Aliases for FGL1 Gene
External Ids for FGL1 Gene
Previous GeneCards Identifiers for FGL1 Gene
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGL1 Gene
UniProtKB/Swiss-Prot Summary for FGL1 Gene
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). In addition to its role in inhibiting inflammatory immune responses, also plays a role in hepatocytes (PubMed:11470158, PubMed:19880967). Under normal physiological conditions, primarily secreted from hepatocytes and contributes to its mitogenic and metabolic functions (PubMed:11470158, PubMed:19880967).