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Aliases for FKBP11 Gene

Subcategory (RNA class) for FKBP11 Gene


Aliases for FKBP11 Gene

  • FK506 Binding Protein 11 2 3 5
  • FK506 Binding Protein 11, 19 KDa 2 3
  • 19 KDa FK506-Binding Protein 3 4
  • PPIase FKBP11 3 4
  • 19 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-11 3 4
  • FKBP-19 3 4
  • FKBP19 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP11 3
  • FK506 Binding Protein 11 (19 KDa) 2
  • FK506-Binding Protein 11 4
  • EC 4

External Ids for FKBP11 Gene

ORGUL Members for FKBP11 Gene

Previous GeneCards Identifiers for FKBP11 Gene

  • GC12P049273
  • GC12M049032
  • GC12M047602
  • GC12M049315
  • GC12M046347

Summaries for FKBP11 Gene

Entrez Gene Summary for FKBP11 Gene

  • FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FKBP11 Gene

FKBP11 (FK506 Binding Protein 11) is a Protein Coding gene, and is affiliated with the antisense RNA class. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is FKBP10.

UniProtKB/Swiss-Prot for FKBP11 Gene

  • PPIases accelerate the folding of proteins during protein synthesis.

Additional gene information for FKBP11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP11 Gene

Genomics for FKBP11 Gene

GeneHancer (GH) Regulatory Elements for FKBP11 Gene

Promoters and enhancers for FKBP11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I048923 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 565.5 +1.5 1548 2.8 RB1 SIN3A RAD21 ZNF143 RUNX3 SMARCA5 SP3 SMAD5 USF2 ELF1 FKBP11 CCDC65 ENSG00000255863 ENSG00000272822
GH12I048926 Enhancer 0.3 ENCODE 550.8 -1.1 -1058 1.9 RUNX3 FKBP11 GC12M048929 CCDC65 WNT10B ENSG00000255863 ENSG00000272822
GH12I048967 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 26.3 -43.6 -43561 4.2 CLOCK SIN3A ZNF2 IRF4 ZNF213 GATA2 KLF7 RUNX3 SP3 JUNB GC12P048969 WNT10B FKBP11 CCDC65
GH12I048881 Enhancer 1.3 FANTOM5 Ensembl ENCODE 23.9 +43.3 43279 2.7 ELF3 FOXA2 SIN3A BMI1 ZNF48 RAD21 RARA YY1 ZNF335 HMG20B FKBP11 ARF3 ENSG00000255863 WNT10B CCDC65 RND1 OR8S1 GC12M048893 RNU6-600P
GH12I048956 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -30.3 -30344 3 HDGF PKNOX1 CLOCK SMAD1 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 ARF3 ENSG00000272822 CCNT1 KANSL2 LMBR1L LOC390314 DDX23 KMT2D SENP1 PRPF40B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FKBP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FKBP11 gene promoter:

Genomic Locations for FKBP11 Gene

Genomic Locations for FKBP11 Gene
4,957 bases
Minus strand

Genomic View for FKBP11 Gene

Genes around FKBP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP11 Gene

Proteins for FKBP11 Gene

  • Protein details for FKBP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP11
    Protein Accession:
    Secondary Accessions:
    • B4DWB7

    Protein attributes for FKBP11 Gene

    201 amino acids
    Molecular mass:
    22180 Da
    Quaternary structure:
    • Interacts with IFITM5.

    Alternative splice isoforms for FKBP11 Gene


neXtProt entry for FKBP11 Gene

Post-translational modifications for FKBP11 Gene

No data available for DME Specific Peptides for FKBP11 Gene

Domains & Families for FKBP11 Gene

Gene Families for FKBP11 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FKBP11 Gene

Suggested Antigen Peptide Sequences for FKBP11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FKBP-type PPIase family.
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP11: view

Function for FKBP11 Gene

Molecular function for FKBP11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Peptidylproline (omega=180) = peptidylproline (omega=0).
UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.

Enzyme Numbers (IUBMB) for FKBP11 Gene

Gene Ontology (GO) - Molecular Function for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IBA --
GO:0005528 FK506 binding IBA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with FKBP11: view
genes like me logo Genes that share phenotypes with FKBP11: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FKBP11 Gene

Localization for FKBP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP11 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP11 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
endoplasmic reticulum 2
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FKBP11: view

Pathways & Interactions for FKBP11 Gene

SuperPathways for FKBP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBP11: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP11 Gene

Drugs & Compounds for FKBP11 Gene

No Compound Related Data Available

Transcripts for FKBP11 Gene

mRNA/cDNA for FKBP11 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FKBP11 Gene

FK506 binding protein 11, 19 kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP11 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP6: -

Relevant External Links for FKBP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FKBP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FKBP11 Gene

This gene is overexpressed in Pancreas (x8.3).

Protein differential expression in normal tissues from HIPED for FKBP11 Gene

This gene is overexpressed in Pancreas (13.5), Islet of Langerhans (9.3), Skin (8.2), and Salivary gland (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBP11 Gene

Protein tissue co-expression partners for FKBP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of FKBP11 Gene:


SOURCE GeneReport for Unigene cluster for FKBP11 Gene:


Evidence on tissue expression from TISSUES for FKBP11 Gene

  • Pancreas(4.5)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with FKBP11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP11 Gene

Orthologs for FKBP11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FKBP11 33 34
  • 100 (n)
(Canis familiaris)
Mammalia FKBP11 33 34
  • 91.99 (n)
(Bos Taurus)
Mammalia FKBP11 33 34
  • 91.58 (n)
(Rattus norvegicus)
Mammalia Fkbp11 33
  • 89.19 (n)
(Mus musculus)
Mammalia Fkbp11 33 16 34
  • 87.73 (n)
(Anolis carolinensis)
Reptilia FKBP11 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp11 33
  • 63.73 (n)
Str.15739 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23956 33
(Danio rerio)
Actinopterygii fkbp11 33 34
  • 57.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14715 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea fkb-1 34
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 34
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for FKBP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP11 Gene

Gene Tree for FKBP11 (if available)
Gene Tree for FKBP11 (if available)

Paralogs for FKBP11 Gene

Variants for FKBP11 Gene

Sequence variations from dbSNP and Humsavar for FKBP11 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000168715 -- 48,926,154(-) T/C upstream_transcript_variant
rs1000288735 -- 48,925,458(-) C/A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001035171 -- 48,927,270(-) T/C upstream_transcript_variant
rs1002139700 -- 48,922,328(-) G/C genic_downstream_transcript_variant, intron_variant
rs1002467821 -- 48,921,825(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP11 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV gain 17160897

Variation tolerance for FKBP11 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP11 Gene

Disorders for FKBP11 Gene

Additional Disease Information for FKBP11

No disorders were found for FKBP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP11 Gene

Publications for FKBP11 Gene

  1. The human FK506-binding proteins: characterization of human FKBP19. (PMID: 16596453) Rulten SL … Kay JE (Mammalian genome : official journal of the International Mammalian Genome Society 2006) 2 3 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson CE … Davis EC (Genomics 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FKBP11 Gene

Sources for FKBP11 Gene

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