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This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]
FILIP1 (Filamin A Interacting Protein 1) is a Protein Coding gene. Diseases associated with FILIP1 include Ureterocele and Glioblastoma Proneural Subtype. Among its related pathways are Integrated Breast Cancer Pathway. An important paralog of this gene is FILIP1L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005730 | nucleolus | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005856 | cytoskeleton | IEA | -- |
GO:0005886 | plasma membrane | IDA | -- |
GO:0015629 | actin cytoskeleton | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Integrated Breast Cancer Pathway |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FILIP1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FILIP1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FILIP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FILIP1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Filip1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Filip1 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FILIP1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FILIP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FILIP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | filip1 30 |
|
||
Str.7271 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6145 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | filip1b 30 31 |
|
OneToMany | |
filip1a 31 |
|
OneToMany | |||
wufb92f04 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9783 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG10915 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | C49H3.6 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709053 | Benign: not provided | 75,313,698(-) | A/G | SYNONYMOUS_VARIANT | |
718440 | Benign: not provided | 75,312,455(-) | G/A | MISSENSE_VARIANT | |
718441 | Benign: not provided | 75,314,995(-) | T/C | SYNONYMOUS_VARIANT | |
718854 | Benign: not provided | 75,314,703(-) | T/C | MISSENSE_VARIANT | |
719710 | Benign: not provided | 75,312,825(-) | G/A | MISSENSE_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10785n54 | CNV | loss | 21841781 |
dgv10786n54 | CNV | loss | 21841781 |
dgv1802e212 | CNV | loss | 25503493 |
esv1005015 | CNV | deletion | 20482838 |
esv1350235 | CNV | deletion | 17803354 |
esv21616 | CNV | loss | 19812545 |
esv2732314 | CNV | deletion | 23290073 |
esv3086938 | CNV | deletion | 24192839 |
esv3385538 | CNV | insertion | 20981092 |
esv3540003 | CNV | deletion | 23714750 |
esv3571210 | CNV | loss | 25503493 |
esv3609574 | CNV | loss | 21293372 |
esv3890880 | CNV | loss | 25118596 |
nsv1114843 | CNV | deletion | 24896259 |
nsv348407 | CNV | deletion | 16902084 |
nsv603763 | CNV | loss | 21841781 |
nsv603764 | CNV | loss | 21841781 |
nsv603770 | CNV | loss | 21841781 |
nsv830698 | CNV | gain | 17160897 |
nsv981158 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
ureterocele |
|
|
glioblastoma proneural subtype |
|
|
periventricular nodular heterotopia |
|
|