Aliases for FKBP1B Gene
External Ids for FKBP1B Gene
Previous HGNC Symbols for FKBP1B Gene
Previous GeneCards Identifiers for FKBP1B Gene
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for FKBP1B Gene
FKBP1B (FKBP Prolyl Isomerase 1B) is a Protein Coding gene. Diseases associated with FKBP1B include Catecholaminergic Polymorphic Ventricular Tachycardia and Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy. Among its related pathways are Ion channel transport and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.
UniProtKB/Swiss-Prot Summary for FKBP1B Gene
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.