This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding doma... See more...

Aliases for FIP1L1 Gene

Aliases for FIP1L1 Gene

  • Factor Interacting With PAPOLA And CPSF1 2 3 5
  • FIP1 2 3 4
  • FIP1L1 Cleavage And Polyadenylation Specific Factor Subunit 2 3
  • Pre-MRNA 3'-End-Processing Factor FIP1 3 4
  • Rearranged In Hypereosinophilia 3 4
  • Factor Interacting With PAP 3 4
  • FIP1-Like 1 Protein 3 4
  • HFip1 3 4
  • FIP1 Like 1 (S. Cerevisiae) 2
  • DKFZp586K0717 2
  • FIP1 Like 1 3
  • EC 4.2.1.33 50
  • EC 1.1.1.86 50
  • FIP1L1 5
  • Rhe 3
  • RHE 4

External Ids for FIP1L1 Gene

Previous GeneCards Identifiers for FIP1L1 Gene

  • GC04P054224
  • GC04P054093
  • GC04P054159
  • GC04P054084
  • GC04P053938
  • GC04P050188
  • GC04P053378
  • GC04P053380
  • GC04P053383
  • GC04P053386

Summaries for FIP1L1 Gene

Entrez Gene Summary for FIP1L1 Gene

  • This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

GeneCards Summary for FIP1L1 Gene

FIP1L1 (Factor Interacting With PAPOLA And CPSF1) is a Protein Coding gene. Diseases associated with FIP1L1 include Chronic Eosinophilic Leukemia and Primary Hypereosinophilic Syndrome. Among its related pathways are Processing of Capped Intronless Pre-mRNA and Tat-mediated elongation of the HIV-1 transcript. Gene Ontology (GO) annotations related to this gene include protein kinase activity.

UniProtKB/Swiss-Prot Summary for FIP1L1 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.

Gene Wiki entry for FIP1L1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FIP1L1 Gene

Genomics for FIP1L1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FIP1L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J053376 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.9 860 3.4 ZNF207 POLR2A ZIC2 YY1 MXD4 KLF11 SMAD5 SIN3A ETS1 TRIM22 SCFD2 ENSG00000282278 FIP1L1 HSALNG0034434 HSALNG0034435 LOC105377654 piR-38562-053 LNX1
GH04J053459 Promoter/Enhancer 1.1 EPDnew Ensembl 259.8 +82.0 81960 1.2 JUND FOXA2 RARA TEAD3 FOSL2 FOXP1 BCL6 SOX5 TBX3 FOXA1 FIP1L1 SCFD2 HSALNG0034436 piR-46002-432 ENSG00000282278 LNX1
GH04J053425 Promoter 0.4 EPDnew 250.3 +48.2 48226 0.1 GATA2 FIP1L1 piR-46002-432 HSALNG0034436 ENSG00000282278 LNX1
GH04J053414 Promoter 0.3 EPDnew 260.9 +37.0 37042 0.1 FIP1L1 SCFD2 piR-46002-432 ENSG00000282278 HSALNG0034436 LNX1
GH04J053389 Promoter 0.3 EPDnew 250.4 +12.2 12193 0.1 FIP1L1 piR-38562-053 ENSG00000282278 HSALNG0034435 LNX1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FIP1L1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FIP1L1

Top Transcription factor binding sites by QIAGEN in the FIP1L1 gene promoter:
  • aMEF-2
  • AML1a
  • AP-1
  • AREB6
  • ATF6
  • MEF-2A
  • MZF-1
  • POU2F1
  • POU2F1a
  • TGIF

Genomic Locations for FIP1L1 Gene

Latest Assembly
chr4:53,377,641-53,462,583
(GRCh38/hg38)
Size:
84,943 bases
Orientation:
Plus strand

Previous Assembly
chr4:54,243,808-54,327,029
(GRCh37/hg19 by Entrez Gene)
Size:
83,222 bases
Orientation:
Plus strand

chr4:54,243,810-55,161,439
(GRCh37/hg19 by Ensembl)
Size:
917,630 bases
Orientation:
Plus strand

Genomic View for FIP1L1 Gene

Genes around FIP1L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIP1L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIP1L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIP1L1 Gene

Proteins for FIP1L1 Gene

  • Protein details for FIP1L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UN15-FIP1_HUMAN
    Recommended name:
    Pre-mRNA 3'-end-processing factor FIP1
    Protein Accession:
    Q6UN15
    Secondary Accessions:
    • B4DIR3
    • G3XAD6
    • Q0VGE0
    • Q499Y4
    • Q49AU3
    • Q7Z608
    • Q8WVN3
    • Q96F80
    • Q9H077

    Protein attributes for FIP1L1 Gene

    Size:
    594 amino acids
    Molecular mass:
    66526 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4, CSTF2 and CSTF3 (PubMed:14749727). Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921). Interacts with NUDT21/CPSF5; this interaction occurs in a RNA sequence-specific manner (PubMed:15937220). Interacts (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain) with CPSF6 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation (PubMed:29276085). Interacts (preferentially via unphosphorylated form and Arg/Asp/Glu-rich domain) with CPSF7 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation (PubMed:29276085). Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (By similarity).
    SequenceCaution:
    • Sequence=AAH24016.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAH52959.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Alternative splice isoforms for FIP1L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FIP1L1 Gene

Selected DME Specific Peptides for FIP1L1 Gene

Q6UN15:
  • VAFPHLP
  • EIQDGRF

Post-translational modifications for FIP1L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for FIP1L1
  • Boster Bio Antibodies for FIP1L1
  • Santa Cruz Biotechnology (SCBT) Antibodies for FIP1L1

Domains & Families for FIP1L1 Gene

Gene Families for FIP1L1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for FIP1L1 Gene

InterPro:

Suggested Antigen Peptide Sequences for FIP1L1 Gene

GenScript: Design optimal peptide antigens:
  • Rearranged in hypereosinophilia (FIP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6UN15

UniProtKB/Swiss-Prot:

FIP1_HUMAN :
  • Belongs to the FIP1 family.
Family:
  • Belongs to the FIP1 family.
genes like me logo Genes that share domains with FIP1L1: view

Function for FIP1L1 Gene

Molecular function for FIP1L1 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.

Enzyme Numbers (IUBMB) for FIP1L1 Gene

Phenotypes From GWAS Catalog for FIP1L1 Gene

Gene Ontology (GO) - Molecular Function for FIP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 contributes_to RNA binding IBA 21873635
GO:0005515 protein binding IPI 15937220
genes like me logo Genes that share ontologies with FIP1L1: view
genes like me logo Genes that share phenotypes with FIP1L1: view

Human Phenotype Ontology for FIP1L1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for FIP1L1 Gene

miRTarBase miRNAs that target FIP1L1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FIP1L1

Clone products for research

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FIP1L1 Gene

Localization for FIP1L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIP1L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIP1L1 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FIP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IEA,IBA 21873635
genes like me logo Genes that share ontologies with FIP1L1: view

Pathways & Interactions for FIP1L1 Gene

genes like me logo Genes that share pathways with FIP1L1: view

Pathways by source for FIP1L1 Gene

SIGNOR curated interactions for FIP1L1 Gene

Activates:

Gene Ontology (GO) - Biological Process for FIP1L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IBA 21873635
GO:0006397 mRNA processing IEA --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with FIP1L1: view

Drugs & Compounds for FIP1L1 Gene

(2) Drugs for FIP1L1 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
imatinib Approved Pharma Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 0
genes like me logo Genes that share compounds with FIP1L1: view

Transcripts for FIP1L1 Gene

mRNA/cDNA for FIP1L1 Gene

45 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FIP1L1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for FIP1L1 Gene

No ASD Table

Relevant External Links for FIP1L1 Gene

GeneLoc Exon Structure for
FIP1L1

Expression for FIP1L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FIP1L1 Gene

Protein differential expression in normal tissues from HIPED for FIP1L1 Gene

This gene is overexpressed in Testis (9.2), Pancreas (8.6), and Peripheral blood mononuclear cells (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FIP1L1 Gene



Protein tissue co-expression partners for FIP1L1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FIP1L1

SOURCE GeneReport for Unigene cluster for FIP1L1 Gene:

Hs.624245

Evidence on tissue expression from TISSUES for FIP1L1 Gene

  • Nervous system(4.9)
  • Blood(4.5)
  • Liver(4.5)
  • Eye(4.1)
  • Bone marrow(3)
  • Spleen(2.8)
  • Heart(2.7)
  • Muscle(2.5)
  • Lung(2.4)
  • Intestine(2.4)
  • Kidney(2.4)
  • Lymph node(2.3)
  • Skin(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FIP1L1 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
  • lymphatic
Regions:
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with FIP1L1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FIP1L1 Gene

