Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin ... See more...

Aliases for FGL1 Gene

Aliases for FGL1 Gene

  • Fibrinogen Like 1 2 3 5
  • Hepatocyte-Derived Fibrinogen-Related Protein 1 3 4
  • Liver Fibrinogen-Related Protein 1 3 4
  • Fibrinogen-Like Protein 1 3 4
  • Hepassocin 3 4
  • LFIRE-1 3 4
  • HFREP1 3 4
  • HP-041 3 4
  • HPS 3 4
  • Hepatocellular Carcinoma-Related Sequence 3
  • HFREP-1 4
  • LFIRE1 3

External Ids for FGL1 Gene

Previous GeneCards Identifiers for FGL1 Gene

  • GC08M017602
  • GC08M017789
  • GC08M017732
  • GC08M017766
  • GC08M016265
  • GC08M017721

Summaries for FGL1 Gene

Entrez Gene Summary for FGL1 Gene

  • Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGL1 Gene

FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Basal Laminar Drusen and Hepatocellular Carcinoma. An important paralog of this gene is FIBCD1.

UniProtKB/Swiss-Prot Summary for FGL1 Gene

  • Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). In addition to its role in inhibiting inflammatory immune responses, also plays a role in hepatocytes (PubMed:11470158, PubMed:19880967). Under normal physiological conditions, primarily secreted from hepatocytes and contributes to its mitogenic and metabolic functions (PubMed:11470158, PubMed:19880967).

Gene Wiki entry for FGL1 Gene

Additional gene information for FGL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGL1 Gene

Genomics for FGL1 Gene

GeneHancer (GH) Regulatory Elements for FGL1 Gene

Promoters and enhancers for FGL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J017895 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 760.3 +14.2 14197 1.9 FOXA1 MLX RBPJ NR2F6 ATF1 CREB1 MIXL1 NFYC HLF ZNF652 FGL1 lnc-MTUS1-3 LOC101930275 MTUS1 ASAH1 ENSG00000254054 RF00017-6860
GH08J017910 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 750.6 +0.2 248 1.4 ATF1 ZNF133 POLR2A CBFA2T2 SP7 PRDM1 KMT2B ZNF501 ZNF692 KAT7 FGL1 lnc-PCM1-5 LOC101930275 CNOT7 ASAH1 MTUS1 ENSG00000254054 RF00017-6860
GH08J017911 Enhancer 0.9 FANTOM5 ENCODE dbSUPER 750.6 -1.2 -1207 1 POLR2A KAT8 FOXA2 SAP130 NFIC ZC3H11A SSRP1 NFIA NANOG FGL1 lnc-PCM1-5 LOC101930275 ASAH1 NAT1 lnc-FGL1-4 RF00017-6860
GH08J017909 Enhancer 0.5 ENCODE 750.6 +1.3 1258 0.2 CTCF POLR2A IKZF1 FOXA2 KAT7 PAF1 SSRP1 TAF1 FGL1 lnc-PCM1-5 ENSG00000254054 RF00017-6860
GH08J017921 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.8 -15.1 -15057 8.1 ZNF785 SP1 ZBTB40 SIX5 ZBTB6 MLX RBPJ SMARCE1 POLR2A USF2 PCM1 LOC101930275 MTMR7 MTUS1 ENSG00000249258 ENSG00000253384 CNOT7 ASAH1 FGL1 SLC7A2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGL1 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO3
  • FOXO4

Genomic Locations for FGL1 Gene

Genomic Locations for FGL1 Gene
chr8:17,864,380-17,910,365
(GRCh38/hg38)
Size:
45,986 bases
Orientation:
Minus strand
chr8:17,721,889-17,767,874
(GRCh37/hg19)
Size:
45,986 bases
Orientation:
Minus strand

Genomic View for FGL1 Gene

Genes around FGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGL1 Gene

Proteins for FGL1 Gene

  • Protein details for FGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08830-FGL1_HUMAN
    Recommended name:
    Fibrinogen-like protein 1
    Protein Accession:
    Q08830
    Secondary Accessions:
    • A6NKU4
    • Q4PJH9
    • Q53YF1
    • Q8NG32
    • Q96KW6
    • Q96QM6

    Protein attributes for FGL1 Gene

    Size:
    312 amino acids
    Molecular mass:
    36379 Da
    Quaternary structure:
    • Homodimer (PubMed:11470158). Interacts (via the Fibrinogen C-terminal domain) with LAG3 (via Ig-like domains 1 and 2) (PubMed:30580966).

neXtProt entry for FGL1 Gene

Post-translational modifications for FGL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FGL1 Gene

Domains & Families for FGL1 Gene

Gene Families for FGL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FGL1 Gene

GenScript: Design optimal peptide antigens:
  • Fibrinogen-like 1, isoform CRA_d (D3DSP9_HUMAN)
  • Liver fibrinogen-related protein 1 (FGL1_HUMAN)
  • cDNA FLJ75986, highly similar to Homo sapiens fibrinogen-like 1 (FGL1), transcript variant 1, mRNA (Q8NG32_HUMAN)
genes like me logo Genes that share domains with FGL1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FGL1 Gene

Function for FGL1 Gene

Molecular function for FGL1 Gene

UniProtKB/Swiss-Prot Function:
Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). In addition to its role in inhibiting inflammatory immune responses, also plays a role in hepatocytes (PubMed:11470158, PubMed:19880967). Under normal physiological conditions, primarily secreted from hepatocytes and contributes to its mitogenic and metabolic functions (PubMed:11470158, PubMed:19880967).
UniProtKB/Swiss-Prot Induction:
Expression is induced by interleukin-6 (IL6) (PubMed:18039467). Up-regulated in a number of cancers, such as lung cancer, prostate cancer, melanoma and colorectal cancer (PubMed:30580966).
GENATLAS Biochemistry:
fibrinogen related gene overexpressed in hepatocellular carcinoma

Phenotypes From GWAS Catalog for FGL1 Gene

Gene Ontology (GO) - Molecular Function for FGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 30580966
genes like me logo Genes that share ontologies with FGL1: view
genes like me logo Genes that share phenotypes with FGL1: view

Animal Models for FGL1 Gene

MGI Knock Outs for FGL1:
  • Fgl1 Fgl1<tm1Cuko>
  • Fgl1 Fgl1<tm1b(EUCOMM)Hmgu>
  • Fgl1 Fgl1<tm1a(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for FGL1

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGL1 Gene

Localization for FGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGL1 Gene

Secreted. Note=Secreted in the blood plasma. {ECO:0000269 PubMed:30580966}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
lysosome 0

Gene Ontology (GO) - Cellular Components for FGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA,IEA 30580966
GO:0005577 fibrinogen complex TAS 8390249
genes like me logo Genes that share ontologies with FGL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGL1 Gene

Pathways & Interactions for FGL1 Gene

PathCards logo

SuperPathways for FGL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0050776 regulation of immune response ISS --
GO:0050868 negative regulation of T cell activation ISS --
GO:0072574 hepatocyte proliferation IDA 19880967
genes like me logo Genes that share ontologies with FGL1: view

No data available for Pathways by source and SIGNOR curated interactions for FGL1 Gene

Drugs & Compounds for FGL1 Gene

(1) Additional Compounds for FGL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGL1: view

Transcripts for FGL1 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGL1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP11:
SP12: -

Relevant External Links for FGL1 Gene

GeneLoc Exon Structure for
FGL1
ECgene alternative splicing isoforms for
FGL1

Expression for FGL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGL1 Gene

mRNA differential expression in normal tissues according to GTEx for FGL1 Gene

This gene is overexpressed in Liver (x47.8) and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for FGL1 Gene

This gene is overexpressed in Plasma (45.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FGL1 Gene:

FGL1

SOURCE GeneReport for Unigene cluster for FGL1 Gene:

Hs.491143

mRNA Expression by UniProt/SwissProt for FGL1 Gene:

Q08830-FGL1_HUMAN
Tissue specificity: Under normal conditions, liver-specific.

Evidence on tissue expression from TISSUES for FGL1 Gene

  • Liver(4.9)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with FGL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL1 Gene

Orthologs for FGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FGL1 33 32
  • 99.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FGL1 33 32
  • 90.4 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FGL1 33 32
  • 89.42 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fgl1 17 33 32
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Fgl1 32
  • 81.4 (n)
oppossum
(Monodelphis domestica)
Mammalia FGL1 33
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGL1 33
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGL1 33 32
  • 72.57 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGL1 33
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgl1 32
  • 67.32 (n)
zebrafish
(Danio rerio)
Actinopterygii FGL1 33
  • 62 (a)
OneToOne
LOC100003029 32
  • 61.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5550 34
  • 39 (a)
Species where no ortholog for FGL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGL1 Gene

ENSEMBL:
Gene Tree for FGL1 (if available)
TreeFam:
Gene Tree for FGL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGL1: view image

Paralogs for FGL1 Gene

(25) SIMAP similar genes for FGL1 Gene using alignment to 2 proteins:

  • FGL1_HUMAN
  • D3DSP9_HUMAN
genes like me logo Genes that share paralogs with FGL1: view

Variants for FGL1 Gene

Sequence variations from dbSNP and Humsavar for FGL1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000009960 -- 17,879,857(-) C/G intron_variant
rs1000085027 -- 17,871,916(-) G/A/T intron_variant
rs1000171537 -- 17,873,492(-) G/C intron_variant
rs1000219416 -- 17,896,314(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000237583 -- 17,868,244(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FGL1 Gene

Variant ID Type Subtype PubMed ID
dgv12044n54 CNV gain 21841781
dgv12045n54 CNV loss 21841781
dgv1385e214 CNV loss 21293372
dgv3787n106 CNV deletion 24896259
dgv7121n100 CNV gain 25217958
esv1012336 CNV insertion 17803354
esv1091529 CNV deletion 17803354
esv1120408 CNV insertion 17803354
esv1981831 CNV deletion 18987734
esv24086 CNV loss 19812545
esv24172 CNV loss 19812545
esv2421689 CNV deletion 20811451
esv2657492 CNV deletion 23128226
esv2664484 CNV deletion 23128226
esv2736697 CNV deletion 23290073
esv2736698 CNV deletion 23290073
esv2736699 CNV deletion 23290073
esv2762735 CNV gain 21179565
esv3543160 CNV deletion 23714750
esv3616500 CNV gain 21293372
esv3616503 CNV gain 21293372
esv3616505 CNV loss 21293372
esv3690 CNV loss 18987735
esv999314 CNV deletion 20482838
nsv1024843 CNV loss 25217958
nsv1034118 CNV loss 25217958
nsv1075121 CNV deletion 25765185
nsv1076066 CNV deletion 25765185
nsv1128407 CNV deletion 24896259
nsv1147006 CNV deletion 26484159
nsv397275 CNV deletion 16902084
nsv477939 CNV novel sequence insertion 20440878
nsv610701 CNV gain 21841781
nsv610706 CNV loss 21841781
nsv610707 CNV loss 21841781
nsv610712 CNV gain 21841781
nsv824560 CNV loss 20364138
nsv831250 CNV loss 17160897
nsv958486 CNV deletion 24416366

Variation tolerance for FGL1 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGL1 Gene

Human Gene Mutation Database (HGMD)
FGL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL1 Gene

Disorders for FGL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGL1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
basal laminar drusen
  • drusen of bruch membrane
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search FGL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGL1 Gene

Publications for FGL1 Gene

  1. Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. (PMID: 8390249) Yamamoto T … Hirohashi S (Biochemical and biophysical research communications 1993) 2 3 4 23 56
  2. Fibrinogen-like protein 1, a hepatocyte derived protein is an acute phase reactant. (PMID: 18039467) Liu Z … Ukomadu C (Biochemical and biophysical research communications 2008) 3 4 23 56
  3. Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. (PMID: 11470158) Hara H … Shiokawa K (Biochimica et biophysica acta 2001) 3 4 23 56
  4. Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3. (PMID: 30580966) Wang J … Chen L (Cell 2019) 3 4 56
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56

Products for FGL1 Gene

Sources for FGL1 Gene