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The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites... See more...
Aliases for FGL2 Gene
Aliases for FGL2 Gene
External Ids for FGL2 Gene
- HGNC: 3696
- Entrez Gene: 10875
- Ensembl: ENSG00000127951
- OMIM: 605351
- UniProtKB: Q14314
Previous GeneCards Identifiers for FGL2 Gene
- GC07M075361
- GC07M076423
- GC07M076437
- GC07M076470
- GC07M076662
- GC07M076822
- GC07M071425
Summaries for FGL2 Gene
-
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGL2 Gene
FGL2 (Fibrinogen Like 2) is a Protein Coding gene. Diseases associated with FGL2 include Viral Hepatitis and Acute Liver Failure. Among its related pathways are Innate Immune System. An important paralog of this gene is TNN.
UniProtKB/Swiss-Prot Summary for FGL2 Gene
-
May play a role in physiologic lymphocyte functions at mucosal sites.
Additional gene information for FGL2 Gene
- HGNC(3696)
- Entrez Gene(10875)
- Ensembl(ENSG00000127951)
- OMIM(605351)
- UniProtKB(Q14314)
- Open Targets Platform(ENSG00000127951)
- Monarch Initiative
- Search for FGL2 at DataMed
- Search for FGL2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGL2 Gene
Genomics for FGL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FGL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGL2
- Top Transcription factor binding sites by QIAGEN in the FGL2 gene promoter:
-
- AML1a
- Brachyury
- FOXF2
- HFH-1
- IRF-1
- Olf-1
- STAT1
- STAT1alpha
- STAT1beta
Genomic Locations for FGL2 Gene
Genomic Locations for FGL2 Gene
- chr7:77,193,369-77,199,848
- (GRCh38/hg38)
- Size:
- 6,480 bases
- Orientation:
- Minus strand
- chr7:76,822,688-76,829,150
- (GRCh37/hg19)
- Size:
- 6,463 bases
- Orientation:
- Minus strand
Genomic View for FGL2 Gene
Genes around FGL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q11.23 by HGNC
- 7q11.23 by Entrez Gene
- 7q11.23 by Ensembl
FGL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGL2 Gene
Proteins for FGL2 Gene
-
Protein details for FGL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q14314-FGL2_HUMAN
- Recommended name:
- Fibroleukin
- Protein Accession:
- Q14314
Protein attributes for FGL2 Gene
- Size:
- 439 amino acids
- Molecular mass:
- 50229 Da
- Quaternary structure:
-
- Homotetramer; disulfide-linked.
Protein Expression for FGL2 Gene
Post-translational modifications for FGL2 Gene
Other Protein References for FGL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ Fgl2 Antibody
- Novus Biologicals Antibodies for FGL2
-
Abcam antibodies for FGL2
- Invitrogen Antibodies for FGL2 (AFLGC-FGL2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGL2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FGL2
- Origene Custom Protein Services for FGL2
-
Abcam proteins for FGL2
Assay Products
No data available for DME Specific Peptides for FGL2 Gene
Domains & Families for FGL2 Gene
Gene Families for FGL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted secreted proteins
Protein Domains for FGL2 Gene
- InterPro:
- Blocks:
-
- Fibrinogen, beta/gamma chain, C-terminal globular
- ProtoNet:
Suggested Antigen Peptide Sequences for FGL2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ93065, Homo sapiens fibrinogen-like 2 (FGL2), mRNA (A4D1B8_HUMAN)
- pT49 (FGL2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FGL2 Gene
Function for FGL2 Gene
Molecular function for FGL2 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in physiologic lymphocyte functions at mucosal sites.
- GENATLAS Biochemistry:
- fibrinogen-like 2,expressed in T lymphocytes
Phenotypes From GWAS Catalog for FGL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IBA | 21873635 |
| GO:0005201 | extracellular matrix structural constituent | RCA | 28327460 |
| GO:0008233 | peptidase activity | IEA | -- |
Phenotypes for FGL2 Gene
- MGI mutant phenotypes for FGL2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FGL2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGL2 - Select products 50% OFF >
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-
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-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL2
miRNA for FGL2 Gene
- miRTarBase miRNAs that target FGL2
-
- hsa-miR-335-5p (MIRT018781)
- hsa-miR-26b-5p (MIRT030088)
- bta-miR-17-5p (MIRT053853)
- bta-miR-21-5p (MIRT053880)
- bta-miR-155 (MIRT053948)
- hsa-miR-155-5p (MIRT440643)
- mmu-miR-199a-5p (MIRT583516)
- mmu-miR-684 (MIRT583517)
- mmu-miR-204-5p (MIRT583518)
- mmu-miR-211-5p (MIRT583519)
- mmu-miR-532-5p (MIRT583520)
- mmu-miR-222-3p (MIRT594437)
- mmu-miR-221-3p (MIRT594438)
- mmu-miR-1928 (MIRT594439)
miRNA Products
Inhibitory RNA Products
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Clone Products
- Applied Biological Materials (abm): Clones for FGL2 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for FGL2
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Cell Line Products
-
Horizon Cell Lines for FGL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGL2 Gene
Localization for FGL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGL2 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005577 | fibrinogen complex | TAS | 7642106 |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0062023 | collagen-containing extracellular matrix | HDA,IBA | 21873635 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGL2 Gene
Pathways & Interactions for FGL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
Pathways by source for FGL2 Gene
3 Reactome pathways for FGL2 Gene
Interacting Proteins for FGL2 Gene
GPS-Prot Interaction Network for FGL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | IEA | -- |
| GO:0002381 | immunoglobulin production involved in immunoglobulin mediated immune response | IEA | -- |
| GO:0002605 | negative regulation of dendritic cell antigen processing and presentation | IEA | -- |
| GO:0002617 | negative regulation of macrophage antigen processing and presentation | IEA | -- |
| GO:0006508 | proteolysis | IEA | -- |
No data available for SIGNOR curated interactions for FGL2 Gene
Transcripts for FGL2 Gene
mRNA/cDNA for FGL2 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000248598 4256 nts (view in UCSC)
- ENST00000637771 989 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGL2 - Select products 50% OFF >
- * FGL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FGL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGL2
- Browse OriGene Inhibitory RNA Products For FGL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGL2
Clone Products
- Applied Biological Materials (abm): Clones for FGL2 - Select products 50% OFF >
- * FGL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FGL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGL2
Relevant External Links for FGL2 Gene
- GeneLoc Exon Structure for
- FGL2
Expression for FGL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
- Plasmacytoid Dendritic cells Peripheral Blood
- T Helper Cells Thymus
- Hematopoietic Bone Marrow
-
Dermis (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
- Dermal Fibroblasts Dorsal Dermis
- Brain (Nervous System)
-
Fibroblasts
- Mature Cardiac Fibroblasts Myocardium
- Dermal Fibroblasts Dorsal Dermis
-
Hair (Integumentary System)
- Zigzag Dermal Papilla Cells Dermal Papilla
- Guard Dermal Papilla Cells Dermal Papilla
-
Heart (Cardiovascular System)
- Mature Cardiac Fibroblasts Myocardium
-
Peripheral Nervous System (Nervous System)
- Immature Schwann Cells Peripheral Nerve Domain
-
Thymus (Hematopoietic System)
- T Helper Cells Thymus
-
Liver (Hepatobiliary System)
- Mature Mesothelial Cells Liver Lobule
- Kidney (Urinary System)
- Neural Crest (Gastrulation Derivatives)
-
Spleen (Hematopoietic System)
-
Gall Bladder (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for FGL2 Gene
This gene is overexpressed in Artery - Aorta (x8.3), Esophagus - Gastroesophageal Junction (x6.6), Esophagus - Muscularis (x5.4), and Whole Blood (x5.2).
This gene is overexpressed in Plasma (21.8), Serum (12.4), and Spleen (9.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGL2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGL2
SOURCE GeneReport for Unigene cluster for FGL2 Gene:
Hs.520989mRNA Expression by UniProt/SwissProt for FGL2 Gene:
Q14314-FGL2_HUMAN
Tissue specificity:
Constitutively expressed in cytotoxic T-cells.
Evidence on tissue expression from TISSUES for FGL2 Gene
- Blood(4.6)
- Liver(4.6)
- Intestine(4.5)
- Bone marrow(4.4)
- Pancreas(4.3)
- Nervous system(3.5)
- Spleen(3.3)
- Heart(2.8)
- Kidney(2.8)
- Lymph node(2.8)
- Muscle(2.5)
- Lung(2.4)
- Skin(2.2)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for FGL2
-
OriGene qPCR primer pairs and template standards for FGL2
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL2 Gene
Orthologs for FGL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FGL2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FGL2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FGL2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fgl2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Fgl2 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FGL2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FGL2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FGL2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgl2 30 |
|
||
| Str.15307 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23684 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fgl2 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG8642 32 |
|
|
|
| CG1889 32 |
|
|
|||
| CG1791 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CS-FIBRINOGEN-LIKE 31 |
|
OneToOne |
- Species where no ortholog for FGL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FGL2 Gene
- ENSEMBL:
- Gene Tree for FGL2 (if available)
- TreeFam:
- Gene Tree for FGL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FGL2: view image
Paralogs for FGL2 Gene
Paralogs for FGL2 Gene
(6) SIMAP similar genes for FGL2 Gene using alignment to 2 proteins:
- FGL2_HUMAN
- A4D1B8_HUMAN
Variants for FGL2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGL2 Gene
| SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2075761 | - | p.Gly53Glu |
Residual Variation Intolerance Score:
26.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.66;
72.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGL2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL2 Gene
Disorders for FGL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| viral hepatitis |
|
|
| acute liver failure |
|
|
| anterior spinal artery syndrome |
|
|
| hepatitis b |
|
|
| pontocerebellar hypoplasia, type 3 |
|
|
Search FGL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FGL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FGL2 Gene
Publications for FGL2 Gene
- Characterization of human fibroleukin, a fibrinogen-like protein secreted by T lymphocytes. (PMID: 9647217) Marazzi S … Rüegg C (Journal of immunology (Baltimore, Md. : 1950) 1998) 3 4 23
- Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. (PMID: 7642106) Rüegg C … Pytela R (Gene 1995) 2 3 4
- The FGL2/fibroleukin prothrombinase is involved in alveolar macrophage activation in COPD through the MAPK pathway. (PMID: 20438701) Liu Y … Ning Q (Biochemical and biophysical research communications 2010) 3 23
- Candidate genes associated with susceptibility for SARS-coronavirus. (PMID: 19590927) Hsieh YH … Ho MS (Bulletin of mathematical biology 2010) 3 41
- Hepatitis B virus-induced hFGL2 transcription is dependent on c-Ets-2 and MAPK signal pathway. (PMID: 18801734) Han M … Ning Q (The Journal of biological chemistry 2008) 3 23
ExternalLinks
Products for FGL2 Gene
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- Abcam proteins for FGL2
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- Browse Primary Antibodies
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- Invitrogen Antibodies for FGL2 (AFLGC-FGL2)
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- antibodies-online: Show 26 available FGL2 Antibodies ranked by validation data
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- antibodies-online: Show 15 available FGL2 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for FGL2
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Sources for FGL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
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