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Aliases for FGF4 Gene

Aliases for FGF4 Gene

  • Fibroblast Growth Factor 4 2 3 3 5
  • Transforming Protein KS3 2 3 4
  • Human Stomach Cancer, Transforming Factor From FGF-Related Oncogene 2 3
  • Heparin Secretory Transforming Protein 1 2 3
  • Heparin-Binding Growth Factor 4 3 4
  • Kaposi Sarcoma Oncogene 2 3
  • HBGF-4 3 4
  • HSTF-1 3 4
  • HSTF1 3 4
  • FGF-4 3 4
  • HST-1 3 4
  • HST 3 4
  • Fibroblast Growth Factor 4 Splice Isoform 3
  • Heparin Secretory-Transforming Protein 1 4
  • Oncogene HST 3
  • K-FGF 3
  • KFGF 3
  • KS3 4

External Ids for FGF4 Gene

Previous HGNC Symbols for FGF4 Gene

  • HSTF1

Previous GeneCards Identifiers for FGF4 Gene

  • GC11M072083
  • GC11M071274
  • GC11M069835
  • GC11M069361
  • GC11M069362
  • GC11M069297
  • GC11M069588
  • GC11M065883

Summaries for FGF4 Gene

Entrez Gene Summary for FGF4 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

GeneCards Summary for FGF4 Gene

FGF4 (Fibroblast Growth Factor 4) is a Protein Coding gene. Diseases associated with FGF4 include Embryonal Carcinoma and Kaposi Sarcoma. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF6.

UniProtKB/Swiss-Prot for FGF4 Gene

  • Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.

Gene Wiki entry for FGF4 Gene

Additional gene information for FGF4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FGF4 Gene

Genomics for FGF4 Gene

GeneHancer (GH) Regulatory Elements for FGF4 Gene

Promoters and enhancers for FGF4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J069775 Promoter 0.6 EPDnew 650.7 +0.0 42 0.1 EZH2 FGF4 GC11M069658 LOC100129779
GH11J070154 Enhancer 1 FANTOM5 ENCODE 9.8 -382.6 -382610 6.1 NFIB SIN3A RAD21 RFX5 SCRT2 ZNF143 RCOR1 FOS DEK SMARCA5 ANO1-AS1 FGF4 ANO1 PPFIA1 CTTN FADD GC11P070167 LOC105369372
GH11J069137 Enhancer 0.9 ENCODE dbSUPER 9.3 +637.3 637348 2 STAT1 MXI1 JUN MAX CEBPB CEBPG DPF2 EP300 RFX5 ZKSCAN1 GC11P069137 MRGPRF-AS1 MRGPRF LTO1 FGF4 PIR35792 TPCN2
GH11J069867 Enhancer 0.7 ENCODE 11 -92.5 -92525 0.2 FOXA2 ATF1 MAX EGR1 ATF7 CREM RXRA ATF2 NR2F2 GABPA FGF3 FGF4 ANO1-AS1 ENSG00000260348
GH11J069801 Enhancer 0.6 ENCODE 12 -26.2 -26235 0.1 SCRT1 CTCF REST GATAD2B RAD21 XRCC5 MTA1 PATZ1 SMC3 ZNF143 GC11M069658 FGF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FGF4 gene promoter:
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP
  • MyoD

Genomic Locations for FGF4 Gene

Genomic Locations for FGF4 Gene
16,361 bases
Minus strand
2,375 bases
Minus strand

Genomic View for FGF4 Gene

Genes around FGF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF4 Gene

Proteins for FGF4 Gene

  • Protein details for FGF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fibroblast growth factor 4
    Protein Accession:
    Secondary Accessions:
    • B7U994

    Protein attributes for FGF4 Gene

    206 amino acids
    Molecular mass:
    22048 Da
    Quaternary structure:
    • Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

    Three dimensional structures from OCA and Proteopedia for FGF4 Gene

    Alternative splice isoforms for FGF4 Gene


neXtProt entry for FGF4 Gene

Post-translational modifications for FGF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FGF4 Gene

Domains & Families for FGF4 Gene

Gene Families for FGF4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for FGF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the heparin-binding growth factors family.
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF4: view

Function for FGF4 Gene

Molecular function for FGF4 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
GENATLAS Biochemistry:
fibroblast growth factor 4,basic,HST oncogene homolog,controlling limb development at the proximodistal axis,involved in anteroposterior polarization of the bud through a positive feedback loop controlled by SHH expression,expressed in ectoderm under SHH control

LifeMap Function Summary for FGF4 Gene

It affects the following cells:
FGF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for FGF4 Gene

Gene Ontology (GO) - Molecular Function for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS --
GO:0005104 fibroblast growth factor receptor binding IEA --
GO:0008083 growth factor activity TAS,IEA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with FGF4: view
genes like me logo Genes that share phenotypes with FGF4: view

Animal Models for FGF4 Gene

MGI Knock Outs for FGF4:

Animal Model Products

miRNA for FGF4 Gene

miRTarBase miRNAs that target FGF4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF4 Gene

Localization for FGF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF4 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with FGF4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF4 Gene

Pathways & Interactions for FGF4 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
4 Negative regulation of FGFR1 signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with FGF4: view

SIGNOR curated interactions for FGF4 Gene


Gene Ontology (GO) - Biological Process for FGF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001502 cartilage condensation IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0007165 signal transduction TAS 2959959
GO:0007267 cell-cell signaling TAS 2959959
genes like me logo Genes that share ontologies with FGF4: view

Drugs & Compounds for FGF4 Gene

(12) Drugs for FGF4 Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma inhibitor, Target 0
Heparin Approved, Investigational Pharma Antagonist, Target 905
TP-508 Investigational Pharma Target 0

(7) Additional Compounds for FGF4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF4: view

Transcripts for FGF4 Gene

mRNA/cDNA for FGF4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FGF4 Gene

Fibroblast growth factor 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FGF4 Gene

No ASD Table

Relevant External Links for FGF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FGF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FGF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF4 Gene

This gene is overexpressed in Nerve - Tibial (x43.8) and Testis (x8.1).

Protein differential expression in normal tissues from HIPED for FGF4 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGF4 Gene

Protein tissue co-expression partners for FGF4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FGF4 Gene:


SOURCE GeneReport for Unigene cluster for FGF4 Gene:


Evidence on tissue expression from TISSUES for FGF4 Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FGF4: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF4 Gene

Orthologs for FGF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FGF4 34 33
  • 99.51 (n)
(Canis familiaris)
Mammalia FGF4 34 33
  • 93.87 (n)
(Bos Taurus)
Mammalia FGF4 34 33
  • 91.89 (n)
(Mus musculus)
Mammalia Fgf4 16 34 33
  • 84.78 (n)
(Rattus norvegicus)
Mammalia Fgf4 33
  • 81.73 (n)
(Monodelphis domestica)
Mammalia FGF4 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia FGF4 34
  • 67 (a)
(Gallus gallus)
Aves FGF4 34 33
  • 73.63 (n)
(Anolis carolinensis)
Reptilia FGF4 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fgf4 33
  • 67.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia fgfe-A 33
(Danio rerio)
Actinopterygii fgf4 34 33 33
  • 64.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.125 34
  • 21 (a)
Species where no ortholog for FGF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FGF4 Gene

Gene Tree for FGF4 (if available)
Gene Tree for FGF4 (if available)
Evolutionary constrained regions (ECRs) for FGF4: view image

Paralogs for FGF4 Gene

Paralogs for FGF4 Gene

(15) SIMAP similar genes for FGF4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FGF4: view

Variants for FGF4 Gene

Sequence variations from dbSNP and Humsavar for FGF4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000471491 -- 69,773,582(-) C/G/T intron_variant
rs1001068009 -- 69,774,745(-) T/A coding_sequence_variant, missense_variant
rs1001404350 -- 69,774,521(-) A/G intron_variant
rs1001534072 -- 69,777,220(-) A/G upstream_transcript_variant
rs1002487096 -- 69,776,345(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FGF4 Gene

Variant ID Type Subtype PubMed ID
dgv16n68 CNV loss 17160897
nsv508640 CNV deletion 20534489
nsv825973 CNV gain 20364138
nsv832199 CNV gain+loss 17160897
nsv832200 CNV loss 17160897

Variation tolerance for FGF4 Gene

Gene Damage Index Score: 0.26; 5.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF4 Gene

Disorders for FGF4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for FGF4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
  • mixed embryonal carcinoma and teratoma
  • craniostenosis
diarrhea 4, malabsorptive, congenital
  • diar4
- elite association - COSMIC cancer census association via MalaCards
Search FGF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF4

Genetic Association Database
Human Genome Epidemiology Navigator
Tumor Gene Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FGF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF4 Gene

Publications for FGF4 Gene

  1. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal. (PMID: 18192227) Mayshar Y … Benvenisty N (Stem cells (Dayton, Ohio) 2008) 3 4 22 58
  2. Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. (PMID: 11486033) Bellosta P … Mohammadi M (Molecular and cellular biology 2001) 3 4 22 58
  3. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 44 58
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58

Products for FGF4 Gene

  • Boster Bio Antibodies for FGF4
  • Boster Bio ELISA Kits for FGF4

Sources for FGF4 Gene

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