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Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
FGF21 (Fibroblast Growth Factor 21) is a Protein Coding gene. Diseases associated with FGF21 include Acquired Lipodystrophy and Hepatocellular Clear Cell Carcinoma. Among its related pathways are Lipoprotein metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF19.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005104 | fibroblast growth factor receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 18829467 |
GO:0008083 | growth factor activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | 10858549 |
GO:0005615 | extracellular space | IEA | -- |
GO:0005623 | cell | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0007165 | signal transduction | TAS | 10858549 |
GO:0007267 | cell-cell signaling | TAS | 10858549 |
GO:0008284 | positive regulation of cell proliferation | IEA | -- |
GO:0008543 | fibroblast growth factor receptor signaling pathway | IEA | -- |
GO:0010898 | positive regulation of triglyceride catabolic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FGF21 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FGF21 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FGF21 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fgf21 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fgf21 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | FGF21 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | fgf21 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
729034 | Benign: not provided | 48,756,248(+) | C/T | SYNONYMOUS_VARIANT | |
742208 | Likely Benign: not provided | 48,756,245(+) | G/A | SYNONYMOUS_VARIANT | |
744295 | Likely Benign: not provided | 48,758,034(+) | G/T | SYNONYMOUS_VARIANT | |
780578 | Benign: not provided | 48,758,211(+) | C/T | SYNONYMOUS_VARIANT | |
rs41308776 | - | p.Gly141Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2718686 | CNV | deletion | 23290073 |
esv2718687 | CNV | deletion | 23290073 |
esv2718688 | CNV | deletion | 23290073 |
esv2718689 | CNV | deletion | 23290073 |
nsv833855 | CNV | loss | 17160897 |
nsv9739 | CNV | gain+loss | 18304495 |
Disorder | Aliases | PubMed IDs |
---|---|---|
acquired lipodystrophy |
|
|
hepatocellular clear cell carcinoma |
|
|
non-alcoholic fatty liver disease |
|
|
fatty liver disease |
|
|
monckeberg arteriosclerosis |
|
|