FILIP1 Gene (Protein Coding)

Filamin A Interacting Protein 1

GC06M075291
GIFtS:
35
This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016] See more...

Aliases for FILIP1 Gene

Aliases for FILIP1 Gene

  • Filamin A Interacting Protein 1 2 3 5
  • Filamin-A-Interacting Protein 1 3 4
  • FILIP 3 4
  • KIAA1275 4

External Ids for FILIP1 Gene

Previous GeneCards Identifiers for FILIP1 Gene

  • GC06M075954
  • GC06M076000
  • GC06M076013
  • GC06M076074
  • GC06M076005
  • GC06M073216

Summaries for FILIP1 Gene

Entrez Gene Summary for FILIP1 Gene

  • This gene encodes a filamin A binding protein. The encoded protein promotes the degradation of filamin A and may regulate cortical neuron migration and dendritic spine morphology. Mice lacking a functional copy of this gene exhibit reduced dendritic spine length and altered excitatory signaling. [provided by RefSeq, Oct 2016]

GeneCards Summary for FILIP1 Gene

FILIP1 (Filamin A Interacting Protein 1) is a Protein Coding gene. Diseases associated with FILIP1 include Ureterocele and Periventricular Nodular Heterotopia. Among its related pathways are Integrated Breast Cancer Pathway. An important paralog of this gene is FILIP1L.

UniProtKB/Swiss-Prot Summary for FILIP1 Gene

  • By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.

Gene Wiki entry for FILIP1 Gene

Additional gene information for FILIP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FILIP1 Gene

Genomics for FILIP1 Gene

GeneHancer (GH) Regulatory Elements for FILIP1 Gene

Promoters and enhancers for FILIP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J075490 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505.2 0.0 -29 6.5 ZSCAN5C TCF12 EP300 TRIM28 JUND RELA TRIM22 BCL11A NR2F2 ZBTB17 FILIP1 piR-48759-266 SENP6 RF00017-5629
GH06J075363 Promoter/Enhancer 0.6 EPDnew Ensembl 533.9 +130.5 130528 0.6 SRF FILIP1 ENSG00000237174 LOC101928540 RF00017-5629
GH06J075347 Promoter/Enhancer 1.3 ENCODE CraniofacialAtlas 46.1 +145.1 145066 3 ZBTB40 ZIC2 ZNF423 TRIM28 ATF2 HDAC2 ZNF341 POLR2A CTCF KLF9 lnc-SENP6-11 FILIP1 RPL26P20 RNU1-34P MYO6 ENSG00000237174 RF00017-5629
GH06J075333 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 37.9 +159.3 159287 2.1 EP300 JUND TEAD4 TRIM28 SAP30 ATF2 HDAC2 ZNF341 POLR2A OSR2 FILIP1 ENSG00000237174 TMEM30A ENSG00000225793 lnc-SENP6-11 lnc-TMEM30A-2 HMGB1P39 RF00017-5629
GH06J075418 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 38.4 +75.3 75328 3.4 TCF12 ZNF316 REST FOS NR3C1 FOSL2 CEBPB JUN ATF3 JUND FILIP1 RPL26P20 SENP6 MIR4463 ENSG00000221332 LOC101928540 RF00017-5629
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FILIP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FILIP1

Top Transcription factor binding sites by QIAGEN in the FILIP1 gene promoter:
  • GR
  • GR-alpha
  • HNF-1
  • HNF-1A
  • HNF-3beta
  • Ik-1
  • LyF-1
  • POU2F1
  • POU2F1a
  • RFX1

Genomic Locations for FILIP1 Gene

Genomic Locations for FILIP1 Gene
chr6:75,291,859-75,493,829
(GRCh38/hg38)
Size:
201,971 bases
Orientation:
Minus strand
chr6:76,001,575-76,203,496
(GRCh37/hg19)
Size:
201,922 bases
Orientation:
Minus strand

Genomic View for FILIP1 Gene

Genes around FILIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FILIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FILIP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FILIP1 Gene

Proteins for FILIP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FILIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7B0-FLIP1_HUMAN
    Recommended name:
    Filamin-A-interacting protein 1
    Protein Accession:
    Q7Z7B0
    Secondary Accessions:
    • B2RMU6
    • Q5VUL6
    • Q86TC3
    • Q8N8B9
    • Q96SK6
    • Q9NVI8
    • Q9ULE5

    Protein attributes for FILIP1 Gene

    Size:
    1213 amino acids
    Molecular mass:
    138109 Da
    Quaternary structure:
    • Interacts with FLNA. Interacts with RHOD (in GTP-bound form).
    SequenceCaution:
    • Sequence=BAA91763.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FILIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FILIP1 Gene

Protein Expression for FILIP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FILIP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FILIP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FILIP1 Gene

Domains & Families for FILIP1 Gene

Gene Families for FILIP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FILIP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FILIP1 Gene

GenScript: Design optimal peptide antigens:
  • Filamin-A-interacting protein 1 (FLIP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q7Z7B0

UniProtKB/Swiss-Prot:

FLIP1_HUMAN :
  • Belongs to the FILIP1 family.
Family:
  • Belongs to the FILIP1 family.
genes like me logo Genes that share domains with FILIP1: view

Function for FILIP1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for FILIP1 Gene

UniProtKB/Swiss-Prot Function:
By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A.

Phenotypes From GWAS Catalog for FILIP1 Gene

genes like me logo Genes that share phenotypes with FILIP1: view

Animal Model Products

CRISPR Products

miRNA for FILIP1 Gene

miRTarBase miRNAs that target FILIP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FILIP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FILIP1 Gene

Localization for FILIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FILIP1 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FILIP1 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytoskeleton 4
cytosol 2
extracellular 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FILIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with FILIP1: view

Pathways & Interactions for FILIP1 Gene

PathCards logo

SuperPathways for FILIP1 Gene

genes like me logo Genes that share pathways with FILIP1: view

Pathways by source for FILIP1 Gene

1 BioSystems pathway for FILIP1 Gene

Gene Ontology (GO) - Biological Process for FILIP1 Gene

None

No data available for SIGNOR curated interactions for FILIP1 Gene

Drugs & Compounds for FILIP1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for FILIP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FILIP1 Gene

3 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FILIP1

Alternative Splicing Database (ASD) splice patterns (SP) for FILIP1 Gene

No ASD Table

Relevant External Links for FILIP1 Gene

GeneLoc Exon Structure for
FILIP1

Expression for FILIP1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FILIP1 Gene

mRNA expression in normal human tissues for FILIP1 Gene
mRNA expression by GTEx for FILIP1 GenemRNA expression by BioGPS for FILIP1 Gene

mRNA differential expression in normal tissues according to GTEx for FILIP1 Gene

This gene is overexpressed in Heart - Left Ventricle (x6.9), Muscle - Skeletal (x6.6), and Heart - Atrial Appendage (x4.7).

Protein differential expression in normal tissues from HIPED for FILIP1 Gene

This gene is overexpressed in Spinal cord (12.2), Urinary Bladder (10.1), Heart (9.0), Colon (8.9), Adrenal (7.1), and Fetal heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FILIP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FILIP1

SOURCE GeneReport for Unigene cluster for FILIP1 Gene:

Hs.696158

mRNA Expression by UniProt/SwissProt for FILIP1 Gene:

Q7Z7B0-FLIP1_HUMAN
Tissue specificity: Moderately expressed in adult heart and brain. Weakly expressed in lung, skeletal muscle, ovary, testis, kidney, and fetal brain, and hardly detectable in liver, pancreas, spleen, and fetal liver. Within brain, moderate expression is found in amygdala and caudate nucleus.

Evidence on tissue expression from TISSUES for FILIP1 Gene

  • Muscle(4.5)
  • Nervous system(4.4)
  • Intestine(4.2)
  • Heart(2.4)
genes like me logo Genes that share expression patterns with FILIP1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FILIP1 Gene

Orthologs for FILIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FILIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FILIP1 31 30
  • 99.73 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia FILIP1 31
  • 92 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia FILIP1 31 30
  • 91.37 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia FILIP1 31 30
  • 86.95 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Filip1 30
  • 85.07 (n)
mouse
(Mus musculus)
 Mammalia Filip1 17 31 30
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia FILIP1 31
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FILIP1 31 30
  • 80.06 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FILIP1 31
  • 85 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia filip1 30
  • 73.16 (n)
Str.7271 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6145 30
zebrafish
(Danio rerio)
 Actinopterygii filip1b 31 30
  • 65.42 (n)
 OneToMany
filip1a 31
  • 51 (a)
 OneToMany
wufb92f04 30
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.9783 30
fruit fly
(Drosophila melanogaster)
 Insecta CG10915 31
  • 17 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea C49H3.6 31
  • 20 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 35 (a)
 OneToMany
Species where no ortholog for FILIP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FILIP1 Gene

ENSEMBL:
Gene Tree for FILIP1 (if available)
TreeFam:
Gene Tree for FILIP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FILIP1: view image

Paralogs for FILIP1 Gene

Paralogs for FILIP1 Gene

(1) SIMAP similar genes for FILIP1 Gene using alignment to 1 proteins:

  • FLIP1_HUMAN
genes like me logo Genes that share paralogs with FILIP1: view

Variants for FILIP1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FILIP1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
709053 Benign: not provided 75,313,698(-) A/G SYNONYMOUS_VARIANT
718440 Benign: not provided 75,312,455(-) G/A MISSENSE_VARIANT
718441 Benign: not provided 75,314,995(-) T/C SYNONYMOUS_VARIANT
718854 Benign: not provided 75,314,703(-) T/C MISSENSE_VARIANT
719710 Benign: not provided 75,312,825(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FILIP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FILIP1 Gene

Variant ID Type Subtype PubMed ID
dgv10785n54 CNV loss 21841781
dgv10786n54 CNV loss 21841781
dgv1802e212 CNV loss 25503493
esv1005015 CNV deletion 20482838
esv1350235 CNV deletion 17803354
esv21616 CNV loss 19812545
esv2732314 CNV deletion 23290073
esv3086938 CNV deletion 24192839
esv3385538 CNV insertion 20981092
esv3540003 CNV deletion 23714750
esv3571210 CNV loss 25503493
esv3609574 CNV loss 21293372
esv3890880 CNV loss 25118596
nsv1114843 CNV deletion 24896259
nsv348407 CNV deletion 16902084
nsv603763 CNV loss 21841781
nsv603764 CNV loss 21841781
nsv603770 CNV loss 21841781
nsv830698 CNV gain 17160897
nsv981158 CNV duplication 23825009

Variation tolerance for FILIP1 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FILIP1 Gene

Human Gene Mutation Database (HGMD)
FILIP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FILIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FILIP1 Gene

Disorders for FILIP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FILIP1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ureterocele
periventricular nodular heterotopia
  • periventricular heterotopia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FILIP1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FILIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FILIP1 Gene

Publications for FILIP1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 54
  2. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. (PMID: 23087206) Gad AK … Aspenström P (Molecular biology of the cell 2012) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 54
  5. Differential effects of Tat proteins derived from HIV-1 subtypes B and recombinant CRF02_AG on human brain microvascular endothelial cells: implications for blood-brain barrier dysfunction. (PMID: 24667918) Woollard SM … Kanmogne GD (Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014) 3 54

ExternalLinks

View latest publications for FILIP1 gene in Mastermind

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