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Aliases for FIGNL2 Gene

Aliases for FIGNL2 Gene

  • Fidgetin Like 2 2 3 5
  • Fidgetin-Like 2 2

External Ids for FIGNL2 Gene

Previous GeneCards Identifiers for FIGNL2 Gene

  • GC12M050497
  • GC12M052211

Summaries for FIGNL2 Gene

GeneCards Summary for FIGNL2 Gene

FIGNL2 (Fidgetin Like 2) is a Protein Coding gene. An important paralog of this gene is FIGN.

Additional gene information for FIGNL2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIGNL2 Gene

Genomics for FIGNL2 Gene

GeneHancer (GH) Regulatory Elements for FIGNL2 Gene

Promoters and enhancers for FIGNL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I051846 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE 552.2 +0.8 765 3.1 PKNOX1 MZF1 SIN3A ZNF335 GLIS2 EGR1 EGR2 SP3 ZBTB11 ZEB2 FIGNL2 LOC105369971 SLC4A8 ACVRL1 ENSG00000261586 RNU6-574P GALNT6 ANKRD33 SCN8A GC12P051832
GH12I052180 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.5 -339.7 -339699 15.1 PKNOX1 SIN3A FEZF1 ZNF2 ZBTB7B ZNF416 FOS KLF13 SP3 REST KRT80 ZNF740 KRT7 HNRNPA3P10 POU6F1 SPRYD3 CSAD ENSG00000257808 C12orf80 NR4A1
GH12I051368 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.6 +478.1 478080 4.4 FOXA2 PKNOX1 FEZF1 IRF4 YY1 ZNF766 ZNF143 FOS DEK JUNB GALNT6 CELA1 BIN2 SLC4A8 DAZAP2 CSRNP2 FIGNL2 SLC11A2
GH12I051855 Enhancer 1 FANTOM5 Ensembl ENCODE 2.6 -7.3 -7333 1.3 SOX13 CEBPB SIN3A REST TEAD3 SP1 POLR2A ZFP36 PRDM10 ZNF600 ANKRD33 SLC4A8 NR4A1 GRASP GALNT6 FIGNL2 GC12P051832 GC12P051835 GC12P051836 GC12P051837
GH12I051884 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 -37.5 -37450 4.4 PKNOX1 FOXA2 ARNT ARID4B YY1 ZNF766 E2F8 FOS SP3 REST ANKRD33 HNRNPA3P10 TFCP2 CSRNP2 NR4A1 KRT78 FIGNL2 GC12P051836 GC12P051837 GC12P051838
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FIGNL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FIGNL2 gene promoter:

Genomic Locations for FIGNL2 Gene

Genomic Locations for FIGNL2 Gene
chr12:51,817,840-51,848,766
(GRCh38/hg38)
Size:
30,927 bases
Orientation:
Minus strand
chr12:52,211,676-52,225,701
(GRCh37/hg19)

Genomic View for FIGNL2 Gene

Genes around FIGNL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIGNL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIGNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGNL2 Gene

Proteins for FIGNL2 Gene

  • Protein details for FIGNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMB9-FIGL2_HUMAN
    Recommended name:
    Putative fidgetin-like protein 2
    Protein Accession:
    A6NMB9

    Protein attributes for FIGNL2 Gene

    Size:
    653 amino acids
    Molecular mass:
    66603 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FIGNL2 Gene

Post-translational modifications for FIGNL2 Gene

No Post-translational modifications

Other Protein References for FIGNL2 Gene

No data available for DME Specific Peptides for FIGNL2 Gene

Domains & Families for FIGNL2 Gene

Gene Families for FIGNL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FIGNL2 Gene

Suggested Antigen Peptide Sequences for FIGNL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NMB9

UniProtKB/Swiss-Prot:

FIGL2_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGNL2: view

Function for FIGNL2 Gene

Phenotypes From GWAS Catalog for FIGNL2 Gene

Gene Ontology (GO) - Molecular Function for FIGNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 contributes_to ATPase activity IBA --
genes like me logo Genes that share ontologies with FIGNL2: view

Phenotypes for FIGNL2 Gene

GenomeRNAi human phenotypes for FIGNL2:
genes like me logo Genes that share phenotypes with FIGNL2: view

Animal Model Products

CRISPR Products

miRNA for FIGNL2 Gene

miRTarBase miRNAs that target FIGNL2

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIGNL2 Gene

Localization for FIGNL2 Gene

Gene Ontology (GO) - Cellular Components for FIGNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FIGNL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FIGNL2 Gene

Pathways & Interactions for FIGNL2 Gene

SuperPathways for FIGNL2 Gene

No Data Available

Interacting Proteins for FIGNL2 Gene

Gene Ontology (GO) - Biological Process for FIGNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010569 regulation of double-strand break repair via homologous recombination IBA --
genes like me logo Genes that share ontologies with FIGNL2: view

No data available for Pathways by source and SIGNOR curated interactions for FIGNL2 Gene

Drugs & Compounds for FIGNL2 Gene

No Compound Related Data Available

Transcripts for FIGNL2 Gene

mRNA/cDNA for FIGNL2 Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(13) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FIGNL2 Gene

Fidgetin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIGNL2 Gene

No ASD Table

Relevant External Links for FIGNL2 Gene

GeneLoc Exon Structure for
FIGNL2
ECgene alternative splicing isoforms for
FIGNL2

Expression for FIGNL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIGNL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FIGNL2 Gene:

FIGNL2

SOURCE GeneReport for Unigene cluster for FIGNL2 Gene:

Hs.648218
genes like me logo Genes that share expression patterns with FIGNL2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIGNL2 Gene

Orthologs for FIGNL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FIGNL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGNL2 33
  • 96.45 (n)
cow
(Bos Taurus)
Mammalia FIGNL2 33
  • 88.62 (n)
rat
(Rattus norvegicus)
Mammalia Fignl2 33
  • 85.66 (n)
mouse
(Mus musculus)
Mammalia Fignl2 33 16
  • 83.93 (n)
Species where no ortholog for FIGNL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FIGNL2 Gene

ENSEMBL:
Gene Tree for FIGNL2 (if available)
TreeFam:
Gene Tree for FIGNL2 (if available)

Paralogs for FIGNL2 Gene

Paralogs for FIGNL2 Gene

(1) SIMAP similar genes for FIGNL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FIGNL2: view

Variants for FIGNL2 Gene

Sequence variations from dbSNP and Humsavar for FIGNL2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000008144 -- 51,846,857(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000081908 -- 51,828,966(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000233378 -- 51,834,407(-) C/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000237075 -- 51,824,259(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000338889 -- 51,829,582(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FIGNL2 Gene

Variant ID Type Subtype PubMed ID
dgv2625n54 CNV gain 21841781
dgv2626n54 CNV gain+loss 21841781
dgv2627n54 CNV gain 21841781
dgv2628n54 CNV loss 21841781
esv2659984 CNV deletion 23128226
esv28148 CNV loss 19812545
nsv558878 CNV gain 21841781
nsv558879 CNV loss 21841781
nsv558885 CNV gain 21841781
nsv558893 CNV loss 21841781
nsv826373 CNV gain 20364138
nsv826374 CNV gain 20364138

Additional Variant Information for FIGNL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIGNL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FIGNL2 Gene

Disorders for FIGNL2 Gene

Additional Disease Information for FIGNL2

No disorders were found for FIGNL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIGNL2 Gene

Publications for FIGNL2 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  2. The mouse fidgetin gene defines a new role for AAA family proteins in mammalian development. (PMID: 11017077) Cox GA … Frankel WN (Nature genetics 2000) 2 3 58
  3. Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia. (PMID: 21107309) McClay JL … van den Oord EJ (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011) 44 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for FIGNL2 Gene

Sources for FIGNL2 Gene

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