Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FKBP7 Gene

Aliases for FKBP7 Gene

  • FK506 Binding Protein 7 2 3 5
  • 23 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 7 2 4
  • PPIase FKBP7 3 4
  • 23 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-23 3 4
  • FKBP-7 3 4
  • FKBP23 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP7 3
  • FK506-Binding Protein 23 3
  • EC 5.2.1.8 4
  • PPIase 3

External Ids for FKBP7 Gene

Previous GeneCards Identifiers for FKBP7 Gene

  • GC02M177392
  • GC02M178001
  • GC02M179294
  • GC02M179532
  • GC02M179155
  • GC02M179038
  • GC02M179328
  • GC02M171200

Summaries for FKBP7 Gene

Entrez Gene Summary for FKBP7 Gene

  • The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. Members of this family exhibit PPIase activity and function as molecular chaperones. A similar protein in mouse is located in the endoplasmic reticulum and binds calcium. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP7 Gene

FKBP7 (FK506 Binding Protein 7) is a Protein Coding gene. Diseases associated with FKBP7 include Osteogenesis Imperfecta, Type Ix. Gene Ontology (GO) annotations related to this gene include calcium ion binding and FK506 binding. An important paralog of this gene is FKBP14.

UniProtKB/Swiss-Prot for FKBP7 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

Additional gene information for FKBP7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP7 Gene

Genomics for FKBP7 Gene

GeneHancer (GH) Regulatory Elements for FKBP7 Gene

Promoters and enhancers for FKBP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J178477 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 669.5 +0.8 845 4.3 PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FKBP7 PLEKHA3 LOC101927027 RBM45 PJVK PRKRA NUDCP2
GH02J178448 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 32.2 +29.6 29571 3.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 PJVK PRKRA FKBP7 LOC101927027 PLEKHA3 RBM45 ENSG00000270574 ENSG00000237477
GH02J178412 Promoter/Enhancer 1.6 Ensembl ENCODE 32 +66.1 66149 2.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 LOC101927027 FKBP7 PLEKHA3 PRKRA PJVK RBM45
GH02J178428 Enhancer 0.9 ENCODE 17.2 +51.9 51866 1 ATF1 FOXA2 ARID4B DMAP1 ETS1 GATA2 RXRA MIER2 ZNF592 KAT8 FKBP7 PRKRA PJVK LOC101927027
GH02J178484 Enhancer 0.8 Ensembl 16.8 -4.3 -4313 0.6 SMAD1 NFIB INSM2 MZF1 FEZF1 ZNF213 ZNF366 ZSCAN5C ZNF350 ZNF174 LOC101927027 RBM45 FKBP7 PLEKHA3 PRKRA PJVK NUDCP2 ENSG00000271401 TTN-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FKBP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FKBP7 gene promoter:

Genomic Locations for FKBP7 Gene

Genomic Locations for FKBP7 Gene
chr2:178,463,664-178,480,393
(GRCh38/hg38)
Size:
16,730 bases
Orientation:
Minus strand
chr2:179,328,391-179,343,355
(GRCh37/hg19)

Genomic View for FKBP7 Gene

Genes around FKBP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP7 Gene

Proteins for FKBP7 Gene

  • Protein details for FKBP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y680-FKBP7_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP7
    Protein Accession:
    Q9Y680
    Secondary Accessions:
    • Q4ZG70
    • Q6V3B2
    • Q86U65
    • Q96DA4
    • Q9Y6B0

    Protein attributes for FKBP7 Gene

    Size:
    222 amino acids
    Molecular mass:
    25794 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Binds calcium.
    SequenceCaution:
    • Sequence=AAD43015.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for FKBP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP7 Gene

Post-translational modifications for FKBP7 Gene

No data available for DME Specific Peptides for FKBP7 Gene

Domains & Families for FKBP7 Gene

Gene Families for FKBP7 Gene

Protein Domains for FKBP7 Gene

Suggested Antigen Peptide Sequences for FKBP7 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FKBP7: view

No data available for UniProtKB/Swiss-Prot for FKBP7 Gene

Function for FKBP7 Gene

Molecular function for FKBP7 Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme Numbers (IUBMB) for FKBP7 Gene

Phenotypes From GWAS Catalog for FKBP7 Gene

Gene Ontology (GO) - Molecular Function for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IBA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15846844
GO:0005528 FK506 binding IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with FKBP7: view
genes like me logo Genes that share phenotypes with FKBP7: view

Animal Model Products

CRISPR Products

miRNA for FKBP7 Gene

miRTarBase miRNAs that target FKBP7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP7 Gene

Localization for FKBP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP7 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP7 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with FKBP7: view

Pathways & Interactions for FKBP7 Gene

SuperPathways for FKBP7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP7: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP7 Gene

Drugs & Compounds for FKBP7 Gene

(1) Drugs for FKBP7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with FKBP7: view

Transcripts for FKBP7 Gene

Unigene Clusters for FKBP7 Gene

FK506 binding protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: - -
SP6:
SP7: - - -
SP8: - -

Relevant External Links for FKBP7 Gene

GeneLoc Exon Structure for
FKBP7
ECgene alternative splicing isoforms for
FKBP7

Expression for FKBP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP7 Gene

This gene is overexpressed in Bone marrow stromal cell (9.9), Uterus (9.7), Heart (7.7), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP7 Gene



Protein tissue co-expression partners for FKBP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP7 Gene:

FKBP7

SOURCE GeneReport for Unigene cluster for FKBP7 Gene:

Hs.410378

Evidence on tissue expression from TISSUES for FKBP7 Gene

  • Lung(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FKBP7: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP7 Gene

Orthologs for FKBP7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP7 34 33
  • 99.7 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP7 34 33
  • 90.83 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP7 34 33
  • 90.37 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp7 33
  • 85.47 (n)
mouse
(Mus musculus)
Mammalia Fkbp7 16 34 33
  • 85.02 (n)
oppossum
(Monodelphis domestica)
Mammalia FKBP7 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves FKBP7 34 33
  • 71.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FKBP7 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp7 33
  • 68.53 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2913 33
zebrafish
(Danio rerio)
Actinopterygii fkbp7 34 33
  • 61.57 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10818 33
fruit fly
(Drosophila melanogaster)
Insecta Fkbp13 34 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-7 34
  • 17 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 34
  • 38 (a)
OneToMany
Species where no ortholog for FKBP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP7 Gene

ENSEMBL:
Gene Tree for FKBP7 (if available)
TreeFam:
Gene Tree for FKBP7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FKBP7: view image

Paralogs for FKBP7 Gene

Paralogs for FKBP7 Gene

(10) SIMAP similar genes for FKBP7 Gene using alignment to 6 proteins:

  • FKBP7_HUMAN
  • D3DPF8_HUMAN
  • F8WBF2_HUMAN
  • F8WCU2_HUMAN
  • F8WE12_HUMAN
  • H7BZJ4_HUMAN

Pseudogenes.org Pseudogenes for FKBP7 Gene

genes like me logo Genes that share paralogs with FKBP7: view

Variants for FKBP7 Gene

Sequence variations from dbSNP and Humsavar for FKBP7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000025434 -- 178,468,864(-) A/G intron_variant
rs1000271469 -- 178,473,178(-) AACAAC/AAC intron_variant
rs1000955904 -- 178,477,626(-) T/A intron_variant
rs1001072054 -- 178,477,876(-) A/G intron_variant
rs1001167856 -- 178,478,674(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP7 Gene

Variant ID Type Subtype PubMed ID
nsv471944 CNV novel sequence insertion 20440878
nsv834467 CNV loss 17160897

Variation tolerance for FKBP7 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP7 Gene

Disorders for FKBP7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FKBP7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type ix
  • oi9
- elite association - COSMIC cancer census association via MalaCards
Search FKBP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FKBP7

genes like me logo Genes that share disorders with FKBP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP7 Gene

Publications for FKBP7 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Molecular cloning, characterization, and chromosomal localization of FKBP23, a novel FK506-binding protein with Ca2+-binding ability. (PMID: 9806833) Nakamura T … Honjo T (Genomics 1998) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline. (PMID: 28385890) Ishikawa Y … Bächinger HP (The Journal of biological chemistry 2017) 3 58

Products for FKBP7 Gene

Sources for FKBP7 Gene

Content
Loading form....