Aliases for FGFR1OP2 Gene

Aliases for FGFR1OP2 Gene

  • FGFR1 Oncogene Partner 2 2 3 4 5
  • Fibroblast Growth Factor Receptor 1 Oncogene Partner 2 3
  • Wound Inducible Transcript 3.0 3
  • DKFZp564O1863 2
  • HSPC123-Like 3
  • FGFR1OP2 5
  • WIT3.0 3

External Ids for FGFR1OP2 Gene

Previous GeneCards Identifiers for FGFR1OP2 Gene

  • GC00U912750
  • GC12P026983
  • GC12P026984
  • GC12P027091
  • GC12P026861

Summaries for FGFR1OP2 Gene

GeneCards Summary for FGFR1OP2 Gene

FGFR1OP2 (FGFR1 Oncogene Partner 2) is a Protein Coding gene. Diseases associated with FGFR1OP2 include 8P11 Myeloproliferative Syndrome and Myeloid And Lymphoid Neoplasms Associated With Fgfr1 Abnormalities. Among its related pathways are VEGF Signaling and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity. An important paralog of this gene is SIKE1.

UniProtKB/Swiss-Prot Summary for FGFR1OP2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGFR1OP2 Gene

Genomics for FGFR1OP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGFR1OP2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGFR1OP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGFR1OP2

Top Transcription factor binding sites by QIAGEN in the FGFR1OP2 gene promoter:
  • AML1a
  • Egr-4
  • Elk-1
  • FAC1
  • GATA-2
  • HFH-1
  • HNF-3beta
  • HSF1 (long)
  • HSF1short
  • Nkx2-2

Genomic Locations for FGFR1OP2 Gene

Latest Assembly
28,181 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
28,179 bases
Plus strand

(GRCh37/hg19 by Ensembl)
28,268 bases
Plus strand

Genomic View for FGFR1OP2 Gene

Genes around FGFR1OP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFR1OP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFR1OP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFR1OP2 Gene

Proteins for FGFR1OP2 Gene

  • Protein details for FGFR1OP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FGFR1 oncogene partner 2
    Protein Accession:
    Secondary Accessions:
    • Q6R955
    • Q8N5L7
    • Q9P034
    • Q9UFK8

    Protein attributes for FGFR1OP2 Gene

    253 amino acids
    Molecular mass:
    29426 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF29087.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAB56012.1; Type=Frameshift; Evidence={ECO:0000305};

    Alternative splice isoforms for FGFR1OP2 Gene


neXtProt entry for FGFR1OP2 Gene

Post-translational modifications for FGFR1OP2 Gene

  • Ubiquitination at Lys188 and Lys212
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFR1OP2 Gene

Antibodies for research

  • Boster Bio Antibodies for FGFR1OP2

No data available for DME Specific Peptides for FGFR1OP2 Gene

Domains & Families for FGFR1OP2 Gene

Gene Families for FGFR1OP2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for FGFR1OP2 Gene


Suggested Antigen Peptide Sequences for FGFR1OP2 Gene

GenScript: Design optimal peptide antigens:
  • FGFR1 oncogene partner 2 (FGOP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SIKE family.
  • Belongs to the SIKE family.
genes like me logo Genes that share domains with FGFR1OP2: view

Function for FGFR1OP2 Gene

Molecular function for FGFR1OP2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in wound healing pathway.

Phenotypes From GWAS Catalog for FGFR1OP2 Gene

Gene Ontology (GO) - Molecular Function for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view
genes like me logo Genes that share phenotypes with FGFR1OP2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFR1OP2

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FGFR1OP2 Gene

Localization for FGFR1OP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFR1OP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFR1OP2 gene
Compartment Confidence
cytosol 4
mitochondrion 2
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FGFR1OP2: view

Pathways & Interactions for FGFR1OP2 Gene

genes like me logo Genes that share pathways with FGFR1OP2: view

Pathways by source for FGFR1OP2 Gene

Gene Ontology (GO) - Biological Process for FGFR1OP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009611 response to wounding IBA 21873635
GO:0042060 wound healing IEA --
genes like me logo Genes that share ontologies with FGFR1OP2: view

No data available for SIGNOR curated interactions for FGFR1OP2 Gene

Drugs & Compounds for FGFR1OP2 Gene

No Compound Related Data Available

Transcripts for FGFR1OP2 Gene

mRNA/cDNA for FGFR1OP2 Gene

10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFR1OP2

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for FGFR1OP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for FGFR1OP2 Gene

GeneLoc Exon Structure for

Expression for FGFR1OP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGFR1OP2 Gene

Protein differential expression in normal tissues from HIPED for FGFR1OP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8), CD8 Tcells (7.8), and Platelet (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FGFR1OP2 Gene

Protein tissue co-expression partners for FGFR1OP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGFR1OP2

SOURCE GeneReport for Unigene cluster for FGFR1OP2 Gene:


mRNA Expression by UniProt/SwissProt for FGFR1OP2 Gene:

Tissue specificity: Expressed in bone marrow, spleen and thymus.