Orthologs for FIP1L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FIP1L1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FIP1L1 29 30
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FIP1L1 30
  • 96 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Fip1l1 30
  • 96 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fip1l1 29
  • 89.39 (n)
Oppossum
(Monodelphis domestica)
Mammalia FIP1L1 30
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FIP1L1 30
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FIP1L1 30
  • 83 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FIP1L1 30
  • 80 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FIP1L1 30
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fip1l1 29
  • 72.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4439 29
Zebrafish
(Danio rerio)
Actinopterygii fip1l1b 30
  • 59 (a)
OneToMany
fip1l1a 30
  • 52 (a)
OneToMany
wufd36f11 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1768 29
Fruit Fly
(Drosophila melanogaster)
Insecta Fip1 30
  • 22 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea fipp-1 30
  • 29 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FIP1 30 32
  • 26 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 49 (a)
OneToOne
Species where no ortholog for FIP1L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FIP1L1 Gene

ENSEMBL:
Gene Tree for FIP1L1 (if available)
TreeFam:
Gene Tree for FIP1L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FIP1L1: view image
Alliance of Genome Resources:
Additional Orthologs for FIP1L1

Paralogs for FIP1L1 Gene

No data available for Paralogs for FIP1L1 Gene

Variants for FIP1L1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FIP1L1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs11723755 Benign: not specified 53,444,114(+) T/G
NM_030917.4(FIP1L1):c.1285+11T>G
INTRON
rs1187998909 Likely Benign: not provided 53,459,298(+) C/T
NM_030917.4(FIP1L1):c.1638-4C>T
INTRON
rs151072018 Not Provided: not specified 53,391,488(+) A/G
NM_030917.4(FIP1L1):c.695A>G (p.Asn232Ser)
MISSENSE_VARIANT,INTRON
rs587778363 Not Provided: not specified 53,399,808(+) T/C
NM_030917.4(FIP1L1):c.784T>C (p.Ser262Pro)
MISSENSE
rs587778364 Not Provided: not specified 53,379,088(+) A/G
NM_030917.4(FIP1L1):c.101A>G (p.His34Arg)
MISSENSE_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FIP1L1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FIP1L1 Gene

Variant ID Type Subtype PubMed ID
esv3569421 CNV loss 25503493
esv3569422 CNV loss 25503493
esv3569423 CNV loss 25503493
esv3569424 CNV loss 25503493

Variation tolerance for FIP1L1 Gene

Residual Variation Intolerance Score: 11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.74; 33.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FIP1L1 Gene

Human Gene Mutation Database (HGMD)
FIP1L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIP1L1
Leiden Open Variation Database (LOVD)
FIP1L1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIP1L1 Gene

Disorders for FIP1L1 Gene

MalaCards: The human disease database

(34) MalaCards diseases for FIP1L1 Gene - From: ORP, COP, and GCD

Disorder Aliases PubMed IDs
chronic eosinophilic leukemia
  • pdgfra-associated chronic eosinophilic leukemia
primary hypereosinophilic syndrome
  • clonal hypereosinophilic syndrome
acute promyelocytic leukemia
  • apl
hypereosinophilic syndrome
  • eosinophilia
mastocytosis, cutaneous
  • mastc
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

FIP1_HUMAN
  • Note=A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA). {ECO:0000269 PubMed:12660384, ECO:0000269 PubMed:12808148}.

Additional Disease Information for FIP1L1

genes like me logo Genes that share disorders with FIP1L1: view

No data available for Genatlas for FIP1L1 Gene

Publications for FIP1L1 Gene

  1. Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. (PMID: 14749727) Kaufmann I … Keller W (The EMBO journal 2004) 2 3 4 22
  2. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. (PMID: 12660384) Cools J … Gilliland DG (The New England journal of medicine 2003) 3 4 22
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  4. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. (PMID: 29276085) Zhu Y … Shi Y (Molecular cell 2018) 3 4
  5. Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL. (PMID: 22523564) Li B … Duan C (PloS one 2012) 3 72

Products for FIP1L1 Gene

Sources for FIP1L1 Gene