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Aliases for FHAD1 Gene

Aliases for FHAD1 Gene

  • Forkhead Associated Phosphopeptide Binding Domain 1 2 3 5
  • Forkhead-Associated (FHA) Phosphopeptide Binding Domain 1 2 3
  • FHA Domain-Containing Protein 1 3 4
  • Forkhead-Associated Domain-Containing Protein 1 3
  • KIAA1937 4

External Ids for FHAD1 Gene

Previous GeneCards Identifiers for FHAD1 Gene

  • GC01P015309
  • GC01P015435
  • GC01P015563
  • GC01P014095

Summaries for FHAD1 Gene

GeneCards Summary for FHAD1 Gene

FHAD1 (Forkhead Associated Phosphopeptide Binding Domain 1) is a Protein Coding gene.

Additional gene information for FHAD1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FHAD1 Gene

Genomics for FHAD1 Gene

GeneHancer (GH) Regulatory Elements for FHAD1 Gene

Promoters and enhancers for FHAD1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J015236 Enhancer 0.7 ENCODE 650.7 -0.1 -132 0.1 PKNOX1 USF1 E4F1 NFYB FOS ZNF362 L3MBTL2 USF2 NFYC ELF1 FHAD1 LOC100421184
GH01J015406 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +177.0 177042 13.8 HDGF PKNOX1 SIN3A IRF4 ZNF143 FOS SP3 JUNB ZNF592 RFX3 EFHD2 LOC101927441 SPEN CTRC LOC101927417 ENSG00000237938 FHAD1 RPL22P3 RPS16P1 FBXO42
GH01J015245 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15 +10.0 9987 2.3 SIN3A ZNF121 GLIS2 ZNF143 ZNF207 KLF13 SP3 ZNF623 RFX3 GLIS1 FHAD1 ENSG00000237938 LOC101927417 ARHGEF19 RPS16P1 PLEKHM2 TMEM51 EFHD2 CASP9 PIR39012
GH01J015258 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.7 +24.1 24076 3.8 PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A FOS JUNB REST TMEM51-AS1 FHAD1 LOC101927417 PLEKHM2 SPEN ENSG00000237301 TMEM51 EFHD2 CASP9 PIR39012
GH01J015322 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +87.8 87759 2.7 HDAC1 PKNOX1 RB1 ARNT ZBTB40 RAD21 RFX5 TCF12 ZNF766 ARID2 FHAD1 CTRC CASP9 EFHD2 PLEKHM2 ENSG00000236045 PIR39012
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FHAD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FHAD1 gene promoter:
  • AML1a
  • FOXF2
  • STAT1
  • POU2F1a
  • POU2F1
  • Lmo2
  • ARP-1
  • Evi-1
  • POU2F1c
  • POU2F1b

Genomic Locations for FHAD1 Gene

Genomic Locations for FHAD1 Gene
163,682 bases
Plus strand
153,012 bases
Plus strand

Genomic View for FHAD1 Gene

Genes around FHAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FHAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FHAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FHAD1 Gene

Proteins for FHAD1 Gene

  • Protein details for FHAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead-associated domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q0P6F5
    • Q8N8D3
    • Q8N9T6
    • Q8NA05

    Protein attributes for FHAD1 Gene

    1412 amino acids
    Molecular mass:
    161904 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04126.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04242.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04913.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI21427.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23268.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FHAD1 Gene


neXtProt entry for FHAD1 Gene

Post-translational modifications for FHAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FHAD1 Gene

Domains & Families for FHAD1 Gene

Gene Families for FHAD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FHAD1 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FHAD1: view

No data available for UniProtKB/Swiss-Prot for FHAD1 Gene

Function for FHAD1 Gene

Phenotypes From GWAS Catalog for FHAD1 Gene

Phenotypes for FHAD1 Gene

genes like me logo Genes that share phenotypes with FHAD1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FHAD1 Gene

Localization for FHAD1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FHAD1 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FHAD1 Gene

Pathways & Interactions for FHAD1 Gene

SuperPathways for FHAD1 Gene

No Data Available

Interacting Proteins for FHAD1 Gene

Selected Interacting proteins: B1AJZ9-FHAD1_HUMAN for FHAD1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for FHAD1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FHAD1 Gene

Drugs & Compounds for FHAD1 Gene

No Compound Related Data Available

Transcripts for FHAD1 Gene

Unigene Clusters for FHAD1 Gene

Forkhead-associated (FHA) phosphopeptide binding domain 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FHAD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
SP1: - - -
SP2: -
SP3: -
SP5: - - - - - -
SP7: - - -
SP8: -

ExUns: 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34
SP1: - - - - -
SP2: -
SP3: - - - - - - - -
SP4: - - - -
SP6: - - - - - -

Relevant External Links for FHAD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FHAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FHAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FHAD1 Gene

This gene is overexpressed in Testis (x21.5).

Protein differential expression in normal tissues from HIPED for FHAD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (39.8) and Plasma (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FHAD1 Gene

Protein tissue co-expression partners for FHAD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FHAD1 Gene:


SOURCE GeneReport for Unigene cluster for FHAD1 Gene:

genes like me logo Genes that share expression patterns with FHAD1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FHAD1 Gene

Orthologs for FHAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FHAD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FHAD1 34 33
  • 98.35 (n)
(Canis familiaris)
Mammalia FHAD1 34 33
  • 81.49 (n)
(Bos Taurus)
Mammalia FHAD1 34 33
  • 80.87 (n)
(Mus musculus)
Mammalia Fhad1 16 34 33
  • 74.9 (n)
(Rattus norvegicus)
Mammalia Fhad1 33
  • 74.56 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
-- 34
  • 15 (a)
-- 34
  • 2 (a)
(Monodelphis domestica)
Mammalia FHAD1 34
  • 7 (a)
(Gallus gallus)
Aves LOC771735 33
  • 57.54 (n)
FHAD1 34
  • 3 (a)
(Anolis carolinensis)
Reptilia FHAD1 34
  • 6 (a)
(Danio rerio)
Actinopterygii FHAD1 (1 of 2) 34
  • 8 (a)
FHAD1 (2 of 2) 34
  • 5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 8 (a)
Species where no ortholog for FHAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FHAD1 Gene

Gene Tree for FHAD1 (if available)
Gene Tree for FHAD1 (if available)
Evolutionary constrained regions (ECRs) for FHAD1: view image

Paralogs for FHAD1 Gene

(1) SIMAP similar genes for FHAD1 Gene using alignment to 11 proteins:

  • H0Y3C6_HUMAN
  • H0Y5P0_HUMAN
  • H0Y605_HUMAN
  • H0YE38_HUMAN
genes like me logo Genes that share paralogs with FHAD1: view

No data available for Paralogs for FHAD1 Gene

Variants for FHAD1 Gene

Sequence variations from dbSNP and Humsavar for FHAD1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000022013 -- 15,252,997(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000053098 -- 15,375,285(+) C/G genic_downstream_transcript_variant, intron_variant
rs1000063159 -- 15,334,086(+) A/G/T intron_variant
rs1000074432 -- 15,297,267(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000090329 -- 15,289,279(+) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FHAD1 Gene

Variant ID Type Subtype PubMed ID
esv2508152 CNV insertion 19546169
esv2671419 CNV deletion 23128226
esv27394 CNV gain 19812545
esv2744297 CNV deletion 23290073
esv2762133 CNV loss 21179565
esv28285 CNV loss 19812545
esv3585308 CNV loss 21293372
esv3585309 CNV loss 21293372
nsv1007255 CNV loss 25217958
nsv460561 CNV loss 19166990
nsv472480 CNV novel sequence insertion 20440878
nsv475629 CNV novel sequence insertion 20440878
nsv478487 CNV novel sequence insertion 20440878
nsv517234 CNV gain 19592680
nsv545594 CNV loss 21841781
nsv833425 CNV gain 17160897
nsv833536 CNV loss 17160897

Variation tolerance for FHAD1 Gene

Gene Damage Index Score: 18.24; 98.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FHAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FHAD1 Gene

Disorders for FHAD1 Gene

Additional Disease Information for FHAD1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FHAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FHAD1 Gene

Publications for FHAD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 58
  5. Epigenome-Wide Tumor DNA Methylation Profiling Identifies Novel Prognostic Biomarkers of Metastatic-Lethal Progression in Men Diagnosed with Clinically Localized Prostate Cancer. (PMID: 27358489) Zhao S … Stanford JL (Clinical cancer research : an official journal of the American Association for Cancer Research 2017) 3 58

Products for FHAD1 Gene

Sources for FHAD1 Gene

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