FKBP1B Gene (Protein Coding)

FKBP Prolyl Isomerase 1B

GC02P024049
GIFtS:
40
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is t... See more...

Aliases for FKBP1B Gene

Aliases for FKBP1B Gene

  • FKBP Prolyl Isomerase 1B 2 3 5
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP1B 3 4
  • FK506 Binding Protein 1B, 12.6 KDa 2 3
  • 12.6 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 1B 3 4
  • Immunophilin FKBP12.6 3 4
  • 12.6 KDa FKBP 3 4
  • PPIase FKBP1B 3 4
  • Calstabin 2 2 3
  • EC 5.2.1.8 4 52
  • FKBP-12.6 3 4
  • H-FKBP-12 3 4
  • Rotamase 3 4
  • FKBP12.6 3 4
  • FKBP-1B 3 4
  • FKBP1L 3 4
  • OTK4 3 4
  • FK506-Binding Protein 1B (12.6 KD) 2
  • FK506-Binding Protein 12.6 3
  • FK506 Binding Protein 1B 2
  • PKBP1L 3
  • PPIase 3
  • FKBP9 4

External Ids for FKBP1B Gene

Previous HGNC Symbols for FKBP1B Gene

  • FKBP1L

Previous GeneCards Identifiers for FKBP1B Gene

  • GC02P024188
  • GC02P024365
  • GC02P024230
  • GC02P024248
  • GC02P024249
  • GC02P024184
  • GC02P024126
  • GC02P024272
  • GC02P024011

Summaries for FKBP1B Gene

Entrez Gene Summary for FKBP1B Gene

  • The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBP1B Gene

FKBP1B (FKBP Prolyl Isomerase 1B) is a Protein Coding gene. Diseases associated with FKBP1B include Catecholaminergic Polymorphic Ventricular Tachycardia and Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/Or Dilated Cardiomyopathy. Among its related pathways are Ion channel transport and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP1A.

UniProtKB/Swiss-Prot Summary for FKBP1B Gene

  • Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Gene Wiki entry for FKBP1B Gene

Additional gene information for FKBP1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FKBP1B Gene

Genomics for FKBP1B Gene

GeneHancer (GH) Regulatory Elements for FKBP1B Gene

Promoters and enhancers for FKBP1B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J024045 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -1.3 -1266 5.5 ZBTB40 ZNF217 NRF1 TCF12 POLR2G SP1 PHF8 SIX5 PHB2 ZNF639 WDCP FKBP1B FAM228B ATAD2B SF3B6 ITSN2 PFN4 MFSD2B TP53I3 UBXN2A
GH02J024063 Promoter 0.3 EPDnew 500.4 +13.4 13363 0.1 FKBP1B MFSD2B NONHSAG027225.2 piR-50015
GH02J023924 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 8.9 -123.1 -123100 4.4 RXRA HNRNPK ZNF217 EP300 CTCF NRF1 POLR2G SP1 GTF2E2 PHF8 ATAD2B UBXN2A FAM228B WDCP MFSD2B SF3B6 PFN4 FKBP1B piR-59769-333
GH02J024014 Enhancer 1.3 Ensembl ENCODE dbSUPER 8.9 -33.2 -33184 4.2 ZNF217 TCF12 POLR2G NCOR1 FOS ZFX KDM6A FOXA1 CUX1 TGIF2 FAM228B FKBP1B PFN4 piR-57460-357 MFSD2B
GH02J024021 Enhancer 1.1 Ensembl ENCODE 8.6 -27.7 -27708 2 EP300 CTCF MYC NCOR1 KDM6A TCF7 REST ZBTB25 CTBP1 ZBTB7A FKBP1B UBXN2A piR-57460-357 MFSD2B piR-38580-154
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FKBP1B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FKBP1B

Top Transcription factor binding sites by QIAGEN in the FKBP1B gene promoter:
  • FOXC1
  • Ik-1
  • RREB-1
  • Sp1
  • YY1

Genomic Locations for FKBP1B Gene

Genomic Locations for FKBP1B Gene
chr2:24,049,701-24,067,743
(GRCh38/hg38)
Size:
18,043 bases
Orientation:
Plus strand
chr2:24,272,571-24,286,551
(GRCh37/hg19)
Size:
13,981 bases
Orientation:
Plus strand

Genomic View for FKBP1B Gene

Genes around FKBP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FKBP1B Gene

Proteins for FKBP1B Gene

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  • Protein details for FKBP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68106-FKB1B_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP1B
    Protein Accession:
    P68106
    Secondary Accessions:
    • Q13664
    • Q16645
    • Q53TM2
    • Q9BQ40

    Protein attributes for FKBP1B Gene

    Size:
    108 amino acids
    Molecular mass:
    11783 Da
    Quaternary structure:
    • Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with RYR2.

    Three dimensional structures from OCA and Proteopedia for FKBP1B Gene

    Alternative splice isoforms for FKBP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP1B Gene

Protein Expression for FKBP1B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FKBP1B Gene

P68106:
  • GHPGVIPPN
  • GDGRTFPK
  • GKKFDSS
  • TLIFDVE
  • AYGATGHPG
  • IPPNATL
  • KFDSSRDR

Post-translational modifications for FKBP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FKBP1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FKBP1B Gene

Gene Families for FKBP1B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FKBP1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP1B Gene

GenScript: Design optimal peptide antigens:
  • h-FKBP-12 (FKB1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P68106

UniProtKB/Swiss-Prot:

FKB1B_HUMAN :
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Family:
  • Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
genes like me logo Genes that share domains with FKBP1B: view

Function for FKBP1B Gene

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  2. CRISPR
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Molecular function for FKBP1B Gene

UniProtKB/Swiss-Prot Function:
Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by both FK506 and rapamycin.

Enzyme Numbers (IUBMB) for FKBP1B Gene

Phenotypes From GWAS Catalog for FKBP1B Gene

Gene Ontology (GO) - Molecular Function for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IDA 7592869
GO:0005102 signaling receptor binding IPI 10830164
GO:0005219 contributes_to ryanodine-sensitive calcium-release channel activity TAS 11322937
GO:0005515 protein binding IPI 7592869
GO:0005528 FK506 binding IDA,IEA 7592869
genes like me logo Genes that share ontologies with FKBP1B: view
genes like me logo Genes that share phenotypes with FKBP1B: view

Animal Models for FKBP1B Gene

MGI Knock Outs for FKBP1B:

Animal Model Products

CRISPR Products

miRNA for FKBP1B Gene

miRTarBase miRNAs that target FKBP1B

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBP1B Gene

Localization for FKBP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP1B Gene

Cytoplasm. Sarcoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP1B gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 4
plasma membrane 2
mitochondrion 2
extracellular 1
cytoskeleton 1
nucleus 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm IDA,IBA 12443530
GO:0005829 cytosol IC 7592869
GO:0016020 membrane IDA 12443530
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with FKBP1B: view

Pathways & Interactions for FKBP1B Gene

genes like me logo Genes that share pathways with FKBP1B: view

Pathways by source for FKBP1B Gene

1 PharmGKB pathway for FKBP1B Gene

Gene Ontology (GO) - Biological Process for FKBP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 7592869
GO:0002027 regulation of heart rate IEA --
GO:0006458 'de novo' protein folding TAS 11322937
GO:0006939 smooth muscle contraction IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with FKBP1B: view

No data available for SIGNOR curated interactions for FKBP1B Gene

Drugs & Compounds for FKBP1B Gene

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  1. Drug

(7) Drugs for FKBP1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FKBP1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FKBP1B: view

Transcripts for FKBP1B Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for FKBP1B Gene

4 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP1B Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - -
SP8:

Relevant External Links for FKBP1B Gene

GeneLoc Exon Structure for
FKBP1B

Expression for FKBP1B Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FKBP1B Gene

mRNA expression in normal human tissues for FKBP1B Gene
mRNA expression by BioGPS for FKBP1B GenemRNA expression by GTEx for FKBP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FKBP1B Gene

This gene is overexpressed in Fetal Brain (46.4), Frontal cortex (9.0), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FKBP1B Gene



Protein tissue co-expression partners for FKBP1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FKBP1B

SOURCE GeneReport for Unigene cluster for FKBP1B Gene:

Hs.709461

mRNA Expression by UniProt/SwissProt for FKBP1B Gene:

P68106-FKB1B_HUMAN
Tissue specificity: Detected in heart muscle (at protein level). Isoform 1 and isoform 2 are ubiquitous with highest levels in brain and thymus.

Evidence on tissue expression from TISSUES for FKBP1B Gene

  • Heart(4.6)
  • Muscle(4.6)
  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with FKBP1B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP1B Gene

Orthologs for FKBP1B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FKBP1B 31 30
  • 100 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia FKBP1B 31 30
  • 97.22 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia FKBP1B 31 30
  • 95.37 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Fkbp1b 17 31 30
  • 94.44 (n)
oppossum
(Monodelphis domestica)
 Mammalia FKBP1B 31
  • 94 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Fkbp1b 30
  • 93.83 (n)
chicken
(Gallus gallus)
 Aves FKBP1B 31 30
  • 86.11 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FKBP1B 31
  • 92 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fkbp1b 30
  • 80.56 (n)
Str.15290 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.21934 30
zebrafish
(Danio rerio)
 Actinopterygii fkbp1b 31 30
  • 78.4 (n)
 OneToOne
zgc73381 30
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.11606 30
fruit fly
(Drosophila melanogaster)
 Insecta FK506-bp2 31 32
  • 70 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea fkb-2 31
  • 56 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes FPR1 31
  • 53 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.3865 31
  • 71 (a)
 OneToMany
Species where no ortholog for FKBP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP1B Gene

ENSEMBL:
Gene Tree for FKBP1B (if available)
TreeFam:
Gene Tree for FKBP1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FKBP1B: view image

Paralogs for FKBP1B Gene

Paralogs for FKBP1B Gene

(16) SIMAP similar genes for FKBP1B Gene using alignment to 4 proteins:

  • FKB1B_HUMAN
  • F8W6G9_HUMAN
  • G5E9U6_HUMAN
  • H7C0Y3_HUMAN

Pseudogenes.org Pseudogenes for FKBP1B Gene

genes like me logo Genes that share paralogs with FKBP1B: view

Variants for FKBP1B Gene

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Additional dbSNP identifiers (rs#s) for FKBP1B Gene

Structural Variations from Database of Genomic Variants (DGV) for FKBP1B Gene

Variant ID Type Subtype PubMed ID
nsv997445 CNV gain 25217958
nsv997725 CNV gain 25217958

Variation tolerance for FKBP1B Gene

Residual Variation Intolerance Score: 43.8% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FKBP1B Gene

Disorders for FKBP1B Gene

MalaCards: The human disease database

(14) MalaCards diseases for FKBP1B Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FKBP1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FKBP1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP1B Gene

Publications for FKBP1B Gene

  1. Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts. (PMID: 7513996) Arakawa H … Nakamura Y (Biochemical and biophysical research communications 1994) 2 3 4 23 54
  2. Genomic organization, chromosomal localization, and promoter of human gene for FK506-binding protein 12.6. (PMID: 16122887) Nakazawa T … Okamoto H (Gene 2005) 3 4 23 54
  3. Association of EDNRA, but not WNK4 or FKBP1B, polymorphisms with essential hypertension. (PMID: 14616768) Benjafield AV … Morris BJ (Clinical genetics 2003) 3 23 41 54
  4. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. (PMID: 10830164) Marx SO … Marks AR (Cell 2000) 3 4 23 54
  5. A novel FK506 binding protein can mediate the immunosuppressive effects of FK506 and is associated with the cardiac ryanodine receptor. (PMID: 7592869) Lam E … Wiederrecht GJ (The Journal of biological chemistry 1995) 3 4 23 54

ExternalLinks

View latest publications for FKBP1B gene in Mastermind

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