Aliases for FHOD1 Gene
External Ids for FHOD1 Gene
Previous GeneCards Identifiers for FHOD1 Gene
This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
GeneCards Summary for FHOD1 Gene
FHOD1 (Formin Homology 2 Domain Containing 1) is a Protein Coding gene. Diseases associated with FHOD1 include Cerebral Amyloid Angiopathy, Itm2b-Related, 2 and Malignant Breast Melanoma. Among its related pathways are Salmonella infection (KEGG). Gene Ontology (GO) annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is FHOD3.
UniProtKB/Swiss-Prot Summary for FHOD1 Gene
Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing.