This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008] See more...

Aliases for FGFBP2 Gene

Aliases for FGFBP2 Gene

  • Fibroblast Growth Factor Binding Protein 2 2 3 5
  • KSP37 2 3 4
  • Killer-Specific Secretory Protein Of 37 KDa 2 3
  • Fibroblast Growth Factor-Binding Protein 2 3 4
  • 37 KDa Killer-Specific Secretory Protein 3 4
  • FGF-Binding Protein 2 3 4
  • HBp17-Related Protein 3 4
  • HBp17-RP 3 4
  • FGF-BP2 3 4
  • FGFBP-2 3 4
  • HBP17RP 3
  • FGFBP2 5
  • Ksp37 4

External Ids for FGFBP2 Gene

Previous GeneCards Identifiers for FGFBP2 Gene

  • GC04M015571
  • GC04M015311

Summaries for FGFBP2 Gene

Entrez Gene Summary for FGFBP2 Gene

  • This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]

GeneCards Summary for FGFBP2 Gene

FGFBP2 (Fibroblast Growth Factor Binding Protein 2) is a Protein Coding gene. Diseases associated with FGFBP2 include Intracranial Abscess and Asthma. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include growth factor binding. An important paralog of this gene is FGFBP1.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGFBP2 Gene

Genomics for FGFBP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGFBP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J015960 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE 274.7 +6.9 6905 2.9 CTCF SMC3 RAD21 BHLHE40 IKZF1 ZNF143 IKZF2 RAD51 MTA2 ZBTB33 FGFBP2 lnc-FGFBP2-1 lnc-CD38-5 HSALNG0033078 FGFBP1 PROM1
GH04J015904 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 15.8 +62.9 62877 4 POLR2A YY1 CTCF CEBPB MAX EP300 FOXA2 PRDM1 RFX5 TCF7L2 lnc-CD38-12 FGFBP1 FGFBP2 PROM1 CD38 FBXL5 BST1 HSALNG0033073
GH04J015919 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +49.2 49223 4.6 JUND ZNF10 NFIC CEBPB EP300 CUX1 STAT3 INSM2 MAFK ZNF24 HSALNG0033076 FGFBP2 PROM1 FGFBP1 HSALNG0033075 lnc-CD38-4 CD38
GH04J015771 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +197.8 197828 1.4 IRF4 EBF1 BHLHE40 BATF IKZF1 MTA3 ATF2 JUNB PKNOX1 KLF5 CD38 FGFBP2 PROM1 FBXL5 HSALNG0033065 piR-32214-519 BST1
GH04J015944 Enhancer 0.3 Ensembl 34.1 +23.7 23708 1.6 MAX POLR2A HSALNG0033077-001 FGFBP2 PROM1 FGFBP1 HSALNG0033078
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGFBP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGFBP2

Top Transcription factor binding sites by QIAGEN in the FGFBP2 gene promoter:
  • AP-1
  • CUTL1
  • FOXI1
  • HFH-3
  • Msx-1
  • POU3F1
  • SRY
  • TBP
  • TFIID

Genomic Locations for FGFBP2 Gene

Latest Assembly
chr4:15,960,245-15,969,309
(GRCh38/hg38)
Size:
9,065 bases
Orientation:
Minus strand

Previous Assembly
chr4:15,961,868-15,964,798
(GRCh37/hg19 by Entrez Gene)
Size:
2,931 bases
Orientation:
Minus strand

chr4:15,961,866-15,970,932
(GRCh37/hg19 by Ensembl)
Size:
9,067 bases
Orientation:
Minus strand

Genomic View for FGFBP2 Gene

Genes around FGFBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP2 Gene

Proteins for FGFBP2 Gene

  • Protein details for FGFBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYJ0-FGFP2_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 2
    Protein Accession:
    Q9BYJ0

    Protein attributes for FGFBP2 Gene

    Size:
    223 amino acids
    Molecular mass:
    24581 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FGFBP2 Gene

Post-translational modifications for FGFBP2 Gene

  • Glycosylation at Ser136, Thr147, Ser149, Thr155, Thr159, and Thr162
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGFBP2 Gene

Domains & Families for FGFBP2 Gene

Gene Families for FGFBP2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for FGFBP2 Gene

InterPro:

Suggested Antigen Peptide Sequences for FGFBP2 Gene

GenScript: Design optimal peptide antigens:
  • HBp17-related protein (FGFP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYJ0

UniProtKB/Swiss-Prot:

FGFP2_HUMAN :
  • Belongs to the fibroblast growth factor-binding protein family.
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP2: view

Function for FGFBP2 Gene

Phenotypes From GWAS Catalog for FGFBP2 Gene

Gene Ontology (GO) - Molecular Function for FGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0019838 growth factor binding IBA 21873635
genes like me logo Genes that share ontologies with FGFBP2: view
genes like me logo Genes that share phenotypes with FGFBP2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFBP2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FGFBP2 Gene

Localization for FGFBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP2 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFBP2 gene
Compartment Confidence
extracellular 4
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for FGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with FGFBP2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGFBP2 Gene

Pathways & Interactions for FGFBP2 Gene

genes like me logo Genes that share pathways with FGFBP2: view

Interacting Proteins for FGFBP2 Gene

Gene Ontology (GO) - Biological Process for FGFBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007267 cell-cell signaling IBA 21873635
genes like me logo Genes that share ontologies with FGFBP2: view

No data available for SIGNOR curated interactions for FGFBP2 Gene

Drugs & Compounds for FGFBP2 Gene

No Compound Related Data Available

Transcripts for FGFBP2 Gene

mRNA/cDNA for FGFBP2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFBP2

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP2 Gene

No ASD Table

Relevant External Links for FGFBP2 Gene

GeneLoc Exon Structure for
FGFBP2

Expression for FGFBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGFBP2 Gene

mRNA differential expression in normal tissues according to GTEx for FGFBP2 Gene

This gene is overexpressed in Whole Blood (x15.6) and Nerve - Tibial (x13.0).

Protein differential expression in normal tissues from HIPED for FGFBP2 Gene

This gene is overexpressed in Synovial fluid (52.5) and Monocytes (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFBP2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGFBP2

SOURCE GeneReport for Unigene cluster for FGFBP2 Gene:

Hs.98785

mRNA Expression by UniProt/SwissProt for FGFBP2 Gene:

Q9BYJ0-FGFP2_HUMAN
Tissue specificity: Expressed in serum, peripheral leukocytes and cytotoxic T-lymphocytes, but not in granulocytes and monocytes (at protein level).

Evidence on tissue expression from TISSUES for FGFBP2 Gene

  • Blood(4.4)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with FGFBP2: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP2 Gene

Orthologs for FGFBP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGFBP2 29 30
  • 98.65 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FGFBP2 30
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FGFBP2 29 30
  • 54.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FGFBP2 30
  • 40 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fgfbp2 29
  • 47.97 (n)
Zebrafish
(Danio rerio)
Actinopterygii fgfbp2b 29 30
  • 49.75 (n)
OneToMany
fgfbp2a 30
  • 26 (a)
OneToMany
Species where no ortholog for FGFBP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGFBP2 Gene

ENSEMBL:
Gene Tree for FGFBP2 (if available)
TreeFam:
Gene Tree for FGFBP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGFBP2: view image
Alliance of Genome Resources:
Additional Orthologs for FGFBP2

Paralogs for FGFBP2 Gene

Paralogs for FGFBP2 Gene

genes like me logo Genes that share paralogs with FGFBP2: view

Variants for FGFBP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGFBP2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs2286459 -- p.Phe84Leu
rs35496730 -- p.Ser28Asn
rs758329 -- p.Pro90Ser

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FGFBP2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FGFBP2 Gene

Variant ID Type Subtype PubMed ID
nsv527861 CNV gain 19592680

Variation tolerance for FGFBP2 Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.11; 80.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGFBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFBP2
Leiden Open Variation Database (LOVD)
FGFBP2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP2 Gene

Disorders for FGFBP2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FGFBP2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
intracranial abscess
asthma
  • asthma, susceptibility to
moyamoya disease 1
  • mymy1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FGFBP2

genes like me logo Genes that share disorders with FGFBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGFBP2 Gene

Publications for FGFBP2 Gene

  1. A novel serum protein that is selectively produced by cytotoxic lymphocytes. (PMID: 11342666) Ogawa K … Nagata K (Journal of immunology (Baltimore, Md. : 1950) 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4
  4. Accumulation of CD16+ cells with secretion of Ksp37 in decidua at the end of pregnancy. (PMID: 12322897) Hayano C … Aso T (American journal of reproductive immunology (New York, N.Y. : 1989) 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for FGFBP2 Gene

Sources for FGFBP2 Gene