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Aliases for FKBP1B Gene

Aliases for FKBP1B Gene

  • FK506 Binding Protein 1B 2 3 5
  • FK506 Binding Protein 1B, 12.6 KDa 2 3
  • 12.6 KDa FK506-Binding Protein 3 4
  • Immunophilin FKBP12.6 3 4
  • 12.6 KDa FKBP 3 4
  • PPIase FKBP1B 3 4
  • Calstabin 2 2 3
  • EC 5.2.1.8 4 56
  • FKBP-12.6 3 4
  • H-FKBP-12 3 4
  • Rotamase 3 4
  • FKBP12.6 3 4
  • FKBP-1B 3 4
  • FKBP1L 3 4
  • OTK4 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP1B 3
  • FK506-Binding Protein 1B (12.6 KD) 2
  • FK506-Binding Protein 12.6 3
  • FK506-Binding Protein 1B 4
  • PPIASE 3
  • PKBP1L 3
  • FKBP9 4

External Ids for FKBP1B Gene

Previous HGNC Symbols for FKBP1B Gene

  • FKBP1L

Previous GeneCards Identifiers for FKBP1B Gene

  • GC02P024188
  • GC02P024365
  • GC02P024230
  • GC02P024248
  • GC02P024249
  • GC02P024184
  • GC02P024126
  • GC02P024272

Summaries for FKBP1B Gene

Entrez Gene Summary for FKBP1B Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP1B Gene

FKBP1B (FK506 Binding Protein 1B) is a Protein Coding gene. Diseases associated with FKBP1B include Catecholaminergic Polymorphic Ventricular Tachycardia and Heart Disease. Among its related pathways are Cardiac conduction and Ion channel transport. Gene Ontology (GO) annotations related to this gene include receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot for FKBP1B Gene

  • Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for FKBP1B Gene

Additional gene information for FKBP1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP1B Gene

Genomics for FKBP1B Gene

GeneHancer (GH) Regulatory Elements for FKBP1B Gene

Promoters and enhancers for FKBP1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I024048 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.2 190 1.8 ELF3 ARID4B KLF17 ZNF2 ZNF48 ZNF335 ZNF121 GLIS2 ZNF366 ZNF391 FKBP1B WDCP FAM228B SF3B6 MFSD2B TP53I3 ATAD2B UBXN2A PFN4 GC02M024079
GH02I023924 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.9 -123.1 -123136 3.7 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 UBXN2A ATAD2B FAM228B MFSD2B SF3B6 FKBP1B PFN4 RPS13P4 GC02P023754
GH02I024014 Enhancer 1.3 Ensembl ENCODE dbSUPER 8.9 -33.3 -33347 3.8 FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A ZNF48 ETS1 SLC30A9 TCF12 FAM228B FKBP1B PFN4 MFSD2B RNU6-370P GC02P023754
GH02I023669 Enhancer 0.7 Ensembl ENCODE 9.5 -379.8 -379799 1.8 SCRT1 USF1 SCRT2 ZBTB33 ZIC2 CHD2 FKBP1B PFN4 FAM228A GC02P023666 ENSG00000283031 KLHL29
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FKBP1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FKBP1B gene promoter:

Genomic Locations for FKBP1B Gene

Genomic Locations for FKBP1B Gene
chr2:24,049,701-24,067,743
(GRCh38/hg38)
Size:
18,043 bases
Orientation:
Plus strand
chr2:24,272,571-24,286,551
(GRCh37/hg19)

Genomic View for FKBP1B Gene

Genes around FKBP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP1B Gene

Proteins for FKBP1B Gene

  • Protein details for FKBP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68106-FKB1B_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1B
    Protein Accession:
    P68106
    Secondary Accessions:
    • Q13664
    • Q16645
    • Q53TM2
    • Q9BQ40

    Protein attributes for FKBP1B Gene

    Size:
    108 amino acids
    Molecular mass:
    11783 Da
    Quaternary structure:
    • Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2.

    Three dimensional structures from OCA and Proteopedia for FKBP1B Gene

    Alternative splice isoforms for FKBP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP1B Gene

Selected DME Specific Peptides for FKBP1B Gene

P68106:
  • GHPGVIPPN
  • GDGRTFPK
  • GKKFDSS
  • TLIFDVE
  • AYGATGHPG
  • IPPNATL
  • KFDSSRDR

Post-translational modifications for FKBP1B Gene

No Post-translational modifications

Domains & Families for FKBP1B Gene

Gene Families for FKBP1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FKBP1B Gene

Suggested Antigen Peptide Sequences for FKBP1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P68106

UniProtKB/Swiss-Prot:

FKB1B_HUMAN :
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Family:
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
genes like me logo Genes that share domains with FKBP1B: view

Function for FKBP1B Gene

Molecular function for FKBP1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin.
UniProtKB/Swiss-Prot Function:
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Enzyme Numbers (IUBMB) for FKBP1B Gene

Phenotypes From GWAS Catalog for FKBP1B Gene

Gene Ontology (GO) - Molecular Function for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IDA,IEA 7592869
GO:0005102 receptor binding IPI 10830164
GO:0005219 contributes_to ryanodine-sensitive calcium-release channel activity TAS 11322937
GO:0005515 protein binding IPI 7592869
GO:0005528 FK506 binding IEA,IDA 7592869
genes like me logo Genes that share ontologies with FKBP1B: view
genes like me logo Genes that share phenotypes with FKBP1B: view

Animal Models for FKBP1B Gene

MGI Knock Outs for FKBP1B:

miRNA for FKBP1B Gene

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP1B Gene

Localization for FKBP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP1B Gene

Cytoplasm. Sarcoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP1B gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 12443530
GO:0005829 cytosol IC 7592869
GO:0016020 membrane IDA 12443530
GO:0016529 sarcoplasmic reticulum IEA --
GO:0030018 Z disc IDA 20431056
genes like me logo Genes that share ontologies with FKBP1B: view

Pathways & Interactions for FKBP1B Gene

genes like me logo Genes that share pathways with FKBP1B: view

Pathways by source for FKBP1B Gene

Gene Ontology (GO) - Biological Process for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 7592869
GO:0002027 regulation of heart rate IEA --
GO:0006458 de novo protein folding TAS 11322937
GO:0006939 smooth muscle contraction IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with FKBP1B: view

No data available for SIGNOR curated interactions for FKBP1B Gene

Drugs & Compounds for FKBP1B Gene

(7) Drugs for FKBP1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FKBP1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FKBP1B: view

Transcripts for FKBP1B Gene

Unigene Clusters for FKBP1B Gene

FK506 binding protein 1B, 12.6 kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -
SP8:

Relevant External Links for FKBP1B Gene

GeneLoc Exon Structure for
FKBP1B
ECgene alternative splicing isoforms for
FKBP1B

Expression for FKBP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP1B Gene

This gene is overexpressed in Fetal Brain (46.4), Frontal cortex (9.0), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FKBP1B Gene



Protein tissue co-expression partners for FKBP1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FKBP1B Gene:

FKBP1B

SOURCE GeneReport for Unigene cluster for FKBP1B Gene:

Hs.709461

mRNA Expression by UniProt/SwissProt for FKBP1B Gene:

P68106-FKB1B_HUMAN
Tissue specificity: Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.

Evidence on tissue expression from TISSUES for FKBP1B Gene

  • Heart(4.6)
  • Muscle(4.6)
  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with FKBP1B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP1B Gene

Orthologs for FKBP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP1B 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia FKBP1B 33 34
  • 97.22 (n)
cow
(Bos Taurus)
Mammalia FKBP1B 33 34
  • 95.37 (n)
mouse
(Mus musculus)
Mammalia Fkbp1b 33 16 34
  • 94.44 (n)
oppossum
(Monodelphis domestica)
Mammalia FKBP1B 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp1b 33
  • 93.83 (n)
chicken
(Gallus gallus)
Aves FKBP1B 33 34
  • 86.11 (n)
lizard
(Anolis carolinensis)
Reptilia FKBP1B 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp1b 33
  • 80.56 (n)
Str.15290 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.21934 33
zebrafish
(Danio rerio)
Actinopterygii fkbp1b 33 34
  • 78.4 (n)
zgc73381 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11606 33
fruit fly
(Drosophila melanogaster)
Insecta FK506-bp2 35 34
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea fkb-2 34
  • 56 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR1 34
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3865 34
  • 71 (a)
OneToMany
Species where no ortholog for FKBP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP1B Gene

ENSEMBL:
Gene Tree for FKBP1B (if available)
TreeFam:
Gene Tree for FKBP1B (if available)

Paralogs for FKBP1B Gene

Paralogs for FKBP1B Gene

Pseudogenes.org Pseudogenes for FKBP1B Gene

genes like me logo Genes that share paralogs with FKBP1B: view

Variants for FKBP1B Gene

Sequence variations from dbSNP and Humsavar for FKBP1B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000029386 -- 24,036,180(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000083777 -- 24,043,561(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000175357 -- 24,055,174(+) A/G intron_variant
rs1000280823 -- 24,061,258(+) A/C intron_variant
rs1000321587 -- 24,066,917(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP1B Gene

Variant ID Type Subtype PubMed ID
nsv997445 CNV gain 25217958
nsv997725 CNV gain 25217958

Variation tolerance for FKBP1B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP1B Gene

Disorders for FKBP1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for FKBP1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
catecholaminergic polymorphic ventricular tachycardia
  • catecholamine-induced polymorphic ventricular tachycardia
heart disease
  • congenital heart disease
left ventricular noncompaction
  • left ventricular hypertrabeculation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FKBP1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FKBP1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP1B Gene

Publications for FKBP1B Gene

  1. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PMID: 7513996) Arakawa H … Nakamura Y (Biochemical and biophysical research communications 1994) 2 3 4 22 58
  2. Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. (PMID: 16122887) Nakazawa T … Okamoto H (Gene 2005) 3 4 22 58
  3. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PMID: 14616768) Benjafield AV … Morris BJ (Clinical genetics 2003) 3 22 44 58
  4. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PMID: 10830164) Marx SO … Marks AR (Cell 2000) 3 4 22 58
  5. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PMID: 7592869) Lam E … Wiederrecht GJ (The Journal of biological chemistry 1995) 3 4 22 58

Products for FKBP1B Gene

Sources for FKBP1B Gene

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