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The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
FGG (Fibrinogen Gamma Chain) is a Protein Coding gene. Diseases associated with FGG include Afibrinogenemia, Congenital and Dysfibrinogenemia, Congenital. Among its related pathways are Activated TLR4 signalling and RET signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and protein binding, bridging. An important paralog of this gene is FGB.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | IEA,IPI | 7822297 |
GO:0005198 | structural molecule activity | IDA | 8910396 |
GO:0005201 | extracellular matrix structural constituent | RCA | 25037231 |
GO:0005515 | protein binding | IPI | 10788510 |
GO:0042802 | identical protein binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005577 | fibrinogen complex | IEA,IDA | 6451630 |
GO:0005615 | extracellular space | HDA,IDA | 6777381 |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005788 | endoplasmic reticulum lumen | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Paradoxical activation of RAF signaling by kinase inactive BRAF | ||
3 | Formation of Fibrin Clot (Clotting Cascade) |
Extrinsic Prothrombin Activation Pathway
.01
|
|
4 | Integrin alphaIIb beta3 signaling | ||
5 | Response to elevated platelet cytosolic Ca2+ |
.44
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002224 | toll-like receptor signaling pathway | TAS | -- |
GO:0002576 | platelet degranulation | TAS | -- |
GO:0007160 | cell-matrix adhesion | IDA | 10903502 |
GO:0007596 | blood coagulation | IEA,TAS | -- |
GO:0007599 | hemostasis | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Sucralfate | Approved | Pharma | Target, binder, protector | 15 | ||
Human thrombin | Approved | Pharma | Target, activator | 0 | ||
Thrombin | Approved, Investigational | Pharma | Target, activator | 411 | ||
Thrombin alfa | Approved | Pharma | Target, activator | 0 | ||
Alfimeprase | Investigational | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP14: |
ExUns: | 14b |
---|---|
SP1: | |
SP2: | |
SP3: | |
SP4: | |
SP5: | |
SP6: | |
SP7: | |
SP8: | |
SP9: | |
SP10: | |
SP11: | |
SP12: | |
SP13: | |
SP14: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FGG 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FGG 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FGG 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fgg 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fgg 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | FGG 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FGG 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FGG 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FGG 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgg 30 |
|
||
Str.15548 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | fgg-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fgg 30 31 |
|
OneToOne | |
Dr.4907 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8421 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
626936 | Likely Pathogenic: Hypofibrinogenemia | 154,608,640(-) | C/A | MISSENSE_VARIANT | |
626954 | Pathogenic: Abnormal bleeding | 154,611,875(-) | T/A | NONSENSE | |
626970 | Likely Pathogenic: Hypofibrinogenemia | 154,606,735(-) | C/T | MISSENSE_VARIANT | |
627074 | Uncertain Significance: Thromboembolism | 154,610,152(-) | G/T | MISSENSE_VARIANT | |
627102 | Uncertain Significance: Hypofibrinogenemia | 154,609,674(-) | A/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
afibrinogenemia, congenital |
|
|
dysfibrinogenemia, congenital |
|
|
colon leiomyoma |
|
|
thrombophilia |
|
|
thrombosis |
|
|