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Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by Ref... See more...
Aliases for FGF21 Gene
External Ids for FGF21 Gene
- HGNC: 3678
- Entrez Gene: 26291
- Ensembl: ENSG00000105550
- OMIM: 609436
- UniProtKB: Q9NSA1
Previous GeneCards Identifiers for FGF21 Gene
- GC19P049818
- GC19P049626
- GC19P053934
- GC19P053950
- GC19P053951
- GC19P049259
- GC19P045638
- GC19P048756
- GC19P048757
- GC19P048764
Summaries for FGF21 Gene
-
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016]
GeneCards Summary for FGF21 Gene
FGF21 (Fibroblast Growth Factor 21) is a Protein Coding gene. Diseases associated with FGF21 include Acquired Lipodystrophy and Hepatocellular Clear Cell Carcinoma. Among its related pathways are Lipoprotein metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF19.
UniProtKB/Swiss-Prot Summary for FGF21 Gene
-
Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.
Additional gene information for FGF21 Gene
- HGNC(3678)
- Entrez Gene(26291)
- Ensembl(ENSG00000105550)
- OMIM(609436)
- UniProtKB(Q9NSA1)
- Open Targets Platform(ENSG00000105550)
- Monarch Initiative
- Search for FGF21 at DataMed
- Search for FGF21 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF21 Gene
Genomics for FGF21 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FGF21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FGF21 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF21
- Top Transcription factor binding sites by QIAGEN in the FGF21 gene promoter:
-
- ATF
- MyoD
- p300
- PPAR-gamma1
- PPAR-gamma2
- STAT3
Genomic Locations for FGF21 Gene
Genomic Locations for FGF21 Gene
- chr19:48,755,524-48,758,333
- (GRCh38/hg38)
- Size:
- 2,810 bases
- Orientation:
- Plus strand
- chr19:49,258,816-49,261,587
- (GRCh37/hg19)
- Size:
- 2,772 bases
- Orientation:
- Plus strand
Genomic View for FGF21 Gene
Genes around FGF21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.33 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
FGF21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FGF21 Gene
Proteins for FGF21 Gene
-
Protein details for FGF21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NSA1-FGF21_HUMAN
- Recommended name:
- Fibroblast growth factor 21
- Protein Accession:
- Q9NSA1
- Q8N683
Protein attributes for FGF21 Gene
- Size:
- 209 amino acids
- Molecular mass:
- 22300 Da
- Quaternary structure:
-
- Interacts (via C-terminus) with KLB; this interaction is direct. Interacts with FGFR4.
Post-translational modifications for FGF21 Gene
No Post-translational modifications
Other Protein References for FGF21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FGF21 Antibody
- GeneTex Anti-FGF21 antibody [N3C3]
-
Custom Antibody ServicesOriGene Antibodies for FGF21
- CF502771
- CF502772
- CF502785
- CF502786
- CF502787
- CF502788
- CF502815
- CF502816
- CF502850
- CF502868
- CF502897
- CF502953
- CF502954
- CF502992
- TA303289
- TA349978
- TA502771
- TA502771S
- TA502772
- TA502772S
- TA502785
- TA502785S
- TA502786
- TA502786S
- TA502787
- TA502787S
- TA502788
- TA502788S
- TA502815
- TA502815S
- TA502816
- TA502816S
- TA502850
- TA502850S
- TA502868
- TA502868S
- TA502897
- TA502897S
- TA502953
- TA502953S
- TA502954
- TA502954S
- TA502992
- TA502992S
- UM500059
- UM500059CF
- UM570059
- Novus Biologicals Antibodies for FGF21
-
Abcam antibodies for FGF21
- Invitrogen Antibodies for FGF21 (AFLGC-FGF21)
- antibodies-online: Show 63 available FGF21 Antibodies ranked by validation data
- Compare Top FGF21 Antibodies
-
Recommended
- 143 WB Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 37 WB Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FGF21
- Sino Biological Antibodies for FGF21
Protein Products
- G Biosciences Human FGF-21, Lyophilized
- RayBiotech Recombinant Human FGF-21
- Search Origene for MassSpec and Protein Over-expression Lysates for FGF21
- Origene Custom Protein Services for FGF21
- Sino Biological Recombinant Proteins for FGF21
- Sino Biological Cell Lysates for FGF21
- ProSpec Recombinant Proteins for FGF21
-
ProSci Proteins for FGF21
- fibroblast growth factor 21 [40-186]
- fibroblast growth factor 21 [90-323]
- fibroblast growth factor 21 [91-203]
- fibroblast growth factor 21 [90-094]
- fibroblast growth factor 21 [90-095]
- fibroblast growth factor 21 [90-100]
- fibroblast growth factor 21 [90-101]
- fibroblast growth factor 21 [90-104]
- fibroblast growth factor 21 [90-105]
-
Abcam proteins for FGF21
Assay Products
- RayBiotech Human FGF-21 ELISA and Custom Porcine FGF-21 ELISA
- Novus Biologicals ELISA Kits for FGF21
- antibodies-online: Show 116 available FGF21 Elisa Kits ranked by validation data
- Compare Top FGF21 Elisa Kits
-
Quality Products:
- ABIN1114914
- ABIN857064
- ABIN418605
- ABIN612700
- ABIN1672889
- ABIN4993074
- ABIN2703011
- ABIN1305174
- ABIN3198429
- ABIN5520533
- ABIN1114913
- ABIN838959
- ABIN2859244
- ABIN2761940
- ABIN4947578
- ABIN1569811
- ABIN5520534
- ABIN1081421
- ABIN5669786
- ABIN5592039
- ABIN4947575
- ABIN4947576
- ABIN4947579
- ABIN1884405
- ABIN5520536
- ABIN2039264
- ABIN1569813
- ABIN5654242
- ABIN5654243
- ABIN5654244
- ABIN1000145
- ABIN5696341
- ABIN6204291
- ABIN6204292
- ABIN1053686
-
Abcam assays for FGF21
No data available for DME Specific Peptides for FGF21 Gene
Domains & Families for FGF21 Gene
Gene Families for FGF21 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for FGF21 Gene
- InterPro:
- Blocks:
-
- Heparin binding growth factor family signature
- IL1/HBGF family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for FGF21 Gene
- GenScript: Design optimal peptide antigens:
-
- Fibroblast growth factor 21 (FGF21_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NSA1- Family:
-
- Belongs to the heparin-binding growth factors family.
Function for FGF21 Gene
Molecular function for FGF21 Gene
- UniProtKB/Swiss-Prot Function:
- Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB.
Phenotypes From GWAS Catalog for FGF21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005104 | fibroblast growth factor receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 18829467 |
| GO:0008083 | growth factor activity | IEA | -- |
Phenotypes for FGF21 Gene
- MGI mutant phenotypes for FGF21:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for FGF21:
Animal Models for FGF21 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for FGF21
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGF21 - Select products 50% OFF >
- * FGF21 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for FGF21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF21
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF21
miRNA for FGF21 Gene
- miRTarBase miRNAs that target FGF21
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF21
- Browse OriGene Inhibitory RNA Products For FGF21
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Clone Products
- Applied Biological Materials (abm): Clones for FGF21 - Select products 50% OFF >
- * FGF21 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FGF21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF21
Cell Line Products
-
Horizon Cell Lines for FGF21
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF21 Gene
Localization for FGF21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FGF21 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 3 |
| nucleus | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| lysosome | 2 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | 10858549 |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005623 | cell | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FGF21 Gene
Pathways & Interactions for FGF21 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
| 2 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
| 3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
JNK Pathway
.51
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
| 4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
|
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
|
| 5 | Nanog in Mammalian ESC Pluripotency |
GSK3 Signaling
.62
Nanog in Mammalian ESC Pluripotency
.62
|
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
|
Pathways by source for FGF21 Gene
3 BioSystems pathways for FGF21 Gene
10 KEGG pathways for FGF21 Gene
59 Qiagen pathways for FGF21 Gene
- 14-3-3 Induced Intracellular Signaling
- Actin-Based Motility by Rho Family GTPases
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Activation of PKC through GPCR
Interacting Proteins for FGF21 Gene
Selected Interacting proteins:
Q9NSA1-FGF21_HUMAN
ENSP00000471477
for FGF21 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FGF21
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | TAS | 10858549 |
| GO:0007267 | cell-cell signaling | TAS | 10858549 |
| GO:0008284 | positive regulation of cell proliferation | IEA | -- |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | IEA | -- |
