Aliases for FIGLA Gene
External Ids for FIGLA Gene
Previous GeneCards Identifiers for FIGLA Gene
This gene encodes a protein that functions in postnatal oocyte-specific gene expression. The protein is a basic helix-loop-helix transcription factor that regulates multiple oocyte-specific genes, including genes involved in folliculogenesis and those that encode the zona pellucida. Mutations in this gene cause premature ovarian failure type 6. [provided by RefSeq, Sep 2009]
GeneCards Summary for FIGLA Gene
FIGLA (Folliculogenesis Specific BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with FIGLA include Premature Ovarian Failure 6 and Amenorrhea. Among its related pathways are Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is PTF1A.
UniProtKB/Swiss-Prot Summary for FIGLA Gene
Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.