Aliases for FICD Gene

Aliases for FICD Gene

  • FIC Domain Containing 2 3 5
  • Huntingtin-Interacting Protein 13 3 4
  • Huntingtin-Interacting Protein E 3 4
  • Protein Adenylyltransferase FICD 3 4
  • FIC Domain-Containing Protein 3 4
  • Huntingtin Yeast Partner E 3 4
  • De-AMPylase FICD 3 4
  • AMPylator FICD 3 4
  • HIP-13 3 4
  • HIP13 3 4
  • HYPE 3 4
  • Fic S-Phase Protein Cell Division Homolog (E. Coli) 2
  • Adenosine Monophosphate-Protein Transferase FICD 3
  • Fic S-Phase Protein Cell Division Homolog 3
  • Huntingtin Interacting Protein 13 2
  • Huntingtin Interacting Protein E 3
  • Huntingtin Interactor Protein E 3
  • EC 2.7.7.n1 4
  • EC 3.1.4.- 4
  • UNQ3041 3

External Ids for FICD Gene

Previous GeneCards Identifiers for FICD Gene

  • GC12P107433
  • GC12P108909
  • GC12P105973

Summaries for FICD Gene

GeneCards Summary for FICD Gene

FICD (FIC Domain Containing) is a Protein Coding gene. Diseases associated with FICD include Progressive Familial Heart Block, Type Ii and Progressive Familial Heart Block. Gene Ontology (GO) annotations related to this gene include protein adenylyltransferase activity.

UniProtKB/Swiss-Prot Summary for FICD Gene

  • Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083).

Additional gene information for FICD Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FICD Gene

Genomics for FICD Gene

GeneHancer (GH) Regulatory Elements for FICD Gene

Promoters and enhancers for FICD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J108514 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 520.9 +0.4 409 2.4 ZBTB40 SIN3A NRF1 POLR2G SP1 PHF8 FOS ZFX ZNF639 ZNF10 FICD LINC01498 PWP1 KCTD10 ALKBH2 SART3 UBE3B ISCU
GH12J108559 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 21.3 +50.3 50274 12.6 EP300 RXRA ZBTB40 ZNF217 CTCF TCF12 SIN3A MYC NRF1 POLR2G ISCU SART3 FICD HSALNG0093830 HSALNG0093831
GH12J108626 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.5 +118.2 118235 13.4 ZBTB40 POLR2G USF1 SP1 GTF2E2 JUND FOS ZNF10 ZBTB5 EP300 SELPLG piR-48759-066 CORO1C FICD SART3 PWP1 KCTD10 PRDM4 TMEM119 RNU7-169P
GH12J108540 Enhancer 0.9 Ensembl ENCODE 31.9 +26.4 26412 2.8 ZBTB40 MEF2C TRIM22 ZNF384 ARNT MEF2B NBN SMARCA5 ASH2L ELF1 FICD ISCU LINC01498 lnc-TMEM119-1 lnc-TMEM119-2 SART3
GH12J108609 Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +101.1 101069 15.4 ZBTB40 CTCF SP1 JUND FOS EP300 ZBTB11 ZNF623 RFX1 REST PRDM4 PWP1 TMEM119 SART3 ALKBH2 UBE3B FICD LINC01498 CORO1C ISCU
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FICD on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FICD

Top Transcription factor binding sites by QIAGEN in the FICD gene promoter:
  • GATA-1
  • GATA-2
  • GATA-3
  • HOXA3
  • NF-kappaB
  • NF-kappaB1
  • p53
  • POU3F2
  • STAT3
  • XBP-1

Genomic Locations for FICD Gene

Genomic Locations for FICD Gene
chr12:108,515,211-108,525,837
(GRCh38/hg38)
Size:
10,627 bases
Orientation:
Plus strand
chr12:108,908,962-108,919,614
(GRCh37/hg19)
Size:
10,653 bases
Orientation:
Plus strand

Genomic View for FICD Gene

Genes around FICD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FICD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FICD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FICD Gene

Proteins for FICD Gene

  • Protein details for FICD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVA6-FICD_HUMAN
    Recommended name:
    Protein adenylyltransferase FICD
    Protein Accession:
    Q9BVA6
    Secondary Accessions:
    • O75406

    Protein attributes for FICD Gene

    Size:
    458 amino acids
    Molecular mass:
    51778 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Homodimer (PubMed:25435325). Interacts with HD (PubMed:9700202).

    Three dimensional structures from OCA and Proteopedia for FICD Gene

neXtProt entry for FICD Gene

Post-translational modifications for FICD Gene

  • Auto-AMPylated in vitro; it is unclear whether auto-AMPylation is relevant in vivo.
  • N-glycosylated; predominantly glycosylated at Asn-275.
  • Glycosylation at Thr168, Asn275, and Asn446
  • Modification sites at PhosphoSitePlus

Other Protein References for FICD Gene

No data available for DME Specific Peptides for FICD Gene

Domains & Families for FICD Gene

Gene Families for FICD Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FICD Gene

Blocks:
  • Filamentation induced by cAMP protein Fic
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FICD Gene

GenScript: Design optimal peptide antigens:
  • Huntingtin-interacting protein E (FICD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BVA6

UniProtKB/Swiss-Prot:

FICD_HUMAN :
  • The fido domain mediates the adenylyltransferase activity.
  • Belongs to the fic family.
Domain:
  • The fido domain mediates the adenylyltransferase activity.
Family:
  • Belongs to the fic family.
genes like me logo Genes that share domains with FICD: view

Function for FICD Gene

Molecular function for FICD Gene

UniProtKB/Swiss-Prot Function:
Protein that can both mediate the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-231 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Acts as a key regulator of the ERN1/IRE1-mediated unfolded protein response (UPR) by mediating AMPylation or de-AMPylation of HSPA5/BiP (PubMed:25601083). In unstressed cells, acts as an adenylyltransferase by mediating AMPylation of HSPA5/BiP at 'Thr-518', thereby inactivating it (By similarity). In response to endoplasmic reticulum stress, acts as a phosphodiesterase by mediating removal of ATP (de-AMPylation) from HSPA5/BiP at 'Thr-518', leading to restore HSPA5/BiP activity (By similarity). Although it is able to AMPylate RhoA, Rac and Cdc42 Rho GTPases in vitro, Rho GTPases do not constitute physiological substrates (PubMed:19362538, PubMed:25601083).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = diphosphate + O-(5'-adenylyl)-L-tyrosyl-[protein]; Xref=Rhea:RHEA:54288, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:13846, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:46858, ChEBI:CHEBI:83624; EC=2.7.7.n1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=3-O-(5'-adenylyl)-L-threonyl-[protein] + H2O = AMP + H(+) + L-threonyl-[protein]; Xref=Rhea:RHEA:55932, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:138113, ChEBI:CHEBI:456215; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = 3-O-(5'-adenylyl)-L-threonyl-[protein] + diphosphate; Xref=Rhea:RHEA:54292, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:13847, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:138113; EC=2.7.7.n1; Evidence={ECO:0000269 PubMed:19362538, ECO:0000269 PubMed:25435325, ECO:0000269 PubMed:25601083};.
UniProtKB/Swiss-Prot EnzymeRegulation:
The side chain of Glu-234 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place. In response to endoplasmic reticulum stress, mediates de-AMPylase activity (By similarity). Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-234 binds ATP and competes with ATP-binding at Arg-374, thereby preventing adenylyltransferase activity (PubMed:22266942, PubMed:25435325). In unstressed cells, disengagement of Glu-234 promotes adenylyltransferase activity (By similarity). Activation dissociates ATP-binding from Glu-234, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain (PubMed:22266942, PubMed:25435325).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to activation of unfolded protein response (UPR).

