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Aliases for FICD Gene

Aliases for FICD Gene

  • FIC Domain Containing 2 3 5
  • Huntingtin-Interacting Protein 13 3 4
  • Huntingtin-Interacting Protein E 3 4
  • Protein Adenylyltransferase FICD 3 4
  • FIC Domain-Containing Protein 3 4
  • Huntingtin Yeast Partner E 3 4
  • De-AMPylase FICD 3 4
  • AMPylator FICD 3 4
  • HIP-13 3 4
  • HIP13 3 4
  • HYPE 3 4
  • Fic S-Phase Protein Cell Division Homolog (E. Coli) 2
  • Adenosine Monophosphate-Protein Transferase FICD 3
  • Fic S-Phase Protein Cell Division Homolog 3
  • Huntingtin Interacting Protein 13 2
  • Huntingtin Interacting Protein E 3
  • Huntingtin Interactor Protein E 3
  • EC 2.7.7.n1 4
  • EC 3.1.4.- 4
  • UNQ3041 3

External Ids for FICD Gene

Previous GeneCards Identifiers for FICD Gene

  • GC12P107433
  • GC12P108909
  • GC12P105973

Summaries for FICD Gene

GeneCards Summary for FICD Gene

FICD (FIC Domain Containing) is a Protein Coding gene. Diseases associated with FICD include Extragonadal Germ Cell Cancer and Aspirin Allergy. Gene Ontology (GO) annotations related to this gene include protein adenylyltransferase activity.

UniProtKB/Swiss-Prot for FICD Gene

  • Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083).

Additional gene information for FICD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FICD Gene

Genomics for FICD Gene

GeneHancer (GH) Regulatory Elements for FICD Gene

Promoters and enhancers for FICD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J108514 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 620.9 +0.3 309 2.6 CC2D1A SP1 ELF3 ZKSCAN8 NKRF POLR2A ZNF121 FOS SP7 ELF1 FICD SART3 PWP1 KCTD10 LOC101929162 PRDM4 ALKBH2 UBE3B ISCU PIR52944
GH12J108559 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 21.3 +53.1 53094 18.2 MTA3 SP1 ZFX CC2D1A ELF3 CTCF MNT SIX5 CBFA2T2 ZNF148 SART3 ISCU PWP1 FICD PRDM4 UBE3B ALKBH2 TMEM119 CMKLR1 GC12P108558
GH12J108626 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.5 +118.2 118235 13.4 SP1 CC2D1A ZFX ELF3 ZKSCAN8 CBFA2T2 ZNF148 NKRF MLLT1 ZNF121 SELPLG GC12P108633 SART3 PWP1 PRDM4 UBE3B CORO1C FICD LOC101929162 TMEM119
GH12J108540 Enhancer 0.7 ENCODE 31.9 +26.2 26233 2.4 NKRF MLLT1 IKZF1 IKZF2 ZNF143 TRIM22 DPF2 ELF1 BMI1 HDGF FICD ISCU LINC01498 GC12M108547 SART3 PIR52944 GC12P108510
GH12J108301 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -209.6 -209585 7.7 ELF3 CTCF EGR1 IKZF1 ZIC2 CTBP1 ZNF341 NR2C1 ZNF585B SOX13 CMKLR1 SART3 LINC01498 FICD ENSG00000257398 BTBD11 UNG CORO1C SELPLG GC12M108289
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FICD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FICD gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • HOXA3
  • NF-kappaB
  • NF-kappaB1
  • p53
  • POU3F2
  • STAT3
  • XBP-1

Genomic Locations for FICD Gene

Genomic Locations for FICD Gene
chr12:108,515,211-108,525,837
(GRCh38/hg38)
Size:
10,627 bases
Orientation:
Plus strand
chr12:108,908,962-108,919,614
(GRCh37/hg19)
Size:
10,653 bases
Orientation:
Plus strand

Genomic View for FICD Gene

Genes around FICD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FICD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FICD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FICD Gene

Proteins for FICD Gene

  • Protein details for FICD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVA6-FICD_HUMAN
    Recommended name:
    Protein adenylyltransferase FICD
    Protein Accession:
    Q9BVA6
    Secondary Accessions:
    • O75406

    Protein attributes for FICD Gene

    Size:
    458 amino acids
    Molecular mass:
    51778 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer (PubMed:25435325). Interacts with HD (PubMed:9700202).

    Three dimensional structures from OCA and Proteopedia for FICD Gene

neXtProt entry for FICD Gene

Post-translational modifications for FICD Gene

  • Auto-AMPylated in vitro; it is unclear whether auto-AMPylation is relevant in vivo.
  • N-glycosylated; predominantly glycosylated at Asn-275.
  • Glycosylation at posLast=168168
  • Modification sites at PhosphoSitePlus

Other Protein References for FICD Gene

No data available for DME Specific Peptides for FICD Gene

Domains & Families for FICD Gene

Gene Families for FICD Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FICD Gene

GenScript: Design optimal peptide antigens:
  • Huntingtin-interacting protein E (FICD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BVA6

UniProtKB/Swiss-Prot:

FICD_HUMAN :
  • The fido domain mediates the adenylyltransferase activity.
  • Belongs to the fic family.
Domain:
  • The fido domain mediates the adenylyltransferase activity.
Family:
  • Belongs to the fic family.
genes like me logo Genes that share domains with FICD: view

Function for FICD Gene

Molecular function for FICD Gene

UniProtKB/Swiss-Prot Function:
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.n1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]; Xref=Rhea:RHEA:55932, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:138113, ChEBI:CHEBI:456215; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate; Xref=Rhea:RHEA:54292, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:138113; EC=2.7.7.n1; Evidence={ECO:0000269 PubMed:19362538, ECO:0000269 PubMed:25435325, ECO:0000269 PubMed:25601083};.
UniProtKB/Swiss-Prot EnzymeRegulation:
The side chain of Glu-234 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. In response to endoplasmic reticulum stress, mediates de-AMPylase activity (By similarity). Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-234 binds ATP and competes with ATP-binding at Arg-374, thereby preventing adenylyltransferase activity (PubMed:22266942, PubMed:25435325). In unstressed cells, disengagement of Glu-234 promotes adenylyltransferase activity (By similarity). Activation dissociates ATP-binding from Glu-234, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain (PubMed:22266942, PubMed:25435325).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to activation of unfolded protein response (UPR).

Enzyme Numbers (IUBMB) for FICD Gene

Phenotypes From GWAS Catalog for FICD Gene

Gene Ontology (GO) - Molecular Function for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IDA,IEA 25435325
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with FICD: view
genes like me logo Genes that share phenotypes with FICD: view

Animal Models for FICD Gene

MGI Knock Outs for FICD:
  • Ficd Ficd<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for FICD Gene

miRTarBase miRNAs that target FICD

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FICD

Clone Products

  • Applied Biological Materials (abm): Clones for FICD - Now 50% OFF >
  • * FICD as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FICD tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FICD Gene

Localization for FICD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FICD Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FICD gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 25601083
genes like me logo Genes that share ontologies with FICD: view

Pathways & Interactions for FICD Gene

PathCards logo

SuperPathways for FICD Gene

No Data Available

Gene Ontology (GO) - Biological Process for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0018117 protein adenylylation IDA 22266942
GO:0034260 negative regulation of GTPase activity TAS 19362538
GO:0034976 response to endoplasmic reticulum stress IDA 25601083
GO:0044602 protein deadenylylation ISS --
genes like me logo Genes that share ontologies with FICD: view

No data available for Pathways by source and SIGNOR curated interactions for FICD Gene

Drugs & Compounds for FICD Gene

(1) Drugs for FICD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for FICD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with FICD: view

Transcripts for FICD Gene

mRNA/cDNA for FICD Gene

Unigene Clusters for FICD Gene

FIC domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FICD

Clone Products

  • Applied Biological Materials (abm): Clones for FICD - Now 50% OFF >
  • * FICD as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FICD tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FICD Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for FICD Gene

GeneLoc Exon Structure for
FICD
ECgene alternative splicing isoforms for
FICD

Expression for FICD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FICD Gene

Protein differential expression in normal tissues from HIPED for FICD Gene

This gene is overexpressed in Pancreas (43.3) and Platelet (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FICD Gene



Protein tissue co-expression partners for FICD Gene

NURSA nuclear receptor signaling pathways regulating expression of FICD Gene:

FICD

SOURCE GeneReport for Unigene cluster for FICD Gene:

Hs.661891

mRNA Expression by UniProt/SwissProt for FICD Gene:

Q9BVA6-FICD_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for FICD Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FICD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FICD Gene

Orthologs for FICD Gene

This gene was present in the common ancestor of animals.

Orthologs for FICD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FICD 35 34
  • 99.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FICD 35 34
  • 88.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FICD 35 34
  • 88.06 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ficd 17 35 34
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Ficd 34
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia FICD 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FICD 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FICD 35 34
  • 74.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FICD 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ficd 34
  • 67.72 (n)
zebrafish
(Danio rerio)
Actinopterygii ficd 35 34
  • 68.14 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009578 34
  • 58.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fic 34
  • 57.39 (n)
l(2)k11101 35
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fic-1 35 34
  • 46.88 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
Species where no ortholog for FICD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FICD Gene

ENSEMBL:
Gene Tree for FICD (if available)
TreeFam:
Gene Tree for FICD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FICD: view image

Paralogs for FICD Gene

No data available for Paralogs for FICD Gene

Variants for FICD Gene

Sequence variations from dbSNP and Humsavar for FICD Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000962338 -- 108,518,782(+) CCAC/CCACCCAC coding_sequence_variant, frameshift
rs1001260224 -- 108,514,346(+) A/C upstream_transcript_variant
rs1001684486 -- 108,517,802(+) C/T intron_variant
rs1001714004 -- 108,517,505(+) G/C intron_variant
rs1002356128 -- 108,514,149(+) A/C upstream_transcript_variant

Variation tolerance for FICD Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FICD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FICD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FICD Gene

Disorders for FICD Gene

MalaCards: The human disease database

(4) MalaCards diseases for FICD Gene - From: DISEASES

Disorder Aliases PubMed IDs
extragonadal germ cell cancer
  • extragonadal germ cell malignant tumor
aspirin allergy
  • acetylsalicylic acid allergy
depersonalization disorder
  • neurotic derealization
progressive familial heart block, type ii
  • pfhb2
- elite association - COSMIC cancer census association via MalaCards
Search FICD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FICD

genes like me logo Genes that share disorders with FICD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FICD Gene

Publications for FICD Gene

  1. The fic domain: regulation of cell signaling by adenylylation. (PMID: 19362538) Worby CA … Dixon JE (Molecular cell 2009) 3 4 23 58
  2. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber PW … MacDonald ME (Human molecular genetics 1998) 2 3 4 58
  3. A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. (PMID: 25601083) Sanyal A … Mattoo S (The Journal of biological chemistry 2015) 3 4 58
  4. Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. (PMID: 25435325) Bunney TD … Katan M (Structure (London, England : 1993) 2014) 3 4 58
  5. Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. (PMID: 22266942) Engel P … Dehio C (Nature 2012) 3 4 58

Products for FICD Gene

Sources for FICD Gene

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