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Aliases for FIZ1 Gene

Aliases for FIZ1 Gene

  • FLT3 Interacting Zinc Finger 1 2 3 5
  • Zinc Finger Protein 798 3 4
  • ZNF798 3 4
  • Flt3-Interacting Zinc Finger Protein 1 3

External Ids for FIZ1 Gene

Previous GeneCards Identifiers for FIZ1 Gene

  • GC19M060795
  • GC19M056102
  • GC19M052413

Summaries for FIZ1 Gene

Entrez Gene Summary for FIZ1 Gene

  • This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIZ1 Gene

FIZ1 (FLT3 Interacting Zinc Finger 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and receptor tyrosine kinase binding. An important paralog of this gene is ZNF579.

UniProtKB/Swiss-Prot for FIZ1 Gene

  • May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

Additional gene information for FIZ1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIZ1 Gene

Genomics for FIZ1 Gene

GeneHancer (GH) Regulatory Elements for FIZ1 Gene

Promoters and enhancers for FIZ1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J055598 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 665.5 +1.7 1686 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZBTB7B FIZ1 ZNF524 U2AF2 ZNF471 ZFP28 ZNF470 ZNF582 ENSG00000267523 ZNF581 ZNF580
GH19J055597 Promoter 0.5 EPDnew 650.7 +4.0 4023 0.1 FIZ1 ZNF524 ZNF579
GH19J055519 Enhancer 1.4 FANTOM5 Ensembl ENCODE 70.6 +81.8 81761 1 HDGF ATF1 ZNF493 ZNF133 YBX1 GLI4 ZNF416 ZNF548 FOS ATF7 U2AF2 ZNF471 FIZ1 ZNF582 ZNF581 ZNF580 SSC5D ENSG00000267523 NAT14 ZNF667
GH19J056594 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 48.8 -993.5 -993470 1.4 HDGF PKNOX1 ZNF133 ARID4B SIN3A FEZF1 YBX1 GLI4 ZNF48 YY1 ZNF71 U2AF2 ZNF264 ZNF17 ZNF543 ZNF773 ZNF549 ZNF550 ENSG00000269696 ENSG00000267523
GH19J056403 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 46.7 -802.2 -802179 2 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF416 ZNF207 ZNF582 ZNF582-AS1 ZFP28 ZNF470 ZNF471 FIZ1 ZNF264 ZNF460-AS1 ENSG00000269696 ZNF542P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FIZ1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FIZ1 gene promoter:
  • HEN1
  • p53
  • Pax-5
  • NF-kappaB
  • MAZR
  • NF-kappaB1
  • RP58
  • E2F
  • STAT5B
  • E2F-1

Regulatory Element Products

Genomic Locations for FIZ1 Gene

Genomic Locations for FIZ1 Gene
10,600 bases
Minus strand
10,600 bases
Minus strand

Genomic View for FIZ1 Gene

Genes around FIZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIZ1 Gene

Proteins for FIZ1 Gene

  • Protein details for FIZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Flt3-interacting zinc finger protein 1
    Protein Accession:
    Secondary Accessions:
    • A2RU72
    • Q6ZMJ7

    Protein attributes for FIZ1 Gene

    496 amino acids
    Molecular mass:
    51996 Da
    Quaternary structure:
    • Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).
    • Sequence=BAD18728.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for FIZ1 Gene

Post-translational modifications for FIZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIZ1 Gene

No data available for DME Specific Peptides for FIZ1 Gene

Domains & Families for FIZ1 Gene

Gene Families for FIZ1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FIZ1 Gene


Suggested Antigen Peptide Sequences for FIZ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIZ1: view

No data available for UniProtKB/Swiss-Prot for FIZ1 Gene

Function for FIZ1 Gene

Molecular function for FIZ1 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

Phenotypes From GWAS Catalog for FIZ1 Gene

Gene Ontology (GO) - Molecular Function for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0030971 receptor tyrosine kinase binding IEA,ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FIZ1: view
genes like me logo Genes that share phenotypes with FIZ1: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIZ1 Gene

Localization for FIZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIZ1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIZ1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FIZ1: view

Pathways & Interactions for FIZ1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with FIZ1: view

No data available for Pathways by source and SIGNOR curated interactions for FIZ1 Gene

Drugs & Compounds for FIZ1 Gene

No Compound Related Data Available

Transcripts for FIZ1 Gene

mRNA/cDNA for FIZ1 Gene

Unigene Clusters for FIZ1 Gene

FLT3-interacting zinc finger 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIZ1 Gene

No ASD Table

Relevant External Links for FIZ1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FIZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIZ1 Gene

This gene is overexpressed in Lung (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FIZ1 Gene

Protein tissue co-expression partners for FIZ1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FIZ1 Gene:


SOURCE GeneReport for Unigene cluster for FIZ1 Gene:


mRNA Expression by UniProt/SwissProt for FIZ1 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for FIZ1 Gene

  • Spleen(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FIZ1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIZ1 Gene

Orthologs for FIZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIZ1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FIZ1 34 33
  • 99.53 (n)
(Canis familiaris)
Mammalia FIZ1 33
  • 88.33 (n)
(Bos Taurus)
Mammalia FIZ1 34 33
  • 88.26 (n)
(Mus musculus)
Mammalia Fiz1 16 34 33
  • 80.37 (n)
(Rattus norvegicus)
Mammalia Fiz1 33
  • 80.08 (n)
(Anolis carolinensis)
Reptilia FIZ1 34
  • 48 (a)
Species where no ortholog for FIZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FIZ1 Gene

Gene Tree for FIZ1 (if available)
Gene Tree for FIZ1 (if available)
Evolutionary constrained regions (ECRs) for FIZ1: view image

Paralogs for FIZ1 Gene

Paralogs for FIZ1 Gene

genes like me logo Genes that share paralogs with FIZ1: view

Variants for FIZ1 Gene

Sequence variations from dbSNP and Humsavar for FIZ1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs546265268 uncertain-significance, not specified 55,593,057(-) A/C coding_sequence_variant, missense_variant
rs1000260260 -- 55,597,958(-) C/G intron_variant
rs1000673695 -- 55,593,070(-) G/A coding_sequence_variant, missense_variant
rs1000789791 -- 55,591,336(-) C/A/T downstream_transcript_variant
rs1001117180 -- 55,597,428(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FIZ1 Gene

Variant ID Type Subtype PubMed ID
nsv828643 CNV loss 20364138
nsv953624 CNV deletion 24416366

Variation tolerance for FIZ1 Gene

Gene Damage Index Score: 2.22; 40.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FIZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIZ1 Gene

Disorders for FIZ1 Gene

Additional Disease Information for FIZ1

No disorders were found for FIZ1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIZ1 Gene

Publications for FIZ1 Gene

  1. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. (PMID: 12566383) Mitton KP … Swaroop A (Human molecular genetics 2003) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Dissection of a novel autocrine signaling pathway via quantitative secretome and interactome mapping. (PMID: 24956037) Larivière N … Trinkle-Mulcahy L (Journal of proteome research 2014) 3 58
  5. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 58

Products for FIZ1 Gene

Sources for FIZ1 Gene

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