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The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and s... See more...
Aliases for FGG Gene
Aliases for FGG Gene
External Ids for FGG Gene
- HGNC: 3694
- Entrez Gene: 2266
- Ensembl: ENSG00000171557
- OMIM: 134850
- UniProtKB: P02679
Previous GeneCards Identifiers for FGG Gene
- GC04M156374
- GC04M155913
- GC04M155991
- GC04M156102
- GC04M155882
- GC04M155744
- GC04M155525
- GC04M151265
Summaries for FGG Gene
-
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
GeneCards Summary for FGG Gene
FGG (Fibrinogen Gamma Chain) is a Protein Coding gene. Diseases associated with FGG include Afibrinogenemia, Congenital and Dysfibrinogenemia, Congenital. Among its related pathways are Activated TLR4 signalling and RET signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein binding, bridging. An important paralog of this gene is FGB.
UniProtKB/Swiss-Prot Summary for FGG Gene
-
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Additional gene information for FGG Gene
- HGNC(3694)
- Entrez Gene(2266)
- Ensembl(ENSG00000171557)
- OMIM(134850)
- UniProtKB(P02679)
- Open Targets Platform(ENSG00000171557)
- Monarch Initiative
- Search for FGG at DataMed
- Search for FGG at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGG Gene
Genomics for FGG Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FGG Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGG on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGG
- Top Transcription factor binding sites by QIAGEN in the FGG gene promoter:
-
- E47
- FOXJ2
- FOXJ2 (long isoform)
- STAT3
- Tal-1
- USF-1
- USF-1:USF-2
- USF1
- USF2
Genomic Locations for FGG Gene
Genomic Locations for FGG Gene
- chr4:154,604,134-154,612,967
- (GRCh38/hg38)
- Size:
- 8,834 bases
- Orientation:
- Minus strand
- chr4:155,525,286-155,534,119
- (GRCh37/hg19)
- Size:
- 8,834 bases
- Orientation:
- Minus strand
Genomic View for FGG Gene
Genes around FGG on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q32.1 by HGNC
- 4q32.1 by Entrez Gene
- 4q32.1 by Ensembl
FGG Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGG Gene
Proteins for FGG Gene
-
Protein details for FGG Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P02679-FIBG_HUMAN
- Recommended name:
- Fibrinogen gamma chain
- Protein Accession:
- P02679
- A8K057
- P04469
- P04470
- Q53Y18
- Q96A14
- Q96KJ3
- Q9UC62
- Q9UC63
- Q9UCF3
Protein attributes for FGG Gene
- Size:
- 453 amino acids
- Molecular mass:
- 51512 Da
- Quaternary structure:
-
- Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
- Miscellaneous:
-
- The gamma-chain carries the main binding site for the platelet receptor.
- [Isoform Gamma-B]: Present in about 10% of the fibrinogen molecules in plasma but absent from those in the platelets.
Three dimensional structures from OCA and Proteopedia for FGG Gene
Protein Expression for FGG Gene
Post-translational modifications for FGG Gene
- Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
- Sulfation of C-terminal tyrosines increases affinity for thrombin.
-
Glycosylation at Asn78 and Asn334
- NX_P02679 (NX_P02679-1)
- Modification sites at PhosphoSitePlus
- Glycosylation from GlyConnect
Other Protein References for FGG Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences FGG / Fibrinogen Gamma Monoclonal Antibody and FGG / Fibrinogen Gamma Antibody
- G Biosciences Immunotag™ FGG Antibody
- NSJ Bioreagents Fibrinogen gamma chain Antibody (FGG)
- Creative Diagnostics Anti-FGG polyclonal antibody
-
Creative Biolabs
- Recombinant Anti-Human FGG Antibody
- Mouse Anti-FGG Recombinant Antibody (5D7)
- Mouse Anti-FGG Recombinant Antibody (CBXF-3752)
- Mouse Anti-FGG Recombinant Antibody (4D3)
- Mouse Anti-FGG Recombinant Antibody (CBXF-3587)
- Mouse Anti-FGG Recombinant Antibody (CBXF-2194)
- Rabbit Anti-FGG Recombinant Antibody (CBXF-1175)
-
Custom Antibody ServicesOriGene Antibodies for FGG
- AM06678SU-N
- AM06682SU-N
- AM31060PU-N
- AP17375PU-N
- CF507117
- CF507119
- CF507128
- CF507129
- CF507131
- CF507132
- CF507150
- CF507151
- CF507154
- CF507155
- CF507156
- CF507161
- TA308425
- TA324921
- TA324922
- TA332808
- TA348962
- TA348963
- TA507117
- TA507117S
- TA507119
- TA507119S
- TA507128
- TA507128S
- TA507129
- TA507129S
- TA507131
- TA507131S
- TA507132
- TA507132S
- TA507150
- TA507150S
- TA507151
- TA507151S
- TA507154
- TA507154S
- TA507155
- TA507155S
- TA507156
- TA507156S
- TA507161
- TA507161S
- TA600476
- TA600477
- TA600478
- TA700476
- Novus Biologicals Antibodies for FGG
-
Abcam antibodies for FGG
- Invitrogen Antibodies for FGG (AFLGC-Fgg)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGG
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FGG
- Origene Custom Protein Services for FGG
- Sino Biological Recombinant Proteins for FGG
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for FGG
- antibodies-online: Show 21 available FGG Proteins ranked by validation data
- Compare Top FGG Proteins
-
Signalway Proteins for FGG
-
Abcam proteins for FGG
Assay Products
-
Abcam assays for FGG
No data available for DME Specific Peptides for FGG Gene
Domains & Families for FGG Gene
Gene Families for FGG Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Candidate cardiovascular disease genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for FGG Gene
- InterPro:
- Blocks:
-
- Fibrinogen, beta/gamma chain, C-terminal globular
- ProtoNet:
Suggested Antigen Peptide Sequences for FGG Gene
- GenScript: Design optimal peptide antigens:
-
- Fibrinogen gamma chain, isoform CRA_a (D3DP16_HUMAN)
- Fibrinogen gamma chain (FIBG_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P02679UniProtKB/Swiss-Prot:
FIBG_HUMAN :- A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
- Domain:
-
- A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.
Function for FGG Gene
Molecular function for FGG Gene
- UniProtKB/Swiss-Prot Function:
- Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
- GENATLAS Biochemistry:
- fibrinogen,gamma polypeptide, (see FG@),with a longer form gamma arising by alternative processing
Phenotypes From GWAS Catalog for FGG Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005102 | signaling receptor binding | IEA,IPI | 7822297 |
| GO:0005198 | structural molecule activity | IDA | 8910396 |
| GO:0005201 | extracellular matrix structural constituent | RCA | 25037231 |
| GO:0005515 | protein binding | IPI | 10788510 |
| GO:0042802 | identical protein binding | IEA | -- |
Phenotypes for FGG Gene
- MGI mutant phenotypes for FGG:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for FGG:
Animal Models for FGG Gene
- MGI Knock Outs for FGG:
-
- Fgg Fgg<tm1Fjc>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGG - Select products 50% OFF >
- * FGG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FGG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGG
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGG
miRNA for FGG Gene
- miRTarBase miRNAs that target FGG
-
- hsa-miR-409-3p (MIRT005519)
- hsa-miR-29a-3p (MIRT005521)
- hsa-miR-29b-3p (MIRT005522)
- hsa-miR-144-3p (MIRT005523)
- hsa-miR-29c-3p (MIRT005525)
- hsa-miR-1304-5p (MIRT716807)
- hsa-miR-6765-5p (MIRT716808)
- hsa-miR-6864-3p (MIRT716809)
- hsa-miR-3672 (MIRT716810)
- hsa-miR-623 (MIRT716811)
- hsa-miR-4755-3p (MIRT716812)
- hsa-miR-6089 (MIRT716813)
- hsa-miR-5008-5p (MIRT716814)
- hsa-miR-769-5p (MIRT716815)
- hsa-miR-4786-5p (MIRT716816)
- hsa-miR-6780b-3p (MIRT716817)
- hsa-miR-4780 (MIRT716818)
- hsa-miR-4645-5p (MIRT716819)
- hsa-miR-4673 (MIRT716820)
- hsa-miR-6866-3p (MIRT716821)
- hsa-miR-188-5p (MIRT716822)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGG
- Browse OriGene Inhibitory RNA Products For FGG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGG
Clone Products
- Applied Biological Materials (abm): Clones for FGG - Select products 50% OFF >
- * FGG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FGG
- Addgene plasmids for FGG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGG
Cell Line Products
-
Horizon Cell Lines for FGG
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGG Gene
Localization for FGG Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGG Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 4 |
| endoplasmic reticulum | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Endoplasmic reticulum (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005577 | fibrinogen complex | IEA,IDA | 6451630 |
| GO:0005615 | extracellular space | HDA,IDA | 6777381 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
Pathways & Interactions for FGG Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
| 3 | Formation of Fibrin Clot (Clotting Cascade) |
Extrinsic Prothrombin Activation Pathway
.01
|
|
| 4 | Integrin alphaIIb beta3 signaling | ||
| 5 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for FGG Gene
3 BioSystems pathways for FGG Gene
69 Reactome pathways for FGG Gene
1 PharmGKB pathway for FGG Gene
3 KEGG pathways for FGG Gene
2 GeneGo (Thomson Reuters) pathways for FGG Gene
- Cell adhesion Integrin inside-out signaling
- Cell adhesion_Plasmin signaling
3 Qiagen pathways for FGG Gene
- Blood Coagulation Cascade
- Extrinsic Prothrombin Activation Pathway
- Intrinsic Prothrombin Activation Pathway
Interacting Proteins for FGG Gene
Selected Interacting proteins:
P02679-FIBG_HUMAN
ENSP00000336829
for FGG Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FGG
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0007160 | cell-matrix adhesion | IDA | 10903502 |
| GO:0007596 | blood coagulation | IEA,TAS | -- |
| GO:0007599 | hemostasis | IEA | -- |
Drugs & Compounds for FGG Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sucralfate | Approved | Pharma | Target, binder, protector | 15 | ||
| Human thrombin | Approved | Pharma | Target, activator | 0 | ||
| Thrombin | Approved, Investigational | Pharma | Target, activator | 411 | ||
| Thrombin alfa | Approved | Pharma | Target, activator | 0 | ||
| Alfimeprase | Investigational | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FGG Gene
mRNA/cDNA for FGG Gene
- 2 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000336098 2072 nts (view in UCSC)
- ENST00000393846 641 nts (view in UCSC)
- ENST00000404648 1760 nts (view in UCSC)
- ENST00000405164 1539 nts (view in UCSC)
- ENST00000407946 1636 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGG - Select products 50% OFF >
- * FGG CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FGG
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGG
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGG
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGG
- Browse OriGene Inhibitory RNA Products For FGG
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGG
Clone Products
- Applied Biological Materials (abm): Clones for FGG - Select products 50% OFF >
- * FGG as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FGG
- Addgene plasmids for FGG
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGG
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: |
| ExUns: | 14b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: | |
| SP13: | |
| SP14: |
Relevant External Links for FGG Gene
- GeneLoc Exon Structure for
- FGG
Expression for FGG Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
- Notochord
- NULL (Uncategorized)
-
Ovary (Reproductive System)
- Mature Granulosa Cells Antral Follicle
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
- Liver (Hepatobiliary System)
- Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for FGG Gene
This gene is overexpressed in Liver (x52.4).
This gene is overexpressed in Synovial fluid (12.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGG Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGG
SOURCE GeneReport for Unigene cluster for FGG Gene:
Hs.727584mRNA Expression by UniProt/SwissProt for FGG Gene:
P02679-FIBG_HUMAN
Tissue specificity:
Detected in blood plasma (at protein level).
Evidence on tissue expression from TISSUES for FGG Gene
- Liver(5)
- Blood(4.7)
- Muscle(4.7)
- Bone marrow(4.2)
- Lung(3.9)
- Heart(3.3)
- Spleen(2.8)
- Kidney(2.6)
- Intestine(2.5)
- Nervous system(2.3)
- Pancreas(2.3)
- Skin(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FGG Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- lymphatic
- reproductive
- skeleton
Regions:
Head and neck:
- face
- head
- mouth
- nose
- pituitary gland
Abdomen:
- intestine
- large intestine
- small intestine
- spleen
- stomach
Pelvis:
- ovary
- uterus
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
Primer Products
-
OriGene qPCR primer pairs for FGG
-
OriGene qPCR primer pairs and template standards for FGG
Gene Expression Assay Products
Orthologs for FGG Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FGG 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FGG 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FGG 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fgg 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fgg 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FGG 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FGG 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FGG 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FGG 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgg 30 |
|
||
| Str.15548 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | fgg-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fgg 30 31 |
|
OneToOne | |
| Dr.4907 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8421 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for FGG was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FGG Gene
- ENSEMBL:
- Gene Tree for FGG (if available)
- TreeFam:
- Gene Tree for FGG (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FGG: view image
Paralogs for FGG Gene
Paralogs for FGG Gene
(12) SIMAP similar genes for FGG Gene using alignment to 6 proteins:
- FIBG_HUMAN
- C9JC84_HUMAN
- C9JEU5_HUMAN
- C9JPQ9_HUMAN
- C9JU00_HUMAN
- D3DP16_HUMAN
Pseudogenes.org Pseudogenes for FGG Gene
Variants for FGG Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGG Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 626936 | Likely Pathogenic: Hypofibrinogenemia | 154,608,640(-) | C/A | MISSENSE_VARIANT | |
| 626954 | Pathogenic: Abnormal bleeding | 154,611,875(-) | T/A | NONSENSE | |
| 626970 | Likely Pathogenic: Hypofibrinogenemia | 154,606,735(-) | C/T | MISSENSE_VARIANT | |
| 627074 | Uncertain Significance: Thromboembolism | 154,610,152(-) | G/T | MISSENSE_VARIANT | |
| 627102 | Uncertain Significance: Hypofibrinogenemia | 154,609,674(-) | A/G | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.90;
48.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGG Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FGG Gene
Disorders for FGG Gene
(9) MalaCards diseases for FGG Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| afibrinogenemia, congenital |
|
|
| dysfibrinogenemia, congenital |
|
|
| colon leiomyoma |
|
|
| thrombophilia |
|
|
| thrombosis |
|
|
Search FGG in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FIBG_HUMAN- Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269 PubMed:25427968}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
- Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269 PubMed:15632207, ECO:0000269 PubMed:2257302, ECO:0000269 PubMed:2976995, ECO:0000269 PubMed:3708159}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for FGG
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for FGG Gene
Publications for FGG Gene
- Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study. (PMID: 20167083) Theodoraki EV … Dedoussis GV (BMC medical genetics 2010) 3 23 41
- Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study. (PMID: 20059469) Carty CL … Reiner AP (Annals of human genetics 2010) 3 23 41
- Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from 2 family-based association studies. (PMID: 19515723) Nowak-Göttl U … Stoll M (Blood 2009) 3 23 41
- Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study. (PMID: 19412134) Sie MP … Witteman JC (Journal of hypertension 2009) 3 23 41
- Variation in fibrinogen FGG and FGA genes and risk of stroke: the Rotterdam Study. (PMID: 18690352) Cheung EY … Breteler MM (Thrombosis and haemostasis 2008) 3 23 41
ExternalLinks
Products for FGG Gene
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Sources for FGG Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (36) Pseudogene
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- (67) Reactome
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- (70) SIMAP
- (71) GenomeRNAi
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