| GO:0010898 | positive regulation of triglyceride catabolic process | IEA | -- |
Drugs & Compounds for FGF21 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FGF21 Gene
mRNA/cDNA for FGF21 Gene
- 1 REFSEQ mRNAs :
- 3 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000222157 893 nts (view in UCSC)
- ENST00000593756 1347 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FGF21 - Select products 50% OFF >
- * FGF21 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FGF21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF21
-
Santa Cruz Biotechnology (SCBT) CRISPR for FGF21
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF21
- Browse OriGene Inhibitory RNA Products For FGF21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF21
Clone Products
- Applied Biological Materials (abm): Clones for FGF21 - Select products 50% OFF >
- * FGF21 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FGF21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF21
Relevant External Links for FGF21 Gene
- GeneLoc Exon Structure for
- FGF21
Expression for FGF21 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for FGF21 Gene
This gene is overexpressed in Liver (x51.4).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FGF21
SOURCE GeneReport for Unigene cluster for FGF21 Gene:
Hs.283015Evidence on tissue expression from TISSUES for FGF21 Gene
- Lung(4.2)
- Liver(3.4)
- Pancreas(2.9)
- Muscle(2.9)
- Blood(2.8)
- Nervous system(2.5)
- Heart(2.4)
- Intestine(2.3)
- Kidney(2.2)
- Skin(2.2)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for FGF21
-
OriGene qPCR primer pairs and template standards for FGF21
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FGF21 Gene
Orthologs for FGF21 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FGF21 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FGF21 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FGF21 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fgf21 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fgf21 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | FGF21 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | fgf21 31 |
|
OneToOne |
- Species where no ortholog for FGF21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FGF21 Gene
- ENSEMBL:
- Gene Tree for FGF21 (if available)
- TreeFam:
- Gene Tree for FGF21 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FGF21: view image
Paralogs for FGF21 Gene
Paralogs for FGF21 Gene
(1) SIMAP similar genes for FGF21 Gene using alignment to 1 proteins:
- FGF21_HUMAN
Variants for FGF21 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FGF21 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 729034 | Benign: not provided | 48,756,248(+) | C/T | SYNONYMOUS_VARIANT | |
| 742208 | Likely Benign: not provided | 48,756,245(+) | G/A | SYNONYMOUS_VARIANT | |
| 744295 | Likely Benign: not provided | 48,758,034(+) | G/T | SYNONYMOUS_VARIANT | |
| 780578 | Benign: not provided | 48,758,211(+) | C/T | SYNONYMOUS_VARIANT | |
| rs41308776 | - | p.Gly141Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2718686 | CNV | deletion | 23290073 |
| esv2718687 | CNV | deletion | 23290073 |
| esv2718688 | CNV | deletion | 23290073 |
| esv2718689 | CNV | deletion | 23290073 |
| nsv833855 | CNV | loss | 17160897 |
| nsv9739 | CNV | gain+loss | 18304495 |
Residual Variation Intolerance Score:
83.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.60;
12.93% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FGF21 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FGF21
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FGF21 Gene
Disorders for FGF21 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| acquired lipodystrophy |
|
|
| hepatocellular clear cell carcinoma |
|
|
| non-alcoholic fatty liver disease |
|
|
| fatty liver disease |
|
|
| monckeberg arteriosclerosis |
|
|
Search FGF21 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FGF21
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FGF21 Gene
Publications for FGF21 Gene
- Different roles of N- and C- termini in the functional activity of FGF21. (PMID: 19117008) Micanovic R … Kharitonenkov A (Journal of cellular physiology 2009) 3 4 23
- Identification of a novel FGF, FGF-21, preferentially expressed in the liver. (PMID: 10858549) Nishimura T … Itoh N (Biochimica et biophysica acta 2000) 2 3 4
- Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha. (PMID: 20332535) Wang Y … Burris TP (The Journal of biological chemistry 2010) 3 23
- FGF21 signalling pathway and metabolic traits - genetic association analysis. (PMID: 20717167) Kaess BM … Tomaszewski M (European journal of human genetics : EJHG 2010) 3 41
- Serum fibroblast growth factor 21 levels in gestational diabetes mellitus in relation to insulin resistance and dyslipidemia. (PMID: 19699495) Stein S … Fasshauer M (Metabolism: clinical and experimental 2010) 3 23
ExternalLinks
Products for FGF21 Gene
- View all 20 R&D Systems FGF21 (FGF-21) Products
- View all R&D Systems FGF21 (FGF-21) Proteins and Enzymes
- View all 16 R&D Systems FGF21 (FGF-21) Primary Antibodies
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- Learn more about R&D Systems custom FGF21 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for FGF21
- CF502771
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- CF502850
- CF502868
- CF502897
- CF502953
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- CF502992
- TA303289
- TA349978
- TA502771
- TA502771S
- TA502772
- TA502772S
- TA502785
- TA502785S
- TA502786
- TA502786S
- TA502787
- TA502787S
- TA502788
- TA502788S
- TA502815
- TA502815S
- TA502816
- TA502816S
- TA502850
- TA502850S
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- TA502897
- TA502897S
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- TA502954S
- TA502992
- TA502992S
- UM500059
- UM500059CF
- UM570059
- Custom Assay Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for FGF21
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- OriGene qPCR primer pairs for FGF21
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FGF21
- Novus Biologicals proteins and lysates for FGF21
- Novus Biologicals ELISA Kits for FGF21
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FGF21
- Abcam proteins for FGF21
- Abcam assays for FGF21
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for FGF21
- Taconic Biosciences Mouse Models for FGF21
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FGF21 (AFLGC-FGF21)
- VectorBuilder Custom and pre-made DNA vectors for FGF21 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FGF21 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FGF21 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FGF21 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FGF21
- antibodies-online: Show 63 available FGF21 Antibodies ranked by validation data
- Compare Top FGF21 Antibodies
- Recommended
- 143 WB Antibodies (anti-human)
- 9 FACS Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 2 RIA Antibodies (anti-human)
- 1 EIA Antibody (anti-human)
- 1 ICC Antibody (anti-human)
- 37 WB Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 15 WB Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- antibodies-online: Show 116 available FGF21 Elisa Kits ranked by validation data
- Compare Top FGF21 Elisa Kits
- Quality Products:
- ABIN1114914
- ABIN857064
- ABIN418605
- ABIN612700
- ABIN1672889
- ABIN4993074
- ABIN2703011
- ABIN1305174
- ABIN3198429
- ABIN5520533
- ABIN1114913
- ABIN838959
- ABIN2859244
- ABIN2761940
- ABIN4947578
- ABIN1569811
- ABIN5520534
- ABIN1081421
- ABIN5669786
- ABIN5592039
- ABIN4947575
- ABIN4947576
- ABIN4947579
- ABIN1884405
- ABIN5520536
- ABIN2039264
- ABIN1569813
- ABIN5654242
- ABIN5654243
- ABIN5654244
- ABIN1000145
- ABIN5696341
- ABIN6204291
- ABIN6204292
- ABIN1053686
- antibodies-online: Show 80 available FGF21 Proteins ranked by validation data
- Compare Top FGF21 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FGF21
- Search Santa Cruz Biotechnology (SCBT) for FGF21 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FGF21
- Search for FGF21 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for FGF21
- fibroblast growth factor 21 [40-186]
- fibroblast growth factor 21 [90-323]
- fibroblast growth factor 21 [91-203]
- fibroblast growth factor 21 [90-094]
- fibroblast growth factor 21 [90-095]
- fibroblast growth factor 21 [90-100]
- fibroblast growth factor 21 [90-101]
- fibroblast growth factor 21 [90-104]
- fibroblast growth factor 21 [90-105]
- Horizon Cell Lines for FGF21
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FGF21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FGF21
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FGF21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FGF21
Sources for FGF21 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB