Aliases for FKBP15 Gene

Aliases for FKBP15 Gene

  • FKBP Prolyl Isomerase 15 2 3 5
  • KIAA0674 2 3 4
  • WAFL 2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 76 2 3
  • FK506 Binding Protein 15, 133kDa 2 3
  • 133 KDa FK506-Binding Protein 3 4
  • WASP And FKBP-Like Protein 2 3
  • FK506-Binding Protein 15 3 4
  • 133 KDa FKBP 3 4
  • FKBP-133 3 4
  • FKBP133 2 3
  • PPP1R76 2 3
  • FKBP-15 3 4
  • FK506-Binding Protein 133kDa 3
  • WASP- And FKBP-Like Protein 4
  • FK506 Binding Protein 15 2
  • FKBP15 5

External Ids for FKBP15 Gene

Previous HGNC Symbols for FKBP15 Gene

  • KIAA0674

Previous GeneCards Identifiers for FKBP15 Gene

  • GC09M114968
  • GC09M115923
  • GC09M085535

Summaries for FKBP15 Gene

GeneCards Summary for FKBP15 Gene

FKBP15 (FKBP Prolyl Isomerase 15) is a Protein Coding gene. Diseases associated with FKBP15 include Megalencephalic Leukoencephalopathy With Subcortical Cysts 1 and Spinocerebellar Ataxia 11. Gene Ontology (GO) annotations related to this gene include actin binding and peptidyl-prolyl cis-trans isomerase activity. An important paralog of this gene is FKBP4.

UniProtKB/Swiss-Prot Summary for FKBP15 Gene

  • May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FKBP15 Gene

Genomics for FKBP15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FKBP15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FKBP15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FKBP15

Top Transcription factor binding sites by QIAGEN in the FKBP15 gene promoter:
  • ATF-2
  • C/EBPalpha
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HSF1 (long)
  • HSF1short

Genomic Locations for FKBP15 Gene

Genomic Locations for FKBP15 Gene
chr9:113,161,006-113,221,325
(GRCh38/hg38)
Size:
60,320 bases
Orientation:
Minus strand
chr9:115,923,286-115,983,641
(GRCh37/hg19)
Size:
60,356 bases
Orientation:
Minus strand

Genomic View for FKBP15 Gene

Genes around FKBP15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP15 Gene

Proteins for FKBP15 Gene

  • Protein details for FKBP15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T1M5-FKB15_HUMAN
    Recommended name:
    FK506-binding protein 15
    Protein Accession:
    Q5T1M5
    Secondary Accessions:
    • Q05DK8
    • Q5T1M2
    • Q6DD85
    • Q9Y4D0

    Protein attributes for FKBP15 Gene

    Size:
    1219 amino acids
    Molecular mass:
    133630 Da
    Quaternary structure:
    • Interacts with WIP and actin (PubMed:19121306). Interacts with TBC1D23 (PubMed:29084197).
    SequenceCaution:
    • Sequence=AAH09609.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA31649.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FKBP15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP15 Gene

Post-translational modifications for FKBP15 Gene

  • Ubiquitination at Lys774
  • Modification sites at PhosphoSitePlus

Other Protein References for FKBP15 Gene

No data available for DME Specific Peptides for FKBP15 Gene

Domains & Families for FKBP15 Gene

Gene Families for FKBP15 Gene

Protein Domains for FKBP15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP15 Gene

GenScript: Design optimal peptide antigens:
  • WASP and FKBP-like (FKB15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T1M5

UniProtKB/Swiss-Prot:

FKB15_HUMAN :
  • The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
  • Belongs to the FKBP-type PPIase family.
Domain:
  • The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity.
  • The central coiled-coil region is responsible for association with early endosomes.
Family:
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP15: view

Function for FKBP15 Gene

Molecular function for FKBP15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement.

Phenotypes From GWAS Catalog for FKBP15 Gene

Gene Ontology (GO) - Molecular Function for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 20923837
genes like me logo Genes that share ontologies with FKBP15: view

Phenotypes for FKBP15 Gene

genes like me logo Genes that share phenotypes with FKBP15: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP15

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBP15 Gene

Localization for FKBP15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP15 Gene

Cytoplasm. Cell projection, axon. Early endosome. Note=Present in axons and neuronal growth cones. {ECO:0000250 UniProtKB:Q6P9Q6}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP15 gene
Compartment Confidence
nucleus 4
endosome 4
cytoskeleton 3
cytosol 3
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005884 colocalizes_with actin filament IBA 21873635
GO:0016020 membrane IDA 22070227
genes like me logo Genes that share ontologies with FKBP15: view

Pathways & Interactions for FKBP15 Gene

PathCards logo

SuperPathways for FKBP15 Gene

No Data Available

SIGNOR curated interactions for FKBP15 Gene

Activates:

Gene Ontology (GO) - Biological Process for FKBP15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0006897 endocytosis IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with FKBP15: view

No data available for Pathways by source for FKBP15 Gene

Drugs & Compounds for FKBP15 Gene

No Compound Related Data Available

Transcripts for FKBP15 Gene

mRNA/cDNA for FKBP15 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FKBP15

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP15 Gene

No ASD Table

Relevant External Links for FKBP15 Gene

GeneLoc Exon Structure for
FKBP15

Expression for FKBP15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FKBP15 Gene

mRNA differential expression in normal tissues according to GTEx for FKBP15 Gene

This gene is overexpressed in Whole Blood (x4.8).

