Aliases for FGL2 Gene
Aliases for FGL2 Gene
External Ids for FGL2 Gene
- HGNC: 3696
- Entrez Gene: 10875
- Ensembl: ENSG00000127951
- OMIM: 605351
- UniProtKB: Q14314
Previous GeneCards Identifiers for FGL2 Gene
- GC07M075361
- GC07M076423
- GC07M076437
- GC07M076470
- GC07M076662
- GC07M076822
- GC07M071425
Summaries for FGL2 Gene
-
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGL2 Gene
FGL2 (Fibrinogen Like 2) is a Protein Coding gene. Diseases associated with FGL2 include Viral Hepatitis and Hepatitis B. Among its related pathways are Innate Immune System. An important paralog of this gene is ANGPT2.
UniProtKB/Swiss-Prot for FGL2 Gene
-
May play a role in physiologic lymphocyte functions at mucosal sites.
Additional gene information for FGL2 Gene
- Monarch Initiative
- Search for FGL2 at DataMed
- Search for FGL2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL2 Gene
Genomics for FGL2 Gene
GeneHancer (GH) Regulatory Elements for FGL2 Gene
Promoters and enhancers for FGL2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH07J077196 | Promoter/Enhancer | 1.5 | EPDnew Ensembl ENCODE | 659.7 | +1.0 | 983 | 4.1 | PKNOX1 POLR2A RB1 RUNX3 RAD21 SPI1 | FGL2 CCDC146 GC07M077200 ENSG00000259628 | |
| GH07J077245 | Enhancer | 1.5 | FANTOM5 Ensembl ENCODE dbSUPER | 11.7 | -46.0 | -46029 | 1.4 | MLX ARID4B DMAP1 ETS1 YY1 TCF12 RXRA MXD4 MIER2 REST | LOC105375359 FGL2 CCDC146 ENSG00000250990 GC07M077229 | |
| GH07J077326 | Promoter/Enhancer | 1.4 | EPDnew Ensembl ENCODE | 11 | -127.7 | -127748 | 3.2 | JUN MAX EBF1 CEBPG BMI1 POLR2A EED ATF7 RCOR1 FOS | GSAP FGL2 PTPN12 DTX2 PIR39731 LOC102723791 CCDC146 | |
| GH07J077269 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 16.2 | -70.3 | -70335 | 1.5 | SP1 EBF1 ETV6 RUNX3 NR2F2 | FGL2 CCDC146 PIR56172 LOC102723791 | |
| GH07J077252 | Enhancer | 0.6 | ENCODE dbSUPER | 22.5 | -54.5 | -54478 | 3 | USF1 USF2 | FGL2 CCDC146 ENSG00000250990 LOC105375359 LOC102723791 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGL2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FGL2 gene promoter:
-
- Brachyury
- FOXF2
- STAT1
- STAT1alpha
- STAT1beta
- AML1a
- IRF-1
- Olf-1
- HFH-1
Regulatory Element Products
Genomic Locations for FGL2 Gene
Genomic Locations for FGL2 Gene
- chr7:77,193,371-77,199,848
- (GRCh38/hg38)
- Size:
- 6,478 bases
- Orientation:
- Minus strand
- chr7:76,822,688-76,829,150
- (GRCh37/hg19)
- Size:
- 6,463 bases
- Orientation:
- Minus strand
Genomic View for FGL2 Gene
Genes around FGL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by Entrez Gene
- 7q11.23 by HGNC
- 7q11.23 by Ensembl
FGL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGL2 Gene
Proteins for FGL2 Gene
-
Protein details for FGL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14314-FGL2_HUMAN
- Recommended name:
- Fibroleukin
- Protein Accession:
- Q14314
Protein attributes for FGL2 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 50229 Da
- Quaternary structure:
-
- Homotetramer; disulfide-linked.
Protein Expression for FGL2 Gene
Post-translational modifications for FGL2 Gene
Other Protein References for FGL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FGL2 (FGL2)
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-
Abcam antibodies for FGL2
- Invitrogen Antibodies for FGL2 (AFLGC-FGL2)
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-
Boster Bio Antibodies for FGL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGL2
Protein Products
-
OriGene Purified Proteins for FGL2
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- Search GeneTex for Proteins for FGL2
-
Abcam proteins for FGL2
Assay Products
No data available for DME Specific Peptides for FGL2 Gene
Domains & Families for FGL2 Gene
Gene Families for FGL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for FGL2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGL2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FGL2 Gene
Function for FGL2 Gene
Molecular function for FGL2 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in physiologic lymphocyte functions at mucosal sites.
- GENATLAS Biochemistry:
- fibrinogen-like 2,expressed in T lymphocytes
Phenotypes From GWAS Catalog for FGL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for FGL2 Gene
- MGI mutant phenotypes for FGL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FGL2:
Animal Model Products
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-
CRISPR Products
-
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- Applied Biological Materials CRISPR for FGL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL2
- GenScript: Design CRISPR guide RNA sequences for FGL2
miRNA for FGL2 Gene
- miRTarBase miRNAs that target FGL2
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for FGL2
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- genomics-online: cdna clones - Search results for available FGL2 gene related products
- orf clones - Search results for available FGL2 gene related products
- Applied Biological Materials Clones for FGL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FGL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGL2 Gene
Localization for FGL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGL2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005577 | fibrinogen complex | TAS | 7642106 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
| GO:1904813 | ficolin-1-rich granule lumen | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGL2 Gene
Pathways & Interactions for FGL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for FGL2 Gene
3 Reactome pathways for FGL2 Gene
Interacting Proteins for FGL2 Gene
GPS-Prot Interaction Network for FGL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006508 | proteolysis | IEA | -- |
| GO:0043312 | neutrophil degranulation | TAS | -- |
No data available for SIGNOR curated interactions for FGL2 Gene
Transcripts for FGL2 Gene
mRNA/cDNA for FGL2 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (89) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000248598 4261 bps (uc003ugb.4)
- ENST00000637771 989 bps
CRISPR Products
-
OriGene CRISPR knockouts for FGL2
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- Applied Biological Materials CRISPR for FGL2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL2
- GenScript: Design CRISPR guide RNA sequences for FGL2
miRNA Products
Inhibitory RNA Products
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGL2
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Clone Products
- Sino Biological Human cDNA Clone for FGL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGL2
- genomics-online: cdna clones - Search results for available FGL2 gene related products
- orf clones - Search results for available FGL2 gene related products
- Applied Biological Materials Clones for FGL2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FGL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- T Helper Cells Thymus
- Hematopoietic Bone Marrow
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Dermal Fibroblasts Dorsal Dermis
- Brain (Nervous System)
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Dorsal Dermis
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
- Kidney (Urinary System)
- Neural Crest (Gastrulation Derivatives)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for FGL2 Gene
This gene is overexpressed in Artery - Aorta (x8.3), Esophagus - Gastroesophageal Junction (x6.6), Esophagus - Muscularis (x5.4), and Whole Blood (x5.2).
This gene is overexpressed in Plasma (21.8), Serum (12.4), and Spleen (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FGL2 Gene:
FGL2SOURCE GeneReport for Unigene cluster for FGL2 Gene:
Hs.520989mRNA Expression by UniProt/SwissProt for FGL2 Gene:
Q14314-FGL2_HUMAN
Tissue specificity:
Constitutively expressed in cytotoxic T-cells.
Evidence on tissue expression from TISSUES for FGL2 Gene
- Blood(4.6)
- Liver(4.6)
- Intestine(4.4)
- Bone marrow(4.2)
- Pancreas(4.1)
- Spleen(3)
- Nervous system(2.9)
- Heart(2.5)
- Kidney(2.5)
- Lymph node(2.4)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for FGL2
-
OriGene qPCR primer pairs and template standards for FGL2
- genomics-online: primer clones - Search results for available FGL2 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL2 Gene
Orthologs for FGL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGL2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FGL2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FGL2 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fgl2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgl2 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FGL2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGL2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FGL2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgl2 33 |
|
||
| Str.15307 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23684 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fgl2 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG8642 35 |
|
|
|
| CG1889 35 |
|
|
|||
| CG1791 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | CS-FIBRINOGEN-LIKE 34 |
|
OneToOne |
- Species where no ortholog for FGL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for FGL2 Gene
- ENSEMBL:
- Gene Tree for FGL2 (if available)
- TreeFam:
- Gene Tree for FGL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FGL2: view image
Paralogs for FGL2 Gene
Paralogs for FGL2 Gene
(6) SIMAP similar genes for FGL2 Gene using alignment to 2 proteins:
- FGL2_HUMAN
- A4D1B8_HUMAN
Variants for FGL2 Gene
| SNP ID | Clin | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000548755 | -- | 77,197,579(-) | G/T | intron_variant | |
| rs1001511048 | -- | 77,198,894(-) | C/T | intron_variant | |
| rs1001543507 | -- | 77,199,281(-) | A/C | coding_sequence_variant, missense_variant | |
| rs1001578494 | -- | 77,193,714(-) | A/G | 3_prime_UTR_variant | |
| rs1001924611 | -- | 77,193,419(-) | G/A | 3_prime_UTR_variant |
Residual Variation Intolerance Score:
26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.66;
72.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGL2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL2 Gene
Disorders for FGL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| viral hepatitis |
|
|
| hepatitis b |
|
Search FGL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FGL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FGL2 Gene
Publications for FGL2 Gene
- Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. (PMID: 9647217) Marazzi S … Rüegg C (Journal of immunology (Baltimore, Md. : 1950) 1998) 3 4 22 58
- Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PMID: 7642106) Rüegg C … Pytela R (Gene 1995) 2 3 4 58
- The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. (PMID: 20438701) Liu Y … Ning Q (Biochemical and biophysical research communications 2010) 3 22 58
- Candidate genes associated with susceptibility for SARS-coronavirus. (PMID: 19590927) Hsieh YH … Ho MS (Bulletin of mathematical biology 2010) 3 44 58
- Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-gamma. (PMID: 18932275) Su K … Ning Q (World journal of gastroenterology 2008) 3 22 58
Products for FGL2 Gene
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- antibodies-online: Search results for 20 available FGL2 Proteins ranked by validation data
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- GeneTex FGL2 Antibody for FGL2
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- genomics-online: cdna clones - Search results for available FGL2 gene related products
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- genomics-online: gRNA clones - Search results for available FGL2 gene related products
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Sources for FGL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
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