FGL2 Gene (Protein Coding)

Fibrinogen Like 2

GC07M077193
GIFtS:
40
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites... See more...

Aliases for FGL2 Gene

Aliases for FGL2 Gene

  • Fibrinogen Like 2 2 3 5
  • Fibrinogen-Like Protein 2 3 4
  • Fibroleukin 3 4
  • PT49 3 4
  • Fibrinogen-Like 2 2
  • T49 3

External Ids for FGL2 Gene

Previous GeneCards Identifiers for FGL2 Gene

  • GC07M075361
  • GC07M076423
  • GC07M076437
  • GC07M076470
  • GC07M076662
  • GC07M076822
  • GC07M071425

Summaries for FGL2 Gene

Entrez Gene Summary for FGL2 Gene

  • The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGL2 Gene

FGL2 (Fibrinogen Like 2) is a Protein Coding gene. Diseases associated with FGL2 include Viral Hepatitis and Acute Liver Failure. Among its related pathways are Innate Immune System. An important paralog of this gene is TNC.

UniProtKB/Swiss-Prot Summary for FGL2 Gene

  • May play a role in physiologic lymphocyte functions at mucosal sites.

Gene Wiki entry for FGL2 Gene

Additional gene information for FGL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGL2 Gene

Genomics for FGL2 Gene

GeneHancer (GH) Regulatory Elements for FGL2 Gene

Promoters and enhancers for FGL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH07J077196 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 509.6 +1.5 1485 5.1 POLR2A SPI1 RB1 RAD21 ZNF660 PKNOX1 RUNX3 FGL2 CCDC146 lnc-FGL2-3 ENSG00000259628
GH07J077245 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -46.0 -46029 1.4 FOXK2 NCOR1 KDM6A TCF7 ZBTB25 TGIF2 SKI TEAD1 TBX3 KMT2B LOC105375359 FGL2 CCDC146 ENSG00000250990 piR-60140-022
GH07J077222 Enhancer 0.6 Ensembl ENCODE 24.9 -24.4 -24441 6.2 CEBPG RFX5 CEBPB SPI1 TFAP4 SREBF1 piR-60140-022 FGL2 CCDC146 ENSG00000250990 FAM185BP LOC105375359
GH07J077326 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11 -127.7 -127748 3.2 JUND FOS MXI1 BCL11A MYNN CEBPB ZNF384 SRF NR3C1 MEF2B GSAP FGL2 PTPN12 DTX2 lnc-FGL2-6-001 lnc-FGL2-6-002 piR-53029-119 CCDC146
GH07J077252 Enhancer 0.7 Ensembl ENCODE dbSUPER 22.5 -54.4 -54356 3.2 USF1 USF2 FGL2 CCDC146 ENSG00000250990 LOC105375359 LOC102723791
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGL2

Top Transcription factor binding sites by QIAGEN in the FGL2 gene promoter:
  • AML1a
  • Brachyury
  • FOXF2
  • HFH-1
  • IRF-1
  • Olf-1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for FGL2 Gene

Genomic Locations for FGL2 Gene
chr7:77,193,369-77,199,848
(GRCh38/hg38)
Size:
6,480 bases
Orientation:
Minus strand
chr7:76,822,688-76,829,150
(GRCh37/hg19)
Size:
6,463 bases
Orientation:
Minus strand

Genomic View for FGL2 Gene

Genes around FGL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGL2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGL2 Gene

Proteins for FGL2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FGL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14314-FGL2_HUMAN
    Recommended name:
    Fibroleukin
    Protein Accession:
    Q14314

    Protein attributes for FGL2 Gene

    Size:
    439 amino acids
    Molecular mass:
    50229 Da
    Quaternary structure:
    • Homotetramer; disulfide-linked.

neXtProt entry for FGL2 Gene

Protein Expression for FGL2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FGL2 Gene

  • Glycosylation at Asn25, Asn179, Asn235, Asn263, and Asn336
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for FGL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGL2 Gene

Domains & Families for FGL2 Gene

Gene Families for FGL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for FGL2 Gene

Blocks:
  • Fibrinogen, beta/gamma chain, C-terminal globular
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGL2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ93065, Homo sapiens fibrinogen-like 2 (FGL2), mRNA (A4D1B8_HUMAN)
  • pT49 (FGL2_HUMAN)
genes like me logo Genes that share domains with FGL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FGL2 Gene

Function for FGL2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FGL2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in physiologic lymphocyte functions at mucosal sites.
GENATLAS Biochemistry:
fibrinogen-like 2,expressed in T lymphocytes

Phenotypes From GWAS Catalog for FGL2 Gene

Gene Ontology (GO) - Molecular Function for FGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent RCA 28327460
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with FGL2: view
genes like me logo Genes that share phenotypes with FGL2: view

Animal Models for FGL2 Gene

MGI Knock Outs for FGL2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGL2 Gene

Localization for FGL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGL2 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005577 fibrinogen complex TAS 7642106
GO:0062023 collagen-containing extracellular matrix HDA 28327460
GO:0070062 extracellular exosome HDA 19056867
GO:1904813 ficolin-1-rich granule lumen TAS --
genes like me logo Genes that share ontologies with FGL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGL2 Gene

Pathways & Interactions for FGL2 Gene

PathCards logo

SuperPathways for FGL2 Gene

genes like me logo Genes that share pathways with FGL2: view

Pathways by source for FGL2 Gene

3 Reactome pathways for FGL2 Gene

Gene Ontology (GO) - Biological Process for FGL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IEA --
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response IEA --
GO:0002605 negative regulation of dendritic cell antigen processing and presentation IEA --
GO:0002617 negative regulation of macrophage antigen processing and presentation IEA --
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with FGL2: view

No data available for SIGNOR curated interactions for FGL2 Gene

Drugs & Compounds for FGL2 Gene

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  1. Drug

(3) Drugs for FGL2 Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antiviral Agents Pharma 11875
Liver Extracts Pharma 5430

(2) Additional Compounds for FGL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGL2: view

Transcripts for FGL2 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FGL2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGL2

Alternative Splicing Database (ASD) splice patterns (SP) for FGL2 Gene

No ASD Table

Relevant External Links for FGL2 Gene

GeneLoc Exon Structure for
FGL2

Expression for FGL2 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGL2 Gene

mRNA expression in normal human tissues for FGL2 Gene
mRNA expression by BioGPS for FGL2 GenemRNA expression by GTEx for FGL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGL2 Gene

This gene is overexpressed in Artery - Aorta (x8.3), Esophagus - Gastroesophageal Junction (x6.6), Esophagus - Muscularis (x5.4), and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for FGL2 Gene

This gene is overexpressed in Plasma (21.8), Serum (12.4), and Spleen (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGL2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGL2

SOURCE GeneReport for Unigene cluster for FGL2 Gene:

Hs.520989

mRNA Expression by UniProt/SwissProt for FGL2 Gene:

Q14314-FGL2_HUMAN
Tissue specificity: Constitutively expressed in cytotoxic T-cells.

Evidence on tissue expression from TISSUES for FGL2 Gene

  • Blood(4.6)
  • Liver(4.6)
  • Intestine(4.4)
  • Bone marrow(4.2)
  • Pancreas(4.1)
  • Spleen(3)
  • Nervous system(2.9)
  • Heart(2.5)
  • Kidney(2.5)
  • Lymph node(2.4)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with FGL2: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL2 Gene

Orthologs for FGL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FGL2 31 30
  • 99.54 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia FGL2 31 30
  • 89.83 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia FGL2 31 30
  • 83.94 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Fgl2 30
  • 80.89 (n)
mouse
(Mus musculus)
 Mammalia Fgl2 17 31 30
  • 80.51 (n)
oppossum
(Monodelphis domestica)
 Mammalia FGL2 31
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves FGL2 31 30
  • 69.55 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia FGL2 31
  • 65 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia fgl2 30
  • 66.1 (n)
Str.15307 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.23684 30
zebrafish
(Danio rerio)
 Actinopterygii fgl2 31 30
  • 61.69 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG8642 32
  • 40 (a)
CG1889 32
  • 37 (a)
CG1791 32
  • 33 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CS-FIBRINOGEN-LIKE 31
  • 26 (a)
 OneToOne
Species where no ortholog for FGL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGL2 Gene

ENSEMBL:
Gene Tree for FGL2 (if available)
TreeFam:
Gene Tree for FGL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGL2: view image

Paralogs for FGL2 Gene

Paralogs for FGL2 Gene

(6) SIMAP similar genes for FGL2 Gene using alignment to 2 proteins:

  • FGL2_HUMAN
  • A4D1B8_HUMAN
genes like me logo Genes that share paralogs with FGL2: view

Variants for FGL2 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGL2 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs2075761 - p.Gly53Glu

Additional dbSNP identifiers (rs#s) for FGL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FGL2 Gene

Variant ID Type Subtype PubMed ID
esv34102 CNV loss 18971310
nsv1034874 CNV loss 25217958
nsv428174 CNV gain 18775914
nsv526097 CNV gain 19592680
nsv951363 CNV duplication 24416366

Variation tolerance for FGL2 Gene

Residual Variation Intolerance Score: 26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.66; 72.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL2 Gene

Disorders for FGL2 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FGL2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
viral hepatitis
  • animal viral hepatitis
acute liver failure
  • acute hepatic failure
anterior spinal artery syndrome
  • anterior spinal artery occlusion syndrome
hepatitis b
  • chronic hepatitis b
brown-sequard syndrome
  • brown-squard syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FGL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGL2 Gene

Publications for FGL2 Gene

  1. Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. (PMID: 9647217) Marazzi S … Rüegg C (Journal of immunology (Baltimore, Md. : 1950) 1998) 3 4 23 54
  2. Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PMID: 7642106) Rüegg C … Pytela R (Gene 1995) 2 3 4 54
  3. The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. (PMID: 20438701) Liu Y … Ning Q (Biochemical and biophysical research communications 2010) 3 23 54
  4. Candidate genes associated with susceptibility for SARS-coronavirus. (PMID: 19590927) Hsieh YH … Ho MS (Bulletin of mathematical biology 2010) 3 41 54
  5. Hepatitis B virus-induced hFGL2 transcription is dependent on c-Ets-2 and MAPK signal pathway. (PMID: 18801734) Han M … Ning Q (The Journal of biological chemistry 2008) 3 23 54

ExternalLinks

View latest publications for FGL2 gene in Mastermind

Products for FGL2 Gene

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