Protein differential expression in normal tissues from HIPED for FKBP15 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.6) and Lymph node (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP15 Gene



Protein tissue co-expression partners for FKBP15 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FKBP15

SOURCE GeneReport for Unigene cluster for FKBP15 Gene:

Hs.522351

Evidence on tissue expression from TISSUES for FKBP15 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with FKBP15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP15 Gene

Orthologs for FKBP15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP15 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FKBP15 30 31
  • 95.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FKBP15 30 31
  • 87.08 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FKBP15 30 31
  • 86.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fkbp15 30 17 31
  • 82.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fkbp15 30
  • 80.31 (n)
Oppossum
(Monodelphis domestica)
Mammalia FKBP15 31
  • 65 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FKBP15 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FKBP15 30 31
  • 70.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 58 (a)
OneToMany
-- 31
  • 34 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fkbp15 30
  • 61.14 (n)
Zebrafish
(Danio rerio)
Actinopterygii FKBP15 (1 of 4) 31
  • 67 (a)
OneToMany
LOC100330102 30
  • 59.88 (n)
FKBP15 (2 of 4) 31
  • 51 (a)
OneToMany
FKBP15 (4 of 4) 31
  • 42 (a)
OneToMany
FKBP15 (3 of 4) 31
  • 25 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta FK506-bp1 31
  • 18 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR4 31
  • 19 (a)
OneToMany
FPR3 31
  • 17 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToOne
Species where no ortholog for FKBP15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FKBP15 Gene

ENSEMBL:
Gene Tree for FKBP15 (if available)
TreeFam:
Gene Tree for FKBP15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FKBP15: view image

Paralogs for FKBP15 Gene

genes like me logo Genes that share paralogs with FKBP15: view

Variants for FKBP15 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FKBP15 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs10817455 Benign: not specified 113,194,438(-) T/A INTRON_VARIANT
rs4989078 Benign: not specified 113,211,764(-) T/G INTRON_VARIANT
rs10435864 - p.His413Gln
rs10465129 - p.Leu434Phe
rs1128116 - p.Ala847Ser

Additional dbSNP identifiers (rs#s) for FKBP15 Gene

Structural Variations from Database of Genomic Variants (DGV) for FKBP15 Gene

Variant ID Type Subtype PubMed ID
dgv4129n106 CNV deletion 24896259
esv1117569 CNV deletion 17803354
esv2238231 CNV deletion 18987734
esv2564104 CNV insertion 19546169
esv2647679 CNV deletion 19546169
esv2738953 CNV deletion 23290073
esv2759710 CNV gain 17122850
esv3545338 CNV deletion 23714750
esv3621539 CNV loss 21293372
esv4206 CNV loss 18987735
esv7708 CNV loss 19470904
esv995741 CNV deletion 20482838
nsv1041112 CNV loss 25217958
nsv1051654 CNV gain 25217958
nsv1075669 CNV deletion 25765185
nsv1146531 CNV deletion 26484159
nsv466507 CNV loss 19166990
nsv615213 CNV loss 21841781
nsv831691 CNV loss 17160897
nsv957141 CNV deletion 24416366

Variation tolerance for FKBP15 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.25; 95.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP15 Gene

Disorders for FKBP15 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FKBP15 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with FKBP15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FKBP15 Gene

Publications for FKBP15 Gene

  1. TBC1D23 is a bridging factor for endosomal vesicle capture by golgins at the trans-Golgi. (PMID: 29084197) Shin JJH … Munro S (Nature cell biology 2017) 3 4
  2. The ulcerative colitis marker protein WAFL interacts with accessory proteins in endocytosis. (PMID: 20376207) Pan YF … Maruyama IN (International journal of biological sciences 2010) 2 3
  3. WAFL, a new protein involved in regulation of early endocytic transport at the intersection of actin and microtubule dynamics. (PMID: 19121306) Viklund IM … Pettersson S (Experimental cell research 2009) 3 4
  4. FKBP133: a novel mouse FK506-binding protein homolog alters growth cone morphology. (PMID: 16756961) Nakajima O … Goshima Y (Biochemical and biophysical research communications 2006) 2 3
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4

Products for FKBP15 Gene

Sources for FKBP15 Gene