FGG Gene (Protein Coding)

Fibrinogen Gamma Chain

GC04M154604
GIFtS:
49
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and s... See more...

Aliases for FGG Gene

Aliases for FGG Gene

  • Fibrinogen Gamma Chain 2 3 4 5
  • Fibrinogen, Gamma Polypeptide 2 3
  • Testicular Tissue Protein Li 70 3
  • FGG 5

External Ids for FGG Gene

Previous GeneCards Identifiers for FGG Gene

  • GC04M156374
  • GC04M155913
  • GC04M155991
  • GC04M156102
  • GC04M155882
  • GC04M155744
  • GC04M155525
  • GC04M151265

Summaries for FGG Gene

Entrez Gene Summary for FGG Gene

  • The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

GeneCards Summary for FGG Gene

FGG (Fibrinogen Gamma Chain) is a Protein Coding gene. Diseases associated with FGG include Afibrinogenemia, Congenital and Dysfibrinogenemia, Congenital. Among its related pathways are IL-6 signaling pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein binding, bridging. An important paralog of this gene is FGA.

UniProtKB/Swiss-Prot Summary for FGG Gene

  • Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Gene Wiki entry for FGG Gene

Additional gene information for FGG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGG Gene

Genomics for FGG Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FGG Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH04J154612 Promoter/Enhancer 1.7 VISTA EPDnew Ensembl ENCODE 250.7 +0.0 15 1.8 CEBPA ATF3 YY1 HOMEZ RAD51 THAP11 FOXA2 MAFF SMAD4 RXRA FGG lnc-FGA-2 FGA
GH04J154718 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE dbSUPER 250.1 -107.3 -107341 4.6 CEBPA CEBPB EP300 JUND IRF9 CTCF ETV1 EP400 ATF4 L3MBTL2 HSALNG0038002 FGG LRAT RBM46 ENSG00000249041 piR-31926-022 lnc-LRAT-1
GH04J154549 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 28.3 +63.0 62980 2.4 ZNF600 MYC POLR2A CEBPA ATF3 NFIC YY1 CTCF REST CEBPB PLRG1 lnc-FGB-7 FGG LRAT RF00026-803 RNU6-1285P DCHS2
GH04J154553 Enhancer 0.9 Ensembl ENCODE 26.2 +60.7 60694 0.7 ZNF654 MYC JUND ATF2 ATF3 CTCF REST ZNF592 TRIM22 NFATC3 PLRG1 lnc-FGB-7 FGG LRAT lnc-FGB-1 FGB
GH04J154559 Enhancer 0.9 ENCODE 16.8 +52.5 52526 1.7 ZNF654 CEBPA ATF3 NFIC CHD4 REST FOXA1 KLF11 TRIM22 HOMEZ FGG PLRG1 FGB LOC100422640
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGG on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGG

Top Transcription factor binding sites by QIAGEN in the FGG gene promoter:
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • STAT3
  • Tal-1
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2

Genomic Locations for FGG Gene

Latest Assembly
chr4:154,604,134-154,612,967
(GRCh38/hg38)
Size:
8,834 bases
Orientation:
Minus strand

Previous Assembly
chr4:155,525,288-155,533,808
(GRCh37/hg19 by Entrez Gene)
Size:
8,521 bases
Orientation:
Minus strand

chr4:155,525,286-155,534,119
(GRCh37/hg19 by Ensembl)
Size:
8,834 bases
Orientation:
Minus strand

Genomic View for FGG Gene

Genes around FGG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGG Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FGG Gene

Proteins for FGG Gene

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  • Protein details for FGG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02679-FIBG_HUMAN
    Recommended name:
    Fibrinogen gamma chain
    Protein Accession:
    P02679
    Secondary Accessions:
    • A8K057
    • P04469
    • P04470
    • Q53Y18
    • Q96A14
    • Q96KJ3
    • Q9UC62
    • Q9UC63
    • Q9UCF3

    Protein attributes for FGG Gene

    Size:
    453 amino acids
    Molecular mass:
    51512 Da
    Quaternary structure:
    • Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
    Miscellaneous:
    • The gamma-chain carries the main binding site for the platelet receptor.
    • [Isoform Gamma-B]: Present in about 10% of the fibrinogen molecules in plasma but absent from those in the platelets.

    Three dimensional structures from OCA and Proteopedia for FGG Gene

    Alternative splice isoforms for FGG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGG Gene

Protein Expression for FGG Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FGG Gene

  • Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
  • Sulfation of C-terminal tyrosines increases affinity for thrombin.
  • Glycosylation at Ser68, Asn78, and Asn334
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for FGG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for FGG Gene

Domains & Families for FGG Gene

Gene Families for FGG Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FGG Gene

InterPro:
Blocks:
  • Fibrinogen, beta/gamma chain, C-terminal globular

Suggested Antigen Peptide Sequences for FGG Gene

GenScript: Design optimal peptide antigens:
  • Fibrinogen gamma chain, isoform CRA_a (D3DP16_HUMAN)
  • Fibrinogen gamma chain (FIBG_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P02679

UniProtKB/Swiss-Prot:

FIBG_HUMAN :
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Domain:
  • A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
genes like me logo Genes that share domains with FGG: view

Function for FGG Gene

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Molecular function for FGG Gene

UniProtKB/Swiss-Prot Function:
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
GENATLAS Biochemistry:
fibrinogen,gamma polypeptide, (see FG@),with a longer form gamma arising by alternative processing

Phenotypes From GWAS Catalog for FGG Gene

Gene Ontology (GO) - Molecular Function for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA,IPI 7822297
GO:0005198 structural molecule activity IDA 8910396
GO:0005201 extracellular matrix structural constituent RCA 25037231
GO:0005515 protein binding IPI 10788510
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with FGG: view
genes like me logo Genes that share phenotypes with FGG: view

Human Phenotype Ontology for FGG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGG Gene

MGI Knock Outs for FGG:
  • Fgg Fgg<tm1Fjc>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGG Gene

Localization for FGG Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGG Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGG gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
mitochondrion 2
nucleus 2
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005577 fibrinogen complex IEA,IDA 6451630
GO:0005615 extracellular space IBA,IDA 6777381
GO:0005737 cytoplasm IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with FGG: view

Pathways & Interactions for FGG Gene

PathCards logo

SuperPathways for FGG Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Paradoxical activation of RAF signaling by kinase inactive BRAF
MAP2K and MAPK activation
.90
Paradoxical activation of RAF signaling by kinase inactive BRAF
.90
Signaling by high-kinase activity BRAF mutants
.90
Signaling by moderate kinase activity BRAF mutants
.90
Signaling by RAS mutants
.78
3 Formation of Fibrin Clot (Clotting Cascade)
Common Pathway of Fibrin Clot Formation
.56
Formation of Fibrin Clot (Clotting Cascade)
.56
Blood Clotting Cascade
.45
Extrinsic Prothrombin Activation Pathway
.01
4 Integrin alphaIIb beta3 signaling
Integrin alphaIIb beta3 signaling
.74
Platelet Aggregation (Plug Formation)
.74
GRB2-SOS provides linkage to MAPK signaling for Integrins
.01
p130Cas linkage to MAPK signaling for integrins
.01
5 Response to elevated platelet cytosolic Ca2+
Platelet activation, signaling and aggregation
.49
Response to elevated platelet cytosolic Ca2+
.49
Platelet degranulation
.47
Hemostasis
.44
genes like me logo Genes that share pathways with FGG: view

Pathways by source for FGG Gene

2 GeneGo (Thomson Reuters) pathways for FGG Gene
  • Cell adhesion Integrin inside-out signaling
  • Cell adhesion_Plasmin signaling
3 Qiagen pathways for FGG Gene
  • Blood Coagulation Cascade
  • Extrinsic Prothrombin Activation Pathway
  • Intrinsic Prothrombin Activation Pathway

SIGNOR curated interactions for FGG Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FGG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002576 platelet degranulation TAS --
GO:0007160 cell-matrix adhesion IDA 10903502
GO:0007596 blood coagulation IEA,TAS --
GO:0007599 hemostasis IEA --
genes like me logo Genes that share ontologies with FGG: view

Drugs & Compounds for FGG Gene

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(6) Drugs for FGG Gene - From: DrugBank, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Sucralfate Approved Pharma Target, binder, protector 15
Human thrombin Approved Pharma Target, activator 0
Thrombin Approved, Investigational Pharma Target, activator 447
Thrombin alfa Approved Pharma Target, activator 0
Alfimeprase Investigational Pharma 0

(2) Additional Compounds for FGG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGG: view

Transcripts for FGG Gene

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mRNA/cDNA for FGG Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGG

Alternative Splicing Database (ASD) splice patterns (SP) for FGG Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a ·
SP1: - - -
SP2: -
SP3: - - - -
SP4: - - -
SP5: - -
SP6: - - -
SP7: -
SP8: -
SP9:
SP10: - -
SP11:
SP12: -
SP13: -
SP14:

ExUns: 14b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for FGG Gene

GeneLoc Exon Structure for
FGG

Expression for FGG Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGG Gene

mRNA expression in normal human tissues for FGG Gene
mRNA expression by BioGPS for FGG GenemRNA expression by GTEx for FGG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGG Gene

This gene is overexpressed in Liver (x52.4).

Protein differential expression in normal tissues from HIPED for FGG Gene

This gene is overexpressed in Synovial fluid (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGG Gene



Protein tissue co-expression partners for FGG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGG

SOURCE GeneReport for Unigene cluster for FGG Gene:

Hs.727584

mRNA Expression by UniProt/SwissProt for FGG Gene:

P02679-FIBG_HUMAN
Tissue specificity: Detected in blood plasma (at protein level).

Evidence on tissue expression from TISSUES for FGG Gene

  • Liver(5)
  • Blood(4.7)
  • Muscle(4.7)
  • Bone marrow(4.2)
  • Lung(3.9)
  • Heart(3.3)
  • Spleen(2.7)
  • Kidney(2.5)
  • Intestine(2.4)
  • Pancreas(2.1)
  • Nervous system(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FGG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • lymphatic
  • reproductive
  • skeleton
Regions:
Head and neck:
  • face
  • head
  • mouth
  • nose
  • pituitary gland
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • spleen
  • stomach
Pelvis:
  • ovary
  • uterus
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • coagulation system
genes like me logo Genes that share expression patterns with FGG: view

Orthologs for FGG Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGG Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FGG 29 30
  • 99.08 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FGG 29 30
  • 86.89 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FGG 29 30
  • 86.27 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Fgg 29 16 30
  • 82.68 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Fgg 29
  • 82.6 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia FGG 30
  • 79 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia FGG 30
  • 76 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FGG 29 30
  • 70.26 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FGG 30
  • 66 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia fgg 29
  • 67.92 (n)
Str.15548 29
African clawed frog
(Xenopus laevis)
 Amphibia fgg-prov 29
Zebrafish
(Danio rerio)
 Actinopterygii fgg 29 30
  • 61.34 (n)
 OneToOne
Dr.4907 29
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8421 29
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 30
  • 45 (a)
 OneToOne
Species where no ortholog for FGG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGG Gene

ENSEMBL:
Gene Tree for FGG (if available)
TreeFam:
Gene Tree for FGG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGG: view image
Alliance of Genome Resources:
Additional Orthologs for FGG

Paralogs for FGG Gene

Paralogs for FGG Gene

(12) SIMAP similar genes for FGG Gene using alignment to 6 proteins:

  • FIBG_HUMAN
  • C9JC84_HUMAN
  • C9JEU5_HUMAN
  • C9JPQ9_HUMAN
  • C9JU00_HUMAN
  • D3DP16_HUMAN

Pseudogenes.org Pseudogenes for FGG Gene

genes like me logo Genes that share paralogs with FGG: view

Variants for FGG Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGG Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
899460 Uncertain Significance: Afibrinogenemia, congenital 154,608,634(-) A/G
NM_021870.3(FGG):c.683T>C (p.Val228Ala) 		MISSENSE
899461 Uncertain Significance: Afibrinogenemia, congenital 154,611,805(-) C/T
NM_021870.3(FGG):c.401G>A (p.Arg134Gln) 		MISSENSE
900592 Uncertain Significance: Afibrinogenemia, congenital 154,611,888(-) G/A
NM_021870.3(FGG):c.318C>T (p.Asp106=) 		SYNONYMOUS
900593 Conflicting Interpretations: Afibrinogenemia, congenital; not provided 154,612,201(-) C/T
NM_021870.3(FGG):c.124G>A (p.Gly42Ser) 		MISSENSE
902203 Likely Benign: Afibrinogenemia, congenital 154,604,299(-) T/C
NM_021870.3(FGG):c.*535A>G 		THREE_PRIME_UTR

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FGG Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for FGG Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.90; 48.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGG Gene

Human Gene Mutation Database (HGMD)
FGG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGG
Leiden Open Variation Database (LOVD)
FGG

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FGG Gene

Disorders for FGG Gene

MalaCards: The human disease database

(10) MalaCards diseases for FGG Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

Disorder Aliases PubMed IDs
afibrinogenemia, congenital
  • hypofibrinogenemia, congenital
dysfibrinogenemia, congenital
  • hypodysfibrinogenemia, congenital
fibrinogen deficiency, congenital
  • congenital fibrinogen deficiency
hemorrhagic disease
  • hemorrhagic diathesis
thrombocytopenia
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UniProtKB/Swiss-Prot

FIBG_HUMAN
  • Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:25427968}. Note=The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
  • Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:15632207, ECO:0000269 PubMed:2257302, ECO:0000269 PubMed:2976995, ECO:0000269 PubMed:3708159}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for FGG

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Publications for FGG Gene

  1. Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PMID: 20059469) Carty CL … Reiner AP (Annals of human genetics 2010) 3 22 40
  2. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PMID: 20167083) Theodoraki EV … Dedoussis GV (BMC medical genetics 2010) 3 22 40
  3. Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies. (PMID: 19515723) Nowak-Göttl U … Stoll M (Blood 2009) 3 22 40
  4. Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study. (PMID: 19412134) Sie MP … Witteman JC (Journal of hypertension 2009) 3 22 40
  5. Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PMID: 18690352) Cheung EY … Breteler MM (Thrombosis and haemostasis 2008) 3 22 40

ExternalLinks

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Products for FGG Gene

  • Addgene plasmids for FGG

Sources for FGG Gene