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Aliases for FGFR1OP2 Gene
Aliases for FGFR1OP2 Gene
External Ids for FGFR1OP2 Gene
- HGNC: 23098
- NCBI Entrez Gene: 26127
- Ensembl: ENSG00000111790
- OMIM®: 608858
- UniProtKB/Swiss-Prot: Q9NVK5
Previous GeneCards Identifiers for FGFR1OP2 Gene
- GC00U912750
- GC12P026983
- GC12P026984
- GC12P027091
- GC12P026861
Summaries for FGFR1OP2 Gene
GeneCards Summary for FGFR1OP2 Gene
FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8P11 Myeloproliferative Syndrome and Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities. Among its related pathways are HIV Life Cycle and FGFR1 mutant receptor activation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.
UniProtKB/Swiss-Prot Summary for FGFR1OP2 Gene
-
May be involved in wound healing pathway.
Additional gene information for FGFR1OP2 Gene
- HGNC (23098)
- NCBI Entrez Gene (26127)
- Ensembl (ENSG00000111790)
- OMIM® (608858)
- UniProtKB/Swiss-Prot (Q9NVK5)
- Open Targets Platform(ENSG00000111790)
- Search for FGFR1OP2 at DataMed
- Search for FGFR1OP2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGFR1OP2 Gene
Genomics for FGFR1OP2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FGFR1OP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGFR1OP2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGFR1OP2
- Top Transcription factor binding sites by QIAGEN in the FGFR1OP2 gene promoter:
-
- AML1a
- Egr-4
- Elk-1
- FAC1
- GATA-2
- HFH-1
- HNF-3beta
- HSF1 (long)
- HSF1short
- Nkx2-2
Genomic Locations for FGFR1OP2 Gene
Latest Assembly
- chr12:26,938,470-26,966,650
- (GRCh38/hg38)
- Size:
- 28,181 bases
- Orientation:
- Plus strand
Previous Assembly
- chr12:27,091,403-27,119,581
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 28,179 bases
- Orientation:
- Plus strand
- chr12:27,091,316-27,119,583
- (GRCh37/hg19 by Ensembl)
- Size:
- 28,268 bases
- Orientation:
- Plus strand
Genomic View for FGFR1OP2 Gene
Genes around FGFR1OP2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p11.23 by HGNC
- 12p11.23 by Entrez Gene
- 12p11.23 by Ensembl
FGFR1OP2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGFR1OP2 Gene
Proteins for FGFR1OP2 Gene
-
Protein details for FGFR1OP2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NVK5-FGOP2_HUMAN
- Recommended name:
- FGFR1 oncogene partner 2
- Protein Accession:
- Q9NVK5
- Q6R955
- Q8N5L7
- Q9P034
- Q9UFK8
Protein attributes for FGFR1OP2 Gene
- Size:
- 253 amino acids
- Molecular mass:
- 29426 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAF29087.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAB56012.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for FGFR1OP2 Gene
Post-translational modifications for FGFR1OP2 Gene
Other Protein References for FGFR1OP2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- Novus Biologicals Antibodies for FGFR1OP2
- Invitrogen Antibodies for FGFR1OP2 (AFLGC-FGFR1OP2)
-
Custom Antibody ServicesProSci Antibodies for FGFR1OP2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGFR1OP2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFR1OP2
- Origene Custom Protein Services for FGFR1OP2
- antibodies-online: Show 9 available FGFR1OP2 Proteins ranked by validation data
- Compare Top FGFR1OP2 Proteins
-
Quality Products:
-
Abcam proteins for FGFR1OP2
Assay products for research
- antibodies-online: Show 7 available FGFR1OP2 Elisa Kits ranked by validation data
- Compare Top FGFR1OP2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FGFR1OP2 Gene
Domains & Families for FGFR1OP2 Gene
Gene Families for FGFR1OP2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for FGFR1OP2 Gene
- GenScript: Design optimal peptide antigens:
-
- FGFR1 oncogene partner 2 (FGOP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NVK5- Family:
-
- Belongs to the SIKE family.
Function for FGFR1OP2 Gene
Molecular function for FGFR1OP2 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in wound healing pathway.
Phenotypes From GWAS Catalog for FGFR1OP2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0042802 | identical protein binding | IEA | -- |
Phenotypes for FGFR1OP2 Gene
- MGI mutant phenotypes for FGFR1OP2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FGFR1OP2:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FGFR1OP2 - Starting at $85 >
- * FGFR1OP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FGFR1OP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGFR1OP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFR1OP2
miRNA for FGFR1OP2 Gene
- miRTarBase miRNAs that target FGFR1OP2
-
- hsa-miR-361-5p (MIRT020087)
- mmu-miR-208a-5p (MIRT595351)
- mmu-miR-20a-5p (MIRT595352)
- mmu-miR-20b-5p (MIRT595353)
- mmu-miR-106a-5p (MIRT595354)
- mmu-miR-106b-5p (MIRT595355)
- mmu-miR-17-5p (MIRT595356)
- mmu-miR-93-5p (MIRT595357)
- mmu-miR-291b-3p (MIRT595358)
- mmu-miR-130a-3p (MIRT595359)
- mmu-miR-130b-3p (MIRT595360)
- mmu-miR-301b-3p (MIRT595361)
- mmu-miR-721 (MIRT595362)
- mmu-miR-301a-3p (MIRT595363)
- mmu-miR-19b-3p (MIRT595364)
- mmu-miR-19a-3p (MIRT595365)
- hsa-miR-6848-3p (MIRT633267)
- hsa-miR-6843-3p (MIRT633268)
- hsa-miR-3187-3p (MIRT633269)
- hsa-miR-588 (MIRT633270)
- hsa-miR-4701-5p (MIRT633271)
- hsa-miR-548s (MIRT633272)
- hsa-miR-519e-5p (MIRT633273)
- hsa-miR-515-5p (MIRT633274)
- hsa-miR-1200 (MIRT633275)
- hsa-miR-378a-5p (MIRT633276)
- hsa-miR-6131 (MIRT633277)
- hsa-miR-3663-5p (MIRT633278)
- hsa-miR-5695 (MIRT633279)
- hsa-miR-519d-5p (MIRT633280)
- hsa-miR-4716-5p (MIRT633281)
- hsa-miR-4781-3p (MIRT633282)
- hsa-miR-3156-3p (MIRT642699)
- hsa-miR-4284 (MIRT642700)
- hsa-miR-4772-3p (MIRT642701)
- hsa-miR-4638-5p (MIRT642702)
- hsa-miR-532-3p (MIRT642703)
- hsa-miR-1304-3p (MIRT642704)
- hsa-miR-6741-3p (MIRT642705)
- hsa-miR-4726-3p (MIRT642706)
- hsa-miR-6764-5p (MIRT642707)
- hsa-miR-1915-3p (MIRT642708)
- hsa-miR-6840-3p (MIRT642709)
- hsa-miR-4301 (MIRT642710)
- hsa-miR-6890-3p (MIRT642711)
- hsa-miR-711 (MIRT712707)
- hsa-miR-6859-3p (MIRT712708)
- hsa-miR-6756-3p (MIRT712709)
- hsa-miR-3127-3p (MIRT712710)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGFR1OP2
- Browse OriGene Inhibitory RNA Products For FGFR1OP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFR1OP2
Clone products for research
- Applied Biological Materials (abm): Clones for FGFR1OP2 - Starting at $45 >
- * FGFR1OP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202379
- MG224661
- MR202379
- MR202379L3
- MR202379L4
- MR224661
- MR224661L3
- MR224661L4
- RC218080
- RC218080L3
- RC218080L4
- RC229630
- RC229630L3
- RC229630L4
- RC229704
- RC229704L3
- RC229704L4
- RG218080
- RG229630
- RG229704
- RR209411
- RR209411L3
- RR209411L4
- MR202379L3V
- MR202379L4V
- MR224661L3V
- MR224661L4V
- RC218080L3V
- RC218080L4V
- RC229630L3V
- RC229630L4V
- RC229704L3V
- RC229704L4V
- RR209411L3V
- RR209411L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGFR1OP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGFR1OP2
Cell Lines for research
-
Horizon Cell Lines for FGFR1OP2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FGFR1OP2 Gene
Localization for FGFR1OP2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP2 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 4 |
| mitochondrion | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
- Mitochondria (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for FGFR1OP2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FGFR1 mutant receptor activation | ||
| 2 | HIV Life Cycle |
.45
|
|
| 3 | VEGF Signaling | ||
| 4 | Signaling by FGFR2 in disease | ||
Pathways by source for FGFR1OP2 Gene
6 Reactome pathways for FGFR1OP2 Gene
1 PharmGKB pathway for FGFR1OP2 Gene
Interacting Proteins for FGFR1OP2 Gene
Selected Interacting proteins:
Q9NVK5-FGOP2_HUMAN
ENSP00000229395
for FGFR1OP2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FGFR1OP2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009611 | response to wounding | IBA | 21873635 |
| GO:0042060 | wound healing | IEA | -- |
No data available for SIGNOR curated interactions for FGFR1OP2 Gene
Transcripts for FGFR1OP2 Gene
mRNA/cDNA for FGFR1OP2 Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000229395 2932 nts (view in UCSC)
- ENST00000327214 2790 nts (view in UCSC)
- ENST00000395941 865 nts (view in UCSC)
- ENST00000538172 2945 nts (view in UCSC)
- ENST00000544111 582 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FGFR1OP2 - Starting at $85 >
- * FGFR1OP2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FGFR1OP2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGFR1OP2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGFR1OP2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGFR1OP2
- Browse OriGene Inhibitory RNA Products For FGFR1OP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFR1OP2
Clone products for research
- Applied Biological Materials (abm): Clones for FGFR1OP2 - Starting at $45 >
- * FGFR1OP2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG202379
- MG224661
- MR202379
- MR202379L3
- MR202379L4
- MR224661
- MR224661L3
- MR224661L4
- RC218080
- RC218080L3
- RC218080L4
- RC229630
- RC229630L3
- RC229630L4
- RC229704
- RC229704L3
- RC229704L4
- RG218080
- RG229630
- RG229704
- RR209411
- RR209411L3
- RR209411L4
- MR202379L3V
- MR202379L4V
- MR224661L3V
- MR224661L4V
- RC218080L3V
- RC218080L4V
- RC229630L3V
- RC229630L4V
- RC229704L3V
- RC229704L4V
- RR209411L3V
- RR209411L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FGFR1OP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGFR1OP2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: |
Relevant External Links for FGFR1OP2 Gene
- GeneLoc Exon Structure for
- FGFR1OP2
Expression for FGFR1OP2 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (27.8), CD8 Tcells (7.8), and Platelet (6.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGFR1OP2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGFR1OP2
SOURCE GeneReport for Unigene cluster for FGFR1OP2 Gene:
Hs.591162mRNA Expression by UniProt/SwissProt for FGFR1OP2 Gene:
Q9NVK5-FGOP2_HUMAN
Tissue specificity:
Expressed in bone marrow, spleen and thymus.
Evidence on tissue expression from TISSUES for FGFR1OP2 Gene
- Nervous system(4.8)
- Blood(4.3)
- Liver(4.2)
- Bone marrow(2.6)
- Thyroid gland(2.1)
Primer products for research
-
OriGene qPCR primer pairs for FGFR1OP2
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFR1OP2 Gene
Orthologs for FGFR1OP2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FGFR1OP2 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | FGFR1OP2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FGFR1OP2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fgfr1op2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fgfr1op2 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FGFR1OP2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FGFR1OP2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FGFR1OP2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgfr1op2 30 |
|
||
| Str.19970 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC52963 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fgfr1op2 30 31 |
|
OneToOne | |
| wufj17h04 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2577 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012118 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG10158 30 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8091 31 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.7504 30 |
|
- Species where no ortholog for FGFR1OP2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FGFR1OP2 Gene
- ENSEMBL:
- Gene Tree for FGFR1OP2 (if available)
- TreeFam:
- Gene Tree for FGFR1OP2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FGFR1OP2: view image
Paralogs for FGFR1OP2 Gene
(1) SIMAP similar genes for FGFR1OP2 Gene using alignment to 2 proteins:
- FGOP2_HUMAN
- F5GX47_HUMAN
Pseudogenes.org Pseudogenes for FGFR1OP2 Gene
Variants for FGFR1OP2 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3892164 | CNV | loss | 25118596 |
| esv3892165 | CNV | loss | 25118596 |
| nsv557804 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.86;
17.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGFR1OP2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGFR1OP2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGFR1OP2 Gene
Disorders for FGFR1OP2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| 8p11 myeloproliferative syndrome |
|
|
| myeloid and lymphoid neoplasms associated with fgfr1 abnormalities |
|
|
| lymphoblastic lymphoma |
|
|
| myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 |
|
|
Search FGFR1OP2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FGOP2_HUMAN- Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.
Additional Disease Information for FGFR1OP2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for FGFR1OP2 Gene
Publications for FGFR1OP2 Gene
- Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. (PMID: 15034873) Grand EK … Cross NC (Genes, chromosomes & cancer 2004) 2 3 4 23
- Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. (PMID: 16946300) Gu TL … Polakiewicz RD (Blood 2006) 3 4 23
- A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4
ExternalLinks
Products for FGFR1OP2 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FGFR1OP2
- Origene Custom Protein Services for FGFR1OP2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGFR1OP2
- Browse OriGene Inhibitory RNA Products For FGFR1OP2
- OriGene qPCR primer pairs for FGFR1OP2
- OriGene CRISPR knockouts for FGFR1OP2
- MG202379
- MG224661
- MR202379
- MR202379L3
- MR202379L4
- MR224661
- MR224661L3
- MR224661L4
- RC218080
- RC218080L3
- RC218080L4
- RC229630
- RC229630L3
- RC229630L4
- RC229704
- RC229704L3
- RC229704L4
- RG218080
- RG229630
- RG229704
- RR209411
- RR209411L3
- RR209411L4
- MR202379L3V
- MR202379L4V
- MR224661L3V
- MR224661L4V
- RC218080L3V
- RC218080L4V
- RC229630L3V
- RC229630L4V
- RC229704L3V
- RC229704L4V
- RR209411L3V
- RR209411L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Novus Biologicals Antibodies for FGFR1OP2
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- Invitrogen Antibodies for FGFR1OP2 (AFLGC-FGFR1OP2)
- VectorBuilder Custom and pre-made DNA vectors for FGFR1OP2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FGFR1OP2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FGFR1OP2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FGFR1OP2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FGFR1OP2
- antibodies-online: Show 11 available FGFR1OP2 Antibodies ranked by validation data
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- antibodies-online: Show 7 available FGFR1OP2 Elisa Kits ranked by validation data
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- antibodies-online: Show 9 available FGFR1OP2 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for FGFR1OP2
- Search Santa Cruz Biotechnology (SCBT) for FGFR1OP2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FGFR1OP2
- Custom Antibody ServicesProSci Antibodies for FGFR1OP2
- Search for FGFR1OP2 Proteins at ProSci
- Horizon Cell Lines for FGFR1OP2
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGFR1OP2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGFR1OP2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FGFR1OP2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFR1OP2
Sources for FGFR1OP2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB