The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation s... See more...

Aliases for FGF2 Gene

Aliases for FGF2 Gene

  • Fibroblast Growth Factor 2 2 3 4 5
  • Fibroblast Growth Factor 2 (Basic) 2 3
  • Heparin-Binding Growth Factor 2 3 4
  • HBGF-2 3 4
  • FGF-2 3 4
  • BFGF 3 4
  • FGFB 3 4
  • Basic Fibroblast Growth Factor BFGF 3
  • Basic Fibroblast Growth Factor 4
  • Prostatropin 3

External Ids for FGF2 Gene

Previous HGNC Symbols for FGF2 Gene

  • FGFB

Previous GeneCards Identifiers for FGF2 Gene

  • GC04P124660
  • GC04P124027
  • GC04P124141
  • GC04P124206
  • GC04P124105
  • GC04P123747
  • GC04P119474

Summaries for FGF2 Gene

Entrez Gene Summary for FGF2 Gene

  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

CIViC Summary for FGF2 Gene

GeneCards Summary for FGF2 Gene

FGF2 (Fibroblast Growth Factor 2) is a Protein Coding gene. Diseases associated with FGF2 include Corneal Neovascularization and Chronic Ulcer Of Skin. Among its related pathways are FGFR1 mutant receptor activation and MicroRNAs in cardiomyocyte hypertrophy. Gene Ontology (GO) annotations related to this gene include cytokine activity and heparin binding. An important paralog of this gene is FGF1.

UniProtKB/Swiss-Prot Summary for FGF2 Gene

  • Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677).

Gene Wiki entry for FGF2 Gene

Additional gene information for FGF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FGF2 Gene

Genomics for FGF2 Gene

GeneHancer (GH) Regulatory Elements for FGF2 Gene

Promoters and enhancers for FGF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J122825 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 510.6 +1.6 1614 5.4 SIN3A NRF1 USF1 SP1 PHF8 CTCF ZIC2 POLR2A ZBTB10 ZBTB26 FGF2 NONHSAG038808.2 RF00224 CETN4P lnc-SPATA5-6 RPS26P23
GH04J122824 Enhancer 0.7 Ensembl 500.7 -1.9 -1907 0.4 AFF1 CTBP1 NCOR1 IRF1 IRF2 TAL1 HDAC2 PRDM1 TCF12 DPF2 FGF2 RF00224 RF00017-4402 NUDT6 SPATA5 ENSG00000244083 RPL34P12 lnc-NUDT6-4
GH04J122795 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 17.1 -28.6 -28556 4.5 USF1 TEAD4 TRIM28 REST EP300 CTBP1 MYC TAF9B POLR2A HDAC2 FGF2 NUDT6 SPATA5 IL21-AS1 CETN4P SPRY1 piR-57133-464 piR-33492-031
GH04J122763 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 15.1 -61.8 -61792 3.8 TCF12 JUND FOS POLR2A AFF1 HES1 EP300 ZNF830 RBM25 NCOR1 CETN4P FGF2 BBS12 NUDT6 SPATA5 CCNA2 RF00994-764 LOC727709
GH04J122781 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 12.7 -43.0 -42973 4.2 JUND TEAD4 REST EP300 POLR2A FOXA2 FOS NR3C1 FOSL2 YY1 HSALNG0036866 FGF2 NUDT6 SPATA5 CETN4P SPRY1 RF00994-764
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FGF2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FGF2

Top Transcription factor binding sites by QIAGEN in the FGF2 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • LyF-1
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for FGF2 Gene

Genomic Locations for FGF2 Gene
chr4:122,826,708-122,898,236
(GRCh38/hg38)
Size:
71,529 bases
Orientation:
Plus strand
chr4:123,747,863-123,819,391
(GRCh37/hg19)
Size:
71,529 bases
Orientation:
Plus strand

Genomic View for FGF2 Gene

Genes around FGF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FGF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FGF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FGF2 Gene

Proteins for FGF2 Gene

  • Protein details for FGF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09038-FGF2_HUMAN
    Recommended name:
    Fibroblast growth factor 2
    Protein Accession:
    P09038
    Secondary Accessions:
    • A4LBB8
    • O00527
    • P78443
    • Q16443
    • Q5PY50
    • Q7KZ11
    • Q7KZ72
    • Q9UC54
    • Q9UCS5
    • Q9UCS6

    Protein attributes for FGF2 Gene

    Size:
    288 amino acids
    Molecular mass:
    30770 Da
    Quaternary structure:
    • Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity).
    Miscellaneous:
    • This protein binds heparin more strongly than does aFGF.
    • [Isoform 1]: Starts at an alternative CUG codon.
    • [Isoform 2]: Starts at an alternative CUG codon.
    • [Isoform 4]: Starts at an alternative CUG codon.
    SequenceCaution:
    • Sequence=AAA52448.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAB21432.2; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABO43041.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA28027.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA73868.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAX05222.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for FGF2 Gene

    Alternative splice isoforms for FGF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FGF2 Gene

Post-translational modifications for FGF2 Gene

  • Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion.
  • Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FGF2 Gene

Antibody Products

  • Abcam antibodies for FGF2

Protein Products

  • Abcam proteins for FGF2

Assay Products

No data available for DME Specific Peptides for FGF2 Gene

Domains & Families for FGF2 Gene

Gene Families for FGF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • FDA approved drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for FGF2 Gene

Blocks:
  • Heparin binding growth factor family signature
  • IL1/HBGF family signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FGF2 Gene

GenScript: Design optimal peptide antigens:
  • Fibroblast growth factor 2 (Basic) (D9ZGF5_HUMAN)
  • Basic fibroblast growth factor (FGF2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P09038

UniProtKB/Swiss-Prot:

FGF2_HUMAN :
  • Belongs to the heparin-binding growth factors family.
Family:
  • Belongs to the heparin-binding growth factors family.
genes like me logo Genes that share domains with FGF2: view

Function for FGF2 Gene

Molecular function for FGF2 Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Retains almost half of its activity after treatment at pH 2.0 for 3 hours at 20 degrees Celsius. {ECO:0000269 PubMed:1721615}; Temperature dependence: Inactivated after 3 minutes at 60 degrees Celsius or 1 minute at 80 degrees Celsius. {ECO:0000269 PubMed:1721615};
GENATLAS Biochemistry:
fibroblast growth factor 2,basic,multifunctional protein,144kDa,expressed by brain,retina cartilage,inducer of anteroposterior neural pattern,essential for FGF8 and FGF10 reciprocal regulation loop in limb induction in mouse. FGF2 expression is under the control of an antisense transcript (see NUDT6)

LifeMap Function Summary for FGF2 Gene

It affects the following cells:
FGF2 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for FGF2 Gene

Gene Ontology (GO) - Molecular Function for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005104 fibroblast growth factor receptor binding IPI 2161540
GO:0005125 cytokine activity IDA 18059339
GO:0005178 integrin binding IDA 28302677
GO:0005515 protein binding IPI 10490103
GO:0008083 growth factor activity IDA 18059339
genes like me logo Genes that share ontologies with FGF2: view
genes like me logo Genes that share phenotypes with FGF2: view

Animal Models for FGF2 Gene

MGI Knock Outs for FGF2:
  • Fgf2 Fgf2<tm2Doe>
  • Fgf2 Fgf2<tm1Doe>
  • Fgf2 Fgf2<tm1Zllr>
  • Fgf2 Fgf2<tm1b(EUCOMM)Wtsi>
  • Fgf2 Fgf2<tm1Bee>
  • Fgf2 Fgf2<tm1Bas>

Animal Model Products

  • Taconic Biosciences Mouse Models for FGF2

miRNA for FGF2 Gene

miRTarBase miRNAs that target FGF2

Clone Products

  • Addgene plasmids for FGF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FGF2 Gene

Localization for FGF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FGF2 Gene

Secreted. Nucleus. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane. Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FGF2 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 3
cytoskeleton 3
mitochondrion 3
cytosol 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 2161540
GO:0005623 cell IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FGF2: view

Pathways & Interactions for FGF2 Gene

PathCards logo

SuperPathways for FGF2 Gene

SuperPathway Contained pathways
1 RET signaling
2 Downstream signaling of activated FGFR2
3 Apoptotic Pathways in Synovial Fibroblasts
.85
.85
.84
.84
.74
.72
.66
.65
.64
.62
.61
.60
.57
.57
4 Negative regulation of FGFR3 signaling
5 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
genes like me logo Genes that share pathways with FGF2: view

Pathways by source for FGF2 Gene

3 GeneGo (Thomson Reuters) pathways for FGF2 Gene
  • Cell adhesion_Plasmin signaling
  • Development FGF-family signaling
  • Development FGFR signaling pathway
61 Qiagen pathways for FGF2 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin-Based Motility by Rho Family GTPases
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
2 Cell Signaling Technology pathways for FGF2 Gene

SIGNOR curated interactions for FGF2 Gene

Activates:
Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS 9712850
GO:0001525 angiogenesis IEA --
GO:0001658 branching involved in ureteric bud morphogenesis IDA 12631064
GO:0001938 positive regulation of endothelial cell proliferation IDA,IMP 18059339
genes like me logo Genes that share ontologies with FGF2: view

Drugs & Compounds for FGF2 Gene

(88) Drugs for FGF2 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pentosan Polysulfate Approved Pharma Target, antagonist, inhibitor 0
Sirolimus Approved, Investigational Pharma Target, other/unknown, inhibitor Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors 2191
Heparin Approved, Investigational Pharma Antagonist, Target 1028
Sucralfate Approved Pharma Target, agonist, inducer 14
Thalidomide Approved, Investigational, Withdrawn Pharma Immunomodulatory agent,sedative drug,angiogenesis inhibitor, TNF-alpha synthesis inhibitor, Immunomodulatory agents 637

(45) Additional Compounds for FGF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FGF2: view

Transcripts for FGF2 Gene

mRNA/cDNA for FGF2 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products