789
P20930-FILA_HUMAN
for FLG Gene via
STRING
IID
UniProtKB
GPS-Prot Interaction Network for FLG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | NAS | 2740331 |
| GO:0008544 | epidermis development | IBA | -- |
| GO:0018149 | peptide cross-linking | IDA | 7543090 |
| GO:0030216 | keratinocyte differentiation | TAS | 17704059 |
| GO:0061436 | establishment of skin barrier | IEP | 23403047 |
No data available for SIGNOR curated interactions for FLG Gene
Transcripts for FLG Gene
mRNA/cDNA for FLG Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000368799 12747 bps (uc001ezu.1)
CRISPR Products
-
OriGene CRISPR knockouts for FLG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLG
- genomics-online: gRNA clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
- Applied Biological Materials CRISPR for FLG
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FLG
- GenScript: Design CRISPR guide RNA sequences for FLG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FLG
- Browse OriGene Inhibitory RNA Products For FLG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLG
- genomics-online: shRNA clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
Clone Products
- VectorBuilder custom plasmid, inducible vectors for FLG
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FLG
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLG
- Applied Biological Materials Clones for FLG
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FLG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Epidermis (Integumentary System)
- Epithelial Cells
- Hair
mRNA differential expression in normal tissues according to GTEx for FLG Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x31.1) and Skin - Not Sun Exposed (Suprapubic) (x17.7).
This gene is overexpressed in Urinary Bladder (31.0) and Skin (12.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FLG Gene
NURSA nuclear receptor signaling pathways regulating expression of FLG Gene:
FLGSOURCE GeneReport for Unigene cluster for FLG Gene:
Hs.654510mRNA Expression by UniProt/SwissProt for FLG Gene:
P20930-FILA_HUMAN
Tissue specificity:
Expressed in skin, thymus, stomach, tonsils, testis, placenta, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, or adrenal gland (PubMed:19384417). In the skin, mainly expressed in stratum granulosum of the epidermis (PubMed:1429717) (PubMed:19384417).
Evidence on tissue expression from TISSUES for FLG Gene
- Skin(4.7)
- Liver(4.1)
- Blood(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FLG Gene
Germ Layers:
- ectoderm
Systems:
- integumentary
Regions:
General:
- skin
Primer Products
-
OriGene qPCR primer pairs for FLG
- genomics-online: primer clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for FLG Gene
Orthologs for FLG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FLG 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| oppossum (Monodelphis domestica) |
Mammalia | FLG 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CRNN 34 |
|
OneToMany | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany |
- Species where no ortholog for FLG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for FLG Gene
- ENSEMBL:
- Gene Tree for FLG (if available)
- TreeFam:
- Gene Tree for FLG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FLG: view image
Paralogs for FLG Gene
(10) SIMAP similar genes for FLG Gene using alignment to 14 proteins:
- FILA_HUMAN
- I0B0K3_HUMAN
- I0B0K4_HUMAN
- I0B0K5_HUMAN
- I0B0K6_HUMAN
- I0B0K7_HUMAN
- I0B0K8_HUMAN
- L8E7P6_HUMAN
- Q03837_HUMAN
- Q03838_HUMAN
- Q03839_HUMAN
- Q15206_HUMAN
- Q16824_HUMAN
- Q4JFL9_HUMAN
Variants for FLG Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1060499587 | likely-pathogenic, Ichthyosis vulgaris | 152,313,983(-) | CCTGTCCTG/CCTG | coding_sequence_variant, frameshift | |
| rs121909626 | pathogenic, risk-factor, Ichthyosis vulgaris, Dermatitis, atopic, 2, susceptibility to | 152,307,225(-) | G/C | coding_sequence_variant, stop_gained | |
| rs141784184 | likely-pathogenic, Ichthyosis vulgaris | 152,309,169(-) | G/A/T | coding_sequence_variant, missense_variant, stop_gained | |
| rs146466242 | conflicting-interpretations-of-pathogenicity, uncertain-significance, not provided, Ichthyosis vulgaris | 152,302,822(-) | T/A/C | coding_sequence_variant, missense_variant, stop_gained | |
| rs147145234 | pathogenic, Inborn genetic diseases | 152,308,647(-) | G/T | coding_sequence_variant, stop_gained |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1003613 | OTHER | inversion | 20482838 |
| esv1330223 | CNV | deletion | 17803354 |
| esv25681 | CNV | loss | 19812545 |
| esv2665362 | CNV | deletion | 23128226 |
| esv2669572 | CNV | deletion | 23128226 |
| esv2671163 | CNV | deletion | 23128226 |
| esv2718117 | CNV | deletion | 23290073 |
| esv2718128 | CNV | deletion | 23290073 |
| esv3394198 | CNV | duplication | 20981092 |
| esv3587546 | CNV | gain | 21293372 |
| nsv1014095 | CNV | gain | 25217958 |
| nsv1110152 | CNV | duplication | 24896259 |
| nsv1115370 | CNV | duplication | 24896259 |
| nsv1152559 | CNV | duplication | 26484159 |
| nsv159623 | CNV | deletion | 16902084 |
| nsv471348 | CNV | gain | 19718026 |
| nsv7183 | OTHER | inversion | 18451855 |
| nsv821364 | CNV | duplication | 20802225 |
| nsv824653 | CNV | loss | 20364138 |
| nsv952208 | CNV | deletion | 24416366 |
| nsv998298 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
100% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
27.35;
99.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FLG Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FLG Gene
Disorders for FLG Gene
(50) MalaCards diseases for FLG Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dermatitis, atopic, 2 |
|
|
| ichthyosis vulgaris |
|
|
| cerebellar hypoplasia |
|
|
| ichthyosis |
|
|
| skin disease |
|
Search FLG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FILA_HUMAN- Ichthyosis vulgaris (VI) [MIM:146700]: The most common form of ichthyosis inherited as an autosomal dominant trait. It is characterized by palmar hyperlinearity, keratosis pilaris and a fine scale that is most prominent over the lower abdomen, arms, and legs. Ichthyosis vulgaris is characterized histologically by absent or reduced keratohyalin granules in the epidermis and mild hyperkeratosis. The disease can be associated with frequent asthma, eczema or hay fever. {ECO:0000269 PubMed:16444271}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Dermatitis atopic 2 (ATOD2) [MIM:605803]: Atopic dermatitis is a complex, inflammatory disease with multiple alleles at several loci thought to be involved in the pathogenesis. It commonly begins in infancy or early childhood and is characterized by a chronic relapsing form of skin inflammation, a disturbance of epidermal barrier function that culminates in dry skin, and IgE-mediated sensitization to food and environmental allergens. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. {ECO:0000269 PubMed:16550169, ECO:0000269 PubMed:16815158, ECO:0000269 PubMed:17030239, ECO:0000269 PubMed:17291859}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Additional Disease Information for FLG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for FLG Gene
Publications for FLG Gene
- Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. (PMID: 17291859) Nomura T … Shimizu H (The Journal of allergy and clinical immunology 2007) 3 4 22 44 58
- Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. (PMID: 16815158) Weidinger S … Novak N (The Journal of allergy and clinical immunology 2006) 3 4 22 44 58
- Human leukocyte antigen (DR1)-DQB1*0501 and (DR15)-DQB1*0602 haplotypes are associated with humoral responses to early food allergens in children. (PMID: 20016199) Savilahti EM … Savilahti E (International archives of allergy and immunology 2010) 3 22 44 58
- Elder siblings enhance the effect of filaggrin mutations on childhood eczema: results from the 2 birth cohort studies LISAplus and GINIplus. (PMID: 20513523) Cramer C … LISAplus Study Group and the GINIplus Study Group (The Journal of allergy and clinical immunology 2010) 3 22 44 58
- Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations. (PMID: 20109745) O'Regan GM … Brown SJ (The Journal of allergy and clinical immunology 2010) 3 22 44 58
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- Mammalian expression: PiggyBac
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- antibodies-online: Search results for 130 available Filaggrin Antibodies ranked by validation data
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- antibodies-online: Search results for 5 available Filaggrin Proteins ranked by validation data
- Compare Top Filaggrin Proteins
- GeneTex FLG Antibody for FLG
- Search GeneTex for Proteins for FLG
- Santa Cruz Biotechnology (SCBT) Antibodies for FLG
- Search Santa Cruz Biotechnology (SCBT) for FLG siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FLG
- Horizon Cell Lines for FLG
- genomics-online: cdna clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
- orf clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
- genomics-online: gRNA clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
- genomics-online: primer clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
- genomics-online: shRNA clones - Search results for 23 available Filaggrin gene related products
- Overview of 23 available Filaggrin gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FLG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FLG
- GeneCopoeia miRNA 3'UTR Target clone products for FLG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FLG
Sources for FLG Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt