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Aliases for FIBCD1 Gene

Aliases for FIBCD1 Gene

  • Fibrinogen C Domain Containing 1 2 3 5
  • Fibrinogen C Domain-Containing Protein 1 3

External Ids for FIBCD1 Gene

Previous GeneCards Identifiers for FIBCD1 Gene

  • GC09M129053
  • GC09M130807
  • GC09M132767
  • GC09M133777
  • GC09M103264

Summaries for FIBCD1 Gene

Entrez Gene Summary for FIBCD1 Gene

  • FIBCD1 is a conserved type II transmembrane endocytic receptor that binds chitin and is located primarily in the intestinal brush border (Schlosser et al., 2009 [PubMed 19710473]).[supplied by OMIM, Apr 2010]

GeneCards Summary for FIBCD1 Gene

FIBCD1 (Fibrinogen C Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include chitin binding. An important paralog of this gene is FCN2.

UniProtKB/Swiss-Prot for FIBCD1 Gene

  • Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.

Additional gene information for FIBCD1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FIBCD1 Gene

Genomics for FIBCD1 Gene

GeneHancer (GH) Regulatory Elements for FIBCD1 Gene

Promoters and enhancers for FIBCD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J130938 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 650.7 +0.2 151 1.1 ZNF2 ZNF335 GLIS2 ZNF366 EGR2 ELK4 SMARCA5 SP3 ZBTB11 ZNF398 FIBCD1 LOC105376297
GH09J130941 Enhancer 0.8 ENCODE 650.7 -1.9 -1923 0.2 CLOCK RB1 KLF17 SIN3A ZNF48 RAD21 RFX5 ZEB1 GLIS2 SCRT2 FIBCD1 LOC105376297 GC09P130986
GH09J130712 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.5 +225.0 225006 4.4 SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF143 FOS SP3 CEBPZ NFYC ABL1 NUP214 EXOSC2 LOC105376301 ENSG00000236986 TOR1B LOC105376297 FIBCD1 QRFP ENSG00000246851
GH09J130856 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 16 +78.9 78948 7.4 CTCF CLOCK FOXA2 ARID4B MAX RAD21 RFX5 ZNF664 POLR2A SCRT2 ABL1 FIBCD1 QRFP LOC105376297 EXOSC2 GC09P130864 GC09P130853 GC09P130854
GH09J130912 Enhancer 0.8 Ensembl ENCODE 27.1 +25.8 25820 1.5 MAX CEBPB BMI1 BRCA1 RFX5 ZKSCAN1 CREB1 SMC3 FIBCD1 LOC105376297 ABL1 NCS1 QRFP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FIBCD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FIBCD1 gene promoter:
  • E2F-3a
  • Egr-4
  • E2F
  • E2F-1
  • E2F-2
  • E2F-4

Genomic Locations for FIBCD1 Gene

Genomic Locations for FIBCD1 Gene
36,849 bases
Minus strand
36,849 bases
Minus strand

Genomic View for FIBCD1 Gene

Genes around FIBCD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FIBCD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FIBCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FIBCD1 Gene

Proteins for FIBCD1 Gene

  • Protein details for FIBCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrinogen C domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A3KFK0
    • Q6UXK6
    • Q96SJ7

    Protein attributes for FIBCD1 Gene

    461 amino acids
    Molecular mass:
    50744 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for FIBCD1 Gene

    Alternative splice isoforms for FIBCD1 Gene


neXtProt entry for FIBCD1 Gene

Post-translational modifications for FIBCD1 Gene

  • Glycosylation at Asn340
  • Modification sites at PhosphoSitePlus

Other Protein References for FIBCD1 Gene

No data available for DME Specific Peptides for FIBCD1 Gene

Domains & Families for FIBCD1 Gene

Gene Families for FIBCD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FIBCD1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FIBCD1: view

No data available for UniProtKB/Swiss-Prot for FIBCD1 Gene

Function for FIBCD1 Gene

Molecular function for FIBCD1 Gene

UniProtKB/Swiss-Prot Function:
Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non-acetylated counterparts. Can facilitate the endocytosis of acetylated components.

Gene Ontology (GO) - Molecular Function for FIBCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008061 chitin binding IEA,IDA 19710473
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FIBCD1: view
genes like me logo Genes that share phenotypes with FIBCD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FIBCD1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FIBCD1 Gene

Localization for FIBCD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FIBCD1 Gene

Membrane; Single-pass type II membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FIBCD1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FIBCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA,IEA 19710473
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FIBCD1: view

Pathways & Interactions for FIBCD1 Gene

SuperPathways for FIBCD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FIBCD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FIBCD1 Gene

Drugs & Compounds for FIBCD1 Gene

No Compound Related Data Available

Transcripts for FIBCD1 Gene

mRNA/cDNA for FIBCD1 Gene

Unigene Clusters for FIBCD1 Gene

Fibrinogen C domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FIBCD1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c
SP1: -
SP2: - -
SP3: - -
SP4: - -

Relevant External Links for FIBCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FIBCD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FIBCD1 Gene

mRNA differential expression in normal tissues according to GTEx for FIBCD1 Gene

This gene is overexpressed in Brain - Hippocampus (x17.3), Adrenal Gland (x8.6), and Testis (x7.5).

Protein differential expression in normal tissues from HIPED for FIBCD1 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FIBCD1 Gene

Protein tissue co-expression partners for FIBCD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FIBCD1 Gene:


SOURCE GeneReport for Unigene cluster for FIBCD1 Gene:


mRNA Expression by UniProt/SwissProt for FIBCD1 Gene:

Tissue specificity: Expressed in the small and large intestinal epithelial cells with a highly polarized localization to the apical surface corresponding to the brush border and in the ducts of the salivary gland.

Evidence on tissue expression from TISSUES for FIBCD1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with FIBCD1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FIBCD1 Gene

Orthologs for FIBCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FIBCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FIBCD1 34 33
  • 99.28 (n)
(Bos Taurus)
Mammalia FIBCD1 34 33
  • 89.28 (n)
(Canis familiaris)
Mammalia FIBCD1 34 33
  • 89.01 (n)
(Mus musculus)
Mammalia Fibcd1 16 34 33
  • 85.98 (n)
(Rattus norvegicus)
Mammalia Fibcd1 33
  • 85.62 (n)
(Ornithorhynchus anatinus)
Mammalia FIBCD1 34
  • 75 (a)
(Monodelphis domestica)
Mammalia FIBCD1 34
  • 72 (a)
(Gallus gallus)
Aves FIBCD1 34 33
  • 75.6 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 85 (a)
-- 34
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fibcd1 33
  • 70.1 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6455 33
(Danio rerio)
Actinopterygii FIBCD1 (2 of 2) 34
  • 81 (a)
si:dkeyp-51b7.3 33
  • 69.21 (n)
fibcd1 34
  • 66 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30280 33
  • 55.83 (n)
CG41520 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
-- 34
  • 52 (a)
-- 34
  • 48 (a)
-- 34
  • 48 (a)
Species where no ortholog for FIBCD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FIBCD1 Gene

Gene Tree for FIBCD1 (if available)
Gene Tree for FIBCD1 (if available)
Evolutionary constrained regions (ECRs) for FIBCD1: view image

Paralogs for FIBCD1 Gene

(20) SIMAP similar genes for FIBCD1 Gene using alignment to 5 proteins:

  • C9J4X0_HUMAN
  • H0Y4Y8_HUMAN
genes like me logo Genes that share paralogs with FIBCD1: view

Variants for FIBCD1 Gene

Sequence variations from dbSNP and Humsavar for FIBCD1 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000000314 -- 130,928,131(-) T/A intron_variant
rs1000011666 -- 130,902,133(-) T/C downstream_transcript_variant
rs1000021119 -- 130,933,026(-) T/A intron_variant
rs1000066641 -- 130,909,705(-) T/C intron_variant
rs1000109547 -- 130,927,850(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FIBCD1 Gene

Variant ID Type Subtype PubMed ID
esv2677011 CNV deletion 23128226
esv2759717 CNV loss 17122850
esv3621866 CNV gain 21293372
esv3621869 CNV loss 21293372
esv3621871 CNV loss 21293372
nsv466601 CNV loss 19166990
nsv469903 CNV loss 18288195
nsv522953 CNV loss 19592680
nsv526527 CNV loss 19592680
nsv615534 CNV loss 21841781
nsv6735 CNV deletion 18451855
nsv825125 CNV gain 20364138
nsv831737 CNV loss 17160897
nsv8572 CNV gain 18304495
nsv951789 CNV deletion 24416366

Variation tolerance for FIBCD1 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.32; 41.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FIBCD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FIBCD1 Gene

Disorders for FIBCD1 Gene

Additional Disease Information for FIBCD1

No disorders were found for FIBCD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FIBCD1 Gene

Publications for FIBCD1 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition. (PMID: 19892701) Thomsen T … Holmskov U (The Journal of biological chemistry 2010) 3 4 58
  3. Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin. (PMID: 19710473) Schlosser A … Holmskov U (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for FIBCD1 Gene

Sources for FIBCD1 Gene

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