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Aliases for FKBP2 Gene

Aliases for FKBP2 Gene

  • FK506 Binding Protein 2 2 3 5
  • FK506 Binding Protein 2, 13kDa 2 3
  • 13 KDa FK506-Binding Protein 3 4
  • Rapamycin-Binding Protein 2 3
  • Immunophilin FKBP13 3 4
  • Proline Isomerase 2 3
  • PPIase FKBP2 3 4
  • 13 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-13 3 4
  • FKBP-2 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP2 3
  • Peptidyl-Prolyl Cis-Trans Isomerase 2
  • FK506 Binding Protein 2 (13kD) 2
  • FK506-Binding Protein 2 (13kD) 2
  • FK506-Binding Protein 2 4
  • EC 5.2.1.8 4
  • PPIase 3
  • FKBP13 4

External Ids for FKBP2 Gene

Previous GeneCards Identifiers for FKBP2 Gene

  • GC11P066524
  • GC11P065689
  • GC11P064259
  • GC11P063783
  • GC11P063764
  • GC11P064008
  • GC11P060336

Summaries for FKBP2 Gene

Entrez Gene Summary for FKBP2 Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

GeneCards Summary for FKBP2 Gene

FKBP2 (FK506 Binding Protein 2) is a Protein Coding gene. Diseases associated with FKBP2 include Osteogenesis Imperfecta, Type Ix. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP11.

UniProtKB/Swiss-Prot for FKBP2 Gene

  • PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for FKBP2 Gene

Additional gene information for FKBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP2 Gene

Genomics for FKBP2 Gene

GeneHancer (GH) Regulatory Elements for FKBP2 Gene

Promoters and enhancers for FKBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J064237 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +4.4 4378 16.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPP1R14B PLCB3 LOC105369340 FKBP2 TRPT1 LOC102723878 VEGFB ENSG00000257086 TRMT112 SF1
GH11J064090 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.3 -149.6 -149640 1 HDAC1 CTCF MAX CEBPG NFXL1 ZFHX2 POLR2A ZNF366 SCRT2 NR2F6 FLRT1 SF1 ENSG00000256341 IMMP1LP1 ATG2A PLCB3 ZFPL1 TRPT1 LOC102723878 FKBP2
GH11J064215 Enhancer 0.5 ENCODE 12.6 -25.7 -25727 0.1 SRF ZFHX2 HLF CEBPB MEF2B RUNX3 FKBP2 LOC105369340 PPP1R14B ENSG00000257086 PLCB3 GPR137 BAD MACROD1 FERMT3 NUDT22
GH11J063999 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 4.3 -241.5 -241454 1.1 CTCF KLF1 ZBTB6 ZFHX2 GLIS2 EGR1 POLR2A PATZ1 VEZF1 KLF8 LOC101927673 SF1 ENSG00000257086 MEN1 OTUB1 RARRES3 NAA40 FKBP2 GC11P063911 MACROD1
GH11J064093 Enhancer 1.2 Ensembl ENCODE dbSUPER 4.3 -146.4 -146392 2.4 HDAC1 PKNOX1 ATF1 SREBF2 RARA RFX5 GLIS2 RCOR1 ZNF548 FOS PLCB3 SF1 ENSG00000256341 ZFPL1 NAALADL1 TRPT1 VEGFB NRXN2 FKBP2 ENSG00000256481
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FKBP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FKBP2 gene promoter:
  • NF-kappaB1
  • E2F
  • E2F-1
  • E2F-2

Genomic Locations for FKBP2 Gene

Genomic Locations for FKBP2 Gene
chr11:64,240,941-64,244,135
(GRCh38/hg38)
Size:
3,195 bases
Orientation:
Plus strand
chr11:64,008,413-64,011,607
(GRCh37/hg19)
Size:
3,195 bases
Orientation:
Plus strand

Genomic View for FKBP2 Gene

Genes around FKBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP2 Gene

Proteins for FKBP2 Gene

  • Protein details for FKBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26885-FKBP2_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP2
    Protein Accession:
    P26885
    Secondary Accessions:
    • Q5BJH9
    • Q9BTS7

    Protein attributes for FKBP2 Gene

    Size:
    142 amino acids
    Molecular mass:
    15649 Da
    Quaternary structure:
    • Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.

    Three dimensional structures from OCA and Proteopedia for FKBP2 Gene

neXtProt entry for FKBP2 Gene

Post-translational modifications for FKBP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FKBP2 Gene

Antibody Products

  • Abcam antibodies for FKBP2
  • Boster Bio Antibodies for FKBP2
  • Santa Cruz Biotechnology (SCBT) Antibodies for FKBP2

No data available for DME Specific Peptides for FKBP2 Gene

Domains & Families for FKBP2 Gene

Gene Families for FKBP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Protein Domains for FKBP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26885

UniProtKB/Swiss-Prot:

FKBP2_HUMAN :
  • Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
Family:
  • Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
genes like me logo Genes that share domains with FKBP2: view

Function for FKBP2 Gene

Molecular function for FKBP2 Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin.
GENATLAS Biochemistry:
FK506-binding protein 2,T cell binding protein FKBP-13 for the immunosuppressive agents FK506-rapamycin,with intrinsic peptidyl-prolyl cis-trans isomerase activity

Enzyme Numbers (IUBMB) for FKBP2 Gene

Phenotypes From GWAS Catalog for FKBP2 Gene

Gene Ontology (GO) - Molecular Function for FKBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005515 protein binding IPI 16713569
GO:0005528 FK506 binding TAS 1713687
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with FKBP2: view
genes like me logo Genes that share phenotypes with FKBP2: view

Animal Model Products

CRISPR Products

miRNA for FKBP2 Gene

miRTarBase miRNAs that target FKBP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP2

Clone Products

  • Addgene plasmids for FKBP2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP2 Gene

Localization for FKBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP2 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP2 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 2
cytosol 2
nucleus 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FKBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum TAS 1713687
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with FKBP2: view

Pathways & Interactions for FKBP2 Gene

SuperPathways for FKBP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP2: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP2 Gene

Drugs & Compounds for FKBP2 Gene

(3) Drugs for FKBP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FKBP2: view

Transcripts for FKBP2 Gene

Unigene Clusters for FKBP2 Gene

FK506 binding protein 2, 13kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP2

Clone Products

  • Addgene plasmids for FKBP2

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - -
SP6: -

Relevant External Links for FKBP2 Gene

GeneLoc Exon Structure for
FKBP2
ECgene alternative splicing isoforms for
FKBP2

Expression for FKBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP2 Gene

This gene is overexpressed in Oral epithelium (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP2 Gene



Protein tissue co-expression partners for FKBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP2 Gene:

FKBP2

SOURCE GeneReport for Unigene cluster for FKBP2 Gene:

Hs.227729

mRNA Expression by UniProt/SwissProt for FKBP2 Gene:

P26885-FKBP2_HUMAN
Tissue specificity: T-cells and thymus.

Evidence on tissue expression from TISSUES for FKBP2 Gene

  • Liver(4.6)
  • Heart(2.4)
  • Kidney(2.4)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with FKBP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP2 Gene

Orthologs for FKBP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FKBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP2 34 33
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP2 34 33
  • 93.57 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP2 34 33
  • 92.86 (n)
OneToMany
-- 34
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fkbp2 16 34 33
  • 88.57 (n)
rat
(Rattus norvegicus)
Mammalia Fkbp2 33
  • 87.62 (n)
lizard
(Anolis carolinensis)
Reptilia FKBP2 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp2 33
  • 71.06 (n)
zebrafish
(Danio rerio)
Actinopterygii fkbp2 34 33
  • 72.49 (n)
OneToOne
Dr.9557 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10889 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003134 33
  • 69.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14715 34 35 33
  • 63.13 (n)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-1 34 35 33
  • 59.37 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 36 34 33
  • 51.4 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C01045g 33
  • 47.7 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons FKBP15-1 33
  • 55.64 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7005 33
rice
(Oryza sativa)
Liliopsida Os09g0501850 33
  • 56.92 (n)
Os.7639 33
barley
(Hordeum vulgare)
Liliopsida Hv.929 33
corn
(Zea mays)
Liliopsida Zm.6224 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 56 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU02455 33
  • 53 (n)
Species where no ortholog for FKBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP2 Gene

ENSEMBL:
Gene Tree for FKBP2 (if available)
TreeFam:
Gene Tree for FKBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FKBP2: view image

Paralogs for FKBP2 Gene

Paralogs for FKBP2 Gene

(13) SIMAP similar genes for FKBP2 Gene using alignment to 3 proteins:

  • FKBP2_HUMAN
  • F5H0N4_HUMAN
  • Q53XJ5_HUMAN
genes like me logo Genes that share paralogs with FKBP2: view

Variants for FKBP2 Gene

Sequence variations from dbSNP and Humsavar for FKBP2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000786292 -- 64,242,055(+) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001341927 -- 64,244,465(+) A/C downstream_transcript_variant
rs1001714431 -- 64,244,345(+) T/C downstream_transcript_variant
rs1002273209 -- 64,242,940(+) C/T intron_variant
rs1002281578 -- 64,239,338(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP2 Gene

Variant ID Type Subtype PubMed ID
dgv1963n54 CNV loss 21841781
esv24861 CNV gain 19812545
esv2744614 CNV deletion 23290073
nsv1159904 CNV deletion 26073780
nsv469961 CNV loss 18288195
nsv555184 CNV loss 21841781
nsv555187 CNV loss 21841781
nsv832186 CNV loss 17160897
nsv951010 CNV deletion 24416366
nsv983032 CNV duplication 23825009

Variation tolerance for FKBP2 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.08; 50.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP2 Gene

Disorders for FKBP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FKBP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
osteogenesis imperfecta, type ix
  • oi9
- elite association - COSMIC cancer census association via MalaCards
Search FKBP2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FKBP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FKBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP2 Gene

Publications for FKBP2 Gene

  1. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. (PMID: 1713687) Jin YJ … Burakoff SJ (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 22 58
  2. Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. (PMID: 12606707) Padilla PI … Vaughan M (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 22 58
  3. Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. (PMID: 1281998) DiLella AG … Griffin CA (Biochemical and biophysical research communications 1992) 3 4 22 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FKBP2 Gene

Sources for FKBP2 Gene

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