This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this g... See more...

Aliases for FGFBP1 Gene

Aliases for FGFBP1 Gene

  • Fibroblast Growth Factor Binding Protein 1 2 3 5
  • FGFBP 2 3 4
  • HBP17 2 3 4
  • 17 KDa Heparin-Binding Growth Factor-Binding Protein 3 4
  • Fibroblast Growth Factor-Binding Protein 1 3 4
  • 17 KDa HBGF-Binding Protein 3 4
  • FGF-Binding Protein 1 3 4
  • FGF-BP1 3 4
  • FGFBP-1 3 4
  • FGF-BP 3 4
  • Heparin-Binding Growth Factor Binding Protein 3
  • FGFBP1 5
  • HBp17 4

External Ids for FGFBP1 Gene

Previous GeneCards Identifiers for FGFBP1 Gene

  • GC04M015689
  • GC04M015613
  • GC04M015546
  • GC04M015286

Summaries for FGFBP1 Gene

Entrez Gene Summary for FGFBP1 Gene

  • This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

GeneCards Summary for FGFBP1 Gene

FGFBP1 (Fibroblast Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with FGFBP1 include Colorectal Adenocarcinoma. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include heparin binding and fibroblast growth factor binding. An important paralog of this gene is FGFBP3.

UniProtKB/Swiss-Prot Summary for FGFBP1 Gene

  • Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.

Gene Wiki entry for FGFBP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGFBP1 Gene

Genomics for FGFBP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGFBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J015936 Promoter/Enhancer 1 Ensembl ENCODE dbSUPER 261.7 +1.1 1113 2.9 KLF9 PRDM1 GLIS1 KLF1 EP300 SCRT2 FGFBP1 FGFBP2 PROM1 HSALNG0033076 CD38
GH04J015904 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 16.1 +32.3 32308 4 POLR2A YY1 CTCF CEBPB MAX EP300 FOXA2 PRDM1 RFX5 TCF7L2 lnc-CD38-12 FGFBP1 FGFBP2 PROM1 CD38 FBXL5 BST1 HSALNG0033073
GH04J015919 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.2 +18.7 18654 4.6 JUND ZNF10 NFIC CEBPB EP300 CUX1 STAT3 INSM2 MAFK ZNF24 HSALNG0033076 FGFBP2 PROM1 FGFBP1 HSALNG0033075 lnc-CD38-4 CD38
GH04J015897 Enhancer 0.4 Ensembl dbSUPER 12.4 +40.8 40839 0.6 EP300 FGFBP1 FGFBP2 PROM1 lnc-CD38-12 HSALNG0033072 HSALNG0033073 CD38
GH04J015898 Enhancer 0.4 Ensembl dbSUPER 12.2 +39.7 39739 1.2 EP300 FGFBP1 FGFBP2 PROM1 lnc-CD38-12 HSALNG0033072 HSALNG0033073 CD38
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGFBP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGFBP1

Top Transcription factor binding sites by QIAGEN in the FGFBP1 gene promoter:
  • AREB6
  • Cdc5
  • CUTL1
  • E47
  • HOXA5
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • RP58

Genomic Locations for FGFBP1 Gene

Latest Assembly
chr4:15,935,577-15,938,740
(GRCh38/hg38)
Size:
3,164 bases
Orientation:
Minus strand

Previous Assembly
chr4:15,937,200-15,940,363
(GRCh37/hg19 by Entrez Gene)
Size:
3,164 bases
Orientation:
Minus strand

chr4:15,937,192-15,940,363
(GRCh37/hg19 by Ensembl)
Size:
3,172 bases
Orientation:
Minus strand

Genomic View for FGFBP1 Gene

Genes around FGFBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGFBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGFBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGFBP1 Gene

Proteins for FGFBP1 Gene

  • Protein details for FGFBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14512-FGFP1_HUMAN
    Recommended name:
    Fibroblast growth factor-binding protein 1
    Protein Accession:
    Q14512
    Secondary Accessions:
    • A8K5J2

    Protein attributes for FGFBP1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26264 Da
    Quaternary structure:
    • Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGF1, FGF2, FGF7, FGF10, FGF22 and HSPG2.
    Miscellaneous:
    • Expression is significantly up-regulated in carcinogen-induced skin tumors, various squamous cell carcinomas, some colon cancer cell lines and tumors.

neXtProt entry for FGFBP1 Gene

Post-translational modifications for FGFBP1 Gene

  • Glycosylation at Ser37, Thr46, Thr73, Ser169, Thr179, Thr180, Ser182, Thr187, Thr189, and Thr192
  • Modification sites at PhosphoSitePlus

Other Protein References for FGFBP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGFBP1 Gene

Domains & Families for FGFBP1 Gene

Gene Families for FGFBP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for FGFBP1 Gene

InterPro:

Suggested Antigen Peptide Sequences for FGFBP1 Gene

GenScript: Design optimal peptide antigens:
  • 17 kDa heparin-binding growth factor-binding protein (FGFP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14512

UniProtKB/Swiss-Prot:

FGFP1_HUMAN :
  • Belongs to the fibroblast growth factor-binding protein family.
Family:
  • Belongs to the fibroblast growth factor-binding protein family.
genes like me logo Genes that share domains with FGFBP1: view

Function for FGFBP1 Gene

Molecular function for FGFBP1 Gene

UniProtKB/Swiss-Prot Function:
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.
UniProtKB/Swiss-Prot Induction:
Up-regulated in epithelial cells after skin injury. Keratinocyte mitogens.

Phenotypes From GWAS Catalog for FGFBP1 Gene

Gene Ontology (GO) - Molecular Function for FGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16257968
GO:0008201 heparin binding TAS 1885605
GO:0017134 fibroblast growth factor binding IEA --
GO:0019838 growth factor binding IBA 21873635
genes like me logo Genes that share ontologies with FGFBP1: view
genes like me logo Genes that share phenotypes with FGFBP1: view

Animal Models for FGFBP1 Gene

MGI Knock Outs for FGFBP1:

Animal Models for research

  • Taconic Biosciences Mouse Models for FGFBP1

miRNA for FGFBP1 Gene

miRTarBase miRNAs that target FGFBP1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFBP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGFBP1 Gene

Localization for FGFBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGFBP1 Gene

Secreted, extracellular space. Cell membrane. Peripheral membrane protein. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. {ECO:0000269 PubMed:11148217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGFBP1 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FGFBP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGFBP1 Gene

Pathways & Interactions for FGFBP1 Gene

genes like me logo Genes that share pathways with FGFBP1: view

Gene Ontology (GO) - Biological Process for FGFBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 1885605
GO:0007267 cell-cell signaling TAS,IBA 21873635
GO:0008284 positive regulation of cell proliferation IEA --
GO:0008285 negative regulation of cell proliferation TAS 1885605
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FGFBP1: view

No data available for SIGNOR curated interactions for FGFBP1 Gene

Drugs & Compounds for FGFBP1 Gene

(1) Drugs for FGFBP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma 1160

(2) Additional Compounds for FGFBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGFBP1: view

Transcripts for FGFBP1 Gene

mRNA/cDNA for FGFBP1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGFBP1

Alternative Splicing Database (ASD) splice patterns (SP) for FGFBP1 Gene

No ASD Table

Relevant External Links for FGFBP1 Gene

GeneLoc Exon Structure for
FGFBP1

Expression for FGFBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGFBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGFBP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x17.3), Minor Salivary Gland (x16.8), Vagina (x6.1), and Cervix - Ectocervix (x4.9).

Protein differential expression in normal tissues from HIPED for FGFBP1 Gene

This gene is overexpressed in Lavage (36.8) and Milk (29.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGFBP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGFBP1

SOURCE GeneReport for Unigene cluster for FGFBP1 Gene:

Hs.1690

mRNA Expression by UniProt/SwissProt for FGFBP1 Gene:

Q14512-FGFP1_HUMAN
Tissue specificity: Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.

Evidence on tissue expression from TISSUES for FGFBP1 Gene

  • Pancreas(4.2)
  • Lung(2.7)
  • Stomach(2.5)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with FGFBP1: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGFBP1 Gene

Orthologs for FGFBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGFBP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGFBP1 29 30
  • 98.58 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC488818 29
  • 73.68 (n)
FGFBP1 30
  • 54 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FGFBP1 29 30
  • 73.3 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fgfbp1 29 16 30
  • 72.99 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgfbp1 29
  • 71.43 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia FGFBP1 30
  • 39 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FGFBP1 30
  • 36 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FGFBP1 30
  • 32 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii fgfbp1 30 30
  • 26 (a)
OneToMany
Species where no ortholog for FGFBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGFBP1 Gene

ENSEMBL:
Gene Tree for FGFBP1 (if available)
TreeFam:
Gene Tree for FGFBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGFBP1: view image
Alliance of Genome Resources:
Additional Orthologs for FGFBP1

Paralogs for FGFBP1 Gene

Paralogs for FGFBP1 Gene

Pseudogenes.org Pseudogenes for FGFBP1 Gene

genes like me logo Genes that share paralogs with FGFBP1: view

Variants for FGFBP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGFBP1 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs76765884 Benign: not provided 15,936,367(-) T/A
NM_005130.5(FGFBP1):c.266A>T (p.Asp89Val)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FGFBP1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FGFBP1 Gene

Variant ID Type Subtype PubMed ID
esv3599744 CNV gain 21293372
nsv527861 CNV gain 19592680
nsv593769 CNV gain 21841781

Variation tolerance for FGFBP1 Gene

Residual Variation Intolerance Score: 75.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGFBP1 Gene

Human Gene Mutation Database (HGMD)
FGFBP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGFBP1
Leiden Open Variation Database (LOVD)
FGFBP1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGFBP1 Gene

Disorders for FGFBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FGFBP1 Gene - From: GCD

Disorder Aliases PubMed IDs
colorectal adenocarcinoma
  • adenocarcinoma of large intestine
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FGFBP1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FGFBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGFBP1 Gene

Publications for FGFBP1 Gene

  1. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. (PMID: 16257968) Xie B … Wellstein A (The Journal of biological chemistry 2006) 3 4 22
  2. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PMID: 15806171) Beer HD … Werner S (Oncogene 2005) 3 4 22
  3. Fibroblast growth factor-binding protein is a novel partner for perlecan protein core. (PMID: 11148217) Mongiat M … Iozzo RV (The Journal of biological chemistry 2001) 2 3 4
  4. A secreted FGF-binding protein can serve as the angiogenic switch in human cancer. (PMID: 9334727) Czubayko F … Wellstein A (Nature medicine 1997) 3 4 22
  5. Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors. (PMID: 1885605) Wu DQ … Sato JD (The Journal of biological chemistry 1991) 2 3 4

Products for FGFBP1 Gene

Sources for FGFBP1 Gene