External Ids for FIGN Gene
Previous GeneCards Identifiers for FIGN Gene
GeneCards Summary for FIGN Gene
FIGN (Fidgetin, Microtubule Severing Factor) is a Protein Coding gene. Diseases associated with FIGN include Skin Carcinoma In Situ and Polyneuropathy Due To Drug. Gene Ontology (GO) annotations related to this gene include protein C-terminus binding and microtubule-severing ATPase activity. An important paralog of this gene is FIGNL2.
UniProtKB/Swiss-Prot Summary for FIGN Gene
ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome.