Aliases for FIGN Gene

Aliases for FIGN Gene

  • Fidgetin, Microtubule Severing Factor 2 3 5
  • Fidgetin 2 3 4

External Ids for FIGN Gene

Previous GeneCards Identifiers for FIGN Gene

  • GC02M162519
  • GC02M163005
  • GC02M164430
  • GC02M164668
  • GC02M164666
  • GC02M164289
  • GC02M164172
  • GC02M156346

Summaries for FIGN Gene

GeneCards Summary for FIGN Gene

FIGN (Fidgetin, Microtubule Severing Factor) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and microtubule-severing ATPase activity. An important paralog of this gene is FIGNL2.

UniProtKB/Swiss-Prot Summary for FIGN Gene

  • ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

Additional gene information for FIGN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FIGN Gene

Genomics for FIGN Gene

GeneHancer (GH) Regulatory Elements for FIGN Gene

Promoters and enhancers for FIGN Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J163732 Promoter/Enhancer 2.6 UCNEbase EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.7 1651 6.5 ZNF217 ZSCAN5C TCF12 USF1 POLR2G TEAD4 ZFX ZIC2 REST POLR2A FIGN HSALNG0020081
GH02J163697 Enhancer 1 Ensembl ENCODE CraniofacialAtlas dbSUPER 16.4 +35.5 35547 6.7 GATA3 NR2C1 NR2F1 ZNF398 CHD7 EP300 BHLHE40 SP1 ZNF449 EBF1 FIGN HSALNG0020081
GH02J163664 Enhancer 1 Ensembl ENCODE 11.5 +69.8 69796 4.4 ZNF217 TCF12 JUND FOS REST KDM6A FOXA1 CUX1 ZBTB25 EP300 FIGN HSALNG0020081
GH02J163680 Enhancer 0.7 Ensembl dbSUPER 16.5 +53.5 53496 1.8 FOS CTCF FOXA2 FOSL2 EHMT2 JUN JUND RAD21 ZNF24 PRDM10 FIGN HSALNG0020081
GH02J163709 Enhancer 0.8 UCNEbase Ensembl dbSUPER 13.7 +24.9 24940 2.1 GATA3 GATA2 FIGN HSALNG0020081
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FIGN on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FIGN

Top Transcription factor binding sites by QIAGEN in the FIGN gene promoter:
  • FOXD3
  • Max1
  • Nkx2-5
  • RSRFC4
  • S8
  • Sox9
  • SRY
  • USF-1
  • USF1
  • ZID

Genomic Locations for FIGN Gene

Genomic Locations for FIGN Gene
chr2:163,593,396-163,736,197
(GRCh38/hg38)
Size:
142,802 bases
Orientation:
Minus strand
chr2:164,449,906-164,592,522
(GRCh37/hg19)
Size:
142,617 bases
Orientation:
Minus strand

Genomic View for FIGN Gene

Genes around FIGN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIGN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIGN Gene

Proteins for FIGN Gene

  • Protein details for FIGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HY92-FIGN_HUMAN
    Recommended name:
    Fidgetin
    Protein Accession:
    Q5HY92
    Secondary Accessions:
    • B3KWM0
    • Q9H6M5
    • Q9NVZ9

    Protein attributes for FIGN Gene

    Size:
    759 amino acids
    Molecular mass:
    82146 Da
    Quaternary structure:
    • Interacts with AKAP8 (via C-terminus).
    SequenceCaution:
    • Sequence=AAX81992.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA91590.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAB15231.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for FIGN Gene

Post-translational modifications for FIGN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FIGN Gene

No data available for DME Specific Peptides for FIGN Gene

Domains & Families for FIGN Gene

Gene Families for FIGN Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FIGN Gene

Blocks:
  • AAA-protein subdomain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FIGN Gene

GenScript: Design optimal peptide antigens:
  • Fidgetin (FIGN_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5HY92

UniProtKB/Swiss-Prot:

FIGN_HUMAN :
  • Belongs to the AAA ATPase family.
Family:
  • Belongs to the AAA ATPase family.
genes like me logo Genes that share domains with FIGN: view

Function for FIGN Gene

Molecular function for FIGN Gene

UniProtKB/Swiss-Prot Function:
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.

