The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists o... See more...

Aliases for FGFR4 Gene

Aliases for FGFR4 Gene

  • Fibroblast Growth Factor Receptor 4 2 3 4 5
  • JTK2 2 3 4
  • EC 2.7.10.1 4 51
  • CD334 2 3
  • TKF 3 4
  • Tyrosine Kinase Related To Fibroblast Growth Factor Receptor 3
  • Hydroxyaryl-Protein Kinase 3
  • Protein-Tyrosine Kinase 3
  • Tyrosylprotein Kinase 3
  • CD334 Antigen 4
  • EC 2.7.10 51
  • FGFR-4 4
  • FGFR4 5

External Ids for FGFR4 Gene

Previous GeneCards Identifiers for FGFR4 Gene

  • GC05P176887
  • GC05P177356
  • GC05P176449
  • GC05P176494
  • GC05P176446
  • GC05P176513
  • GC05P171435

Summaries for FGFR4 Gene

Entrez Gene Summary for FGFR4 Gene

  • The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017]

CIViC Summary for FGFR4 Gene

GeneCards Summary for FGFR4 Gene

FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroendocrine Carcinoma. Among its related pathways are RET signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3.

UniProtKB/Swiss-Prot Summary for FGFR4 Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Tocris Summary for FGFR4 Gene

  • Fibroblast growth factors (FGFs) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGF receptors (FGFRs) are transmembrane catalytic receptors with intracellular tyrosine kinase activity.

Gene Wiki entry for FGFR4 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGFR4 Gene

Genomics for FGFR4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGFR4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGFR4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGFR4

Top Transcription factor binding sites by QIAGEN in the FGFR4 gene promoter:
  • AhR
  • AML1a
  • AP-4
  • AREB6
  • ER-alpha
  • SEF-1 (1)

Genomic Locations for FGFR4 Gene

Genomic Locations for FGFR4 Gene
chr5:177,086,905-177,098,144
(GRCh38/hg38)
Size:
11,240 bases
Orientation:
Plus strand
chr5:176,513,887-176,525,145
(GRCh37/hg19)
Size:
11,259 bases
Orientation:
Plus strand

Genomic View for FGFR4 Gene

Genes around FGFR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR4 Gene

Proteins for FGFR4 Gene

  • Protein details for FGFR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22455-FGFR4_HUMAN
    Recommended name:
    Fibroblast growth factor receptor 4
    Protein Accession:
    P22455
    Secondary Accessions:
    • G3JVM2
    • G3JVM5
    • G3JVM7
    • G3JVM9
    • O43785
    • Q14309
    • Q71TW8
    • Q8TDA0
    • Q96KE5

    Protein attributes for FGFR4 Gene

    Size:
    802 amino acids
    Molecular mass:
    87954 Da
    Quaternary structure:
    • Monomer. Homodimer after ligand binding. Interacts with FGF1, FGF2, FGF4, FGF6, FGF8, FGF9, FGF16, FGF17, FGF18, FGF19, FGF21 and FGF23 (in vitro). Binding affinity for FGF family members is enhanced by interactions between FGFs and heparan sulfate proteoglycans. Interacts with KLB; this strongly increases the affinity for FGF19 and FGF23. Affinity for FGF19 is strongly increased by KLB and sulfated glycosaminoglycans. KLB and KL both interact with the core-glycosylated FGFR4 in the endoplasmic reticulum and promote its degradation, so that only FGFR4 with fully mature N-glycans is expressed at the cell surface. Identified in a complex with NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts with MMP14 and HIP1 (PubMed:11433297, PubMed:16597617, PubMed:17623664, PubMed:18670643, PubMed:20683963, PubMed:20798051, PubMed:21653700, PubMed:7518429, PubMed:8663044). Interacts with STAT3 (PubMed:26675719).
    Miscellaneous:
    • [Isoform 3]: Lacks a signal peptide. Constitutively phosphorylated.

    Three dimensional structures from OCA and Proteopedia for FGFR4 Gene

    Alternative splice isoforms for FGFR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGFR4 Gene

Selected DME Specific Peptides for FGFR4 Gene

P22455:
  • WEIFTLGGSP
  • RDLAARN
  • NIINLLG
  • WSLVMES
  • MRECWHA
  • LGKPLGEGCFGQV
  • VAVKMLK
  • LPVKWMA
  • EDAGEYTCLAGNSIG
  • SEVEVLYL
  • EALFDRVYT
  • SAWLTVL
  • VMKIADFGLAR
  • LRARRPP
  • IDYYKKT
  • PSQRPTFKQLVE
  • MESVVPSD
  • AARNVLV
  • PHIQWLK
  • GILLWEIF
  • CIHRDLAARNVLV
  • WEFPRDRL
  • CKVYSDAQPH
  • PILQAGLPAN
  • PVKWMAPE
  • YTHQSDVWS
  • LDVLERS
  • YTCLVEN
  • GPLYVIVE
  • ERSPHRPILQAGLP

Post-translational modifications for FGFR4 Gene

  • N-glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19.
  • Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated.
  • Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer.
  • Glycosylation at Asn258, Asn290, Asn311, Asn112, Asn322, and Asn508
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FGFR4_HUMAN (1938)

Antibody Products

  • Abcam antibodies for FGFR4
  • Santa Cruz Biotechnology (SCBT) Antibodies for FGFR4

Domains & Families for FGFR4 Gene

Gene Families for FGFR4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for FGFR4 Gene

InterPro:
Blocks:
  • Immunoglobulin C-2 type
  • Immunoglobulin I-set
  • Tyrosine protein kinase, active site
ProtoNet:

Suggested Antigen Peptide Sequences for FGFR4 Gene

GenScript: Design optimal peptide antigens:
  • Soluble FGFR4 variant 2 (B5A965_HUMAN)
  • Fibroblast growth factor receptor 4 (FGFR4_HUMAN)
  • Acidic fibroblast growth factor (Q6LBK2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22455

UniProtKB/Swiss-Prot:

FGFR4_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
genes like me logo Genes that share domains with FGFR4: view

Function for FGFR4 Gene

Molecular function for FGFR4 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:11433297, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:18670643};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues.
GENATLAS Biochemistry:
fibroblast growth factor receptor 4,involved in the development of endoderm derivatives and in skeletal muscle formation

Enzyme Numbers (IUBMB) for FGFR4 Gene

Phenotypes From GWAS Catalog for FGFR4 Gene

Gene Ontology (GO) - Molecular Function for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005007 fibroblast growth factor-activated receptor activity IGI 10525310
genes like me logo Genes that share ontologies with FGFR4: view
genes like me logo Genes that share phenotypes with FGFR4: view

Animal Models for FGFR4 Gene

MGI Knock Outs for FGFR4:
  • Fgfr4 Fgfr4<tm1Cxd>
  • Fgfr4 Fgfr4<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFR4

Clone Products

  • Addgene plasmids for FGFR4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFR4 Gene

Localization for FGFR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR4 Gene

Cell membrane. Single-pass type I membrane protein. Endosome. Endoplasmic reticulum. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane.
[Isoform 2]: Secreted.
[Isoform 3]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFR4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
endosome 5
golgi apparatus 5
nucleus 4
cytosol 3
cytoskeleton 2
mitochondrion 2
lysosome 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA,IDA 20683963
GO:0005794 Golgi apparatus IDA 18061161
genes like me logo Genes that share ontologies with FGFR4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGFR4 Gene

Pathways & Interactions for FGFR4 Gene

PathCards logo

SuperPathways for FGFR4 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.62
.61
.60
.57
.57
3 Downstream signaling of activated FGFR2
4 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
5 GAB1 signalosome
genes like me logo Genes that share pathways with FGFR4: view

Pathways by source for FGFR4 Gene

60 Qiagen pathways for FGFR4 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
2 Cell Signaling Technology pathways for FGFR4 Gene

SIGNOR curated interactions for FGFR4 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FGFR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006468 protein phosphorylation IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0007275 multicellular organism development IBA 21873635
GO:0008284 positive regulation of cell proliferation IGI 8663044
genes like me logo Genes that share ontologies with FGFR4: view

Drugs & Compounds for FGFR4 Gene

(39) Drugs for FGFR4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palifermin Approved Pharma Target, binder 0
Heparin Approved, Investigational Pharma Antagonist, Target 1058
Tyrosine Approved, Investigational Nutra 1044
erdafitinib Approved, Investigational Pharma Target, inhibitor 0
Lenvatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 155

(6) Additional Compounds for FGFR4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0

(3) Tocris Compounds for FGFR4 Gene

Compound Action Cas Number
PD 161570 Selective FGFR inhibitor 192705-80-9
PD 173074 FGFR1 and -3 inhibitor 219580-11-7
SU 5402 Potent FGFR and VEGFR inhibitor 215543-92-3

(11) ApexBio Compounds for FGFR4 Gene

Compound Action Cas Number
ACTB-1003 939805-30-8
AZD4547 FGFR inhibitor 1035270-39-3
BGJ398 FGFR inhibitor ,potent and selective 872511-34-7
BLU9931 FGFR4 inhibitor,potent and irreversible 1538604-68-0
CH5183284 (Debio-1347) 1265229-25-1
LY2874455 FGF/FGFR Inhibitor 1254473-64-7
NVP-BGJ398 phosphate FGFR inhibitor 1310746-10-1
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor 635702-64-6
PD 161570 192705-80-9
PD 173074 FGFR inhibitor 219580-11-7
Vandetanib (ZD6474) VEGFR2/EGFR antagonist 443913-73-3
genes like me logo Genes that share compounds with FGFR4: view

Transcripts for FGFR4 Gene

mRNA/cDNA for FGFR4 Gene

5 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFR4

Clone Products

  • Addgene plasmids for FGFR4

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ·
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - - - -
SP7: - -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:

ExUns: 12d ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FGFR4 Gene

GeneLoc Exon Structure for
FGFR4

Expression for FGFR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGFR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGFR4 Gene

This gene is overexpressed in Liver (x8.8), Lung (x7.6), Kidney - Cortex (x5.4), and Pancreas (x4.0).

Protein differential expression in normal tissues from HIPED for FGFR4 Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFR4 Gene



Protein tissue co-expression partners for FGFR4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGFR4

SOURCE GeneReport for Unigene cluster for FGFR4 Gene:

Hs.165950

mRNA Expression by UniProt/SwissProt for FGFR4 Gene:

P22455-FGFR4_HUMAN
Tissue specificity: Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.

Evidence on tissue expression from TISSUES for FGFR4 Gene

  • Muscle(4.7)
  • Liver(4.7)
  • Intestine(4.6)
  • Nervous system(4.5)
  • Blood(4.5)
  • Gall bladder(2.8)
  • Kidney(2.8)
  • Lung(2.6)
  • Pancreas(2.5)
  • Heart(2.4)
  • Skin(2.1)
  • Stomach(2.1)
  • Thyroid gland(2.1)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with FGFR4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFR4 Gene

Orthologs for FGFR4 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFR4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGFR4 30 31
  • 99.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FGFR4 30 31
  • 89.48 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FGFR4 30 31
  • 89.45 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fgfr4 30 17 31
  • 85.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgfr4 30
  • 85.26 (n)
Oppossum
(Monodelphis domestica)
Mammalia FGFR4 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FGFR4 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FGFR4 30 31
  • 74.47 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FGFR4 31
  • 67 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fgfr4 30
  • 65.47 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397701 30
Zebrafish
(Danio rerio)
Actinopterygii fgfr4 30 31
  • 63.91 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta tor 32
  • 52 (a)
htl 31 32
  • 37 (a)
ManyToMany
btl 31 32
  • 27 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea ver-2 32
  • 39 (a)
kin-9 32
  • 38 (a)
W04G5.10 32
  • 38 (a)
R151.4 32
  • 38 (a)
old-2 32
  • 36 (a)
old-1 32
  • 36 (a)
kin-16 32
  • 36 (a)
C24G6.2a 32
  • 35 (a)
C24G6.2b 32
  • 35 (a)
Y50D4B.6 32
  • 34 (a)
kin-23 32
  • 34 (a)
ver-4 32
  • 33 (a)
R09D1.13 32
  • 33 (a)
Y38H6C.20 32
  • 32 (a)
F09G2.1 32
  • 32 (a)
R09D1.12 32
  • 32 (a)
egl-15 31
  • 25 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToMany
Species where no ortholog for FGFR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FGFR4 Gene

ENSEMBL:
Gene Tree for FGFR4 (if available)
TreeFam:
Gene Tree for FGFR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGFR4: view image

Paralogs for FGFR4 Gene

genes like me logo Genes that share paralogs with FGFR4: view

Variants for FGFR4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGFR4 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
712581 Benign: not provided 177,095,674(+) C/T MISSENSE_VARIANT
738032 Likely Benign: not provided 177,093,558(+) T/G INTRON_VARIANT
745172 Likely Benign: not provided 177,093,660(+) G/A SYNONYMOUS_VARIANT
764410 Likely Benign: not provided 177,096,186(+) G/A INTRON_VARIANT
773176 Benign: not provided 177,090,800(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FGFR4 Gene

Structural Variations from Database of Genomic Variants (DGV) for FGFR4 Gene

Variant ID Type Subtype PubMed ID
dgv363n21 CNV gain 19592680
esv24424 CNV loss 19812545
esv2657291 CNV deletion 23128226
esv3607685 CNV loss 21293372
nsv482093 CNV gain 20164927
nsv509101 CNV insertion 20534489
nsv521574 CNV loss 19592680
nsv823351 CNV gain 20364138

Variation tolerance for FGFR4 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.38; 94.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGFR4 Gene

Human Gene Mutation Database (HGMD)
FGFR4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFR4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFR4 Gene

Disorders for FGFR4 Gene

MalaCards: The human disease database

(37) MalaCards diseases for FGFR4 Gene - From: UniProtKB/Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
neuroendocrine carcinoma
  • neuroendocrine cancer
rhabdomyosarcoma
bjornstad syndrome
  • bjs
adenocarcinoma
  • adenocarcinomas
- elite association - COSMIC cancer census association via MalaCards
Search FGFR4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FGFR4_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:18670643, ECO:0000269 PubMed:18756523, ECO:0000269 PubMed:20876804, ECO:0000269 PubMed:21349172}. Note=The gene represented in this entry is involved in disease pathogenesis. FGFR4 variant Arg-388 has been associated with prostate cancer as well as cancers of the breast, colon, head and neck, larynx, lung, skin. Arg-388 predisposes cancer patients for accelerated disease progression and is associated with poor prognosis. {ECO:0000269 PubMed:11781352, ECO:0000269 PubMed:11830541, ECO:0000269 PubMed:18670643, ECO:0000269 PubMed:18756523, ECO:0000269 PubMed:20638838, ECO:0000269 PubMed:20876804, ECO:0000269 PubMed:21349172, ECO:0000269 PubMed:21412156, ECO:0000269 PubMed:21882254, ECO:0000269 PubMed:26675719}.

Additional Disease Information for FGFR4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FGFR4: view

No data available for Genatlas for FGFR4 Gene

Publications for FGFR4 Gene