Aliases for FKBP8 Gene
External Ids for FKBP8 Gene
Previous GeneCards Identifiers for FKBP8 Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
GeneCards Summary for FKBP8 Gene
FKBP8 (FKBP Prolyl Isomerase 8) is a Protein Coding gene. Diseases associated with FKBP8 include Pineal Region Germinoma and Spina Bifida Occulta. Among its related pathways are Role of Calcineurin-dependent NFAT signaling in lymphocytes and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include identical protein binding and FK506 binding. An important paralog of this gene is FKBP15.
UniProtKB/Swiss-Prot Summary for FKBP8 Gene
Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.