Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
FKBP1B (FKBP Prolyl Isomerase 1B) is a Protein Coding gene. Diseases associated with FKBP1B include Catecholaminergic Polymorphic Ventricular Tachycardia and Arrhythmogenic Right Ventricular Dysplasia, Familial, 2. Among its related pathways are Cardiac conduction and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA,IDA | 7592869 |
GO:0005102 | signaling receptor binding | IPI | 10830164 |
GO:0005219 | contributes_to ryanodine-sensitive calcium-release channel activity | TAS | 11322937 |
GO:0005515 | protein binding | IPI | 7592869 |
GO:0005528 | FK506 binding | IEA,IDA | 7592869 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005623 | cell | IEA | -- |
GO:0005737 | cytoplasm | IBA,IDA | 12443530 |
GO:0005829 | cytosol | IC | 7592869 |
GO:0016020 | membrane | IDA | 12443530 |
GO:0016529 | sarcoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cardiac conduction |
.39
|
|
2 | Ion channel transport | ||
3 | Antiarrhythmic Pathway, Pharmacodynamics | ||
4 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000413 | protein peptidyl-prolyl isomerization | IEA,IDA | 7592869 |
GO:0002027 | regulation of heart rate | IEA | -- |
GO:0006458 | 'de novo' protein folding | TAS | 11322937 |
GO:0006939 | smooth muscle contraction | IEA | -- |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA | -- |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g | · | 6h | · | 6i |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FKBP1B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FKBP1B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FKBP1B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fkbp1b 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FKBP1B 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fkbp1b 30 |
|
||
Chicken (Gallus gallus) |
Aves | FKBP1B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FKBP1B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fkbp1b 30 |
|
||
Str.15290 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.21934 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fkbp1b 30 31 |
|
OneToOne | |
zgc73381 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11606 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | FK506-bp2 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | fkb-2 31 |
|
ManyToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | FPR1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3865 31 |
|
OneToMany |
Disorder | Aliases | PubMed IDs |
---|---|---|
catecholaminergic polymorphic ventricular tachycardia |
|
|
arrhythmogenic right ventricular dysplasia, familial, 2 |
|
|
ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy |
|
|
heart disease |
|
|
cardiac conduction defect |
|