Aliases for FGFBP3 Gene

Aliases for FGFBP3 Gene

  • Fibroblast Growth Factor Binding Protein 3 2 3 5
  • Fibroblast Growth Factor-Binding Protein 3 3 4
  • FGF-Binding Protein 3 3 4
  • C10orf13 3 4
  • FGF-BP3 3 4
  • FGFBP-3 3 4
  • Chromosome 10 Open Reading Frame 13 2
  • MGC39320 2
  • FGFBP3 5

External Ids for FGFBP3 Gene

Previous HGNC Symbols for FGFBP3 Gene

  • C10orf13

Previous GeneCards Identifiers for FGFBP3 Gene

  • GC10M093657
  • GC10M087295

Summaries for FGFBP3 Gene

GeneCards Summary for FGFBP3 Gene

FGFBP3 (Fibroblast Growth Factor Binding Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include heparin binding and fibroblast growth factor binding. An important paralog of this gene is FGFBP1.

UniProtKB/Swiss-Prot Summary for FGFBP3 Gene

  • Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.

Additional gene information for FGFBP3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGFBP3 Gene

Genomics for FGFBP3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGFBP3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGFBP3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGFBP3

Top Transcription factor binding sites by QIAGEN in the FGFBP3 gene promoter:
  • aMEF-2
  • ATF
  • E47
  • MEF-2A
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • TBP

Genomic Locations for FGFBP3 Gene

Genomic Locations for FGFBP3 Gene
chr10:91,906,584-91,909,486
(GRCh38/hg38)
Size:
2,903 bases
Orientation:
Minus strand
chr10:93,666,345-93,669,258
(GRCh37/hg19)
Size:
2,914 bases
Orientation:
Minus strand

Genomic View for FGFBP3 Gene

Genes around FGFBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP3 Gene

Proteins for FGFBP3 Gene

  • Protein details for FGFBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAT2-FGFP3_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 3
    Protein Accession:
    Q8TAT2
    Secondary Accessions:
    • B2RD68
    • Q8NBN0

    Protein attributes for FGFBP3 Gene

    Size:
    258 amino acids
    Molecular mass:
    27590 Da
    Quaternary structure:
    • Interacts with FGF2.

neXtProt entry for FGFBP3 Gene

Post-translational modifications for FGFBP3 Gene

  • Glycosylation at Thr158
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGFBP3 Gene

Domains & Families for FGFBP3 Gene

Gene Families for FGFBP3 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FGFBP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGFBP3 Gene

GenScript: Design optimal peptide antigens:
  • Fibroblast growth factor-binding protein 3 (FGFP3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TAT2

UniProtKB/Swiss-Prot:

FGFP3_HUMAN :
  • Belongs to the fibroblast growth factor-binding protein family.
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP3: view

Function for FGFBP3 Gene

Molecular function for FGFBP3 Gene

UniProtKB/Swiss-Prot Function:
Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability.

Phenotypes From GWAS Catalog for FGFBP3 Gene

Gene Ontology (GO) - Molecular Function for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008201 heparin binding IDA 18669637
GO:0017134 fibroblast growth factor binding IPI 18669637
GO:0019838 growth factor binding IEA,IBA 21873635
genes like me logo Genes that share ontologies with FGFBP3: view
genes like me logo Genes that share phenotypes with FGFBP3: view

Animal Models for FGFBP3 Gene

MGI Knock Outs for FGFBP3:

Animal Model Products

  • Taconic Biosciences Mouse Models for FGFBP3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFBP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFBP3 Gene

Localization for FGFBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFBP3 gene
Compartment Confidence
extracellular 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IDA 18669637
GO:0062023 collagen-containing extracellular matrix HDA 23658023
genes like me logo Genes that share ontologies with FGFBP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGFBP3 Gene

Pathways & Interactions for FGFBP3 Gene

genes like me logo Genes that share pathways with FGFBP3: view

Interacting Proteins for FGFBP3 Gene

Gene Ontology (GO) - Biological Process for FGFBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IBA 21873635
GO:0043117 positive regulation of vascular permeability IDA 18669637
GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway IGI 18669637
genes like me logo Genes that share ontologies with FGFBP3: view

No data available for SIGNOR curated interactions for FGFBP3 Gene

Drugs & Compounds for FGFBP3 Gene

No Compound Related Data Available

Transcripts for FGFBP3 Gene

mRNA/cDNA for FGFBP3 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFBP3

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP3 Gene

No ASD Table

Relevant External Links for FGFBP3 Gene

GeneLoc Exon Structure for
FGFBP3

Expression for FGFBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGFBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGFBP3 Gene

This gene is overexpressed in Fetal gut (32.4), Heart (20.9), and Fetal Brain (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFBP3 Gene



Protein tissue co-expression partners for FGFBP3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGFBP3

SOURCE GeneReport for Unigene cluster for FGFBP3 Gene:

Hs.466120

Evidence on tissue expression from TISSUES for FGFBP3 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with FGFBP3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP3 Gene

Orthologs for FGFBP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGFBP3 30 31
  • 99.1 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FGFBP3 30 31
  • 82.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FGFBP3 30 31
  • 81.82 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgfbp3 30
  • 73.58 (n)
Mouse
(Mus musculus)
Mammalia Fgfbp3 30 17 31
  • 70.97 (n)
OneToOne
Chicken
(Gallus gallus)
Aves FGFBP3 30
  • 63.04 (n)
Lizard
(Anolis carolinensis)
Reptilia FGFBP3 31
  • 35 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fgfbp3 30
  • 44.85 (n)
Zebrafish
(Danio rerio)
Actinopterygii zgc:165461 30
  • 47.81 (n)
FGFBP3 31
  • 23 (a)
OneToOne
Species where no ortholog for FGFBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGFBP3 Gene

ENSEMBL:
Gene Tree for FGFBP3 (if available)
TreeFam:
Gene Tree for FGFBP3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGFBP3: view image

Paralogs for FGFBP3 Gene

Paralogs for FGFBP3 Gene

genes like me logo Genes that share paralogs with FGFBP3: view

Variants for FGFBP3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGFBP3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10881994 - p.Ala107Thr
rs1107947 - p.Glu206Val

Additional dbSNP identifiers (rs#s) for FGFBP3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FGFBP3 Gene

Variant ID Type Subtype PubMed ID
esv22161 CNV loss 19812545
nsv551921 CNV gain 21841781
nsv551922 CNV loss 21841781
nsv7491 CNV deletion 18451855

Variation tolerance for FGFBP3 Gene

Gene Damage Index Score: 5.70; 73.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGFBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP3 Gene

Disorders for FGFBP3 Gene

No disorders were found for FGFBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FGFBP3 Gene

Publications for FGFBP3 Gene

  1. Effect of FGF-binding protein 3 on vascular permeability. (PMID: 18669637) Zhang W … Wellstein A (The Journal of biological chemistry 2008) 3 4
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  5. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. (PMID: 23658023) Soteriou D … Kimber SJ (The Journal of biological chemistry 2013) 3

Products for FGFBP3 Gene

Sources for FGFBP3 Gene