Evidence on tissue expression from TISSUES for FGFR1OP2 Gene

  • Nervous system(4.8)
  • Blood(4.3)
  • Liver(4.2)
  • Bone marrow(2.6)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with FGFR1OP2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFR1OP2 Gene

Orthologs for FGFR1OP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FGFR1OP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGFR1OP2 29 30
  • 99.87 (n)
(Monodelphis domestica)
Mammalia -- 30
  • 98 (a)
-- 30
  • 92 (a)
-- 30
  • 90 (a)
-- 30
  • 78 (a)
(Bos Taurus)
Mammalia FGFR1OP2 29 30
  • 93.96 (n)
(Canis familiaris)
Mammalia FGFR1OP2 29 30
  • 93.33 (n)
(Mus musculus)
Mammalia Fgfr1op2 29 16 30
  • 89.06 (n)
(Rattus norvegicus)
Mammalia Fgfr1op2 29
  • 88.67 (n)
(Ornithorhynchus anatinus)
Mammalia FGFR1OP2 30
  • 77 (a)
(Gallus gallus)
Aves FGFR1OP2 29 30
  • 82.02 (n)
(Anolis carolinensis)
Reptilia FGFR1OP2 30
  • 81 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fgfr1op2 29
  • 71.01 (n)
Str.19970 29
African clawed frog
(Xenopus laevis)
Amphibia MGC52963 29
(Danio rerio)
Actinopterygii fgfr1op2 29 30
  • 71.01 (n)
wufj17h04 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2577 29
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012118 29
  • 50.79 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG10158 29 30
  • 47.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8091 30
  • 39 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.7504 29
Species where no ortholog for FGFR1OP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGFR1OP2 Gene

Gene Tree for FGFR1OP2 (if available)
Gene Tree for FGFR1OP2 (if available)
Evolutionary constrained regions (ECRs) for FGFR1OP2: view image
Alliance of Genome Resources:
Additional Orthologs for FGFR1OP2

Paralogs for FGFR1OP2 Gene

Paralogs for FGFR1OP2 Gene

(1) SIMAP similar genes for FGFR1OP2 Gene using alignment to 2 proteins:

  • F5GX47_HUMAN Pseudogenes for FGFR1OP2 Gene

genes like me logo Genes that share paralogs with FGFR1OP2: view

Variants for FGFR1OP2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FGFR1OP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FGFR1OP2 Gene

Variant ID Type Subtype PubMed ID
esv3892164 CNV loss 25118596
esv3892165 CNV loss 25118596
nsv557804 CNV loss 21841781

Variation tolerance for FGFR1OP2 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 17.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGFR1OP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGFR1OP2 Gene

Disorders for FGFR1OP2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FGFR1OP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
8p11 myeloproliferative syndrome
  • 8p11 stem cell leukemia/lymphoma syndrome
myeloid and lymphoid neoplasms associated with fgfr1 abnormalities
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1
  • myeloid and lymphoid neoplasms with eosinophilia and abnormalities of platelet-derived growth factor receptor alpha , platelet-derived growth factor receptor beta , and fibroblast growth factor receptor-1 are a group of hematologic neoplasms
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving FGFR1OP2 may be a cause of stem cell myeloproliferative disorder (MPD). Insertion ins(12;8)(p11;p11p22) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein FGFR1OP2-FGFR1 may exhibit constitutive kinase activity and be responsible for the transforming activity.

Additional Disease Information for FGFR1OP2

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FGFR1OP2: view

No data available for Genatlas for FGFR1OP2 Gene

Publications for FGFR1OP2 Gene

  1. Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. (PMID: 15034873) Grand EK … Cross NC (Genes, chromosomes & cancer 2004) 2 3 4 22
  2. Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. (PMID: 16946300) Gu TL … Polakiewicz RD (Blood 2006) 3 4 22
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 40
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang QH … Chen Z (Genome research 2000) 3 4

Products for FGFR1OP2 Gene

Sources for FGFR1OP2 Gene