FHOD3 Gene (Protein Coding)

Formin Homology 2 Domain Containing 3

GC18P036297
GIFtS:
37
The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyoc... See more...

Aliases for FHOD3 Gene

Aliases for FHOD3 Gene

  • Formin Homology 2 Domain Containing 3 2 3 5
  • FHOS2 2 3 4
  • Formin Homolog Overexpressed In Spleen 2 3 4
  • FH1/FH2 Domain-Containing Protein 3 3 4
  • Formactin-2 3 4
  • KIAA1695 2 4
  • Formactin2 3
  • FLJ22297 2
  • FLJ22717 2
  • HFHOS2 4
  • FHOD3 5

External Ids for FHOD3 Gene

Previous GeneCards Identifiers for FHOD3 Gene

  • GC18P032344
  • GC18P032129
  • GC18P032131
  • GC18P033877
  • GC18P030735

Summaries for FHOD3 Gene

Entrez Gene Summary for FHOD3 Gene

  • The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]

GeneCards Summary for FHOD3 Gene

FHOD3 (Formin Homology 2 Domain Containing 3) is a Protein Coding gene. Diseases associated with FHOD3 include Hypertrophic Cardiomyopathy and Hemochromatosis, Type 2B. Gene Ontology (GO) annotations related to this gene include binding and actin binding. An important paralog of this gene is FHOD1.

UniProtKB/Swiss-Prot Summary for FHOD3 Gene

  • Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.

Additional gene information for FHOD3 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FHOD3 Gene

Genomics for FHOD3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FHOD3 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J036296 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 602.2 +0.5 487 4.4 CTCF PRDM10 IKZF1 ZNF692 BACH1 LARP7 PRDM1 ZIC2 POLR2A PATZ1 FHOD3 lnc-MOCOS-4 KIAA1328
GH18J036718 Promoter 0.3 EPDnew 600 +420.8 420790 0.1 FHOD3 lnc-TPGS2-11 LOC105372071 KIAA1328
GH18J036390 Enhancer 0.8 Ensembl ENCODE dbSUPER 21.8 +94.2 94246 4.5 ATF7 POLR2A ATF2 JUND FHOD3 lnc-MOCOS-4 ENSG00000286890 KIAA1328
GH18J036386 Enhancer 0.6 Ensembl dbSUPER 21.4 +89.3 89288 1.6 PRDM10 POLR2A PKNOX1 FHOD3 lnc-MOCOS-4 ENSG00000286890 KIAA1328
GH18J036329 Enhancer 1 Ensembl ENCODE dbSUPER 11.6 +33.1 33088 4 ZIC2 IKZF2 PKNOX1 EED DPF2 RUNX3 GATAD2B TCF12 YY1 ZFHX2 FHOD3 KIAA1328 lnc-MOCOS-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FHOD3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FHOD3

Top Transcription factor binding sites by QIAGEN in the FHOD3 gene promoter:
  • ATF-2
  • MyoD
  • NF-1
  • Nkx2-5
  • Nkx5-1
  • p53
  • Pax-4a
  • POU2F1a
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for FHOD3 Gene

Genomic Locations for FHOD3 Gene
chr18:36,297,713-36,780,220
(GRCh38/hg38)
Size:
482,508 bases
Orientation:
Plus strand
chr18:33,877,677-34,360,018
(GRCh37/hg19)
Size:
482,342 bases
Orientation:
Plus strand

Genomic View for FHOD3 Gene

Genes around FHOD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHOD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHOD3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FHOD3 Gene

Proteins for FHOD3 Gene

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  • Protein details for FHOD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2V2M9-FHOD3_HUMAN
    Recommended name:
    FH1/FH2 domain-containing protein 3
    Protein Accession:
    Q2V2M9
    Secondary Accessions:
    • A8MQT4
    • E5F5Q0
    • Q642I2
    • Q6ZRQ7
    • Q86TF9
    • Q8N3A5
    • Q9C0G8
    • Q9H604
    • Q9H6G7

    Protein attributes for FHOD3 Gene

    Size:
    1422 amino acids
    Molecular mass:
    158613 Da
    Quaternary structure:
    • Interacts with nestin/NES-based interfilament (IF) (By similarity). Interacts with SQSTM1; isoform 4 threonine phosphorylation disrupts SQSTM1-binding.
    SequenceCaution:
    • Sequence=BAB15292.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB15463.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FHOD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FHOD3 Gene

Protein Expression for FHOD3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FHOD3 Gene

  • [Isoform 4]: Phosphorylated on Thr-1474 and Thr-1476 by CK2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FHOD3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FHOD3 Gene

Domains & Families for FHOD3 Gene

Gene Families for FHOD3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FHOD3 Gene

InterPro:
Blocks:
  • Actin-binding FH2
ProtoNet:

Suggested Antigen Peptide Sequences for FHOD3 Gene

GenScript: Design optimal peptide antigens:
  • Formin homology 2 domain containing 3 variant (E5F5Q0_HUMAN)
  • Formin homolog overexpressed in spleen 2 (FHOD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2V2M9

UniProtKB/Swiss-Prot:

FHOD3_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with FHOD3: view

Function for FHOD3 Gene

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Molecular function for FHOD3 Gene

UniProtKB/Swiss-Prot Function:
Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes.

Phenotypes From GWAS Catalog for FHOD3 Gene

Gene Ontology (GO) - Molecular Function for FHOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 21149568
GO:0051015 actin filament binding IBA 21873635
genes like me logo Genes that share ontologies with FHOD3: view
genes like me logo Genes that share phenotypes with FHOD3: view

Animal Models for FHOD3 Gene

MGI Knock Outs for FHOD3:

Animal Model Products

CRISPR Products

miRNA for FHOD3 Gene

miRTarBase miRNAs that target FHOD3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FHOD3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FHOD3 Gene

Localization for FHOD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FHOD3 Gene

Cytoplasm, cytoskeleton. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. {ECO:0000250}.
[Isoform 4]: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FHOD3 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FHOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA 21873635
GO:0005856 cytoskeleton IEA,IBA 21873635
GO:0005865 striated muscle thin filament IEA,IBA 21873635
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with FHOD3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FHOD3 Gene

Pathways & Interactions for FHOD3 Gene

PathCards logo

SuperPathways for FHOD3 Gene

No Data Available

SIGNOR curated interactions for FHOD3 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for FHOD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization IEA --
GO:0030837 negative regulation of actin filament polymerization IEA --
GO:0030866 cortical actin cytoskeleton organization IBA 21873635
GO:0045214 sarcomere organization IEA,IBA 21873635
GO:0051639 actin filament network formation IBA 21873635
genes like me logo Genes that share ontologies with FHOD3: view

No data available for Pathways by source for FHOD3 Gene

Drugs & Compounds for FHOD3 Gene

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No Compound Related Data Available

Transcripts for FHOD3 Gene

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mRNA/cDNA for FHOD3 Gene

3 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FHOD3

Alternative Splicing Database (ASD) splice patterns (SP) for FHOD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - - - - - -
SP2: -
SP3:
SP4: - - - - -
SP5: -
SP6:

Relevant External Links for FHOD3 Gene

GeneLoc Exon Structure for
FHOD3

Expression for FHOD3 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FHOD3 Gene

mRNA expression in normal human tissues for FHOD3 Gene
mRNA expression by BioGPS for FHOD3 GenemRNA expression by GTEx for FHOD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHOD3 Gene

This gene is overexpressed in Heart - Left Ventricle (x13.6) and Heart - Atrial Appendage (x4.5).

Protein differential expression in normal tissues from HIPED for FHOD3 Gene

This gene is overexpressed in Cervix (39.2) and Adrenal (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FHOD3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FHOD3

SOURCE GeneReport for Unigene cluster for FHOD3 Gene:

Hs.630884

mRNA Expression by UniProt/SwissProt for FHOD3 Gene:

Q2V2M9-FHOD3_HUMAN
Tissue specificity: Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level).

Evidence on tissue expression from TISSUES for FHOD3 Gene

  • Nervous system(4.6)
  • Intestine(4.2)
  • Heart(2.9)
  • Muscle(2.7)
genes like me logo Genes that share expression patterns with FHOD3: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FHOD3 Gene

Orthologs for FHOD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FHOD3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FHOD3 30 31
  • 99.37 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FHOD3 30 31
  • 89.49 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FHOD3 30 31
  • 87.63 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Fhod3 30 17 31
  • 85.45 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Fhod3 30
  • 85.29 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia FHOD3 31
  • 73 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia FHOD3 31
  • 69 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FHOD3 30 31
  • 75.09 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FHOD3 31
  • 65 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia fhod3 30
  • 67.42 (n)
Zebrafish
(Danio rerio)
 Actinopterygii zgc:103746 30
  • 71.25 (n)
FHOD3 (2 of 2) 31
  • 64 (a)
 OneToMany
FHOD3 (1 of 2) 31
  • 63 (a)
 OneToMany
Fruit Fly
(Drosophila melanogaster)
 Insecta Fhos 31
  • 18 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea fhod-1 31
  • 28 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.2479 31
  • 49 (a)
 ManyToMany
Species where no ortholog for FHOD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FHOD3 Gene

ENSEMBL:
Gene Tree for FHOD3 (if available)
TreeFam:
Gene Tree for FHOD3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FHOD3: view image

Paralogs for FHOD3 Gene

Paralogs for FHOD3 Gene

(1) SIMAP similar genes for FHOD3 Gene using alignment to 4 proteins:

  • FHOD3_HUMAN
  • K7EKZ0_HUMAN
  • K7EP24_HUMAN
  • K7ER94_HUMAN
genes like me logo Genes that share paralogs with FHOD3: view

Variants for FHOD3 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FHOD3 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
709375 Likely Benign: not provided 36,718,214(+) G/A SYNONYMOUS_VARIANT
713615 Benign: not provided 36,612,056(+) G/A SYNONYMOUS_VARIANT
718054 Likely Benign: not provided 36,681,510(+) G/A MISSENSE_VARIANT
721884 Benign: not provided 36,611,946(+) T/C INTRON_VARIANT
773340 Benign: not provided 36,693,351(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FHOD3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FHOD3 Gene

Variant ID Type Subtype PubMed ID
esv1093578 CNV insertion 17803354
esv1752551 CNV insertion 17803354
esv21615 CNV loss 19812545
esv24629 CNV loss 19812545
esv2656572 CNV deletion 23128226
esv2656975 CNV deletion 23128226
esv2658053 CNV deletion 23128226
esv2664060 CNV deletion 23128226
esv2672452 CNV deletion 23128226
esv2716960 CNV deletion 23290073
esv2716961 CNV deletion 23290073
esv2758721 CNV gain 17122850
esv2758722 CNV gain 17122850
esv3347088 CNV duplication 20981092
esv3369397 CNV duplication 20981092
esv34228 CNV gain 17911159
esv3429064 CNV duplication 20981092
esv3555235 CNV deletion 23714750
esv3583014 CNV loss 25503493
esv3583016 CNV loss 25503493
esv3583017 CNV loss 25503493
esv3583018 CNV loss 25503493
esv3642224 CNV loss 21293372
esv3642225 CNV loss 21293372
esv3642226 CNV loss 21293372
esv3642227 CNV loss 21293372
esv3642228 CNV loss 21293372
esv3642229 CNV loss 21293372
esv3642230 CNV loss 21293372
esv3642232 CNV loss 21293372
esv3642233 CNV gain 21293372
esv3642234 CNV gain 21293372
esv3642236 CNV loss 21293372
esv3642237 CNV gain 21293372
esv3642238 CNV loss 21293372
esv996876 CNV insertion 20482838
nsv1064616 CNV gain 25217958
nsv1067355 CNV loss 25217958
nsv1134710 CNV deletion 24896259
nsv1136251 CNV deletion 24896259
nsv130624 CNV deletion 16902084
nsv132037 CNV deletion 16902084
nsv2256 CNV insertion 18451855
nsv436238 CNV deletion 17901297
nsv437823 CNV loss 16327808
nsv438280 CNV loss 16468122
nsv438282 CNV loss 16468122
nsv442433 CNV gain+loss 18776908
nsv473480 CNV novel sequence insertion 20440878
nsv477797 CNV novel sequence insertion 20440878
nsv513492 CNV insertion 21212237
nsv518778 CNV loss 19592680
nsv522170 CNV loss 19592680
nsv525007 CNV loss 19592680
nsv526596 CNV gain 19592680
nsv527769 CNV loss 19592680
nsv576651 CNV loss 21841781
nsv817789 CNV gain 17921354
nsv819365 CNV loss 19587683
nsv828211 CNV loss 20364138
nsv833620 CNV gain 17160897
nsv9625 CNV loss 18304495
nsv9626 CNV loss 18304495

Variation tolerance for FHOD3 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.20; 98.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FHOD3 Gene

Human Gene Mutation Database (HGMD)
FHOD3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FHOD3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHOD3 Gene

Disorders for FHOD3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FHOD3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypertrophic cardiomyopathy
  • familial hypertrophic cardiomyopathy
hemochromatosis, type 2b
  • hfe2b
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
distal muscular dystrophy with anterior tibial onset
  • dmat
- elite association - COSMIC cancer census association via MalaCards
Search FHOD3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FHOD3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FHOD3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FHOD3 Gene

Publications for FHOD3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. (PMID: 20195266) Adkins DE … van den Oord EJ (Molecular psychiatry 2011) 3 41
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. (PMID: 21149568) Iskratsch T … Ehler E (The Journal of cell biology 2010) 3 4
  5. Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament. (PMID: 15966898) Kanaya H … Sumimoto H (Genes to cells : devoted to molecular & cellular mechanisms 2005) 3 4

ExternalLinks

View latest publications for FHOD3 gene in Mastermind

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