This gene produces a long non-coding RNA that is induced by forkhead box O proteins and plays a role in stress-induced apoptosis. Knock down of transcripts at this locus results in increased renal tumor growth and alteration in genes involved in glucose metabolism. This RNA interacts with heterogeneous nuclear ribonucleoprotein D and prevents it from binding to Myc mRNA, theref... See more...

Aliases for FILNC1 Gene

Subcategory (RNA class) for FILNC1 Gene

lncRNA

Number of RNA Genes sources:

4 / 17

Aliases for FILNC1 Gene

  • FOXO Induced Long Non-Coding RNA 1 2 3 5
  • FILNC1 2 5 165
  • FoxO-Induced Long Non-Coding RNA 1 2
  • NONHSAG044995.2 91
  • HSALNG0053894 164

External Ids for FILNC1 Gene

Previous GeneCards Identifiers for FILNC1 Gene

  • GC06P139772

Summaries for FILNC1 Gene

Entrez Gene Summary for FILNC1 Gene

  • This gene produces a long non-coding RNA that is induced by forkhead box O proteins and plays a role in stress-induced apoptosis. Knock down of transcripts at this locus results in increased renal tumor growth and alteration in genes involved in glucose metabolism. This RNA interacts with heterogeneous nuclear ribonucleoprotein D and prevents it from binding to Myc mRNA, therefore suppressing Myc activity. Alternative splicing and transcriptional start site usage results in multiple transcript variants. [provided by RefSeq, Oct 2017]

GeneCards Summary for FILNC1 Gene

FILNC1 (FOXO Induced Long Non-Coding RNA 1) is an RNA Gene, and is affiliated with the lncRNA class.

Additional gene information for FILNC1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FILNC1 Gene

Genomics for FILNC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FILNC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J139838 Promoter/Enhancer 1.5 EPDnew FANTOM5 Ensembl ENCODE 600.1 +162.1 162144 1.6 ATF7 REST PKNOX1 HMBOX1 ZSCAN5C ATF2 FOSL1 RFX5 SPI1 RXRA FILNC1 lnc-HECA-7 ENSG00000225148 CITED2
GH06J139851 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas 600.1 +176.4 176411 5.9 GATAD2A PRDM10 FOXA1 SP1 GABPA CEBPA ZNF10 CEBPB FOXA2 ZNF138 FILNC1 ENSG00000236013 ENSG00000225148 lnc-HECA-7 CITED2
GH06J139677 Promoter 0.5 EPDnew 600.7 0.0 -18 0.1 CHAMP1 ZBTB33 FILNC1 ENSG00000205695 lnc-HECA-6 CITED2
GH06J139679 Enhancer 0.6 Ensembl 0.7 +2.3 2263 1.8 GATAD2A RXRB SP1 CEBPA CEBPB FOXA2 NR2F2 CEBPG RAD21 HNF4A FILNC1 piR-33303-155 CITED2
GH06J139707 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.3 +33.6 33638 7.4 CEBPG CREB1 PRDM10 FOXA1 CEBPA CEBPB SP1 JUND ZXDB FOS CITED2 MN298344 piR-33303-156 FILNC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FILNC1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for FILNC1 Gene

Genomic Locations for FILNC1 Gene
chr6:139,677,638-139,877,391
(GRCh38/hg38)
Size:
199,754 bases
Orientation:
Plus strand
chr6:140,092,210-140,181,608
(GRCh37/hg19)
Size:
89,399 bases
Orientation:
Plus strand

Genomic View for FILNC1 Gene

Genes around FILNC1 on UCSC Golden Path with GeneCards custom track
FILNC1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
FILNC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FILNC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FILNC1 Gene

Proteins for FILNC1 Gene

Post-translational modifications for FILNC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FILNC1 Gene

Domains & Families for FILNC1 Gene

Gene Families for FILNC1 Gene

genes like me logo Genes that share domains with FILNC1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FILNC1 Gene

Function for FILNC1 Gene

Phenotypes From GWAS Catalog for FILNC1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FILNC1 Gene

Localization for FILNC1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FILNC1 Gene

Pathways & Interactions for FILNC1 Gene

PathCards logo

SuperPathways for FILNC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FILNC1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for FILNC1 Gene

Drugs & Compounds for FILNC1 Gene

No Compound Related Data Available

Transcripts for FILNC1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for FILNC1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00008B354E_9606 lncRNA 1294 5

HGNC: 53755,

RefSeq: NR_038399,

LncBook: HSALNT0114192,

LNCipedia: FILNC1:16,

NONCODE: NONHSAT115258.2,

URS0000369B98_9606 lncRNA 956 3

Ensembl: ENST00000431609 (view in UCSC) ,

LNCipedia: FILNC1:23,

NONCODE: NONHSAT115260.2,

URS00001A0570_9606 lncRNA 708 3

Ensembl: ENST00000414038 (view in UCSC) ,

LNCipedia: FILNC1:19,

NONCODE: NONHSAT115259.2,

URS0000D5FF26_9606 lncRNA 1502 2

Ensembl: ENST00000647189 (view in UCSC) ,

LNCipedia: FILNC1:2,

URS0000D60751_9606 lncRNA 1499 2

Ensembl: ENST00000642381 (view in UCSC) ,

LNCipedia: FILNC1:4,

FILNC1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for FILNC1 Gene

3 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for FILNC1 Gene

No ASD Table

Relevant External Links for FILNC1 Gene

GeneLoc Exon Structure for
FILNC1

Expression for FILNC1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FILNC1

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FILNC1 Gene

Orthologs for FILNC1 Gene

Evolution for FILNC1 Gene

ENSEMBL:
Gene Tree for FILNC1 (if available)
TreeFam:
Gene Tree for FILNC1 (if available)

No data available for Orthologs for FILNC1 Gene

Paralogs for FILNC1 Gene

No data available for Paralogs for FILNC1 Gene

Variants for FILNC1 Gene

Additional dbSNP identifiers (rs#s) for FILNC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FILNC1 Gene

Variant ID Type Subtype PubMed ID
dgv6153n100 CNV loss 25217958
nsv1018752 CNV loss 25217958
nsv1022881 CNV loss 25217958
nsv1109819 CNV deletion 24896259
nsv604765 CNV gain 21841781
nsv830820 CNV loss 17160897

Additional Variant Information for FILNC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FILNC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for FILNC1 Gene

Disorders for FILNC1 Gene

No disorders were found for FILNC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FILNC1 Gene

Publications for FILNC1 Gene

  1. Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. (PMID: 28978906) Xiao ZD … Gan B (Nature communications 2017) 2 3
  2. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G … Rudan I (PLoS genetics 2013) 3
  3. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3
  4. Generation and analysis of 280,000 human expressed sequence tags. (PMID: 8889549) Hillier LD … Marra M (Genome research 1996) 3

Products for FILNC1 Gene

Sources for FILNC1 Gene