Aliases for FGFBP1 Gene
External Ids for FGFBP1 Gene
Previous GeneCards Identifiers for FGFBP1 Gene
This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]
GeneCards Summary for FGFBP1 Gene
FGFBP1 (Fibroblast Growth Factor Binding Protein 1) is a Protein Coding gene. Diseases associated with FGFBP1 include Colorectal Adenocarcinoma. Among its related pathways are Signaling by FGFR2 and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include heparin binding and fibroblast growth factor binding. An important paralog of this gene is FGFBP3.
UniProtKB/Swiss-Prot Summary for FGFBP1 Gene
Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth.