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Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Hepatocellular Carcinoma. An important paralog of this gene is FGA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 30580966 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,IDA | 30580966 |
GO:0005577 | fibrinogen complex | TAS | 8390249 |
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0062023 | collagen-containing extracellular matrix | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0050776 | regulation of immune response | IBA,ISS | -- |
GO:0050868 | negative regulation of T cell activation | IBA,ISS | -- |
GO:0072574 | hepatocyte proliferation | IDA | 19880967 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FGL1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FGL1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FGL1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fgl1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fgl1 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FGL1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FGL1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FGL1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FGL1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgl1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | FGL1 31 |
|
OneToOne | |
LOC100003029 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG5550 32 |
|
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs139324987 | Benign: not provided | 17,882,115(-) |
C/T NM_004467.4(FGL1):c.128G>A (p.Arg43Gln) |
MISSENSE | |
rs34019488 | Benign: not provided | 17,882,182(-) |
G/C NM_004467.4(FGL1):c.64-3C>G |
INTRON | |
rs34239530 | Likely Benign: not provided. - | 17,874,405(-) |
T/Ap.Thr121Ser NM_004467.4(FGL1):c.361A>T (p.Thr121Ser) |
MISSENSE | |
rs34871936 | Benign: not provided | 17,874,367(-) |
A/G NM_004467.4(FGL1):c.399T>C (p.Phe133=) |
SYNONYMOUS | |
rs2653406 | - |
p.Pro105Leu |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|
|