Aliases for FKBP2 Gene
External Ids for FKBP2 Gene
Previous GeneCards Identifiers for FKBP2 Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
GeneCards Summary for FKBP2 Gene
FKBP2 (FK506 Binding Protein 2) is a Protein Coding gene. Diseases associated with FKBP2 include Osteogenesis Imperfecta, Type Ix. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP11.
UniProtKB/Swiss-Prot for FKBP2 Gene
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.