Aliases for FKBP1B Gene
Aliases for FKBP1B Gene
External Ids for FKBP1B Gene
- HGNC: 3712
- Entrez Gene: 2281
- Ensembl: ENSG00000119782
- OMIM: 600620
- UniProtKB: P68106
Previous HGNC Symbols for FKBP1B Gene
- FKBP1L
Previous GeneCards Identifiers for FKBP1B Gene
- GC02P024188
- GC02P024365
- GC02P024230
- GC02P024248
- GC02P024249
- GC02P024184
- GC02P024126
- GC02P024272
Summaries for FKBP1B Gene
-
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for FKBP1B Gene
FKBP1B (FK506 Binding Protein 1B) is a Protein Coding gene. Diseases associated with FKBP1B include Catecholaminergic Polymorphic Ventricular Tachycardia and Heart Disease. Among its related pathways are Cardiac conduction and Ion channel transport. Gene Ontology (GO) annotations related to this gene include receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.
UniProtKB/Swiss-Prot for FKBP1B Gene
-
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Additional gene information for FKBP1B Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP1B Gene
Genomics for FKBP1B Gene
GeneHancer (GH) Regulatory Elements for FKBP1B Gene
Promoters and enhancers for FKBP1B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02I024048 | Promoter/Enhancer | 1.9 | EPDnew Ensembl ENCODE | 550.8 | +0.2 | 190 | 1.8 | ELF3 ARID4B KLF17 ZNF2 ZNF48 ZNF335 ZNF121 GLIS2 ZNF366 ZNF391 | FKBP1B WDCP FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 GC02M024079 | |
| GH02I023924 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE | 8.9 | -123.1 | -123136 | 3.7 | HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 | UBXN2A ATAD2B FAM228B MFSD2B SF3B6 FKBP1B PFN4 RPS13P4 GC02P023754 | |
| GH02I024014 | Enhancer | 1.3 | Ensembl ENCODE dbSUPER | 8.9 | -33.3 | -33347 | 3.8 | FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A ZNF48 ETS1 SLC30A9 TCF12 | FAM228B FKBP1B PFN4 MFSD2B RNU6-370P GC02P023754 | |
| GH02I023669 | Enhancer | 0.7 | Ensembl ENCODE | 9.5 | -379.8 | -379799 | 1.8 | SCRT1 USF1 SCRT2 ZBTB33 ZIC2 CHD2 | FKBP1B PFN4 FAM228A GC02P023666 ENSG00000283031 KLHL29 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around FKBP1B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for FKBP1B Gene
Genomic Locations for FKBP1B Gene
- chr2:24,049,701-24,067,743
- (GRCh38/hg38)
- Size:
- 18,043 bases
- Orientation:
- Plus strand
- chr2:24,272,571-24,286,551
- (GRCh37/hg19)
Genomic View for FKBP1B Gene
Genes around FKBP1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p23.3 by Ensembl
- 2p23.3 by Entrez Gene
- 2p23.3 by HGNC
FKBP1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FKBP1B Gene
Proteins for FKBP1B Gene
-
Protein details for FKBP1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P68106-FKB1B_HUMAN
- Recommended name:
- Peptidyl-prolyl cis-trans isomerase FKBP1B
- Protein Accession:
- P68106
- Q13664
- Q16645
- Q53TM2
- Q9BQ40
Protein attributes for FKBP1B Gene
- Size:
- 108 amino acids
- Molecular mass:
- 11783 Da
- Quaternary structure:
-
- Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2.
Three dimensional structures from OCA and Proteopedia for FKBP1B Gene
Alternative splice isoforms for FKBP1B Gene
- UniProtKB/Swiss-Prot:
Protein Expression for FKBP1B Gene
Selected DME Specific Peptides for FKBP1B Gene
- P68106:
-
- GHPGVIPPN
- GDGRTFPK
- GKKFDSS
- TLIFDVE
- AYGATGHPG
- IPPNATL
- KFDSSRDR
Post-translational modifications for FKBP1B Gene
No Post-translational modifications
Other Protein References for FKBP1B Gene
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Cloud-Clone Corp. Assay Kits for FKBP1B
Domains & Families for FKBP1B Gene
Gene Families for FKBP1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for FKBP1B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FKBP1B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P68106- Family:
-
- Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Function for FKBP1B Gene
Molecular function for FKBP1B Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by both FK506 and rapamycin.
- UniProtKB/Swiss-Prot Function:
- Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Enzyme Numbers (IUBMB) for FKBP1B Gene
Phenotypes From GWAS Catalog for FKBP1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IDA,IEA | 7592869 |
| GO:0005102 | receptor binding | IPI | 10830164 |
| GO:0005219 | contributes_to ryanodine-sensitive calcium-release channel activity | TAS | 11322937 |
| GO:0005515 | protein binding | IPI | 7592869 |
| GO:0005528 | FK506 binding | IEA,IDA | 7592869 |
Phenotypes for FKBP1B Gene
- MGI mutant phenotypes for FKBP1B:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for FKBP1B:
Animal Models for FKBP1B Gene
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miRNA for FKBP1B Gene
- miRTarBase miRNAs that target FKBP1B
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP1B Gene
Localization for FKBP1B Gene
Subcellular locations from UniProtKB/Swiss-Prot for FKBP1B Gene
- Cytoplasm. Sarcoplasmic reticulum.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| plasma membrane | 2 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IDA | 12443530 |
| GO:0005829 | cytosol | IC | 7592869 |
| GO:0016020 | membrane | IDA | 12443530 |
| GO:0016529 | sarcoplasmic reticulum | IEA | -- |
| GO:0030018 | Z disc | IDA | 20431056 |
Pathways & Interactions for FKBP1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cardiac conduction |
.39
|
|
| 2 | Ion channel transport | ||
| 3 | Antiarrhythmic Pathway, Pharmacodynamics | ||
| 4 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
Pathways by source for FKBP1B Gene
6 Reactome pathways for FKBP1B Gene
1 PharmGKB pathway for FKBP1B Gene
Interacting Proteins for FKBP1B Gene
Selected Interacting proteins:
ENSP00000370373
P68106-FKB1B_HUMAN
for FKBP1B Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000413 | protein peptidyl-prolyl isomerization | IDA | 7592869 |
| GO:0002027 | regulation of heart rate | IEA | -- |
| GO:0006458 | de novo protein folding | TAS | 11322937 |
| GO:0006939 | smooth muscle contraction | IEA | -- |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA | -- |
No data available for SIGNOR curated interactions for FKBP1B Gene
Transcripts for FKBP1B Gene
mRNA/cDNA for FKBP1B Gene
- (9) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (106) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FKBP1B Gene
CRISPR Products
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OriGene CRISPR knockouts for FKBP1B
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FKBP1B
- Applied Biological Materials Clones for FKBP1B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for FKBP1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Brain (Nervous System)
This gene is overexpressed in Fetal Brain (46.4), Frontal cortex (9.0), and Peripheral blood mononuclear cells (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FKBP1B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FKBP1B Gene:
FKBP1BSOURCE GeneReport for Unigene cluster for FKBP1B Gene:
Hs.709461mRNA Expression by UniProt/SwissProt for FKBP1B Gene:
P68106-FKB1B_HUMAN
Tissue specificity:
Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.
Evidence on tissue expression from TISSUES for FKBP1B Gene
- Heart(4.6)
- Muscle(4.6)
- Nervous system(4.5)
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OriGene qPCR primer pairs for FKBP1B
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No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP1B Gene
Orthologs for FKBP1B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FKBP1B 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | FKBP1B 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | FKBP1B 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Fkbp1b 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FKBP1B 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fkbp1b 33 |
|
||
| chicken (Gallus gallus) |
Aves | FKBP1B 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | FKBP1B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fkbp1b 33 |
|
||
| Str.15290 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.21934 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fkbp1b 33 34 |
|
||
| zgc73381 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11606 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | FK506-bp2 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | fkb-2 34 |
|
ManyToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FPR1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3865 34 |
|
OneToMany |
- Species where no ortholog for FKBP1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for FKBP1B Gene
(16) SIMAP similar genes for FKBP1B Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for FKBP1B Gene
Variants for FKBP1B Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000029386 | -- | 24,036,180(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000083777 | -- | 24,043,561(+) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000175357 | -- | 24,055,174(+) | A/G | intron_variant | |
| rs1000280823 | -- | 24,061,258(+) | A/C | intron_variant | |
| rs1000321587 | -- | 24,066,917(+) | G/A | 3_prime_UTR_variant, genic_downstream_transcript_variant |
Residual Variation Intolerance Score:
43.8% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FKBP1B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FKBP1B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP1B Gene
Disorders for FKBP1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| catecholaminergic polymorphic ventricular tachycardia |
|
|
| heart disease |
|
|
| left ventricular noncompaction |
|
|
Search FKBP1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FKBP1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP1B Gene
Publications for FKBP1B Gene
- Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PMID: 7513996) Arakawa H … Nakamura Y (Biochemical and biophysical research communications 1994) 2 3 4 22 58
- Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. (PMID: 16122887) Nakazawa T … Okamoto H (Gene 2005) 3 4 22 58
- Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PMID: 14616768) Benjafield AV … Morris BJ (Clinical genetics 2003) 3 22 44 58
- PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PMID: 10830164) Marx SO … Marks AR (Cell 2000) 3 4 22 58
- A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PMID: 7592869) Lam E … Wiederrecht GJ (The Journal of biological chemistry 1995) 3 4 22 58
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- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for FKBP1B
- Cloud-Clone Corp. Antibodies for FKBP1B
- Cloud-Clone Corp. Proteins for FKBP1B
- Cloud-Clone Corp. Assay Kits for FKBP1B
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for FKBP1B
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for FKBP1B
- VectorBuilder custom plasmid, inducible vectors for FKBP1B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FKBP1B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FKBP1B
- antibodies-online: Search results for 30 available FKBP1B Antibodies ranked by validation data
- Compare Top FKBP1B Antibodies
- antibodies-online: Search results for 5 available FKBP1B Elisa Kits ranked by validation data
- Compare Top FKBP1B Elisa Kits
- Recommended
- antibodies-online: Search results for 14 available FKBP1B Proteins ranked by validation data
- Compare Top FKBP1B Proteins
- Search GeneTex for Antibodies for FKBP1B
- Search GeneTex for Proteins for FKBP1B
- ViGene Biosciences adenoviral particle packaged cDNA for FKBP1B gene
- ViGene Biosciences lentiviral particle packaged cDNA for FKBP1B gene
- ViGene Biosciences ready-to-package AAV shRNAs for FKBP1B gene
- Search ViGene Biosciences for FKBP1B
- Santa Cruz Biotechnology (SCBT) Antibodies for FKBP1B
- Search Santa Cruz Biotechnology (SCBT) for FKBP1B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FKBP1B
- Horizon Cell Lines for FKBP1B
- genomics-online: cdna clones - Search results for 120 available FKBP1B gene related products
- Overview of 120 available FKBP1B gene related products
- orf clones - Search results for 120 available FKBP1B gene related products
- Overview of 120 available FKBP1B gene related products
- genomics-online: gRNA clones - Search results for 120 available FKBP1B gene related products
- Overview of 120 available FKBP1B gene related products
- genomics-online: primer clones - Search results for 120 available FKBP1B gene related products
- Overview of 120 available FKBP1B gene related products
- genomics-online: shRNA clones - Search results for 120 available FKBP1B gene related products
- Overview of 120 available FKBP1B gene related products
Sources for FKBP1B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew