External Ids for FIGNL1 Gene
Previous GeneCards Identifiers for FIGNL1 Gene
This gene encodes a member of the AAA ATPase family of proteins. The encoded protein is recruited to sites of DNA damage where it plays a role in DNA double-strand break repair via homologous recombination. This protein has also been shown to localize to the centrosome and inhibit ciliogenesis, and may regulate the proliferation and differentiation of osteoblasts. [provided by RefSeq, Oct 2016]
GeneCards Summary for FIGNL1 Gene
FIGNL1 (Fidgetin Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and four-way junction helicase activity. An important paralog of this gene is FIGN.
UniProtKB/Swiss-Prot for FIGNL1 Gene
Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation (PubMed:23754376). May play a role in the control of male meiosis dynamic (By similarity).