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This gene encodes the enzyme that catalyzes adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
FLAD1 (Flavin Adenine Dinucleotide Synthetase 1) is a Protein Coding gene. Diseases associated with FLAD1 include Lipid Storage Myopathy Due To Flavin Adenine Dinucleotide Synthetase Deficiency and Multiple Acyl-Coa Dehydrogenase Deficiency. Among its related pathways are Folate Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include FMN adenylyltransferase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003824 | catalytic activity | IEA | -- |
GO:0003919 | FMN adenylyltransferase activity | TAS | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0005524 | ATP binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005759 | mitochondrial matrix | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of water-soluble vitamins and cofactors | ||
2 | Metabolism |
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3 | Folate Metabolism | ||
4 | Riboflavin metabolism |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006747 | FAD biosynthetic process | IBA,IEA | -- |
GO:0006771 | riboflavin metabolic process | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Flavin Mononucleotide | Approved, Investigational | Pharma | 12 | |||
FAD | Approved | Pharma | 0 | |||
Magnesium | Approved, Experimental, Investigational | Pharma | 0 | |||
Phosphoric acid | Approved | Pharma | 0 | |||
ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
pyrophosphate |
|
14000-31-8 |
|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | - |
ExUns: | 12 | ^ | 13a | · | 13b |
---|---|---|---|---|---|
SP1: | |||||
SP2: | |||||
SP3: | |||||
SP4: | |||||
SP5: | |||||
SP6: | |||||
SP7: | - | ||||
SP8: | |||||
SP9: | |||||
SP10: | |||||
SP11: | |||||
SP12: | |||||
SP13: | |||||
SP14: | |||||
SP15: | |||||
SP16: | |||||
SP17: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FLAD1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FLAD1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FLAD1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Flad1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Flad1 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FLAD1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FLAD1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FLAD1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FLAD1 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | flad1 30 31 |
|
OneToOne | |
Dr.27212 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1643 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002740 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG4407 30 31 |
|
OneToMany | |
CG16848 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | flad-1 30 31 |
|
OneToOne | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AER198W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FAD1 30 31 33 33 |
|
OneToOne | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E13377g 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU09233 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPCC1235.04c 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10620 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
676267 | Benign: not provided | 154,983,248(+) | C/T | ||
676268 | Benign: not provided | 154,987,406(+) | A/G | INTRON_VARIANT | |
676269 | Benign: not provided | 154,987,543(+) | T/G | FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
676270 | Benign: not provided | 154,992,637(+) | G/T | INTRON_VARIANT | |
725543 | Likely Benign: not provided | 154,992,757(+) | T/C | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
lipid storage myopathy due to flavin adenine dinucleotide synthetase deficiency |
|
|
multiple acyl-coa dehydrogenase deficiency |
|
|
multiple acyl-coa dehydrogenase deficiency, mild type |
|
|
multiple acyl-coa dehydrogenase deficiency, severe neonatal type |
|
|
acyl-coa dehydrogenase deficiency |
|
|