The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth f... See more...

Aliases for FGF7 Gene

Aliases for FGF7 Gene

  • Fibroblast Growth Factor 7 2 3 4 5
  • Keratinocyte Growth Factor 2 3 4
  • KGF 2 3 4
  • Heparin-Binding Growth Factor 7 3 4
  • HBGF-7 3 4
  • FGF-7 3 4
  • Fibroblast Growth Factor 7 (Keratinocyte Growth Factor) 2
  • FGF7 5

External Ids for FGF7 Gene

Previous GeneCards Identifiers for FGF7 Gene

  • GC15P045272
  • GC15P042761
  • GC15P047294
  • GC15P047431
  • GC15P047502
  • GC15P049715
  • GC15P026547

Summaries for FGF7 Gene

Entrez Gene Summary for FGF7 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF7 Gene

FGF7 (Fibroblast Growth Factor 7) is a Protein Coding gene. Diseases associated with FGF7 include Mucositis and Clear Cell Acanthoma. Among its related pathways are RET signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include growth factor activity and chemoattractant activity. An important paralog of this gene is FGF10.

UniProtKB/Swiss-Prot Summary for FGF7 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.

Gene Wiki entry for FGF7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF7 Gene

Genomics for FGF7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGF7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF7

Top Transcription factor binding sites by QIAGEN in the FGF7 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • C/EBPbeta
  • FOXD1
  • HNF-3beta
  • Msx-1
  • STAT3

Genomic Locations for FGF7 Gene

Latest Assembly
chr15:49,423,237-49,488,775
(GRCh38/hg38)
Size:
65,539 bases
Orientation:
Plus strand

Previous Assembly
chr15:49,715,439-49,780,972
(GRCh37/hg19 by Entrez Gene)
Size:
65,534 bases
Orientation:
Plus strand

chr15:49,715,293-49,780,972
(GRCh37/hg19 by Ensembl)
Size:
65,680 bases
Orientation:
Plus strand

Genomic View for FGF7 Gene

Genes around FGF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF7 Gene

Proteins for FGF7 Gene

  • Protein details for FGF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21781-FGF7_HUMAN
    Recommended name:
    Fibroblast growth factor 7
    Protein Accession:
    P21781
    Secondary Accessions:
    • H0YNY5
    • Q6FGV5
    • Q96FG5

    Protein attributes for FGF7 Gene

    Size:
    194 amino acids
    Molecular mass:
    22509 Da
    Quaternary structure:
    • Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Alternative splice isoforms for FGF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF7 Gene

Post-translational modifications for FGF7 Gene

  • Glycosylation at Asn45
  • Modification sites at PhosphoSitePlus

Other Protein References for FGF7 Gene

No data available for DME Specific Peptides for FGF7 Gene

Domains & Families for FGF7 Gene

Gene Families for FGF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for FGF7 Gene

InterPro:
Blocks:
  • Heparin binding growth factor family signature
  • IL1/HBGF family signature

Suggested Antigen Peptide Sequences for FGF7 Gene

GenScript: Design optimal peptide antigens:
  • Heparin-binding growth factor 7 (FGF7_HUMAN)
  • cDNA, FLJ93655, Homo sapiens fibroblast growth factor 7 (keratinocyte growthfactor) (FGF7), mRNA (Q6FGV5_HUMAN)
  • Keratinocyte growth factor (Q6RK68_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21781

UniProtKB/Swiss-Prot:

FGF7_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF7: view

Function for FGF7 Gene

Molecular function for FGF7 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
GENATLAS Biochemistry:
fibroblast growth factor 7,expressed in epithelial tissues,including corneal and mammary epithelial cells,mitogenic for epithelial cells

Phenotypes From GWAS Catalog for FGF7 Gene

Gene Ontology (GO) - Molecular Function for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IEA,IBA 21873635
GO:0005111 type 2 fibroblast growth factor receptor binding IBA 21873635
GO:0005515 protein binding IPI 1309608
GO:0008083 growth factor activity IEA,IBA 21873635
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FGF7: view
genes like me logo Genes that share phenotypes with FGF7: view

Animal Models for FGF7 Gene

MGI Knock Outs for FGF7:
  • Fgf7 Fgf7<tm1Efu>
  • Fgf7 Fgf7<tm1b(EUCOMM)Hmgu>

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF7 Gene

Localization for FGF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF7 gene
Compartment Confidence
extracellular 5
golgi apparatus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with FGF7: view

Pathways & Interactions for FGF7 Gene

PathCards logo

SuperPathways for FGF7 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
3 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
4 PI3K/AKT activation
5 TGF-Beta Pathway
.60
.60
.57
.51
.43
.40
genes like me logo Genes that share pathways with FGF7: view

Pathways by source for FGF7 Gene

1 GeneGo (Thomson Reuters) pathway for FGF7 Gene
  • Development FGF-family signaling
59 Qiagen pathways for FGF7 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

SIGNOR curated interactions for FGF7 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for FGF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001934 positive regulation of protein phosphorylation IBA 21873635
GO:0007165 signal transduction NAS 2475908
GO:0008284 positive regulation of cell proliferation IEA,IGI 8663044
GO:0008543 fibroblast growth factor receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with FGF7: view

Drugs & Compounds for FGF7 Gene

(47) Drugs for FGF7 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma 1160

(34) Additional Compounds for FGF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF7: view

Transcripts for FGF7 Gene

mRNA/cDNA for FGF7 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF7

Alternative Splicing Database (ASD) splice patterns (SP) for FGF7 Gene

No ASD Table

Relevant External Links for FGF7 Gene

GeneLoc Exon Structure for
FGF7

Expression for FGF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FGF7 Gene

This gene is overexpressed in Urinary Bladder (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGF7 Gene



Protein tissue co-expression partners for FGF7 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF7

SOURCE GeneReport for Unigene cluster for FGF7 Gene:

Hs.567268

mRNA Expression by UniProt/SwissProt for FGF7 Gene:

P21781-FGF7_HUMAN
Tissue specificity: Epithelial cell.

Evidence on tissue expression from TISSUES for FGF7 Gene

  • Nervous system(4.7)
  • Lung(3.3)
  • Heart(3.1)
  • Intestine(3)
  • Muscle(2.6)
  • Skin(2.6)
  • Liver(2.5)
  • Kidney(2.5)
  • Lymph node(2.4)
  • Gall bladder(2.4)
  • Blood(2.3)
  • Bone marrow(2.2)
  • Thyroid gland(2.2)
  • Eye(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with FGF7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF7 Gene

Orthologs for FGF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FGF7 29 30
  • 100 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FGF7 29 30
  • 96.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FGF7 29 30
  • 94.85 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fgf7 29 16 30
  • 91.92 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgf7 29
  • 89.35 (n)
Oppossum
(Monodelphis domestica)
Mammalia FGF7 30
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FGF7 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FGF7 29 30
  • 85.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FGF7 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fgf7 29
  • 76.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii fgf7 29 30
  • 60.99 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 30
  • 17 (a)
OneToMany
Species where no ortholog for FGF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGF7 Gene

ENSEMBL:
Gene Tree for FGF7 (if available)
TreeFam:
Gene Tree for FGF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGF7: view image
Alliance of Genome Resources:
Additional Orthologs for FGF7

Paralogs for FGF7 Gene

(19) SIMAP similar genes for FGF7 Gene using alignment to 5 proteins:

  • FGF7_HUMAN
  • H0YNE7_HUMAN
  • H0YNY5_HUMAN
  • Q6FGV5_HUMAN
  • Q6RK68_HUMAN
genes like me logo Genes that share paralogs with FGF7: view

Variants for FGF7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF7 Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs17850705 -- p.Gly62Glu
rs34531231 -- p.Met59Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FGF7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FGF7 Gene

Variant ID Type Subtype PubMed ID
esv27180 CNV loss 19812545
esv3581696 CNV loss 25503493
esv3636428 CNV gain 21293372
nsv1043119 CNV loss 25217958
nsv526246 CNV loss 19592680
nsv819023 CNV loss 19587683
nsv833002 CNV gain 17160897
nsv9263 CNV gain 18304495
nsv974651 CNV duplication 23825009
nsv976934 CNV duplication 23825009
nsv984069 CNV duplication 23825009

Variation tolerance for FGF7 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF7
Leiden Open Variation Database (LOVD)
FGF7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF7 Gene

Disorders for FGF7 Gene

MalaCards: The human disease database

(47) MalaCards diseases for FGF7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
mucositis
  • inflammatory disease of mucous membrane
clear cell acanthoma
  • pale acanthoma
apert syndrome
  • acrocephalosyndactyly, type i; acs1
acanthoma
short bowel syndrome
  • acquired short bowel syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FGF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FGF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF7 Gene

Publications for FGF7 Gene

  1. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PMID: 15806171) Beer HD … Werner S (Oncogene 2005) 3 4 22
  2. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. (PMID: 21565293) Teumer A … Völzke H (American journal of human genetics 2011) 3 40
  3. The effects of TGF-alpha, IL-1beta and PDGF on fibroblast adhesion to ECM-derived matrix and KGF gene expression. (PMID: 20036421) Wang X … Kao WJ (Biomaterials 2010) 3 22
  4. Modulation of calprotectin in human keratinocytes by keratinocyte growth factor and interleukin-1alpha. (PMID: 20065999) Bando M … Kido J (Immunology and cell biology 2010) 3 22
  5. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 40

Products for FGF7 Gene

Sources for FGF7 Gene