The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglob... See more...

Aliases for FGFR2 Gene

Aliases for FGFR2 Gene

  • Fibroblast Growth Factor Receptor 2 2 3 4 5
  • Keratinocyte Growth Factor Receptor 2 3 4
  • Bacteria-Expressed Kinase 2 3
  • EC 2.7.10.1 4 54
  • KGFR 3 4
  • BEK 3 4
  • Protein Tyrosine Kinase, Receptor Like 14 3
  • BEK Fibroblast Growth Factor Receptor 3
  • Craniofacial Dysostosis 1 2
  • Jackson-Weiss Syndrome 2
  • Pfeiffer Syndrome 2
  • Crouzon Syndrome 2
  • CD332 Antigen 4
  • EC 2.7.10 54
  • FGFR-2 4
  • BFR-1 3
  • CD332 3
  • K-SAM 3
  • K-Sam 4
  • BBDS 3
  • CEK3 3
  • ECT1 3
  • TK14 3
  • TK25 3
  • CFD1 3
  • KSAM 4
  • JWS 3

External Ids for FGFR2 Gene

Previous HGNC Symbols for FGFR2 Gene

  • KGFR
  • BEK
  • CFD1
  • JWS

Previous GeneCards Identifiers for FGFR2 Gene

  • GC10M121401
  • GC10M122481
  • GC10M123369
  • GC10M122902
  • GC10M122147
  • GC10M122473
  • GC10M123223
  • GC10M116868

Summaries for FGFR2 Gene

Entrez Gene Summary for FGFR2 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

CIViC Summary for FGFR2 Gene

  • The FGFR proteins are involved in a wide array of pathways known to play a signficant role in cancer. Activation of these receptors can lead to activation of the RAS-MAPK pathway and the PI3K-AKT pathway, among others. The mechanisms by which FGFR can be misregulated vary between cancers. Amplification of the receptors has been observed in lung and breast cancers, coding mutations and deletions have been seen in many cancers, and more recently, FGFR fusions that lead to pathway actiation have been demonstrated to have oncogenic potential across multiple cancer types. The targeted therapeutics ponatinib, dovitinib and pazopanib have seen success in treating over-active FGFR signalling, prompting use of diagnostic sequencing targeting the FGFR genes, especially in lung cancer patients.

GeneCards Summary for FGFR2 Gene

FGFR2 (Fibroblast Growth Factor Receptor 2) is a Protein Coding gene. Diseases associated with FGFR2 include Pfeiffer Syndrome and Crouzon Syndrome. Among its related pathways are PI3K/AKT activation and RET signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is FGFR1.

UniProtKB/Swiss-Prot Summary for FGFR2 Gene

  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

Tocris Summary for FGFR2 Gene

  • Fibroblast growth factors (FGFs) are mitogenic signaling molecules that have roles in angiogenesis, wound healing, cell migration, neural outgrowth and embryonic development. FGF receptors (FGFRs) are transmembrane catalytic receptors with intracellular tyrosine kinase activity.

Gene Wiki entry for FGFR2 Gene

Additional gene information for FGFR2 Gene

No data available for PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGFR2 Gene

Genomics for FGFR2 Gene

GeneHancer (GH) Regulatory Elements for FGFR2 Gene

Promoters and enhancers for FGFR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J121593 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +2.3 2300 6.5 RBPJ CTBP1 ZNF362 NFYC L3MBTL2 RAD21 POU5F1 SP1 ELF3 CEBPG FGFR2 WDR11 lnc-ATE1-6
GH10J121531 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 760.8 +66.7 66655 3.2 MIXL1 HLF ELF3 SP1 CEBPG ZIC2 CEBPA RXRA GATAD2A IRF2 FGFR2 lnc-ATE1-7 RF00017-823
GH10J121553 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 37.5 +42.4 42355 7 TCF7L2 ZNF362 ZNF121 MNT NFIB SP7 SP5 IKZF1 GLIS2 PKNOX1 RF00017-823 FGFR2 WDR11 lnc-ATE1-6
GH10J121522 Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.5 +72.3 72312 7.3 MLX CTBP1 NR2F6 ATF1 CREB1 HLF ELF3 CEBPG SP7 ZNF680 FGFR2 lnc-ATE1-7 RF00017-823
GH10J121452 Enhancer 0.8 Ensembl ENCODE 20.8 +144.3 144327 2.7 SP1 RXRA TCF7L2 ZBTB20 YY1 JUND RCOR1 RAD21 HNF4A MAX FGFR2 piR-38350-001 lnc-FGFR2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGFR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGFR2 gene promoter:
  • AP-1
  • Sox9

Genomic Locations for FGFR2 Gene

Genomic Locations for FGFR2 Gene
chr10:121,478,330-121,598,656
(GRCh38/hg38)
Size:
120,327 bases
Orientation:
Minus strand
chr10:123,237,844-123,357,972
(GRCh37/hg19)
Size:
120,129 bases
Orientation:
Minus strand

Genomic View for FGFR2 Gene

Genes around FGFR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR2 Gene

Proteins for FGFR2 Gene

  • Protein details for FGFR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21802-FGFR2_HUMAN
    Recommended name:
    Fibroblast growth factor receptor 2
    Protein Accession:
    P21802
    Secondary Accessions:
    • B4DFC2
    • E7EVR6
    • E9PCR0
    • P18443
    • Q01742
    • Q12922
    • Q14300
    • Q14301
    • Q14302
    • Q14303
    • Q14304
    • Q14305
    • Q14672
    • Q14718
    • Q14719
    • Q1KHY5
    • Q86YI4
    • Q8IXC7
    • Q96KL9
    • Q96KM0
    • Q96KM1
    • Q96KM2
    • Q9NZU2
    • Q9NZU3
    • Q9UD01
    • Q9UD02
    • Q9UIH3
    • Q9UIH4
    • Q9UIH5
    • Q9UIH6
    • Q9UIH7
    • Q9UIH8
    • Q9UM87
    • Q9UMC6
    • Q9UNS7
    • Q9UQH7
    • Q9UQH8
    • Q9UQH9
    • Q9UQI0

    Protein attributes for FGFR2 Gene

    Size:
    821 amino acids
    Molecular mass:
    92025 Da
    Quaternary structure:
    • Monomer. Homodimer after ligand binding. Interacts predominantly with FGF1 and FGF2, but can also interact with FGF3, FGF4, FGF6, FGF7, FGF8, FGF9, FGF10, FGF17, FGF18 and FGF22 (in vitro). Ligand specificity is determined by tissue-specific expression of isoforms, and differences in the third Ig-like domain are crucial for ligand specificity. Isoform 1 has high affinity for FGF1 and FGF2, but low affinity for FGF7. Isoform 3 has high affinity for FGF1 and FGF7, and has much higher affinity for FGF7 than isoform 1 (in vitro). Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Likewise, KLB increases the affinity for FGF19 and FGF21. Interacts with PLCG1, GRB2 and PAK4. Interacts with FLRT2 (By similarity).
    SequenceCaution:
    • Sequence=BAG57383.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGFR2 Gene

neXtProt entry for FGFR2 Gene

Selected DME Specific Peptides for FGFR2 Gene

P21802:
  • SEYELPEDP
  • WEIFTLGGSP
  • NCTNELY
  • RDLAARN
  • CTQDGPLY
  • NIINLLG
  • LGKPLGEGCFGQV
  • VAVKMLK
  • AGVNTTD
  • GSINHTY
  • SDVWSFGVLMWE
  • LPVKWMA
  • DSGLYAC
  • EDAGEYTCLAGNSIG
  • PVEELFKLLKEGHRMD
  • TFKDLVSC
  • EGHRMDKP
  • LVEDLDR
  • GIDKDKP
  • EALFDRVYT
  • SQPAVHKL
  • WLKNGKEF
  • SAWLTVL
  • VMKIADFGLAR
  • SSGDDED
  • SSMNSNTPLVRI
  • PSQRPTFKQLVE
  • LRARRPP
  • IDYYKKT
  • MESVVPSD
  • AARNVLV
  • LDVVERSPH
  • PLRRQVTV
  • SGDDSVF
  • SEMEMMK
  • TNEEYLDL
  • RRQVTVS
  • CIHRDLAARNVLV
  • AVPAANT
  • CKVYSDAQPH
  • SVVPSDKG
  • PILQAGLPAN
  • PVKWMAPE
  • GDDSVFSPDPM
  • PYLKVLKAAG
  • YTHQSDVWS
  • EKDLSDL
  • GPLYVIVE
  • PEEPPTK
  • ERSPHRPILQAGLP
  • DFGLARDI
  • RRPPGMEY
  • ARGMEYLAS

Post-translational modifications for FGFR2 Gene

  • Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on several tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. Phosphorylation at Tyr-769 is essential for interaction with PLCG1.
  • N-glycosylated in the endoplasmic reticulum. The N-glycan chains undergo further maturation to an Endo H-resistant form in the Golgi apparatus.
  • Ubiquitinated. FGFR2 is rapidly ubiquitinated after autophosphorylation, leading to internalization and degradation. Subject to degradation both in lysosomes and by the proteasome.
  • Glycosylation at Asn83, Asn228, Asn123, Asn241, Asn265, Asn297, Asn318, and Asn331
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FGFR2_HUMAN (1997)

Antibody Products

  • Abcam antibodies for FGFR2
  • Boster Bio Antibodies for FGFR2
  • Santa Cruz Biotechnology (SCBT) Antibodies for FGFR2

Protein Products

  • Abcam proteins for FGFR2

Domains & Families for FGFR2 Gene

Gene Families for FGFR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FGFR2 Gene

GenScript: Design optimal peptide antigens:
  • Soluble FGFR2 variant 1 (B5A960_HUMAN)
  • Soluble FGFR2 variant 2 (B5A961_HUMAN)
  • Soluble FGFR2 variant 3 (B5A962_HUMAN)
  • Soluble FGFR4 variant 4 (B5A963_HUMAN)
  • Fibroblast growth factor receptor 2 (Bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome), isoform CRA_j (D3DRD3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21802

UniProtKB/Swiss-Prot:

FGFR2_HUMAN :
  • The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Alternative splicing events affecting the third Ig-like domain are crucial for ligand selectivity.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Domain:
  • The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. Alternative splicing events affecting the third Ig-like domain are crucial for ligand selectivity.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
genes like me logo Genes that share domains with FGFR2: view

Function for FGFR2 Gene

Molecular function for FGFR2 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255 PROSITE-ProRule:PRU10028, ECO:0000269 PubMed:16844695, ECO:0000269 PubMed:18056630, ECO:0000269 PubMed:19410646, ECO:0000269 PubMed:21454610};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by ARQ 523 and ARQ 069; these compounds maintain the kinase in an inactive conformation and inhibit autophosphorylation.
GENATLAS Biochemistry:
fibroblast growth factor receptor 2,involved in vertebral development

Enzyme Numbers (IUBMB) for FGFR2 Gene

Phenotypes From GWAS Catalog for FGFR2 Gene

Gene Ontology (GO) - Molecular Function for FGFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity NAS,IEA 1697263
GO:0004714 transmembrane receptor protein tyrosine kinase activity IBA,IEA 21873635
GO:0005007 fibroblast growth factor-activated receptor activity IEA,NAS 1400433
genes like me logo Genes that share ontologies with FGFR2: view
genes like me logo Genes that share phenotypes with FGFR2: view

Human Phenotype Ontology for FGFR2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FGFR2 Gene

MGI Knock Outs for FGFR2:

Animal Model Products

CRISPR Products

miRNA for FGFR2 Gene

Clone Products

  • Addgene plasmids for FGFR2

No data available for Transcription Factor Targets and HOMER Transcription for FGFR2 Gene

Localization for FGFR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR2 Gene

Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.
Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.
Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.
Isoform 14: Secreted.
Isoform 19: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFR2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
golgi apparatus 5
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FGFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IDA 16597614
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 16597614
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FGFR2: view

Pathways & Interactions for FGFR2 Gene

PathCards logo

SuperPathways for FGFR2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.62
.61
.60
.57
.57
3 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
4 PI3K/AKT activation
5 Downstream signaling of activated FGFR2
genes like me logo Genes that share pathways with FGFR2: view

Pathways by source for FGFR2 Gene

61 Qiagen pathways for FGFR2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
2 Cell Signaling Technology pathways for FGFR2 Gene

SIGNOR curated interactions for FGFR2 Gene

Activates:
Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for FGFR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II ISS --
GO:0000165 MAPK cascade TAS --
GO:0001525 angiogenesis ISS --
GO:0001657 ureteric bud development ISS --
GO:0001701 in utero embryonic development ISS --
genes like me logo Genes that share ontologies with FGFR2: view

Drugs & Compounds for FGFR2 Gene

(94) Drugs for FGFR2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palifermin Approved Pharma Target, binder 0
erdafitinib Approved, Investigational Pharma Target, inhibitor 0
Lenvatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 116
Nintedanib Approved Pharma Target, inhibitor VEGFR, FGFR, PDGFR, and FLT3 inhibitor, Kinase Inhibitors 139
Ponatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors, Fibroblast growth factor receptor (FGFR)inhibitors 53

(35) Additional Compounds for FGFR2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
cis,trans-5'-Hydroxythalidomide
  • 5'-OH-Thalidomide

(3) Tocris Compounds for FGFR2 Gene

Compound Action Cas Number
PD 161570 Selective FGFR inhibitor 192705-80-9
PD 173074 FGFR1 and -3 inhibitor 219580-11-7
SU 5402 Potent FGFR and VEGFR inhibitor 215543-92-3

(12) ApexBio Compounds for FGFR2 Gene

Compound Action Cas Number
ACTB-1003 939805-30-8
AZD4547 FGFR inhibitor 1035270-39-3
BGJ398 FGFR inhibitor ,potent and selective 872511-34-7
CH5183284 (Debio-1347) 1265229-25-1
Dovitinib (TKI258) Lactate Oral tyrosine kinase inhibitor (TKI) against FGFR1–3, VEGFR1–3, and platelet-derived growth factor receptor (PDGFR) 915769-50-5
LY2874455 FGF/FGFR Inhibitor 1254473-64-7
NVP-BGJ398 phosphate FGFR inhibitor 1310746-10-1
Pazopanib Hydrochloride VEGFR/PDGFR/FGFR/c-Kit/ c-Fms inhibitor 635702-64-6
PD 161570 192705-80-9
PD 173074 FGFR inhibitor 219580-11-7
Vandetanib (ZD6474) VEGFR2/EGFR antagonist 443913-73-3
XL228 IGF1R/AURORA /FGFR1-3/ABL/SRC family kinases inhibitor 898280-07-4
genes like me logo Genes that share compounds with FGFR2: view

Drug Products

Transcripts for FGFR2 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for FGFR2

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - -
SP6:
SP7:
SP8:
SP9:
SP10:

ExUns: 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FGFR2 Gene

GeneLoc Exon Structure for
FGFR2
ECgene alternative splicing isoforms for
FGFR2

Expression for FGFR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGFR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery