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Aliases for FGL1 Gene

Aliases for FGL1 Gene

  • Fibrinogen Like 1 2 3 5
  • Hepatocyte-Derived Fibrinogen-Related Protein 1 3 4
  • Liver Fibrinogen-Related Protein 1 3 4
  • Hepassocin 3 4
  • LFIRE-1 3 4
  • HFREP1 3 4
  • HP-041 3 4
  • Hepatocellular Carcinoma-Related Sequence 3
  • Fibrinogen-Like Protein 1 3
  • HFREP-1 4
  • LFIRE1 3

External Ids for FGL1 Gene

Previous GeneCards Identifiers for FGL1 Gene

  • GC08M017602
  • GC08M017789
  • GC08M017732
  • GC08M017766
  • GC08M016265
  • GC08M017721

Summaries for FGL1 Gene

Entrez Gene Summary for FGL1 Gene

  • Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGL1 Gene

FGL1 (Fibrinogen Like 1) is a Protein Coding gene. Diseases associated with FGL1 include Basal Laminar Drusen and Hepatocellular Carcinoma. An important paralog of this gene is FGG.

UniProtKB/Swiss-Prot for FGL1 Gene

  • Has hepatocyte mitogenic activity.

Gene Wiki entry for FGL1 Gene

Additional gene information for FGL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGL1 Gene

Genomics for FGL1 Gene

GeneHancer (GH) Regulatory Elements for FGL1 Gene

Promoters and enhancers for FGL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J017895 Promoter/Enhancer 1.2 EPDnew ENCODE 650.4 +14.9 14878 0.2 SOX13 FOXA2 TAF1 MAX YY1 POLR2A FOSL2 PAF1 TEAD1 NFIA FGL1 ENSG00000254054 PIR60344 GC08P017880 GC08M017885
GH08J017911 Enhancer 1 FANTOM5 ENCODE dbSUPER 650.7 -1.2 -1207 1 SSRP1 NFIC FOXA2 NANOG SAP130 POLR2A ZC3H11A FGL1 ENSG00000253671 ASAH1 NAT1 PCM1 GC08P017880
GH08J017910 Enhancer 0.9 ENCODE dbSUPER 650.7 +0.2 185 1.3 ZNF133 FEZF1 TCF12 NCOR1 POLR2A ZNF366 CBFA2T2 ZNF600 PAF1 RNF2 FGL1 ENSG00000253671 ASAH1 MTUS1 ENSG00000254054 GC08P017880
GH08J017909 Enhancer 0.6 ENCODE 650.7 +1.3 1258 0.2 PAF1 CTCF SOX13 FOXA2 TAF1 KAT7 SSRP1 POLR2A IKZF1 MIXL1 FGL1 ENSG00000254054 GC08P017880
GH08J017921 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 8.8 -15.1 -15057 8.1 MLX DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 GLIS1 PCM1 ENSG00000253671 MTUS1 ASAH1 FGL1 SLC7A2 GC08P017880 ENSG00000245281 LOC101929066
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGL1 gene promoter:
  • AML1a
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • FOXO3

Genomic Locations for FGL1 Gene

Genomic Locations for FGL1 Gene
45,986 bases
Minus strand
45,986 bases
Minus strand

Genomic View for FGL1 Gene

Genes around FGL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGL1 Gene

Proteins for FGL1 Gene

  • Protein details for FGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibrinogen-like protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NKU4
    • Q4PJH9
    • Q53YF1
    • Q8NG32
    • Q96KW6
    • Q96QM6

    Protein attributes for FGL1 Gene

    312 amino acids
    Molecular mass:
    36379 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for FGL1 Gene

Post-translational modifications for FGL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FGL1 Gene

Domains & Families for FGL1 Gene

Gene Families for FGL1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FGL1: view

No data available for UniProtKB/Swiss-Prot for FGL1 Gene

Function for FGL1 Gene

Molecular function for FGL1 Gene

UniProtKB/Swiss-Prot Function:
Has hepatocyte mitogenic activity.
GENATLAS Biochemistry:
fibrinogen related gene overexpressed in hepatocellular carcinoma

Phenotypes From GWAS Catalog for FGL1 Gene

genes like me logo Genes that share phenotypes with FGL1: view

Animal Models for FGL1 Gene

MGI Knock Outs for FGL1:
  • Fgl1 Fgl1<tm1Cuko>
  • Fgl1 Fgl1<tm1a(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for FGL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FGL1 Gene

Localization for FGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGL1 gene
Compartment Confidence
extracellular 5
mitochondrion 2
lysosome 1

Gene Ontology (GO) - Cellular Components for FGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005577 fibrinogen complex TAS 8390249
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with FGL1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGL1 Gene

Pathways & Interactions for FGL1 Gene

No Data Available

Interacting Proteins for FGL1 Gene

Gene Ontology (GO) - Biological Process for FGL1 Gene


No data available for Pathways by source and SIGNOR curated interactions for FGL1 Gene

Drugs & Compounds for FGL1 Gene

(1) Additional Compounds for FGL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGL1: view

Transcripts for FGL1 Gene

Unigene Clusters for FGL1 Gene

Fibrinogen-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGL1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - -
SP9: - - - - -
SP10: - - - -
SP12: -

Relevant External Links for FGL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGL1 Gene

mRNA differential expression in normal tissues according to GTEx for FGL1 Gene

This gene is overexpressed in Liver (x47.8) and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for FGL1 Gene

This gene is overexpressed in Plasma (45.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGL1 Gene:


SOURCE GeneReport for Unigene cluster for FGL1 Gene:


mRNA Expression by UniProt/SwissProt for FGL1 Gene:

Tissue specificity: Liver specific.