Enzyme Numbers (IUBMB) for FICD Gene

Phenotypes From GWAS Catalog for FICD Gene

Gene Ontology (GO) - Molecular Function for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA,IDA 25435325
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with FICD: view
genes like me logo Genes that share phenotypes with FICD: view

Animal Models for FICD Gene

MGI Knock Outs for FICD:
  • Ficd Ficd<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

miRNA for FICD Gene

miRTarBase miRNAs that target FICD

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FICD

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FICD Gene

Localization for FICD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FICD Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FICD gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030176 integral component of endoplasmic reticulum membrane IDA 25601083
genes like me logo Genes that share ontologies with FICD: view

Pathways & Interactions for FICD Gene

PathCards logo

SuperPathways for FICD Gene

No Data Available

Gene Ontology (GO) - Biological Process for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006986 response to unfolded protein IEA --
GO:0018117 protein adenylylation IDA 22266942
GO:0034260 negative regulation of GTPase activity TAS 19362538
GO:0034976 response to endoplasmic reticulum stress IDA 25601083
GO:0044602 protein deadenylylation ISS --
genes like me logo Genes that share ontologies with FICD: view

No data available for Pathways by source and SIGNOR curated interactions for FICD Gene

Drugs & Compounds for FICD Gene

(1) Drugs for FICD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for FICD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with FICD: view

Transcripts for FICD Gene

mRNA/cDNA for FICD Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FICD

Alternative Splicing Database (ASD) splice patterns (SP) for FICD Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for FICD Gene

GeneLoc Exon Structure for
FICD

Expression for FICD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FICD Gene

Protein differential expression in normal tissues from HIPED for FICD Gene

This gene is overexpressed in Pancreas (43.3) and Platelet (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FICD Gene



Protein tissue co-expression partners for FICD Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FICD

SOURCE GeneReport for Unigene cluster for FICD Gene:

Hs.661891

mRNA Expression by UniProt/SwissProt for FICD Gene:

Q9BVA6-FICD_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for FICD Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FICD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FICD Gene

Orthologs for FICD Gene

This gene was present in the common ancestor of animals.

Orthologs for FICD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FICD 31 30
  • 99.13 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FICD 31 30
  • 88.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FICD 31 30
  • 88.06 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ficd 17 31 30
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Ficd 30
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia FICD 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FICD 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FICD 31 30
  • 74.93 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FICD 31
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ficd 30
  • 67.72 (n)
zebrafish
(Danio rerio)
Actinopterygii ficd 31 30
  • 68.14 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009578 30
  • 58.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fic 30
  • 57.39 (n)
l(2)k11101 31
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fic-1 31 30
  • 46.88 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 52 (a)
OneToOne
Species where no ortholog for FICD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FICD Gene

ENSEMBL:
Gene Tree for FICD (if available)
TreeFam:
Gene Tree for FICD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FICD: view image

Paralogs for FICD Gene

No data available for Paralogs for FICD Gene

Variants for FICD Gene

Additional dbSNP identifiers (rs#s) for FICD Gene

Variation tolerance for FICD Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FICD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FICD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for FICD Gene

Disorders for FICD Gene

MalaCards: The human disease database

(3) MalaCards diseases for FICD Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search FICD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FICD

genes like me logo Genes that share disorders with FICD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FICD Gene

Publications for FICD Gene

  1. The fic domain: regulation of cell signaling by adenylylation. (PMID: 19362538) Worby CA … Dixon JE (Molecular cell 2009) 3 4 23 54
  2. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber PW … MacDonald ME (Human molecular genetics 1998) 2 3 4 54
  3. A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. (PMID: 25601083) Sanyal A … Mattoo S (The Journal of biological chemistry 2015) 3 4 54
  4. Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. (PMID: 25435325) Bunney TD … Katan M (Structure (London, England : 1993) 2014) 3 4 54
  5. Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. (PMID: 22266942) Engel P … Dehio C (Nature 2012) 3 4 54

Products for FICD Gene

Sources for FICD Gene