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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibi... See more...
Aliases for FGF9 Gene
Aliases for FGF9 Gene
External Ids for FGF9 Gene
- HGNC: 3687
- NCBI Entrez Gene: 2254
- Ensembl: ENSG00000102678
- OMIM®: 600921
- UniProtKB/Swiss-Prot: P31371
Previous GeneCards Identifiers for FGF9 Gene
- GC13P020225
- GC13P016225
- GC13P021175
- GC13P020044
- GC13P020045
- GC13P021144
- GC13P022245
- GC13P003046
Summaries for FGF9 Gene
-
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF9 Gene
FGF9 (Fibroblast Growth Factor 9) is a Protein Coding gene. Diseases associated with FGF9 include Multiple Synostoses Syndrome 3 and Multiple Synostoses Syndrome. Among its related pathways are RET signaling and Downstream signaling of activated FGFR2. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF20.
UniProtKB/Swiss-Prot Summary for FGF9 Gene
-
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
Additional gene information for FGF9 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF9 Gene
Genomics for FGF9 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FGF9 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH13J021668 | Promoter/Enhancer | 2.4 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 253.3 | +2.1 | 2094 | 9 | EZH2 BCLAF1 SP1 ZNF207 ZNF654 ZNF600 ZNF580 ZNF223 POLR2A ZIC2 | FGF9 HSALNG0095624 SKA3 HSALNG0095621 lnc-MICU2-1 | |
| GH13J021635 | Enhancer | 0.9 | Ensembl ENCODE | 11.5 | -33.6 | -33605 | 3.6 | ZNF654 ZNF600 NFIC CTCF REST TRIM22 ZFP64 RAD21 SMC3 JUND | FGF9 MICU2 piR-32214-130 HSALNG0095622 | |
| GH13J021701 | Enhancer | 0.3 | Ensembl | 11.6 | +30.5 | 30528 | 0.4 | MAFK ZSCAN4 | FGF9 HSALNG0095626 HSALNG0095624 | |
| GH13J021630 | Enhancer | 0.2 | Ensembl | 11.5 | -40.2 | -40172 | 0.2 | RPS7P10 FGF9 piR-32214-130 MICU2 | ||
| GH13J021682 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | +12.2 | 12235 | 1.3 | ZIC2 BHLHE40 SP7 ZNF366 ZNF629 ZNF660 PRDM10 FOS | HSALNG0095624 FGF9 HSALNG0095626 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGF9 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF9
- Top Transcription factor binding sites by QIAGEN in the FGF9 gene promoter:
-
- c-Myc
- E47
- HNF-4alpha1
- Max1
- Nkx2-5
- Pax-5
- POU2F1
- POU2F1a
- Tal-1
Genomic Locations for FGF9 Gene
Latest Assembly
- chr13:21,671,073-21,704,501
- (GRCh38/hg38)
- Size:
- 33,429 bases
- Orientation:
- Plus strand
Previous Assembly
- chr13:22,245,212-22,278,637
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 33,426 bases
- Orientation:
- Plus strand
Genomic View for FGF9 Gene
Genes around FGF9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q12.11 by HGNC
- 13q12.11 by Entrez Gene
- 13q12.11 by Ensembl
FGF9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF9 Gene
Proteins for FGF9 Gene
-
Protein details for FGF9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31371-FGF9_HUMAN
- Recommended name:
- Fibroblast growth factor 9
- Protein Accession:
- P31371
- A8K427
- Q3SY32
Protein attributes for FGF9 Gene
- Size:
- 208 amino acids
- Molecular mass:
- 23441 Da
- Quaternary structure:
-
- Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
- Miscellaneous:
-
- Biochemical analysis of the Asn-99 mutation reveals a significantly impaired FGF signaling, as evidenced by diminished activity of the MAPK1/MAPK2 pathway and decreases CTNNB1 and MYC expression when compared with wild-type protein. Binding of mutant protein to the receptor FGFR3 is severely impaired, although homodimerization of mutant to itself or wild-type is not detectably affected, providing a basis for the observed defective FGF9 signaling.
Post-translational modifications for FGF9 Gene
- Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.
- N-glycosylated.
-
Glycosylation at Asn79
- NX_P31371 (NX_P31371-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FGF9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences FGF9 Antibody (LS-B11953) and FGF9 Antibody (LS-B16567)
- G Biosciences Immunotag™ FGF9 Antibody
- NSJ Bioreagents FGF9 Antibody
- Novus Biologicals Antibodies for FGF9
-
Abcam antibodies for FGF9
- Invitrogen Antibodies for FGF9 (AFLGC-FGF9)
- antibodies-online: Show 26 available FGF-9 Antibodies ranked by validation data
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGF9
- Sino Biological Antibodies for FGF9
Protein products for research
- G Biosciences Human FGF-9/Fibroblast Growth Factor 9, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF9
- Origene Custom Protein Services for FGF9
- Sino Biological Recombinant Proteins for FGF9
- Sino Biological Cell Lysates for FGF9
- ProSpec Recombinant Proteins for FGF9
-
Abcam proteins for FGF9
No data available for DME Specific Peptides for FGF9 Gene
Domains & Families for FGF9 Gene
Gene Families for FGF9 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for FGF9 Gene
- InterPro:
- Blocks:
-
- Heparin binding growth factor family signature
- IL1/HBGF family signature
Suggested Antigen Peptide Sequences for FGF9 Gene
- GenScript: Design optimal peptide antigens:
-
- Heparin-binding growth factor 9 (FGF9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P31371- Family:
-
- Belongs to the heparin-binding growth factors family.
Function for FGF9 Gene
Molecular function for FGF9 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors.
- GENATLAS Biochemistry:
- fibroblast growth factor 9
LifeMap Function Summary for FGF9 Gene
During embryonic development, FGF9 as signaling molecule is secreted from the following cells
- Head Mesenchyme
- Bone
- Heart
It affects the following cells:
- Neural Tube
- Heart
- Head Mesenchyme
- Gonad
-
Bone
- Hypertrophic Chondrocytes (Vertebrae)
- Hypertrophic Chondrocytes (Stylopod Growth Plate)
- Hypertrophic Chondrocytes (Zeugopod Growth Plate)
- Hypertrophic Chondrocytes (Autopod Growth Plate)
- Hypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Rib)
- Prehypertrophic Chondrocytes (Zeugopod Growth Plate)
- Prehypertrophic Chondrocytes (Autopod Growth Plate)
- Prehypertrophic Chondrocytes (Stylopod Growth Plate)
- Prehypertrophic Chondrocytes (Vertebrae)
- Testis
FGF9 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Kidney
- Intermediate Mesoderm
Phenotypes From GWAS Catalog for FGF9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005104 | fibroblast growth factor receptor binding | IBA | 21873635 |
| GO:0008083 | growth factor activity | TAS,IBA | 21873635 |
| GO:0008201 | heparin binding | IEA | -- |
Phenotypes for FGF9 Gene
- MGI mutant phenotypes for FGF9:
-
inferred from 8 alleles
- normal phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- cardiovascular system phenotype
- behavior/neurological phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- limbs/digits/tail phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for FGF9:
Animal Models for FGF9 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FGF9 - Starting at $85 >
- * FGF9 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FGF9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF9
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF9
miRNA for FGF9 Gene
- miRTarBase miRNAs that target FGF9
-
- hsa-miR-182-5p (MIRT006823)
- hsa-miR-140-5p (MIRT007378)
- hsa-miR-26b-5p (MIRT029384)
- hsa-miR-26a-5p (MIRT053574)
- hsa-miR-599 (MIRT441711)
- hsa-miR-5007-3p (MIRT441712)
- hsa-miR-4662a-5p (MIRT441713)
- hsa-miR-4480 (MIRT441714)
- hsa-miR-1279 (MIRT441715)
- hsa-miR-3941 (MIRT608291)
- hsa-miR-4789-3p (MIRT608292)
- hsa-miR-603 (MIRT608293)
- hsa-miR-362-3p (MIRT608294)
- hsa-miR-8485 (MIRT608295)
- hsa-miR-329-3p (MIRT608296)
- hsa-miR-483-3p (MIRT613055)
- hsa-miR-6833-3p (MIRT632924)
- hsa-miR-4768-5p (MIRT632925)
- hsa-miR-6873-3p (MIRT632926)
- hsa-miR-6881-3p (MIRT632927)
- hsa-miR-433-3p (MIRT632928)
- hsa-miR-6895-3p (MIRT632929)
- hsa-miR-942-5p (MIRT632930)
- hsa-miR-6817-3p (MIRT632931)
- hsa-miR-7110-3p (MIRT632932)
- hsa-miR-6845-3p (MIRT632933)
- hsa-miR-4264 (MIRT632934)
- hsa-miR-877-3p (MIRT632935)
- hsa-miR-622 (MIRT632936)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF9
- Browse OriGene Inhibitory RNA Products For FGF9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF9
Clone products for research
- Applied Biological Materials (abm): Clones for FGF9 - Starting at $45 >
- * FGF9 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FGF9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF9
Cell Lines for research
-
Horizon Cell Lines for FGF9
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FGF9 Gene
Localization for FGF9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF9 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005604 | basement membrane | IEA | -- |
| GO:0005615 | extracellular space | IDA | 8321227 |
| GO:0005737 | cytoplasm | IEA,IBA | 21873635 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF9 Gene
Pathways & Interactions for FGF9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Downstream signaling of activated FGFR2 | ||
| 3 | Negative regulation of FGFR3 signaling | ||
| 4 | PI3K/AKT activation |
.89
|
|
| 5 | Signaling by activated point mutants of FGFR3 | ||
Pathways by source for FGF9 Gene
1 BioSystems pathway for FGF9 Gene
108 Reactome pathways for FGF9 Gene
10 KEGG pathways for FGF9 Gene
1 GeneGo (Thomson Reuters) pathway for FGF9 Gene
- Development FGF-family signaling
5 Qiagen pathways for FGF9 Gene
- FGF Pathway
- P2Y Receptor Signaling
- Regulation of eIF4 and p70S6K
- RhoGDI Pathway
- SOCS Pathway
Interacting Proteins for FGF9 Gene
GPS-Prot Interaction Network for FGF9
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IBA | 21873635 |
| GO:0007165 | signal transduction | TAS | 8575785 |
| GO:0007267 | cell-cell signaling | TAS | 8575785 |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for FGF9 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FGF9 Gene
mRNA/cDNA for FGF9 Gene
- 1 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000382353 4530 nts (view in UCSC)
- ENST00000461657 424 nts (view in UCSC)
- ENST00000478546 784 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FGF9 - Starting at $85 >
- * FGF9 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FGF9
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF9
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF9
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF9
- Browse OriGene Inhibitory RNA Products For FGF9
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF9
Clone products for research
- Applied Biological Materials (abm): Clones for FGF9 - Starting at $45 >
- * FGF9 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FGF9
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF9
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||
| SP2: |
Relevant External Links for FGF9 Gene
- GeneLoc Exon Structure for
- FGF9
Expression for FGF9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Endochondral Preosteoblasts Stylopod Perichondrium
- Endochondral Preosteoblasts Zeugopod Perichondrium
- Presumptive Suture Cells Rostral Sutures
- Endochondral Preosteoblasts Rib
- Mesenchymal Stem Cells
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
- Chondrocytes Stylopod Epiphyseal End
- Chondrocytes Autopod Epiphyseal End
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Surface Ectoderm Cells Surface Ectoderm
- Ectoderm Cells Branchial Arch 1
- Umbilical Cord (Extraembryonic Tissues)
- Neural Tube (Nervous System)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Sertoli cells Seminiferous Tubules
-
Tooth (Integumentary System)
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
-
Epithelial Cells
- Dental Placode Cells Dental Placode
- Inner Enamel Epithelial Cells Dental Enamel
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Surface Ectoderm (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
- Surface Ectoderm
- Placenta (Extraembryonic Tissues)
-
Heart (Cardiovascular System)
- Epicardial Progenitors Cells Epicardium
-
Epidermis (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
-
Head Mesenchyme (Muscoskeletal System)
- Ectoderm Cells Branchial Arch 1
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
- Brain (Nervous System)
- Uterus (Reproductive System)
- Neural Ectoderm (Nervous System)
mRNA differential expression in normal tissues according to GTEx for FGF9 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.8) and Brain - Cerebellum (x6.7).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF9
SOURCE GeneReport for Unigene cluster for FGF9 Gene:
Hs.111mRNA Expression by UniProt/SwissProt for FGF9 Gene:
P31371-FGF9_HUMAN
Tissue specificity:
Glial cells.
Evidence on tissue expression from TISSUES for FGF9 Gene
- Kidney(4.5)
- Nervous system(2.6)
- Lung(2.4)
- Intestine(2.3)
- Liver(2.2)
- Muscle(2.1)
- Heart(2.1)
- Adrenal gland(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF9 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- integumentary
- nervous
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cheek
- cranial nerve
- ear
- eye
- face
- head
- jaw
- lip
- mandible
- maxilla
- middle ear
- mouth
- nose
- outer ear
- skull
Thorax:
- chest wall
- clavicle
- rib
- rib cage
- sternum
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- nail
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer products for research
-
OriGene qPCR primer pairs for FGF9
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FGF9 Gene
Orthologs for FGF9 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FGF9 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FGF9 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FGF9 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FGF9 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fgf9 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Fgf9 29 16 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FGF9 29 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FGF9 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FGF9 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgf9 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | fgf9-A 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CS-FGF9/16/20 30 |
|
OneToMany |
- Species where no ortholog for FGF9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for FGF9 Gene
- ENSEMBL:
- Gene Tree for FGF9 (if available)
- TreeFam:
- Gene Tree for FGF9 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FGF9: view image
- Alliance of Genome Resources:
- Additional Orthologs for FGF9
Paralogs for FGF9 Gene
Paralogs for FGF9 Gene
(15) SIMAP similar genes for FGF9 Gene using alignment to 1 proteins:
- FGF9_HUMAN
Variants for FGF9 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF9 Gene
| SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 881303 | Uncertain Significance: Multiple synostoses syndrome 3 | 21,701,472(+) |
A/T NM_002010.3(FGF9):c.*37A>T |
THREE_PRIME_UTR | |
| 881304 | Uncertain Significance: Multiple synostoses syndrome 3 | 21,701,556(+) |
A/C NM_002010.3(FGF9):c.*121A>C |
THREE_PRIME_UTR | |
| 881305 | Uncertain Significance: Multiple synostoses syndrome 3 | 21,701,709(+) |
A/G NM_002010.3(FGF9):c.*274A>G |
THREE_PRIME_UTR | |
| 881306 | Uncertain Significance: Multiple synostoses syndrome 3 | 21,701,713(+) |
G/A NM_002010.3(FGF9):c.*278G>A |
THREE_PRIME_UTR | |
| 881360 | Benign: Multiple synostoses syndrome 3 | 21,702,846(+) |
T/C NM_002010.3(FGF9):c.*1411T>C |
THREE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3396861 | CNV | duplication | 20981092 |
| nsv1071085 | CNV | deletion | 25765185 |
| nsv1078303 | OTHER | inversion | 25765185 |
| nsv1140246 | OTHER | inversion | 24896259 |
| nsv1151909 | OTHER | inversion | 26484159 |
| nsv509497 | CNV | insertion | 20534489 |
| nsv832560 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.80;
16.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGF9 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF9 Gene
Disorders for FGF9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| multiple synostoses syndrome 3 |
|
|
| multiple synostoses syndrome |
|
|
| pleuropulmonary blastoma |
|
|
| apert syndrome |
|
|
| synostoses, tarsal, carpal, and digital |
|
|
Search FGF9 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FGF9_HUMAN- Multiple synostoses syndrome 3 (SYNS3) [MIM:612961]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism. {ECO:0000269 PubMed:19589401}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for FGF9
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
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- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for FGF9 Gene
Publications for FGF9 Gene
- Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. (PMID: 19589401) Wu XL … Wang ZG (American journal of human genetics 2009) 3 4 22 72
- Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. (PMID: 8321227) Miyamoto M … Kurokawa T (Molecular and cellular biology 1993) 2 3 4 22
- Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition. (PMID: 11060292) Plotnikov AN … Mohammadi M (The Journal of biological chemistry 2001) 3 4 22
- Structure of fibroblast growth factor 9 shows a symmetric dimer with unique receptor- and heparin-binding interfaces. (PMID: 11223514) Hecht HJ … Yayon A (Acta crystallographica. Section D, Biological crystallography 2001) 3 4 22
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 40
ExternalLinks
Products for FGF9 Gene
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- antibodies-online: Show 26 available FGF-9 Antibodies ranked by validation data
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Sources for FGF9 Gene
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