Aliases for FGF9 Gene
Aliases for FGF9 Gene
External Ids for FGF9 Gene
- HGNC: 3687
- Entrez Gene: 2254
- Ensembl: ENSG00000102678
- OMIM: 600921
- UniProtKB: P31371
Previous GeneCards Identifiers for FGF9 Gene
- GC13P020225
- GC13P016225
- GC13P021175
- GC13P020044
- GC13P020045
- GC13P021144
- GC13P022245
- GC13P003046
Summaries for FGF9 Gene
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF9 Gene
FGF9 (Fibroblast Growth Factor 9) is a Protein Coding gene. Diseases associated with FGF9 include Multiple Synostoses Syndrome 3 and Multiple Synostoses Syndrome. Among its related pathways are Downstream signaling of activated FGFR2 and Development FGFR signaling pathway. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF20.
UniProtKB/Swiss-Prot for FGF9 Gene
-
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Additional gene information for FGF9 Gene
- Monarch Initiative
- Search for FGF9 at DataMed
- Search for FGF9 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF9 Gene
Genomics for FGF9 Gene
GeneHancer (GH) Regulatory Elements for FGF9 Gene
Promoters and enhancers for FGF9 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH13J021668 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE | 653.4 | +2.1 | 2085 | 8.8 | PKNOX1 ARNT SIN3A GLI4 ZNF48 YY1 GLIS2 ZNF207 ZNF143 ZFP91 | FGF9 SKA3 RN7SL766P | |
| GH13J021635 | Enhancer | 1 | Ensembl ENCODE | 11.5 | -33.9 | -33870 | 3.1 | ZFP64 ZBTB40 RAD21 SCRT2 ZNF143 FOS ZNF654 REST ZFP69B NFIC | FGF9 MICU2 RPS7P10 | |
| GH13J021638 | Enhancer | 0.5 | ENCODE | 11.5 | -32.0 | -32045 | 0.5 | CTCF PRDM4 ZNF18 SP7 SPI1 ZNF558 | FGF9 RPS7P10 | |
| GH13J021682 | Enhancer | 0.5 | ENCODE | 0.4 | +12.2 | 12232 | 1.3 | ZNF366 ZNF629 PRDM10 FOS ZIC2 SP7 | FGF9 RN7SL766P | |
| GH13J021749 | Enhancer | 0.3 | ENCODE | 0.2 | +78.5 | 78531 | 0.2 | FOS | RN7SL766P FGF9 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGF9 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FGF9 gene promoter:
-
- Max1
- c-Myc
- Nkx2-5
- Pax-5
- E47
- Tal-1
- POU2F1
- POU2F1a
- HNF-4alpha1
Regulatory Element Products
Genomic Locations for FGF9 Gene
Genomic Locations for FGF9 Gene
- chr13:21,671,076-21,704,501
- (GRCh38/hg38)
- Size:
- 33,426 bases
- Orientation:
- Plus strand
- chr13:22,245,215-22,278,640
- (GRCh37/hg19)
- Size:
- 33,426 bases
- Orientation:
- Plus strand
Genomic View for FGF9 Gene
Genes around FGF9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q12.11 by Entrez Gene
- 13q12.11 by HGNC
- 13q12.11 by Ensembl
FGF9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF9 Gene
Proteins for FGF9 Gene
-
Protein details for FGF9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31371-FGF9_HUMAN
- Recommended name:
- Fibroblast growth factor 9
- Protein Accession:
- P31371
- A8K427
- Q3SY32
Protein attributes for FGF9 Gene
- Size:
- 208 amino acids
- Molecular mass:
- 23441 Da
- Quaternary structure:
-
- Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
- Miscellaneous:
-
- Biochemical analysis of the Asn-99 mutation reveals a significantly impaired FGF signaling, as evidenced by diminished activity of the MAPK1/MAPK2 pathway and decreases CTNNB1 and MYC expression when compared with wild-type protein. Binding of mutant protein to the receptor FGFR3 is severely impaired, although homodimerization of mutant to itself or wild-type is not detectably affected, providing a basis for the observed defective FGF9 signaling.
Post-translational modifications for FGF9 Gene
- Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
- N-glycosylated.
- Glycosylation at Asn79
- Modification sites at PhosphoSitePlus
Other Protein References for FGF9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FGF9 (FGF-9)
- Novus Biologicals Antibodies for FGF9
-
Abcam antibodies for FGF9
- Invitrogen Antibodies for FGF9 (AFLGC-FGF9)
- antibodies-online: Search results for available Fgf9 related products ranked by validation data
- GeneTex FGF9 Antibody for FGF9
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGF9
- Sino Biological Antibodies for FGF9
Protein Products
- R&D Systems Proteins and Enzymes for FGF9 (FGF-9)
-
OriGene Purified Proteins for FGF9
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF9
- Origene Custom Protein Services for FGF9
- Sino Biological Recombinant Proteins for FGF9
- Sino Biological Cell Lysates for FGF9
- ProSpec Recombinant Proteins for FGF9
- antibodies-online: Search results for available Fgf9 related products ranked by validation data
- GeneTex Proteins for FGF9
-
Abcam proteins for FGF9
Assay Products
-
Custom Assay ServicesOriGene ELISA Kits for FGF9
- R&D Systems ELISAs and other biochemical assays for FGF9 (FGF-9)
- Novus Biologicals ELISA Kits for FGF9
- antibodies-online: Search results for available Fgf9 related products ranked by validation data
No data available for DME Specific Peptides for FGF9 Gene
Domains & Families for FGF9 Gene
Gene Families for FGF9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for FGF9 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FGF9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31371- Family:
-
- Belongs to the heparin-binding growth factors family.
Function for FGF9 Gene
Molecular function for FGF9 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
- GENATLAS Biochemistry:
- fibroblast growth factor 9
LifeMap Function Summary for FGF9 Gene
During embryonic development, FGF9 as signaling molecule is secreted from the following cells
- Head Mesenchyme
- Bone
- Heart
It affects the following cells:
- Neural Tube
- Heart
- Head Mesenchyme
- Gonad
-
Bone
- Hypertrophic Chondrocytes (Vertebrae)
- Hypertrophic Chondrocytes (Stylopod Growth Plate)
- Hypertrophic Chondrocytes (Zeugopod Growth Plate)
- Hypertrophic Chondrocytes (Autopod Growth Plate)
- Hypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Zeugopod Growth Plate)
- Prehypertrophic Chondrocytes (Autopod Growth Plate)
- Prehypertrophic Chondrocytes (Stylopod Growth Plate)
- Prehypertrophic Chondrocytes (Vertebrae)
- Testis
FGF9 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Kidney
- Intermediate Mesoderm
Phenotypes From GWAS Catalog for FGF9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004713 | protein tyrosine kinase activity | TAS | -- |
| GO:0005088 | Ras guanyl-nucleotide exchange factor activity | TAS | -- |
| GO:0005104 | fibroblast growth factor receptor binding | IEA | -- |
| GO:0008083 | growth factor activity | TAS,IEA | -- |
| GO:0008201 | heparin binding | IEA | -- |
Phenotypes for FGF9 Gene
- MGI mutant phenotypes for FGF9:
-
inferred from 7 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- limbs/digits/tail phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- behavior/neurological phenotype
- integument phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for FGF9:
Animal Models for FGF9 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FGF9
-
CRISPR Products
-
OriGene CRISPR knockouts for FGF9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF9
- genomics-online: gRNA clones - Search results for available Fgf9 gene related products
- Applied Biological Materials CRISPR for FGF9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF9
- GenScript: Design CRISPR guide RNA sequences for FGF9
miRNA for FGF9 Gene
- miRTarBase miRNAs that target FGF9
-
- hsa-mir-182-5p (MIRT006823)
- hsa-mir-140-5p (MIRT007378)
- hsa-mir-26b-5p (MIRT029384)
- hsa-mir-26a-5p (MIRT053574)
- hsa-mir-599 (MIRT441711)
- hsa-mir-5007-3p (MIRT441712)
- hsa-mir-4662a-5p (MIRT441713)
- hsa-mir-4480 (MIRT441714)
- hsa-mir-1279 (MIRT441715)
- hsa-mir-3941 (MIRT608291)
- hsa-mir-4789-3p (MIRT608292)
- hsa-mir-603 (MIRT608293)
- hsa-mir-362-3p (MIRT608294)
- hsa-mir-8485 (MIRT608295)
- hsa-mir-329-3p (MIRT608296)
- hsa-mir-483-3p (MIRT613055)
- hsa-mir-6833-3p (MIRT632924)
- hsa-mir-4768-5p (MIRT632925)
- hsa-mir-6873-3p (MIRT632926)
- hsa-mir-6881-3p (MIRT632927)
- hsa-mir-433-3p (MIRT632928)
- hsa-mir-6895-3p (MIRT632929)
- hsa-mir-942-5p (MIRT632930)
- hsa-mir-6817-3p (MIRT632931)
- hsa-mir-7110-3p (MIRT632932)
- hsa-mir-6845-3p (MIRT632933)
- hsa-mir-4264 (MIRT632934)
- hsa-mir-877-3p (MIRT632935)
- hsa-mir-622 (MIRT632936)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF9
- Browse OriGene Inhibitory RNA Products For FGF9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF9
- genomics-online: shRNA clones - Search results for available Fgf9 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FGF9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF9
- genomics-online: cdna clones - Search results for available Fgf9 gene related products
- orf clones - Search results for available Fgf9 gene related products
- Applied Biological Materials Clones for FGF9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FGF9
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF9 Gene
Localization for FGF9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF9 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005615 | extracellular space | IDA | 8321227 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0070062 | extracellular exosome | HDA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF9 Gene
Pathways & Interactions for FGF9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Negative regulation of FGFR1 signaling | ||
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | FGFR3 mutant receptor activation | ||
Pathways by source for FGF9 Gene
1 BioSystems pathway for FGF9 Gene
108 Reactome pathways for FGF9 Gene
9 KEGG pathways for FGF9 Gene
1 GeneGo (Thomson Reuters) pathway for FGF9 Gene
5 Qiagen pathways for FGF9 Gene
Interacting Proteins for FGF9 Gene
GPS-Prot Interaction Network for FGF9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001525 | angiogenesis | IEA | -- |
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0001654 | eye development | IEA | -- |
Transcripts for FGF9 Gene
mRNA/cDNA for FGF9 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (38) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000382353 4220 bps (uc001uog.3)
- ENST00000461657 424 bps (uc058vwe.1)
- ENST00000478546 784 bps (uc058vwf.1)
Unigene Clusters for FGF9 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FGF9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF9
- genomics-online: gRNA clones - Search results for available Fgf9 gene related products
- Applied Biological Materials CRISPR for FGF9
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF9
- GenScript: Design CRISPR guide RNA sequences for FGF9
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF9
- Browse OriGene Inhibitory RNA Products For FGF9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF9
- genomics-online: shRNA clones - Search results for available Fgf9 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FGF9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF9
- genomics-online: cdna clones - Search results for available Fgf9 gene related products
- orf clones - Search results for available Fgf9 gene related products
- Applied Biological Materials Clones for FGF9
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: |
Expression for FGF9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Endochondral Preosteoblasts Stylopod Perichondrium
- Endochondral Preosteoblasts Zeugopod Perichondrium
- Presumptive Suture Cells Rostral Sutures
- Endochondral Preosteoblasts Rib
- Mesenchymal Stem Cells
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Chondrocytes Stylopod Epiphyseal End
- Chondrocytes Autopod Epiphyseal End
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Surface Ectoderm Cells Surface Ectoderm
- Ectoderm Cells Branchial Arch 1
- Umbilical Cord (Extraembryonic Tissues)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Sertoli cells Seminiferous Tubules
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Surface Ectoderm (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
- Surface Ectoderm
- Placenta (Extraembryonic Tissues)
-
Heart (Cardiovascular System)
- Epicardial Progenitors Cells Epicardium
-
Epidermis (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
-
Head Mesenchyme (Muscoskeletal System)
- Ectoderm Cells Branchial Arch 1
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
- Brain (Nervous System)
- Uterus (Reproductive System)
- Neural Ectoderm (Nervous System)
mRNA differential expression in normal tissues according to GTEx for FGF9 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.8) and Brain - Cerebellum (x6.7).
NURSA nuclear receptor signaling pathways regulating expression of FGF9 Gene:
FGF9SOURCE GeneReport for Unigene cluster for FGF9 Gene:
Hs.111mRNA Expression by UniProt/SwissProt for FGF9 Gene:
P31371-FGF9_HUMAN
Tissue specificity:
Glial cells.
Evidence on tissue expression from TISSUES for FGF9 Gene
- Kidney(4.3)
- Lung(2.3)
- Nervous system(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF9 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- cranial nerve
- ear
- eye
- face
- head
- jaw
- lip
- mandible
- maxilla
- middle ear
- mouth
- nose
- outer ear
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- sternum
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for FGF9
- genomics-online: primer clones - Search results for available Fgf9 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FGF9 Gene
Orthologs for FGF9 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FGF9 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FGF9 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FGF9 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FGF9 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Fgf9 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Fgf9 16 34 33 |
|
||
| cow (Bos Taurus) |
Mammalia | FGF9 34 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FGF9 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FGF9 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fgf9 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | fgf9-A 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CS-FGF9/16/20 34 |
|
OneToMany |
- Species where no ortholog for FGF9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Evolution for FGF9 Gene
- ENSEMBL:
- Gene Tree for FGF9 (if available)
- TreeFam:
- Gene Tree for FGF9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FGF9: view image
Paralogs for FGF9 Gene
Paralogs for FGF9 Gene
(15) SIMAP similar genes for FGF9 Gene using alignment to 1 proteins:
- FGF9_HUMAN
Variants for FGF9 Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1022345288 | uncertain-significance, Symphalangism-brachydactyly syndrome | 21,701,870(+) | C/G/T | 3_prime_UTR_variant | |
| rs10624265 | benign, Symphalangism-brachydactyly syndrome | 21,671,789(+) | TTTTTTTT/TTTTTTTTT/TTTTTTTTTT | 5_prime_UTR_variant, genic_upstream_transcript_variant | |
| rs111765283 | likely-benign, Symphalangism-brachydactyly syndrome | 21,703,039(+) | C/G/T | 3_prime_UTR_variant | |
| rs115025644 | likely-benign, Symphalangism-brachydactyly syndrome | 21,671,484(+) | G/A | 5_prime_UTR_variant, genic_upstream_transcript_variant | |
| rs121918322 | pathogenic, Multiple synostoses syndrome 3, Multiple synostoses syndrome 3 (SYNS3) [MIM:612961] | 21,681,060(+) | G/A | coding_sequence_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3396861 | CNV | duplication | 20981092 |
| nsv1071085 | CNV | deletion | 25765185 |
| nsv1078303 | OTHER | inversion | 25765185 |
| nsv1140246 | OTHER | inversion | 24896259 |
| nsv1151909 | OTHER | inversion | 26484159 |
| nsv509497 | CNV | insertion | 20534489 |
| nsv832560 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.80;
16.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGF9 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF9 Gene
Disorders for FGF9 Gene
(15) MalaCards diseases for FGF9 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple synostoses syndrome 3 |
|
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| multiple synostoses syndrome |
|
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| pleuropulmonary blastoma |
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| apert syndrome |
|
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| proximal symphalangism |
|
|
Search FGF9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FGF9_HUMAN- Multiple synostoses syndrome 3 (SYNS3) [MIM:612961]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism. {ECO:0000269 PubMed:19589401}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for FGF9
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for FGF9 Gene
Publications for FGF9 Gene
- Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. (PMID: 8321227) Miyamoto M … Kurokawa T (Molecular and cellular biology 1993) 2 3 4 22 58
- Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. (PMID: 19589401) Wu XL … Wang ZG (American journal of human genetics 2009) 3 4 22 58
- Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. (PMID: 11060292) Plotnikov AN … Mohammadi M (The Journal of biological chemistry 2001) 3 4 22 58
- Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. (PMID: 11223514) Hecht HJ … Yayon A (Acta crystallographica. Section D, Biological crystallography 2001) 3 4 22 58
- L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58
Products for FGF9 Gene
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Sources for FGF9 Gene
- (1) GeneCards
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