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Aliases for FGFRL1 Gene

Aliases for FGFRL1 Gene

  • Fibroblast Growth Factor Receptor Like 1 2 3 5
  • Fibroblast Growth Factor Receptor 5 3 4
  • FGF Homologous Factor Receptor 3 4
  • FGF Receptor-Like Protein 1 3 4
  • FGFR-Like Protein 3 4
  • FGFR-5 3 4
  • FGFR5 3 4
  • FHFR 3 4
  • Fibroblast Growth Factor Receptor-Like 1 3

External Ids for FGFRL1 Gene

Previous GeneCards Identifiers for FGFRL1 Gene

  • GC04M001066
  • GC04P000994
  • GC04P000996

Summaries for FGFRL1 Gene

Entrez Gene Summary for FGFRL1 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGFRL1 Gene

FGFRL1 (Fibroblast Growth Factor Receptor Like 1) is a Protein Coding gene. Diseases associated with FGFRL1 include Chromosome 4P Deletion. Among its related pathways are VEGF Signaling Pathway and Negative regulation of FGFR1 signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and fibroblast growth factor-activated receptor activity.

UniProtKB/Swiss-Prot for FGFRL1 Gene

  • Has a negative effect on cell proliferation.

Gene Wiki entry for FGFRL1 Gene

Additional gene information for FGFRL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGFRL1 Gene

Genomics for FGFRL1 Gene

GeneHancer (GH) Regulatory Elements for FGFRL1 Gene

Promoters and enhancers for FGFRL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J001009 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 656 +1.3 1302 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A ZNF48 YY1 GLIS2 CBX5 ZNF143 FGFRL1 DGKQ CRIPAK UVSSA LETM1 GAK GC04M001024
GH04J001010 Enhancer 0.8 ENCODE dbSUPER 650.7 -0.7 -728 0.3 SMARCA5 BCOR L3MBTL2 SIN3A ZMYM3 E2F1 ZNF335 RLF ZNF143 ZFP36 FGFRL1 SLC26A1
GH04J000921 Enhancer 1.2 FANTOM5 Ensembl ENCODE 18.5 -86.1 -86118 4 NFXL1 ZBTB40 BATF ZNF121 GLIS2 ZNF143 ETV6 BCLAF1 IKZF2 RUNX3 PCGF3 PIGG FGFRL1 GAK ZNF718 IDUA ENSG00000270195 ZNF141 ENSG00000272588 MAEA
GH04J001288 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.5 +280.1 280094 3.5 PKNOX1 ARID4B SIN3A YY1 POLR2B ZNF766 E2F8 ZNF207 ZNF143 FOS MAEA LOC105374347 HAUS3 PCGF3 CRIPAK UVSSA PIGG SPON2 NELFA ZNF141
GH04J000929 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.8 -78.3 -78307 3.5 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF207 ZNF143 GAK TMEM175 PCGF3 DGKQ CRIPAK PIGG MAEA ZNF141 ZNF718 ENSG00000281016
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGFRL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGFRL1 gene promoter:
  • CUTL1
  • Nkx2-5
  • SRF
  • SRF (504 AA)

Genomic Locations for FGFRL1 Gene

Genomic Locations for FGFRL1 Gene
chr4:1,009,936-1,026,898
(GRCh38/hg38)
Size:
16,963 bases
Orientation:
Plus strand
chr4:1,003,724-1,020,686
(GRCh37/hg19)
Size:
16,963 bases
Orientation:
Plus strand

Genomic View for FGFRL1 Gene

Genes around FGFRL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFRL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFRL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFRL1 Gene

Proteins for FGFRL1 Gene

  • Protein details for FGFRL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N441-FGRL1_HUMAN
    Recommended name:
    Fibroblast growth factor receptor-like 1
    Protein Accession:
    Q8N441
    Secondary Accessions:
    • B2RAU9
    • Q6PJN1
    • Q9BXN7
    • Q9H4D7

    Protein attributes for FGFRL1 Gene

    Size:
    504 amino acids
    Molecular mass:
    54537 Da
    Quaternary structure:
    • Interacts with FGF2 with a low affinity.

neXtProt entry for FGFRL1 Gene

Post-translational modifications for FGFRL1 Gene

  • Glycosylation at isoforms=293, Asn255, isoforms=231, and Asn111
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FGFRL1 Gene

Domains & Families for FGFRL1 Gene

Gene Families for FGFRL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Suggested Antigen Peptide Sequences for FGFRL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FGFRL1: view

No data available for UniProtKB/Swiss-Prot for FGFRL1 Gene

Function for FGFRL1 Gene

Molecular function for FGFRL1 Gene

UniProtKB/Swiss-Prot Function:
Has a negative effect on cell proliferation.

Phenotypes From GWAS Catalog for FGFRL1 Gene

Gene Ontology (GO) - Molecular Function for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005007 fibroblast growth factor-activated receptor activity IDA 12813049
GO:0008201 heparin binding IMP 18061161
GO:0017134 fibroblast growth factor binding IEA --
genes like me logo Genes that share ontologies with FGFRL1: view
genes like me logo Genes that share phenotypes with FGFRL1: view

Human Phenotype Ontology for FGFRL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGFRL1 Gene

MGI Knock Outs for FGFRL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGFRL1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGFRL1 Gene

Localization for FGFRL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFRL1 Gene

Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFRL1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
extracellular 2
endoplasmic reticulum 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 18061161
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA 18061161
genes like me logo Genes that share ontologies with FGFRL1: view

Pathways & Interactions for FGFRL1 Gene

genes like me logo Genes that share pathways with FGFRL1: view

Pathways by source for FGFRL1 Gene

1 PharmGKB pathway for FGFRL1 Gene

Gene Ontology (GO) - Biological Process for FGFRL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0003179 heart valve morphogenesis IEA --
GO:0007165 signal transduction IBA --
GO:0008285 negative regulation of cell proliferation IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FGFRL1: view

No data available for SIGNOR curated interactions for FGFRL1 Gene

Drugs & Compounds for FGFRL1 Gene

(2) Drugs for FGFRL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LY2874455 Pharma FGF/FGFR Inhibitor 0
genes like me logo Genes that share compounds with FGFRL1: view

Transcripts for FGFRL1 Gene

Unigene Clusters for FGFRL1 Gene

Fibroblast growth factor receptor-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGFRL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c
SP1: - - - -
SP2: - - -
SP3:
SP4: -
SP5: -

Relevant External Links for FGFRL1 Gene

GeneLoc Exon Structure for
FGFRL1
ECgene alternative splicing isoforms for
FGFRL1

Expression for FGFRL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGFRL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFRL1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FGFRL1 Gene:

FGFRL1

SOURCE GeneReport for Unigene cluster for FGFRL1 Gene:

Hs.193326

mRNA Expression by UniProt/SwissProt for FGFRL1 Gene:

Q8N441-FGRL1_HUMAN
Tissue specificity: Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.

Evidence on tissue expression from TISSUES for FGFRL1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with FGFRL1: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFRL1 Gene

Orthologs for FGFRL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFRL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FGFRL1 34 33
  • 88.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102151155 33
  • 88.26 (n)
FGFRL1 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fgfrl1 16 34 33
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia Fgfrl1 33
  • 85.44 (n)
oppossum
(Monodelphis domestica)
Mammalia FGFRL1 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FGFRL1 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves FGFRL1 34 33
  • 72.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FGFRL1 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fgfrl1 33
  • 67.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17937 33
zebrafish
(Danio rerio)
Actinopterygii fgfrl1a 34 33
  • 69.46 (n)
OneToOne
zgc64084 33
fruit fly
(Drosophila melanogaster)
Insecta CG31431 34
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea igcm-4 34 33
  • 41.37 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToOne
Species where no ortholog for FGFRL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FGFRL1 Gene

ENSEMBL:
Gene Tree for FGFRL1 (if available)
TreeFam:
Gene Tree for FGFRL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGFRL1: view image

Paralogs for FGFRL1 Gene

(6) SIMAP similar genes for FGFRL1 Gene using alignment to 4 proteins:

  • FGRL1_HUMAN
  • A0PJ49_HUMAN
  • D6RBN8_HUMAN
  • D6REM7_HUMAN
genes like me logo Genes that share paralogs with FGFRL1: view

No data available for Paralogs for FGFRL1 Gene

Variants for FGFRL1 Gene

Sequence variations from dbSNP and Humsavar for FGFRL1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000129345 -- 1,017,283(+) C/T intron_variant
rs1000184487 -- 1,023,125(+) C/G intron_variant
rs1000284494 -- 1,010,887(+) T/C upstream_transcript_variant
rs1000397629 -- 1,014,383(+) C/T intron_variant
rs1000886618 -- 1,011,982(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FGFRL1 Gene

Variant ID Type Subtype PubMed ID
dgv2703n106 CNV deletion 24896259
esv28049 CNV loss 19812545
nsv1003219 CNV gain 25217958
nsv1008352 CNV gain 25217958
nsv1073282 CNV deletion 25765185
nsv1120469 CNV tandem duplication 24896259
nsv1133572 CNV deletion 24896259
nsv469998 CNV loss 18288195
nsv593226 CNV loss 21841781
nsv593228 CNV loss 21841781
nsv593231 CNV gain 21841781
nsv593233 CNV loss 21841781
nsv593234 CNV loss 21841781
nsv593235 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv822428 CNV gain 20364138
nsv950328 CNV deletion 24416366

Variation tolerance for FGFRL1 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.40; 81.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGFRL1 Gene

Human Gene Mutation Database (HGMD)
FGFRL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFRL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFRL1 Gene

Disorders for FGFRL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGFRL1 Gene - From: GTR

Disorder Aliases PubMed IDs
chromosome 4p deletion
  • 4p deletion
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FGFRL1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGFRL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGFRL1 Gene

Publications for FGFRL1 Gene

  1. Characterization of FGFRL1, a novel fibroblast growth factor (FGF) receptor preferentially expressed in skeletal tissues. (PMID: 12813049) Trueb B … Wiedemann M (The Journal of biological chemistry 2003) 3 4 22 58
  2. A novel fibroblast growth factor receptor-5 preferentially expressed in the pancreas(1). (PMID: 11267671) Kim I … Koh GY (Biochimica et biophysica acta 2001) 3 4 22 58
  3. Identification of a new fibroblast growth factor receptor, FGFR5. (PMID: 11418238) Sleeman M … Murison JG (Gene 2001) 3 4 22 58
  4. Biology of FGFRL1, the fifth fibroblast growth factor receptor. (PMID: 21080029) Trueb B (Cellular and molecular life sciences : CMLS 2011) 2 3 58
  5. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu CY … Christiani DC (Carcinogenesis 2010) 3 44 58

Products for FGFRL1 Gene

Sources for FGFRL1 Gene

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