Aliases for FHL3 Gene
External Ids for FHL3 Gene
Previous GeneCards Identifiers for FHL3 Gene
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for FHL3 Gene
FHL3 (Four And A Half LIM Domains 3) is a Protein Coding gene. Diseases associated with FHL3 include Retinitis Pigmentosa 37 and Glycogen Storage Disease Vii. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is FHL2.
UniProtKB/Swiss-Prot Summary for FHL3 Gene
Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1.