This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008] See more...

Aliases for FIZ1 Gene

Aliases for FIZ1 Gene

  • FLT3 Interacting Zinc Finger 1 2 3 5
  • Flt3-Interacting Zinc Finger Protein 1 3 4
  • Zinc Finger Protein 798 3 4
  • ZNF798 3 4

External Ids for FIZ1 Gene

Previous GeneCards Identifiers for FIZ1 Gene

  • GC19M060795
  • GC19M056102
  • GC19M052413

Summaries for FIZ1 Gene

Entrez Gene Summary for FIZ1 Gene

  • This gene encodes zinc finger protein, which interacts with a receptor tyrosine kinase involved in the regulation of hematopoietic and lymphoid cells. This gene product also interacts with a transcription factor that regulates the expression of rod-specific genes in retina. [provided by RefSeq, Jul 2008]

GeneCards Summary for FIZ1 Gene

FIZ1 (FLT3 Interacting Zinc Finger 1) is a Protein Coding gene. Diseases associated with FIZ1 include Bardet-Biedl Syndrome 9 and Complex Partial Epilepsy. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and receptor tyrosine kinase binding. An important paralog of this gene is ZNF618.

UniProtKB/Swiss-Prot Summary for FIZ1 Gene

  • May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

Additional gene information for FIZ1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FIZ1 Gene

Genomics for FIZ1 Gene

GeneHancer (GH) Regulatory Elements for FIZ1 Gene

Promoters and enhancers for FIZ1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FIZ1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FIZ1

Top Transcription factor binding sites by QIAGEN in the FIZ1 gene promoter:
  • E2F
  • E2F-1
  • HEN1
  • MAZR
  • NF-kappaB
  • NF-kappaB1
  • p53
  • Pax-5
  • RP58
  • STAT5B

Genomic Locations for FIZ1 Gene

Genomic Locations for FIZ1 Gene
chr19:55,591,371-55,601,970
(GRCh38/hg38)
Size:
10,600 bases
Orientation:
Minus strand
chr19:56,102,737-56,113,336
(GRCh37/hg19)
Size:
10,600 bases
Orientation:
Minus strand

Genomic View for FIZ1 Gene

Genes around FIZ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIZ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIZ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIZ1 Gene

Proteins for FIZ1 Gene

  • Protein details for FIZ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SL8-FIZ1_HUMAN
    Recommended name:
    Flt3-interacting zinc finger protein 1
    Protein Accession:
    Q96SL8
    Secondary Accessions:
    • A2RU72
    • Q6ZMJ7

    Protein attributes for FIZ1 Gene

    Size:
    496 amino acids
    Molecular mass:
    51996 Da
    Quaternary structure:
    • Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).
    SequenceCaution:
    • Sequence=BAD18728.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

neXtProt entry for FIZ1 Gene

Post-translational modifications for FIZ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIZ1 Gene

No data available for DME Specific Peptides for FIZ1 Gene

Domains & Families for FIZ1 Gene

Gene Families for FIZ1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FIZ1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FIZ1 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 798 (FIZ1_HUMAN)
genes like me logo Genes that share domains with FIZ1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FIZ1 Gene

Function for FIZ1 Gene

Molecular function for FIZ1 Gene

UniProtKB/Swiss-Prot Function:
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).

Phenotypes From GWAS Catalog for FIZ1 Gene

Gene Ontology (GO) - Molecular Function for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0030971 receptor tyrosine kinase binding IEA,ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FIZ1: view
genes like me logo Genes that share phenotypes with FIZ1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FIZ1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIZ1 Gene

Localization for FIZ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIZ1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIZ1 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FIZ1: view

Pathways & Interactions for FIZ1 Gene

PathCards logo

SuperPathways for FIZ1 Gene

No Data Available

SIGNOR curated interactions for FIZ1 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for FIZ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with FIZ1: view

No data available for Pathways by source for FIZ1 Gene

Drugs & Compounds for FIZ1 Gene

No Compound Related Data Available

Transcripts for FIZ1 Gene

mRNA/cDNA for FIZ1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FIZ1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIZ1 Gene

No ASD Table

Relevant External Links for FIZ1 Gene

GeneLoc Exon Structure for
FIZ1

Expression for FIZ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FIZ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FIZ1 Gene

This gene is overexpressed in Lung (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FIZ1 Gene



Protein tissue co-expression partners for FIZ1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FIZ1

SOURCE GeneReport for Unigene cluster for FIZ1 Gene:

Hs.515617

mRNA Expression by UniProt/SwissProt for FIZ1 Gene:

Q96SL8-FIZ1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for FIZ1 Gene

  • Spleen(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FIZ1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIZ1 Gene

Orthologs for FIZ1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FIZ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIZ1 31 30
  • 99.53 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FIZ1 30
  • 88.33 (n)
cow
(Bos Taurus)
Mammalia FIZ1 31 30
  • 88.26 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fiz1 17 31 30
  • 80.37 (n)
rat
(Rattus norvegicus)
Mammalia Fiz1 30
  • 80.08 (n)
lizard
(Anolis carolinensis)
Reptilia FIZ1 31
  • 48 (a)
OneToOne
Species where no ortholog for FIZ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FIZ1 Gene

ENSEMBL:
Gene Tree for FIZ1 (if available)
TreeFam:
Gene Tree for FIZ1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FIZ1: view image

Paralogs for FIZ1 Gene

Paralogs for FIZ1 Gene

genes like me logo Genes that share paralogs with FIZ1: view

Variants for FIZ1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FIZ1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs546265268 Uncertain Significance: not specified 55,593,057(-) A/C MISSENSE_VARIANT
rs7247236 - p.Thr391Ala

Additional dbSNP identifiers (rs#s) for FIZ1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FIZ1 Gene

Variant ID Type Subtype PubMed ID
nsv828643 CNV loss 20364138
nsv953624 CNV deletion 24416366

Variation tolerance for FIZ1 Gene

Gene Damage Index Score: 2.22; 40.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FIZ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIZ1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIZ1 Gene

Disorders for FIZ1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FIZ1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 9
  • bbs9
complex partial epilepsy
  • complex partial epileptic seizure
- elite association - COSMIC cancer census association via MalaCards
Search FIZ1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FIZ1

genes like me logo Genes that share disorders with FIZ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FIZ1 Gene

Publications for FIZ1 Gene

  1. Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor. (PMID: 12566383) Mitton KP … Swaroop A (Human molecular genetics 2003) 2 3 4 23 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Dissection of a novel autocrine signaling pathway via quantitative secretome and interactome mapping. (PMID: 24956037) Larivière N … Trinkle-Mulcahy L (Journal of proteome research 2014) 3 54
  5. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 54

Products for FIZ1 Gene

Sources for FIZ1 Gene