Evidence on tissue expression from TISSUES for FGL1 Gene

  • Liver(4.9)
  • Pancreas(2.3)
genes like me logo Genes that share expression patterns with FGL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGL1 Gene

Orthologs for FGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGL1 34 33
  • 99.25 (n)
(Canis familiaris)
Mammalia FGL1 34 33
  • 90.4 (n)
(Bos Taurus)
Mammalia FGL1 34 33
  • 89.42 (n)
(Mus musculus)
Mammalia Fgl1 16 34 33
  • 84.4 (n)
(Rattus norvegicus)
Mammalia Fgl1 33
  • 81.4 (n)
(Monodelphis domestica)
Mammalia FGL1 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia FGL1 34
  • 70 (a)
(Gallus gallus)
Aves FGL1 34 33
  • 72.57 (n)
(Anolis carolinensis)
Reptilia FGL1 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgl1 33
  • 67.32 (n)
(Danio rerio)
Actinopterygii FGL1 34
  • 62 (a)
LOC100003029 33
  • 61.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5550 35
  • 39 (a)
Species where no ortholog for FGL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGL1 Gene

Gene Tree for FGL1 (if available)
Gene Tree for FGL1 (if available)
Evolutionary constrained regions (ECRs) for FGL1: view image

Paralogs for FGL1 Gene

Paralogs for FGL1 Gene

(25) SIMAP similar genes for FGL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FGL1: view

Variants for FGL1 Gene

Sequence variations from dbSNP and Humsavar for FGL1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000009960 -- 17,879,857(-) C/G intron_variant
rs1000085027 -- 17,871,916(-) G/A intron_variant
rs1000171537 -- 17,873,492(-) G/C intron_variant
rs1000219416 -- 17,896,314(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000237583 -- 17,868,244(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FGL1 Gene

Variant ID Type Subtype PubMed ID
dgv12044n54 CNV gain 21841781
dgv12045n54 CNV loss 21841781
dgv1385e214 CNV loss 21293372
dgv3787n106 CNV deletion 24896259
dgv7121n100 CNV gain 25217958
esv1012336 CNV insertion 17803354
esv1091529 CNV deletion 17803354
esv1120408 CNV insertion 17803354
esv1981831 CNV deletion 18987734
esv24086 CNV loss 19812545
esv24172 CNV loss 19812545
esv2421689 CNV deletion 20811451
esv2657492 CNV deletion 23128226
esv2664484 CNV deletion 23128226
esv2736697 CNV deletion 23290073
esv2736698 CNV deletion 23290073
esv2736699 CNV deletion 23290073
esv2762735 CNV gain 21179565
esv3543160 CNV deletion 23714750
esv3616500 CNV gain 21293372
esv3616503 CNV gain 21293372
esv3616505 CNV loss 21293372
esv3690 CNV loss 18987735
esv999314 CNV deletion 20482838
nsv1024843 CNV loss 25217958
nsv1034118 CNV loss 25217958
nsv1075121 CNV deletion 25765185
nsv1076066 CNV deletion 25765185
nsv1128407 CNV deletion 24896259
nsv1147006 CNV deletion 26484159
nsv397275 CNV deletion 16902084
nsv477939 CNV novel sequence insertion 20440878
nsv610701 CNV gain 21841781
nsv610706 CNV loss 21841781
nsv610707 CNV loss 21841781
nsv610712 CNV gain 21841781
nsv824560 CNV loss 20364138
nsv831250 CNV loss 17160897
nsv958486 CNV deletion 24416366

Variation tolerance for FGL1 Gene

Residual Variation Intolerance Score: 92.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGL1 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGL1 Gene

Disorders for FGL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGL1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
basal laminar drusen
  • drusen of bruch membrane
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
Search FGL1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGL1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGL1 Gene

Publications for FGL1 Gene

  1. Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. (PMID: 8390249) Yamamoto T … Hirohashi S (Biochemical and biophysical research communications 1993) 2 3 4 22 58
  2. Molecular cloning and functional expression analysis of a cDNA for human hepassocin, a liver-specific protein with hepatocyte mitogenic activity. (PMID: 11470158) Hara H … Shiokawa K (Biochimica et biophysica acta 2001) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for FGL1 Gene

Sources for FGL1 Gene

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