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Aliases for FICD Gene

Aliases for FICD Gene

  • FIC Domain Containing 2 3 5
  • Huntingtin-Interacting Protein 13 3 4
  • Huntingtin-Interacting Protein E 3 4
  • FIC Domain-Containing Protein 3 4
  • Huntingtin Yeast Partner E 3 4
  • AMPylator FICD 3 4
  • HIP-13 3 4
  • HIP13 3 4
  • HYPE 3 4
  • Fic S-Phase Protein Cell Division Homolog (E. Coli) 2
  • Adenosine Monophosphate-Protein Transferase FICD 3
  • Fic S-Phase Protein Cell Division Homolog 3
  • Huntingtin Interacting Protein 13 2
  • Huntingtin Interacting Protein E 3
  • Huntingtin Interactor Protein E 3
  • EC 2.7.7.n1 4
  • UNQ3041 3

External Ids for FICD Gene

Previous GeneCards Identifiers for FICD Gene

  • GC12P107433
  • GC12P108909
  • GC12P105973

Summaries for FICD Gene

GeneCards Summary for FICD Gene

FICD (FIC Domain Containing) is a Protein Coding gene. Diseases associated with FICD include Depersonalization Disorder and Extragonadal Germ Cell Cancer. Gene Ontology (GO) annotations related to this gene include protein adenylyltransferase activity.

UniProtKB/Swiss-Prot for FICD Gene

  • Adenylyltransferase that mediates the addition of adenosine 5-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified.

Additional gene information for FICD Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FICD Gene

Genomics for FICD Gene

GeneHancer (GH) Regulatory Elements for FICD Gene

Promoters and enhancers for FICD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I108514 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 571 +0.5 517 2.3 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 ZNF143 FOS FICD PWP1 SART3 KCTD10 LOC101929162 ALKBH2 UBE3B ISCU GC12P108510 PIR52944
GH12I108559 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 21.3 +50.4 50390 12.4 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SART3 ISCU PWP1 FICD UBE3B PRDM4 GC12P108558 TMEM119 GC12M108565 GC12P108510
GH12I108626 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.5 +123.7 123679 24.2 HDGF PKNOX1 SMAD1 ARNT FEZF1 IRF4 POLR2B ZNF766 CBX5 ZNF207 SELPLG PWP1 SART3 PRDM4 UBE3B RNU4-32P CORO1C FICD LOC101929162 TMEM119
GH12I108540 Enhancer 0.9 Ensembl ENCODE 31.9 +26.3 26259 2.4 HDGF BMI1 E4F1 ZNF143 ATF7 RCOR1 FOS IKZF2 CHD2 SMARCA5 FICD ISCU LINC01498 GC12M108547 SART3 PIR52944 GC12P108510
GH12I108301 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -209.6 -209559 7.7 ELF3 RAD21 EGR1 RCOR1 FOS RUNX3 EGR2 ELF1 NR2F2 ZNF217 CMKLR1 SART3 LINC01498 FICD ENSG00000257398 BTBD11 UNG CORO1C SELPLG GC12M108289
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FICD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FICD gene promoter:

Genomic Locations for FICD Gene

Genomic Locations for FICD Gene
chr12:108,515,185-108,525,837
(GRCh38/hg38)
Size:
10,653 bases
Orientation:
Plus strand
chr12:108,908,962-108,919,614
(GRCh37/hg19)

Genomic View for FICD Gene

Genes around FICD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FICD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FICD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FICD Gene

Proteins for FICD Gene

  • Protein details for FICD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVA6-FICD_HUMAN
    Recommended name:
    Adenosine monophosphate-protein transferase FICD
    Protein Accession:
    Q9BVA6
    Secondary Accessions:
    • O75406

    Protein attributes for FICD Gene

    Size:
    458 amino acids
    Molecular mass:
    51778 Da
    Quaternary structure:
    • Interacts with HD.

    Three dimensional structures from OCA and Proteopedia for FICD Gene

neXtProt entry for FICD Gene

Post-translational modifications for FICD Gene

Other Protein References for FICD Gene

No data available for DME Specific Peptides for FICD Gene

Domains & Families for FICD Gene

Gene Families for FICD Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FICD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BVA6

UniProtKB/Swiss-Prot:

FICD_HUMAN :
  • The fido domain mediates the adenylyltransferase activity.
  • Belongs to the fic family.
Domain:
  • The fido domain mediates the adenylyltransferase activity.
Family:
  • Belongs to the fic family.
genes like me logo Genes that share domains with FICD: view

Function for FICD Gene

Molecular function for FICD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [protein]-L-tyrosine = diphosphate + [protein]-O(4)-(5-adenylyl)-L-tyrosine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [protein]-L-threonine = diphosphate + [protein]-O(4)-(5-adenylyl)-L-threonine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Adenylyltransferase activity is inhibited by the inhibitory helix present at the N-terminus: Glu-234 binds ATP and competes with ATP-binding at Arg-374, thereby preventing adenylyltransferase activity. Activation dissociates ATP-binding from Glu-234, allowing ordered binding of the entire ATP moiety with the alpha-phosphate in an orientation that is productive for accepting an incoming target hydroxyl side chain.
UniProtKB/Swiss-Prot Function:
Adenylyltransferase that mediates the addition of adenosine 5-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified.

Enzyme Numbers (IUBMB) for FICD Gene

Phenotypes From GWAS Catalog for FICD Gene

Gene Ontology (GO) - Molecular Function for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
GO:0042802 identical protein binding IPI 22266942
GO:0070733 protein adenylyltransferase activity IDA 19362538
genes like me logo Genes that share ontologies with FICD: view
genes like me logo Genes that share phenotypes with FICD: view

Animal Model Products

CRISPR Products

miRNA for FICD Gene

miRTarBase miRNAs that target FICD

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FICD Gene

Localization for FICD Gene

Subcellular locations from UniProtKB/Swiss-Prot for FICD Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FICD gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FICD: view

Pathways & Interactions for FICD Gene

No Data Available

Gene Ontology (GO) - Biological Process for FICD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018117 protein adenylylation IDA 22266942
GO:0034260 negative regulation of GTPase activity TAS 19362538
genes like me logo Genes that share ontologies with FICD: view

No data available for Pathways by source and SIGNOR curated interactions for FICD Gene

Drugs & Compounds for FICD Gene

(1) Drugs for FICD Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for FICD Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with FICD: view

Transcripts for FICD Gene

Unigene Clusters for FICD Gene

FIC domain containing:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FICD Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for FICD Gene

GeneLoc Exon Structure for
FICD
ECgene alternative splicing isoforms for
FICD

Expression for FICD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FICD Gene

Protein differential expression in normal tissues from HIPED for FICD Gene

This gene is overexpressed in Pancreas (43.3) and Platelet (20.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FICD Gene



Protein tissue co-expression partners for FICD Gene

NURSA nuclear receptor signaling pathways regulating expression of FICD Gene:

FICD

SOURCE GeneReport for Unigene cluster for FICD Gene:

Hs.661891

mRNA Expression by UniProt/SwissProt for FICD Gene:

Q9BVA6-FICD_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for FICD Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FICD: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FICD Gene

Orthologs for FICD Gene

This gene was present in the common ancestor of animals.

Orthologs for FICD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FICD 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia FICD 33 34
  • 88.72 (n)
cow
(Bos Taurus)
Mammalia FICD 33 34
  • 88.06 (n)
mouse
(Mus musculus)
Mammalia Ficd 33 16 34
  • 86.61 (n)
rat
(Rattus norvegicus)
Mammalia Ficd 33
  • 85.66 (n)
oppossum
(Monodelphis domestica)
Mammalia FICD 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FICD 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves FICD 33 34
  • 74.93 (n)
lizard
(Anolis carolinensis)
Reptilia FICD 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ficd 33
  • 67.72 (n)
zebrafish
(Danio rerio)
Actinopterygii ficd 33 34
  • 68.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009578 33
  • 58.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta Fic 33
  • 57.39 (n)
l(2)k11101 34
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fic-1 33 34
  • 46.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToOne
Species where no ortholog for FICD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FICD Gene

ENSEMBL:
Gene Tree for FICD (if available)
TreeFam:
Gene Tree for FICD (if available)

Paralogs for FICD Gene

No data available for Paralogs for FICD Gene

Variants for FICD Gene

Sequence variations from dbSNP and Humsavar for FICD Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000962338 -- 108,518,782(+) CCAC/CCACCCAC coding_sequence_variant, frameshift
rs1001260224 -- 108,514,346(+) A/C upstream_transcript_variant
rs1001684486 -- 108,517,802(+) C/T intron_variant
rs1001714004 -- 108,517,505(+) G/C intron_variant
rs1002356128 -- 108,514,149(+) A/C upstream_transcript_variant

Variation tolerance for FICD Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FICD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FICD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FICD Gene

Disorders for FICD Gene

MalaCards: The human disease database

(2) MalaCards diseases for FICD Gene - From: DISEASES

Disorder Aliases PubMed IDs
depersonalization disorder
  • neurotic derealization
extragonadal germ cell cancer
  • extragonadal germ cell malignant tumor
- elite association - COSMIC cancer census association via MalaCards
Search FICD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FICD

genes like me logo Genes that share disorders with FICD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FICD Gene

Publications for FICD Gene

  1. The fic domain: regulation of cell signaling by adenylylation. (PMID: 19362538) Worby CA … Dixon JE (Molecular cell 2009) 3 4 22 58
  2. Huntingtin interacts with a family of WW domain proteins. (PMID: 9700202) Faber PW … MacDonald ME (Human molecular genetics 1998) 2 3 4 58
  3. Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. (PMID: 22266942) Engel P … Dehio C (Nature 2012) 3 4 58
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  5. FICD acts bifunctionally to AMPylate and de-AMPylate the endoplasmic reticulum chaperone BiP. (PMID: 27918543) Preissler S … Ron D (Nature structural & molecular biology 2017) 3 58

Products for FICD Gene

Sources for FICD Gene

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