Aliases for FIS1 Gene
External Ids for FIS1 Gene
Previous HGNC Symbols for FIS1 Gene
Previous GeneCards Identifiers for FIS1 Gene
The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008]
GeneCards Summary for FIS1 Gene
FIS1 (Fission, Mitochondrial 1) is a Protein Coding gene. Diseases associated with FIS1 include Spinocerebellar Ataxia 12 and 3-Methylglutaconic Aciduria, Type Iii. Among its related pathways are Mitophagy - animal. Gene Ontology (GO) annotations related to this gene include signaling receptor binding.
UniProtKB/Swiss-Prot for FIS1 Gene
Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.