The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentiall... See more...

Aliases for FGF22 Gene

Aliases for FGF22 Gene

  • Fibroblast Growth Factor 22 2 3 4 5
  • FGF-22 3 4
  • FGF22 5

External Ids for FGF22 Gene

Previous GeneCards Identifiers for FGF22 Gene

  • GC19P000691
  • GC19P000580
  • GC19P000590
  • GC19P000410

Summaries for FGF22 Gene

Entrez Gene Summary for FGF22 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for FGF22 Gene

FGF22 (Fibroblast Growth Factor 22) is a Protein Coding gene. Diseases associated with FGF22 include Breast Giant Fibroadenoma and Lacrimoauriculodentodigital Syndrome. Among its related pathways are RET signaling and Signaling by FGFR2. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF10.

UniProtKB/Swiss-Prot Summary for FGF22 Gene

  • Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF22 Gene

Genomics for FGF22 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FGF22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J000638 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 256.3 -0.1 -84 2 SP1 MYC NONO MBD2 MNT KLF9 SIN3B SP2 SAP130 NKRF FGF22 ENSG00000261204 POLRMT
GH19J000642 Enhancer 0.3 Ensembl 250.7 -2.0 -1978 0.2 PKNOX1 CEBPB ENSG00000261204 FGF22 POLRMT LOC105372234
GH19J000530 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -107.5 -107530 4.3 ZNF207 MYC NCOR1 IKZF1 SIX5 ZNF592 ZMYM3 KLF9 NFIC CHD4 CDC34 POLRMT FGF22 GZMM BSG-AS1 MIER2 TMEM259 ARID3A R3HDM4 MN298678-033
GH19J001382 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +744.3 744283 2.5 BCLAF1 SP1 ZNF207 ZNF600 NCOR1 MYC SIX5 SSRP1 ZNF580 ZNF592 K01921-014 TRF-GAA1-6 NDUFS7 TRN-GTT2-6 NONHSAG024361.2 piR-32939 piR-33470-012 SF3A2 TMEM259 CIRBP
GH19J001437 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +799.6 799604 4.3 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 MYC ZNF600 SSRP1 ZNF580 ZNF592 RPS15 AB372681 ENSG00000268798 SF3A2 TMEM259 TCF3 LOC100288123 DAZAP1 GRIN3B PTBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF22 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF22

Top Transcription factor binding sites by QIAGEN in the FGF22 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • E47
  • Egr-1
  • HEN1
  • MyoD
  • POU3F2
  • SEF-1 (1)

Genomic Locations for FGF22 Gene

Latest Assembly
chr19:639,879-644,373
(GRCh38/hg38)
Size:
4,495 bases
Orientation:
Plus strand

Previous Assembly
chr19:639,879-644,373
(GRCh37/hg19 by Entrez Gene)
Size:
4,495 bases
Orientation:
Plus strand

chr19:639,879-643,703
(GRCh37/hg19 by Ensembl)
Size:
3,825 bases
Orientation:
Plus strand

Genomic View for FGF22 Gene

Genes around FGF22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF22 Gene

Proteins for FGF22 Gene

  • Protein details for FGF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCT0-FGF22_HUMAN
    Recommended name:
    Fibroblast growth factor 22
    Protein Accession:
    Q9HCT0
    Secondary Accessions:
    • B2RPH4

    Protein attributes for FGF22 Gene

    Size:
    170 amino acids
    Molecular mass:
    19663 Da
    Quaternary structure:
    • Interacts with FGFR1 and FGFR2. Interacts with FGFBP1.

neXtProt entry for FGF22 Gene

Post-translational modifications for FGF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF22 Gene

No data available for DME Specific Peptides for FGF22 Gene

Domains & Families for FGF22 Gene

Gene Families for FGF22 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FGF22 Gene

InterPro:
Blocks:
  • Heparin binding growth factor family signature
  • IL1/HBGF family signature

Suggested Antigen Peptide Sequences for FGF22 Gene

GenScript: Design optimal peptide antigens:
  • Fibroblast growth factor 22 (FGF22_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCT0

UniProtKB/Swiss-Prot:

FGF22_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF22: view

Function for FGF22 Gene

Molecular function for FGF22 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

Phenotypes From GWAS Catalog for FGF22 Gene

Gene Ontology (GO) - Molecular Function for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IBA 21873635
GO:0008083 growth factor activity IBA 21873635
genes like me logo Genes that share ontologies with FGF22: view
genes like me logo Genes that share phenotypes with FGF22: view

Animal Models for FGF22 Gene

MGI Knock Outs for FGF22:

Animal Models for research

  • Taconic Biosciences Mouse Models for FGF22

miRNA for FGF22 Gene

miRTarBase miRNAs that target FGF22

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF22

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF22 Gene

Localization for FGF22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF22 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF22 gene
Compartment Confidence
extracellular 5
nucleus 3
mitochondrion 2
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS 11342227
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with FGF22: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF22 Gene

Pathways & Interactions for FGF22 Gene

PathCards logo

SuperPathways for FGF22 Gene

SuperPathway Contained pathways
1 RET signaling
2 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
3 Downstream signaling of activated FGFR2
4 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
5 PI3K/AKT activation
genes like me logo Genes that share pathways with FGF22: view

Pathways by source for FGF22 Gene

59 Qiagen pathways for FGF22 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR

Gene Ontology (GO) - Biological Process for FGF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0001934 positive regulation of protein phosphorylation IBA 21873635
GO:0008284 positive regulation of cell proliferation IBA 21873635
GO:0008543 fibroblast growth factor receptor signaling pathway IBA,TAS --
GO:0009887 animal organ morphogenesis IBA 21873635
genes like me logo Genes that share ontologies with FGF22: view

No data available for SIGNOR curated interactions for FGF22 Gene

Drugs & Compounds for FGF22 Gene

No Compound Related Data Available

Transcripts for FGF22 Gene

mRNA/cDNA for FGF22 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF22

Alternative Splicing Database (ASD) splice patterns (SP) for FGF22 Gene

No ASD Table

Relevant External Links for FGF22 Gene

GeneLoc Exon Structure for
FGF22

Expression for FGF22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FGF22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FGF22 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x8.5) and Skin - Sun Exposed (Lower leg) (x7.4).

Protein differential expression in normal tissues from HIPED for FGF22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FGF22 Gene



Protein tissue co-expression partners for FGF22 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF22

SOURCE GeneReport for Unigene cluster for FGF22 Gene:

Hs.248087

Evidence on tissue expression from TISSUES for FGF22 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with FGF22: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF22 Gene

Orthologs for FGF22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FGF22 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia FGF22 29 30
  • 86.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FGF22 29 30
  • 81.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fgf22 29
  • 81.38 (n)
Mouse
(Mus musculus)
Mammalia Fgf22 29 16 30
  • 81.38 (n)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia FGF22 30
  • 81 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FGF22 30
  • 68 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FGF22 30
  • 60 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FGF22 29 30
  • 74.2 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii fgf22 30 30
  • 43 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CS-FGF9/16/20 30
  • 19 (a)
OneToMany
Species where no ortholog for FGF22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FGF22 Gene

ENSEMBL:
Gene Tree for FGF22 (if available)
TreeFam:
Gene Tree for FGF22 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FGF22: view image
Alliance of Genome Resources:
Additional Orthologs for FGF22

Paralogs for FGF22 Gene

(16) SIMAP similar genes for FGF22 Gene using alignment to 3 proteins:

  • FGF22_HUMAN
  • K7ELB9_HUMAN
  • O60371_HUMAN
genes like me logo Genes that share paralogs with FGF22: view

Variants for FGF22 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FGF22 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FGF22 Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
esv1315871 CNV insertion 17803354
esv2176059 CNV deletion 18987734
esv2717757 CNV deletion 23290073
esv2740886 CNV deletion 23290073
esv3425099 CNV insertion 20981092
esv3643357 CNV loss 21293372
esv3643358 CNV gain 21293372
esv990334 CNV insertion 20482838
nsv428360 CNV gain 18775914
nsv470101 CNV loss 18288195
nsv577978 CNV gain 21841781
nsv578163 CNV loss 21841781
nsv953938 CNV deletion 24416366

Variation tolerance for FGF22 Gene

Gene Damage Index Score: 2.92; 48.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FGF22 Gene

Human Gene Mutation Database (HGMD)
FGF22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FGF22
Leiden Open Variation Database (LOVD)
FGF22

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF22 Gene

Disorders for FGF22 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FGF22 Gene - From: COP

Disorder Aliases PubMed IDs
breast giant fibroadenoma
  • giant fibroadenoma
lacrimoauriculodentodigital syndrome
  • ladd
- elite association - COSMIC cancer census association via MalaCards
Search FGF22 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FGF22

genes like me logo Genes that share disorders with FGF22: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FGF22 Gene

Publications for FGF22 Gene

  1. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. (PMID: 16597617) Zhang X … Ornitz DM (The Journal of biological chemistry 2006) 2 3 4
  2. Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle. (PMID: 11342227) Nakatake Y … Itoh N (Biochimica et biophysica acta 2001) 3 4 22
  3. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. (PMID: 15806171) Beer HD … Werner S (Oncogene 2005) 3 4
  4. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain. (PMID: 15260994) Umemori H … Sanes JR (Cell 2004) 2 3
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for FGF22 Gene

Sources for FGF22 Gene