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Aliases for FKBP11 Gene

Subcategory (RNA class) for FKBP11 Gene

antisense

Aliases for FKBP11 Gene

  • FKBP Prolyl Isomerase 11 2 3 5
  • Peptidyl-Prolyl Cis-Trans Isomerase FKBP11 3 4
  • FK506 Binding Protein 11, 19 KDa 2 3
  • 19 KDa FK506-Binding Protein 3 4
  • FK506-Binding Protein 11 3 4
  • PPIase FKBP11 3 4
  • 19 KDa FKBP 3 4
  • Rotamase 3 4
  • FKBP-11 3 4
  • FKBP-19 3 4
  • FKBP19 3 4
  • FK506 Binding Protein 11 (19 KDa) 2
  • FK506 Binding Protein 11 2
  • EC 5.2.1.8 4

External Ids for FKBP11 Gene

ORGUL Members for FKBP11 Gene

Previous GeneCards Identifiers for FKBP11 Gene

  • GC12P049273
  • GC12M049032
  • GC12M047602
  • GC12M049315
  • GC12M046347

Summaries for FKBP11 Gene

Entrez Gene Summary for FKBP11 Gene

  • FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

GeneCards Summary for FKBP11 Gene

FKBP11 (FKBP Prolyl Isomerase 11) is a Protein Coding gene, and is affiliated with the antisense RNA class. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding. An important paralog of this gene is ENSG00000286264.

UniProtKB/Swiss-Prot for FKBP11 Gene

Additional gene information for FKBP11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBP11 Gene

Genomics for FKBP11 Gene

GeneHancer (GH) Regulatory Elements for FKBP11 Gene

Promoters and enhancers for FKBP11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J048923 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 615.4 +1.5 1548 2.8 NKRF POLR2A ZNF687 CTCF RELA SP1 CREM RAD21 IKZF1 ZBTB8A FKBP11 CCDC65 ENSG00000255863 ENSG00000272822
GH12J048926 Enhancer 0.3 ENCODE 600.7 -1.1 -1058 1.9 RUNX3 FKBP11 GC12M048929 CCDC65 WNT10B ENSG00000255863 ENSG00000272822
GH12J048881 Enhancer 1.1 FANTOM5 ENCODE 23.9 +43.3 43279 2.7 SP1 ZSCAN21 MAFK PPARG SP5 PRDM1 KAT8 HMG20B RXRA IKZF1 FKBP11 ARF3 ENSG00000255863 WNT10B CCDC65 RND1 OR8S1 GC12M048893 RNU6-600P
GH12J048955 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -30.1 -30127 4 ELF3 ZNF148 NKRF MLLT1 POLR2A CSDE1 ZBTB7A TRIM24 SP7 ELF1 ARF3 ENSG00000272822 CCNT1 KANSL2 LMBR1L LOC390314 DDX23 KMT2D SENP1 PRPF40B
GH12J048890 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 11 +35.5 35473 1.2 ELF3 CTCF SP7 KLF14 PRDM1 EGR1 RAD21 KAT8 GLIS2 ARID2 GC12M048893 RNU6-600P CCDC65 CCDC184 ENSG00000255863 BCDIN3D-AS1 FKBP11 RND1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FKBP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FKBP11 gene promoter:
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for FKBP11 Gene

Genomic Locations for FKBP11 Gene
chr12:48,921,518-48,926,474
(GRCh38/hg38)
Size:
4,957 bases
Orientation:
Minus strand
chr12:49,315,301-49,320,257
(GRCh37/hg19)
Size:
4,957 bases
Orientation:
Minus strand

Genomic View for FKBP11 Gene

Genes around FKBP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBP11 Gene

Proteins for FKBP11 Gene

  • Protein details for FKBP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYL4-FKB11_HUMAN
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP11
    Protein Accession:
    Q9NYL4
    Secondary Accessions:
    • B4DWB7

    Protein attributes for FKBP11 Gene

    Size:
    201 amino acids
    Molecular mass:
    22180 Da
    Quaternary structure:
    • Interacts with IFITM5.

    Alternative splice isoforms for FKBP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FKBP11 Gene

Post-translational modifications for FKBP11 Gene

  • Glycosylation at posLast=7676
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FKBP11 Gene

Domains & Families for FKBP11 Gene

Gene Families for FKBP11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FKBP11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FKBP11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53772, highly similar to FK506-binding protein 11 (EC 5.2.1.8) (B4DWB7_HUMAN)
  • Rotamase (FKB11_HUMAN)
  • FKBP11 protein (Q86SR8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NYL4

UniProtKB/Swiss-Prot:

FKB11_HUMAN :
  • Belongs to the FKBP-type PPIase family.
Family:
  • Belongs to the FKBP-type PPIase family.
genes like me logo Genes that share domains with FKBP11: view

Function for FKBP11 Gene

Molecular function for FKBP11 Gene

UniProtKB/Swiss-Prot Function:
PPIases accelerate the folding of proteins during protein synthesis.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;.

Enzyme Numbers (IUBMB) for FKBP11 Gene

Phenotypes From GWAS Catalog for FKBP11 Gene

Gene Ontology (GO) - Molecular Function for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA --
GO:0016853 isomerase activity IEA --
genes like me logo Genes that share ontologies with FKBP11: view
genes like me logo Genes that share phenotypes with FKBP11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FKBP11

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FKBP11 - Now 50% OFF >
  • * FKBP11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FKBP11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FKBP11 Gene

Localization for FKBP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FKBP11 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBP11 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
cytosol 1
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FKBP11: view

Pathways & Interactions for FKBP11 Gene

PathCards logo

SuperPathways for FKBP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FKBP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IEA --
genes like me logo Genes that share ontologies with FKBP11: view

No data available for Pathways by source and SIGNOR curated interactions for FKBP11 Gene

Drugs & Compounds for FKBP11 Gene

No Compound Related Data Available

Transcripts for FKBP11 Gene

mRNA/cDNA for FKBP11 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for FKBP11 Gene

FK506 binding protein 11, 19 kDa:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FKBP11 - Now 50% OFF >
  • * FKBP11 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FKBP11 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FKBP11 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8
SP1: - - - - -
SP2: - - - - - -
SP3: - - -
SP4: -
SP5:
SP6: -

Relevant External Links for FKBP11 Gene

GeneLoc Exon Structure for
FKBP11
ECgene alternative splicing isoforms for
FKBP11

Expression for FKBP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FKBP11 Gene

This gene is overexpressed in Pancreas (x8.3).

Protein differential expression in normal tissues from HIPED for FKBP11 Gene

This gene is overexpressed in Pancreas (13.5), Islet of Langerhans (9.3), Skin (8.2), and Salivary gland (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FKBP11 Gene



Protein tissue co-expression partners for FKBP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of FKBP11 Gene:

FKBP11

SOURCE GeneReport for Unigene cluster for FKBP11 Gene:

Hs.655103

Evidence on tissue expression from TISSUES for FKBP11 Gene

  • Pancreas(4.5)
  • Spleen(4.3)
genes like me logo Genes that share expression patterns with FKBP11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBP11 Gene

Orthologs for FKBP11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FKBP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBP11 35 34
  • 100 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FKBP11 35 34
  • 91.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FKBP11 35 34
  • 91.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbp11 34
  • 89.19 (n)
mouse
(Mus musculus)
Mammalia Fkbp11 17 35 34
  • 87.73 (n)
lizard
(Anolis carolinensis)
Reptilia FKBP11 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbp11 34
  • 63.73 (n)
Str.15739 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23956 34
zebrafish
(Danio rerio)
Actinopterygii fkbp11 35 34
  • 57.77 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14715 35
  • 33 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea fkb-1 35
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FPR2 35
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 34 (a)
OneToMany
Species where no ortholog for FKBP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FKBP11 Gene

ENSEMBL:
Gene Tree for FKBP11 (if available)
TreeFam:
Gene Tree for FKBP11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FKBP11: view image

Paralogs for FKBP11 Gene

(25) SIMAP similar genes for FKBP11 Gene using alignment to 7 proteins:

  • FKB11_HUMAN
  • E9PAR0_HUMAN
  • F8VU90_HUMAN
  • F8VXK0_HUMAN
  • H0YHM7_HUMAN
  • J3KN11_HUMAN
  • Q86SR8_HUMAN
genes like me logo Genes that share paralogs with FKBP11: view

Variants for FKBP11 Gene

Sequence variations from dbSNP and Humsavar for FKBP11 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000168715 -- 48,926,154(-) T/C upstream_transcript_variant
rs1000288735 -- 48,925,458(-) C/A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001035171 -- 48,927,270(-) T/C upstream_transcript_variant
rs1002139700 -- 48,922,328(-) G/C genic_downstream_transcript_variant, intron_variant
rs1002467821 -- 48,921,825(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FKBP11 Gene

Variant ID Type Subtype PubMed ID
nsv832404 CNV gain 17160897

Variation tolerance for FKBP11 Gene

Residual Variation Intolerance Score: 32.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FKBP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBP11 Gene

Disorders for FKBP11 Gene

Additional Disease Information for FKBP11

No disorders were found for FKBP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBP11 Gene

Publications for FKBP11 Gene

  1. The human FK506-binding proteins: characterization of human FKBP19. (PMID: 16596453) Rulten SL … Kay JE (Mammalian genome : official journal of the International Mammalian Genome Society 2006) 2 3 23 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genomic organization of mouse and human 65 kDa FK506-binding protein genes and evolution of the FKBP multigene family. (PMID: 12036304) Patterson CE … Davis EC (Genomics 2002) 2 3 58
  5. Ziploc-ing the structure 2.0: Endoplasmic reticulum-resident peptidyl prolyl isomerases show different activities toward hydroxyproline. (PMID: 28385890) Ishikawa Y … Bächinger HP (The Journal of biological chemistry 2017) 3 58

Products for FKBP11 Gene

Sources for FKBP11 Gene

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