Phenotypes From GWAS Catalog for FIGN Gene

Gene Ontology (GO) - Molecular Function for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding IEA --
GO:0008568 microtubule-severing ATPase activity IBA 21873635
GO:0016887 ATPase activity IBA 21873635
genes like me logo Genes that share ontologies with FIGN: view
genes like me logo Genes that share phenotypes with FIGN: view

Animal Models for FIGN Gene

MGI Knock Outs for FIGN:

Animal Model Products

CRISPR Products

miRNA for FIGN Gene

miRTarBase miRNAs that target FIGN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FIGN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FIGN Gene

Localization for FIGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIGN Gene

Nucleus matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIGN gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 3
extracellular 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with FIGN: view

Pathways & Interactions for FIGN Gene

PathCards logo

SuperPathways for FIGN Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0010569 regulation of double-strand break repair via homologous recombination IBA 21873635
GO:0031122 cytoplasmic microtubule organization IBA 21873635
GO:0051013 microtubule severing IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with FIGN: view

No data available for Pathways by source and SIGNOR curated interactions for FIGN Gene

Drugs & Compounds for FIGN Gene

No Compound Related Data Available

Transcripts for FIGN Gene

mRNA/cDNA for FIGN Gene

2 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FIGN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIGN Gene

No ASD Table

Relevant External Links for FIGN Gene

GeneLoc Exon Structure for
FIGN

Expression for FIGN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FIGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FIGN Gene

This gene is overexpressed in Nerve - Tibial (x4.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FIGN Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FIGN

SOURCE GeneReport for Unigene cluster for FIGN Gene:

Hs.593650
genes like me logo Genes that share expression patterns with FIGN: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FIGN Gene

Orthologs for FIGN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FIGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FIGN 31 30
  • 99.78 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FIGN 31
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FIGN 31 30
  • 94.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fign 30
  • 92.84 (n)
mouse
(Mus musculus)
Mammalia Fign 17 31 30
  • 92.67 (n)
dog
(Canis familiaris)
Mammalia FIGN 31
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FIGN 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FIGN 31 30
  • 88.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FIGN 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fign 30
  • 81.48 (n)
zebrafish
(Danio rerio)
Actinopterygii fign 31 30
  • 70.58 (n)
OneToMany
BX005368.2 31
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3326 31
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K04D7.2a 32
  • 31 (a)
K04D7.2b 32
  • 31 (a)
figl-1 31
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YTA6 31
  • 19 (a)
ManyToMany
SAP1 31
  • 19 (a)
ManyToMany
Species where no ortholog for FIGN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FIGN Gene

ENSEMBL:
Gene Tree for FIGN (if available)
TreeFam:
Gene Tree for FIGN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FIGN: view image

Paralogs for FIGN Gene

(7) SIMAP similar genes for FIGN Gene using alignment to 2 proteins:

  • FIGN_HUMAN
  • B8ZZS6_HUMAN

Pseudogenes.org Pseudogenes for FIGN Gene

genes like me logo Genes that share paralogs with FIGN: view

Variants for FIGN Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FIGN Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs2231902 - p.Ser96Leu
rs2231904 - p.Arg448Cys
rs2231905 - p.Lys565Arg

Additional dbSNP identifiers (rs#s) for FIGN Gene

Structural Variations from Database of Genomic Variants (DGV) for FIGN Gene

Variant ID Type Subtype PubMed ID
esv3444904 CNV insertion 20981092
nsv1109307 CNV deletion 24896259
nsv1123404 CNV deletion 24896259
nsv1123405 CNV deletion 24896259
nsv1160879 CNV deletion 26073780
nsv213604 CNV deletion 16902084
nsv834442 CNV gain 17160897

Variation tolerance for FIGN Gene

Residual Variation Intolerance Score: 4.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FIGN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FIGN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIGN Gene

Disorders for FIGN Gene

Additional Disease Information for FIGN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FIGN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIGN Gene

Publications for FIGN Gene

  1. Human Fidgetin is a microtubule severing the enzyme and minus-end depolymerase that regulates mitosis. (PMID: 22672901) Mukherjee S … Sharp DJ (Cell cycle (Georgetown, Tex.) 2012) 3 4 54
  2. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. (PMID: 21909110) Wain LV … van Duijn CM (Nature genetics 2011) 3 41 54
  3. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PMID: 21572416) Kato N … He J (Nature genetics 2011) 3 41 54
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54

Products for FIGN Gene

Sources for FIGN Gene