Aliases for FGF4 Gene
External Ids for FGF4 Gene
Previous HGNC Symbols for FGF4 Gene
Previous GeneCards Identifiers for FGF4 Gene
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for FGF4 Gene
FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include Embryonal Carcinoma and Germ Cell Cancer. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and RET signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF6.
UniProtKB/Swiss-Prot Summary for FGF4 Gene
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.