Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]
FGL2 (Fibrinogen Like 2) is a Protein Coding gene. Diseases associated with FGL2 include Viral Hepatitis and Acute Liver Failure. Among its related pathways are Innate Immune System. An important paralog of this gene is TNN.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IBA | 21873635 |
GO:0005201 | extracellular matrix structural constituent | RCA | 28327460 |
GO:0008233 | peptidase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005577 | fibrinogen complex | TAS | 7642106 |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0062023 | collagen-containing extracellular matrix | HDA,IBA | 21873635 |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002291 | T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | IEA | -- |
GO:0002381 | immunoglobulin production involved in immunoglobulin mediated immune response | IEA | -- |
GO:0002605 | negative regulation of dendritic cell antigen processing and presentation | IEA | -- |
GO:0002617 | negative regulation of macrophage antigen processing and presentation | IEA | -- |
GO:0006508 | proteolysis | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FGL2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FGL2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FGL2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fgl2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Fgl2 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FGL2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FGL2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FGL2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgl2 30 |
|
||
Str.15307 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23684 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fgl2 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG8642 32 |
|
|
|
CG1889 32 |
|
|
|||
CG1791 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CS-FIBRINOGEN-LIKE 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 07 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2075761 | - | p.Gly53Glu |
Disorder | Aliases | PubMed IDs |
---|---|---|
viral hepatitis |
|
|
acute liver failure |
|
|
anterior spinal artery syndrome |
|
|
hepatitis b |
|
|
pontocerebellar hypoplasia, type 3 |
|
|