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Aliases for FKBP9 Gene

Aliases for FKBP9 Gene

  • FK506 Binding Protein 9 2 3 5
  • FK506 Binding Protein 9, 63 KDa 2 3
  • 63 KDa FK506-Binding Protein 3 4
  • PPIase FKBP9 3 4
  • 63 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-63 3 4
  • FKBP-9 3 4
  • FKBP60 3 4
  • FKBP63 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP9 3
  • FK506-Binding Protein 9 (63 KD) 2
  • FK506-Binding Protein 9 4
  • EC 5.2.1.8 4
  • PPIase 3

External Ids for FKBP9 Gene

Previous GeneCards Identifiers for FKBP9 Gene

  • GC07M055212
  • GC07M055456
  • GC07M055491
  • GC07P032739
  • GC07P032770
  • GC07P032963
  • GC07P032997
  • GC07P032875

Summaries for FKBP9 Gene

GeneCards Summary for FKBP9 Gene

FKBP9 (FK506 Binding Protein 9) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Chaperonin-mediated protein folding. Gene Ontology (GO) annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP10.

UniProtKB/Swiss-Prot for FKBP9 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

Gene Wiki entry for FKBP9 Gene

Additional gene information for FKBP9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP9 Gene

Genomics for FKBP9 Gene

GeneHancer (GH) Regulatory Elements for FKBP9 Gene

Promoters and enhancers for FKBP9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J032956 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 413 2.7 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF263 SP3 SP5 SMARCB1 FKBP9 RP9P KBTBD2 NT5C3A RP9 RNU6-388P
GH07J033038 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.6 +84.4 84375 7.4 ATF1 FOXA2 ARNT ARID4B SIN3A YY1 TCF12 ATF7 RUNX3 RXRA KBTBD2 NT5C3A FKBP9 RP9P RP9 RN7SL505P GC07M033036
GH07J033060 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.6 +105.0 105017 3 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF143 NT5C3A PIR46017 FKBP9 AVL9 RN7SL505P
GH07J032990 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.4 +34.6 34602 3.9 PRDM6 CEBPB ZBTB33 EGR2 FKBP9 RP9P KBTBD2 NT5C3A RNU6-388P
GH07J032941 Promoter/Enhancer 1.5 Ensembl ENCODE 5.8 -14.9 -14866 2.7 SIN3A DMAP1 ZNF48 YY1 ZNF280A TCF12 ZNF766 GLIS2 ELK1 ZNF143 RP9P KBTBD2 FKBP9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FKBP9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FKBP9 gene promoter:
  • PPAR-alpha
  • COMP1
  • NRSF form 2
  • NRSF form 1
  • HOXA5
  • Pax-2
  • Pax-2a
  • Nkx6-1
  • Olf-1

Genomic Locations for FKBP9 Gene

Genomic Locations for FKBP9 Gene
chr7:32,957,404-33,006,931
(GRCh38/hg38)
Size:
49,528 bases
Orientation:
Plus strand
chr7:32,997,005-33,046,543
(GRCh37/hg19)
Size:
49,539 bases
Orientation:
Plus strand

Genomic View for FKBP9 Gene

Genes around FKBP9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP9 Gene

Proteins for FKBP9 Gene

  • Protein details for FKBP9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95302-FKBP9_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP9
    Protein Accession:
    O95302
    Secondary Accessions:
    • B3KY35
    • B7Z1G9
    • B7Z6H3
    • Q2M2A1
    • Q3MIR7
    • Q6IN76
    • Q6P2N1
    • Q96EX5
    • Q96IJ9

    Protein attributes for FKBP9 Gene

    Size:
    570 amino acids
    Molecular mass:
    63084 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FKBP9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP9 Gene

Post-translational modifications for FKBP9 Gene

Other Protein References for FKBP9 Gene

No data available for DME Specific Peptides for FKBP9 Gene

Domains & Families for FKBP9 Gene

Gene Families for FKBP9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FKBP9 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FKBP9: view

No data available for UniProtKB/Swiss-Prot for FKBP9 Gene

Function for FKBP9 Gene

Molecular function for FKBP9 Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by FK506.

Enzyme Numbers (IUBMB) for FKBP9 Gene

Phenotypes From GWAS Catalog for FKBP9 Gene

Gene Ontology (GO) - Molecular Function for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005509 calcium ion binding ISS --
GO:0005528 FK506 binding IBA --
GO:0016853 isomerase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FKBP9: view
genes like me logo Genes that share phenotypes with FKBP9: view

Animal Models for FKBP9 Gene

MGI Knock Outs for FKBP9:
  • Fkbp9 Fkbp9<tm1a(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP9

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP9 Gene

Localization for FKBP9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP9 Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP9 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with FKBP9: view

Pathways & Interactions for FKBP9 Gene

genes like me logo Genes that share pathways with FKBP9: view

Gene Ontology (GO) - Biological Process for FKBP9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006457 protein folding ISS --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP9: view

No data available for SIGNOR curated interactions for FKBP9 Gene

Drugs & Compounds for FKBP9 Gene

No Compound Related Data Available

Transcripts for FKBP9 Gene

Unigene Clusters for FKBP9 Gene

FK506 binding protein 9, 63 kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP9 Gene

No ASD Table

Relevant External Links for FKBP9 Gene

GeneLoc Exon Structure for
FKBP9
ECgene alternative splicing isoforms for
FKBP9

Expression for FKBP9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP9 Gene

This gene is overexpressed in Bone marrow stromal cell (26.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP9 Gene



Protein tissue co-expression partners for FKBP9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP9 Gene:

FKBP9

SOURCE GeneReport for Unigene cluster for FKBP9 Gene:

Hs.103934

Evidence on tissue expression from TISSUES for FKBP9 Gene

  • Nervous system(4.7)
  • Lung(4.6)
  • Kidney(4.4)
  • Liver(4.2)
  • Skin(3.1)
  • Intestine(2.7)
  • Muscle(2)
genes like me logo Genes that share expression patterns with FKBP9: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP9 Gene

Orthologs for FKBP9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP9 34 33
  • 99.77 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FKBP9 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP9 34 33
  • 91.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP9 34 33
  • 91.55 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp9 33
  • 88.44 (n)
mouse
(Mus musculus)
Mammalia Fkbp9 16 34 33
  • 87.91 (n)
oppossum
(Monodelphis domestica)
Mammalia FKBP9 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP9 34 33
  • 76.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP9 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp9 33
  • 72.74 (n)
Str.10967 33
zebrafish
(Danio rerio)
Actinopterygii fkbp9 34 33
  • 67.66 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14715 34
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-5 34 33
  • 47.42 (n)
ManyToMany
fkb-3 34
  • 33 (a)
ManyToMany
fkb-4 34
  • 31 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 34
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5986 34
  • 42 (a)
OneToMany
Cin.12333 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12333 33
Species where no ortholog for FKBP9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP9 Gene

ENSEMBL:
Gene Tree for FKBP9 (if available)
TreeFam:
Gene Tree for FKBP9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FKBP9: view image

Paralogs for FKBP9 Gene

Paralogs for FKBP9 Gene

(11) SIMAP similar genes for FKBP9 Gene using alignment to 6 proteins:

  • FKBP9_HUMAN
  • A7YQ73_HUMAN
  • B7Z1G9_HUMAN
  • B7Z230_HUMAN
  • B7Z6H3_HUMAN
  • C9J4P8_HUMAN

Pseudogenes.org Pseudogenes for FKBP9 Gene

genes like me logo Genes that share paralogs with FKBP9: view

Variants for FKBP9 Gene

Sequence variations from dbSNP and Humsavar for FKBP9 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000008034 -- 32,987,447(+) A/C intron_variant
rs1000131311 -- 32,979,340(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000239079 -- 33,004,395(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000305806 -- 32,958,177(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000397367 -- 32,986,366(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP9 Gene

Variant ID Type Subtype PubMed ID
dgv1080e201 CNV deletion 23290073
esv27091 CNV gain+loss 19812545
esv2734229 CNV deletion 23290073
esv3612750 OTHER inversion 21293372
nsv1029220 CNV gain 25217958
nsv1033096 CNV loss 25217958
nsv1128310 CNV deletion 24896259
nsv1135982 CNV deletion 24896259
nsv436907 CNV insertion 17901297
nsv981447 CNV duplication 23825009

Variation tolerance for FKBP9 Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP9

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP9 Gene

Disorders for FKBP9 Gene

Additional Disease Information for FKBP9

No disorders were found for FKBP9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP9 Gene

Publications for FKBP9 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PMID: 12754519) Zhang H … Aebersold R (Nature biotechnology 2003) 3 4 58
  3. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson CE … Davis EC (Genomics 2002) 2 3 58
  4. Biochemical analysis of mouse FKBP60, a novel member of the FKPB family. (PMID: 10524204) Shadidy M … Krauss S (Biochimica et biophysica acta 1999) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FKBP9 Gene

Sources for FKBP9 Gene

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