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The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]
FGF20 (Fibroblast Growth Factor 20) is a Protein Coding gene. Diseases associated with FGF20 include Renal Hypodysplasia/Aplasia 2 and Renal Agenesis, Bilateral. Among its related pathways are RET signaling and Signaling by FGFR2 in disease. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF9.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005102 | signaling receptor binding | TAS | 11306498 |
GO:0005104 | fibroblast growth factor receptor binding | IEA | -- |
GO:0008083 | growth factor activity | IEA,ISS | -- |
GO:0043395 | heparan sulfate proteoglycan binding | TAS | 11306498 |
GO:0090722 | receptor-receptor interaction | IDA | 24157794 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Downstream signaling of activated FGFR2 | ||
3 | Apoptotic Pathways in Synovial Fibroblasts |
Cellular Apoptosis Pathway
.85
Mitochondrial Apoptosis
.85
Apoptotic Pathways in Synovial Fibroblasts
.84
p53 Mediated Apoptosis
.84
DHA Signaling
.74
Telomerase Components in Cell Signaling
.72
PPAR Pathway
.66
|
Rac1 Pathway
.65
Glioma Invasiveness
.64
Actin-Based Motility by Rho Family GTPases
.62
ERK5 Signaling
.61
eIF2 Pathway
.60
Rap1 Pathway
.57
Nuclear Receptor Activation by Vitamin-A
.57
|
4 | Negative regulation of FGFR3 signaling | ||
5 | GPCR Pathway |
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
|
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | TAS | -- |
GO:0007165 | signal transduction | TAS | 10913340 |
GO:0007267 | cell-cell signaling | TAS | 10913340 |
GO:0008284 | positive regulation of cell proliferation | IEA,TAS | 11306498 |
GO:0008543 | fibroblast growth factor receptor signaling pathway | IEA,TAS | 11306498 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FGF20 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FGF20 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FGF20 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fgf20 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fgf20 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FGF20 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FGF20 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FGF20 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fgf20 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.2769 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fgf20a 31 |
|
OneToMany | |
fgf20b 30 31 |
|
OneToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CS-FGF9/16/20 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708485 | Benign: not provided | 17,001,751(-) | G/T | SYNONYMOUS_VARIANT | |
733416 | Likely Benign: not provided | 17,001,798(-) | T/C | MISSENSE_VARIANT | |
736558 | Benign: not provided | 16,995,699(-) | C/G | MISSENSE_VARIANT | |
745723 | Likely Benign: not provided | 17,001,955(-) | C/T | SYNONYMOUS_VARIANT | |
753587 | Likely Benign: not provided | 16,995,688(-) | A/G | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv250e55 | CNV | gain | 17911159 |
esv2759599 | CNV | gain | 17122850 |
esv3572602 | CNV | loss | 25503493 |
nsv1018645 | CNV | gain | 25217958 |
nsv8304 | CNV | gain+loss | 18304495 |
nsv831243 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
renal hypodysplasia/aplasia 2 |
|
|
renal agenesis, bilateral |
|
|
bilateral renal aplasia |
|
|
parkinson disease, late-onset |
|
|
deafness, autosomal recessive 71 |
|
|