The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, ... See more...

Aliases for FKBP3 Gene

Aliases for FKBP3 Gene

  • FKBP Prolyl Isomerase 3 2 3 5
  • FKBP-25 2 3 4
  • FKBP25 2 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP3 3 4
  • Rapamycin-Selective 25 KDa Immunophilin 3 4
  • FK506 Binding Protein 3, 25kDa 2 3
  • 25 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 3 3 4
  • Immunophilin FKBP25 3 4
  • PPIase FKBP3 3 4
  • 25 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-3 3 4
  • FK506-Binding Protein 25, T-Cell 3
  • FK506-Binding Protein 3 (25kD) 2
  • Rapamycin Binding Protein 3
  • FK506 Binding Protein 3 2
  • EC 5.2.1.8 4
  • PPIase 3
  • FKBP3 5

External Ids for FKBP3 Gene

Previous GeneCards Identifiers for FKBP3 Gene

  • GC14M042906
  • GC14M039381
  • GC14M043574
  • GC14M043575
  • GC14M044654
  • GC14M045584
  • GC14M025695

Summaries for FKBP3 Gene

Entrez Gene Summary for FKBP3 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

GeneCards Summary for FKBP3 Gene

FKBP3 (FKBP Prolyl Isomerase 3) is a Protein Coding gene. Among its related pathways are Signaling events mediated by HDAC Class I. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP9.

UniProtKB/Swiss-Prot Summary for FKBP3 Gene

  • FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.

Gene Wiki entry for FKBP3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FKBP3 Gene

Genomics for FKBP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FKBP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J045133 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 -0.4 -382 6.2 BCLAF1 SP1 ZNF207 ZNF600 MYC IKZF1 JUND ATF2 POLR2A BRCA1 FANCM FKBP3 HSALNG0100955 HSALNG0100959 lnc-FANCM-13 SNORD127 ENSG00000212615 PRPF39 ENSG00000249163 LINC02302
GH14J045083 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.2 +50.6 50618 3.4 IKZF1 MYC ZNF600 ZNF580 POLR2A NFIC YY1 CTCF SMAD5 SIN3A ENSG00000249163 LOC105370474 PRPF39 lnc-FKBP3-2 LINC02302 ENSG00000212615 FKBP3
GH14J045113 Enhancer 0.9 Ensembl ENCODE 0.4 +21.9 21875 1.1 CEBPA JUND NFIC ZNF217 FOXA2 CTBP1 CUX1 TEAD3 ZSCAN9 RBM22 LINC02302 SNORD127 HSALNG0100956 FKBP3 PRPF39
GH14J045090 Enhancer 0.6 ENCODE 0.3 +45.2 45226 0.2 BATF MAFK MAFF JUNB SP7 PKNOX1 IKZF1 FOS MTA2 RUNX3 ENSG00000212615 SNORD127 HSALNG0100952 PRPF39 FKBP3
GH14J045094 Promoter 0.3 EPDnew 0.3 +40.9 40907 0.1 HSALNG0100952 PRPF39 ENSG00000212615 FKBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FKBP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FKBP3

Top Transcription factor binding sites by QIAGEN in the FKBP3 gene promoter:
  • AML1a
  • Cart-1
  • FOXC1
  • Lmo2
  • MyoD
  • NCX
  • Pax-2
  • Pax-2a
  • USF-1
  • USF1

Genomic Locations for FKBP3 Gene

Latest Assembly
chr14:45,115,292-45,135,319
(GRCh38/hg38)
Size:
20,028 bases
Orientation:
Minus strand

Previous Assembly
chr14:45,584,802-45,603,684
(GRCh37/hg19 by Entrez Gene)
Size:
18,883 bases
Orientation:
Minus strand

chr14:45,584,803-45,604,522
(GRCh37/hg19 by Ensembl)
Size:
19,720 bases
Orientation:
Minus strand

Genomic View for FKBP3 Gene

Genes around FKBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP3 Gene

Proteins for FKBP3 Gene

  • Protein details for FKBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00688-FKBP3_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP3
    Protein Accession:
    Q00688
    Secondary Accessions:
    • B2R4Q9
    • Q14317

    Protein attributes for FKBP3 Gene

    Size:
    224 amino acids
    Molecular mass:
    25177 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA58474.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FKBP3 Gene

neXtProt entry for FKBP3 Gene

Post-translational modifications for FKBP3 Gene

  • Ubiquitination at Lys27
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP3 Gene

Antibodies for research

  • Abcam antibodies for FKBP3
  • Santa Cruz Biotechnology (SCBT) Antibodies for FKBP3

No data available for DME Specific Peptides for FKBP3 Gene

Domains & Families for FKBP3 Gene

Gene Families for FKBP3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FKBP3 Gene

Suggested Antigen Peptide Sequences for FKBP3 Gene

GenScript: Design optimal peptide antigens:
  • Rotamase (FKBP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q00688

UniProtKB/Swiss-Prot:

FKBP3_HUMAN :
  • Belongs to the FKBP-type PPIase family.
Family:
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP3: view

Function for FKBP3 Gene

Molecular function for FKBP3 Gene

UniProtKB/Swiss-Prot Function:
FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited preferentially by rapamycin over FK506.
GENATLAS Biochemistry:
FK506-binding protein 3,T cell binding protein FKBP-25 for the immunosuppressive agents FK506-rapamycin ,with intrinsic peptidyl-prolyl cis-trans isomerase activity

Enzyme Numbers (IUBMB) for FKBP3 Gene

Gene Ontology (GO) - Molecular Function for FKBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0005515 protein binding IPI 19166840
GO:0005528 FK506 binding TAS 1374240
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with FKBP3: view
genes like me logo Genes that share phenotypes with FKBP3: view

Animal Models for FKBP3 Gene

MGI Knock Outs for FKBP3:
  • Fkbp3 Fkbp3<tm2a(EUCOMM)Wtsi>

miRNA for FKBP3 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP3

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP3 Gene

Localization for FKBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP3 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FKBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FKBP3: view

Pathways & Interactions for FKBP3 Gene

PathCards logo

SuperPathways for FKBP3 Gene

genes like me logo Genes that share pathways with FKBP3: view

Pathways by source for FKBP3 Gene

1 BioSystems pathway for FKBP3 Gene

Gene Ontology (GO) - Biological Process for FKBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with FKBP3: view

No data available for SIGNOR curated interactions for FKBP3 Gene

Drugs & Compounds for FKBP3 Gene

(2) Drugs for FKBP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FKBP3: view

Transcripts for FKBP3 Gene

mRNA/cDNA for FKBP3 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP3

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP3 Gene

No ASD Table

Relevant External Links for FKBP3 Gene

GeneLoc Exon Structure for
FKBP3

Expression for FKBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FKBP3 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP3 Gene



Protein tissue co-expression partners for FKBP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FKBP3

SOURCE GeneReport for Unigene cluster for FKBP3 Gene:

Hs.509226

Evidence on tissue expression from TISSUES for FKBP3 Gene

  • Muscle(4.5)
  • Skin(4.4)
  • Liver(4.4)
  • Blood(4.4)
  • Nervous system(4)
  • Heart(2.3)
  • Kidney(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FKBP3: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP3 Gene

Orthologs for FKBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FKBP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FKBP3 29 30
  • 99.85 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 30
  • 97 (a)
OneToMany
FKBP3 29
  • 95.39 (n)
-- 30
  • 93 (a)
OneToMany
-- 30
  • 92 (a)
OneToMany
-- 30
  • 89 (a)
OneToMany
-- 30
  • 75 (a)
OneToMany
-- 30
  • 65 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia FKBP3 29 30
  • 95.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fkbp3 29 16 30
  • 92.11 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FKBP3 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fkbp3 29
  • 91.22 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FKBP3 30
  • 78 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FKBP25 30
  • 74 (a)
OneToOne
FKBP3 29
  • 72.05 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 77 (a)
OneToMany
-- 30
  • 75 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fkbp3 29
  • 74.14 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34809 29
Zebrafish
(Danio rerio)
Actinopterygii fkbp3 29 30
  • 67.88 (n)
OneToOne
-- 29
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6826 30
  • 54 (a)
OneToOne
Species where no ortholog for FKBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FKBP3 Gene

ENSEMBL:
Gene Tree for FKBP3 (if available)
TreeFam:
Gene Tree for FKBP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FKBP3: view image
Alliance of Genome Resources:
Additional Orthologs for FKBP3

Paralogs for FKBP3 Gene

Pseudogenes.org Pseudogenes for FKBP3 Gene

genes like me logo Genes that share paralogs with FKBP3: view

Variants for FKBP3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FKBP3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FKBP3 Gene

Variant ID Type Subtype PubMed ID
esv2667757 CNV deletion 23128226
esv2748676 CNV deletion 23290073
esv3634342 CNV loss 21293372
nsv1113644 CNV deletion 24896259
nsv476081 CNV novel sequence insertion 20440878
nsv826941 CNV loss 20364138
nsv832785 CNV loss 17160897

Variation tolerance for FKBP3 Gene

Residual Variation Intolerance Score: 46.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.33; 85.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP3
Leiden Open Variation Database (LOVD)
FKBP3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FKBP3 Gene

Disorders for FKBP3 Gene

Additional Disease Information for FKBP3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for FKBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP3 Gene

Publications for FKBP3 Gene

  1. cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein. (PMID: 1374240) Hung DT … Schreiber SL (Biochemical and biophysical research communications 1992) 2 3 4 22
  2. Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. (PMID: 1375932) Jin YJ … Bierer BE (The Journal of biological chemistry 1992) 3 4 22
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein. (PMID: 1376117) Wiederrecht G … Siekierka JJ (Biochemical and biophysical research communications 1992) 3 4

Products for FKBP3 Gene

Sources for FKBP3 Gene