External Ids for FGF20 Gene
Previous GeneCards Identifiers for FGF20 Gene
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]
GeneCards Summary for FGF20 Gene
FGF20 (Fibroblast Growth Factor 20) is a Protein Coding gene. Diseases associated with FGF20 include Renal Hypodysplasia/Aplasia 2 and Renal Agenesis, Bilateral. Among its related pathways are RET signaling and Downstream signaling of activated FGFR2. Gene Ontology (GO) annotations related to this gene include growth factor activity and fibroblast growth factor receptor binding. An important paralog of this gene is FGF9.
UniProtKB/Swiss-Prot Summary for FGF20 Gene
Neurotrophic factor that regulates central nervous development and function.